Article
Chemistry, Medicinal
Maria Grazia Morgese, Stefania Schiavone, Maria Bove, Anna Laura Colia, Stefania Dimonte, Paolo Tucci, Luigia Trabace
Summary: The study investigated the protective role of lifelong exposure to n-3 PUFA-enriched or n-6/n-3 balanced diets in a rat model of A beta-induced toxicity. Both diets were found to reduce ROS production and oxidative stress, while affecting neurotransmitter levels.
Article
Biochemistry & Molecular Biology
Nadine Rohwer, Julia Jelleschitz, Annika Hoehn, Daniela Weber, Anja A. Kuehl, Chaoxuan Wang, Rei-Ichi Ohno, Nadja Kampschulte, Anne Pietzner, Nils Helge Schebb, Karsten-H. Weylandt, Tilman Grune
Summary: Inflammatory bowel disease (IBD) is associated with liver inflammation, and omega-3 polyunsaturated fatty acids (n-3 PUFA) can reduce the severity of IBD. This study found that increasing n-3 PUFA levels in mice also reduced liver inflammation and oxidative damage caused by colon inflammation. The anti-inflammatory effects of n-3 PUFA were accompanied by an increase in specific lipid compounds derived from n-3 PUFA. These findings demonstrate a correlation between the lipidome of n-3 PUFA and inflammatory changes in the liver during colitis, suggesting the potential of n-3 PUFA in reducing liver stress.
Article
Environmental Sciences
Nagwa Mohamed, Dalia H. El-Kashef, Ghada M. Suddek
Summary: Flavocoxid demonstrated a potential protective effect in acetic acid-induced colitis model, by attenuating oxidative stress, inflammation, and apoptosis in colonic tissues of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Nutrition & Dietetics
Nazek Noureddine, Ivan Hartling, Paulina Wawrzyniak, Pakeerathan Srikanthan, Phing-How Lou, Eliana Lucchinetti, Stefanie D. Kraemer, Gerhard Rogler, Michael Zaugg, Martin Hersberger
Summary: Through the study of mouse models and human cells, it was found that lipid emulsions rich in n-3 PUFA have more favorable clinical outcomes in total parenteral nutrition, which is associated with the generation of lipid mediators, especially SPMs and endocannabinoids in the spleen.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Immunology
Nagwa I. Mohamed, Ghada M. Suddek, Dalia H. El-Kashef
Summary: In an experimental colitis model in rats, pretreatment with molsidomine significantly reduced disease activity index, colon mass index, colonic macroscopic and histological damage, while also influencing various biochemical markers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Diva de Aguiar Magalhaes, Jalles Arruda Batista, Stefany Guimaraes Sousa, Jayro dos Santos Ferreira, Lauanda da Rocha Rodrigues, Cynthia Maria Carvalho Pereira, Jose Victor do Nascimento Lima, Ieda Figueira de Albuquerque, Nayonara Lanara Sousa Dutra Bezerra, Carlos Eduardo da Silva Monteiro, Alvaro Xavier Franco, Humberto Barbosa da Costa Filho, Francisco Cleber Silva Ferreira, Alexandre Havt, David Di Lenardo, Daniel Fernando Pereira Vasconcelos, Jefferson Soares de Oliveira, Pedro Marcos Gomes Soares, Andre Luiz dos Reis Barbosa
Summary: The study revealed that the M1 muscarinic acetylcholine receptor plays an anti-inflammatory role in experimental colitis, with McN-A-343 treatment significantly reducing intestinal damage and inflammation. Blocking the M1 receptor can lead to the failure of the anti-inflammatory response.
Article
Medicine, Research & Experimental
Mohamed Shalaby, Rania R. Abdelaziz, Hamdy A. Ghoneim, Ghada M. Suddek
Summary: The study evaluated the effects of tyrosine kinase inhibitor (imatinib) on experimentally induced ulcerative colitis (UC) in rats. Imatinib pretreatment significantly reduced UC-induced damage and inflammation markers, as well as oxidative stress levels. Imatinib also suppressed the activity of the NF-kB/JAK2/ STAT3/COX2 signaling pathway. Therefore, imatinib may be a potential therapeutic option for UC.
Article
Biochemistry & Molecular Biology
Carla F. S. Guazelli, Victor Fattori, Camila R. Ferraz, Sergio M. Borghi, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri
Summary: Hesperidin methyl chalcone (HMC) exhibits significant protective effects in a mouse model of acetic acid-induced colitis, reducing neutrophil infiltration, edema, and colon damage while increasing antioxidant status. In addition, HMC inhibits pro-inflammatory cytokines in the colon, possibly through NF-kappa B inhibition. These findings suggest HMC as a promising therapeutic approach for the treatment of ulcerative colitis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Plant Sciences
Gonzalez-Ramirez Adriana Estrella, Gonzalez-Trujano Maria Eva, Hernandez-Leon Alberto, Valle-Dorado Maria Guadalupe, Carballo-Villalobos Azucena, Orozco-Suarez Sandra, Alvarado-Vasquez Noe, Lopez-Munoz Francisco Javier
Summary: The study aimed to evaluate the protective properties of Agastache mexicana and its bioactive compounds in improving pathological gastrointestinal conditions in rodents. Results showed that limonene, found in A. mexicana, exhibited significant antinociceptive and anti-inflammatory effects, highlighting the potential of monoterpenes as natural products for treating gastrointestinal afflictions such as ulcers, colitis, and abdominal pain.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hongrui Guo, Hai Guo, Yue Xie, Yinyin Chen, Changfang Lu, Zhouping Yang, Yanqiu Zhu, Yujuan Ouyang, Yu Zhang, Xianxiang Wang
Summary: This study demonstrates that PMNFs have an inhibitory effect on ulcerative colitis by preventing oxidative damage, inflammation, and intestinal barrier breakdown. It activates the antioxidant pathway and suppresses the expression of pro-inflammatory factors, leading to the prevention of colitis. PMNFs also prevent the reduction of tight junction proteins and mucin-2 and the up-regulation of epithelial apoptosis caused by colitis. Thus, PMNFs have the potential to be applied in the treatment of various oxidative stress or inflammation-related diseases.
Article
Immunology
Michel Archange Fokam Tagne, Anatole Tchoffo, Paul Aime Noubissi, Aimee Gisolene Mazo, Blaise Kom, Joseph Ngakou Mukam, Selestin Sokeng Dongmo, Rene Kamgang
Summary: The study showed that the hydroethanolic extract of Maesa lanceolata leaves demonstrated significant efficacy in treating acetic acid-induced colitis in rats by reducing symptoms such as fever, diarrhea, mucus, and bloody stools, while increasing body weight. Additionally, the extract exhibited anti-inflammatory and antioxidant effects by reducing inflammatory markers and increasing antioxidant levels in the colon and blood.
INFLAMMOPHARMACOLOGY
(2021)
Article
Immunology
Maryam Ghasemi-Dehnoo, Hossein Amini-Khoei, Zahra Lorigooini, Maryam AnjomShoa, Elham Bijad, Mahmoud Rafieian-Kopaei
Summary: The study found that syringic acid significantly reduced inflammatory and apoptotic gene expressions in rats with UC, improved colon tissue damage, decreased oxidative stress and inflammation, and increased antioxidant capacity.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qi Liu, Pengyue Du, Yue Zhu, Xintong Zhang, Jingzeng Cai, Ziwei Zhang
Summary: Txnrd3 overexpression leads to intracellular calcium outflow and increased ROS, which eventually leads to necrosis and focal death of colon cancer cells, while causing Txnrd3-/- mice depth of the crypt deeper, weakened intestinal secretion and immune function and aggravate the occurrence of ulcerative colitis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Ramanpreet Kaur, Dhimant Desai, Shantu Amin, Kaisar Raza, Aman Bhalla, Pooja Yadav, Naveen Kaushal
Summary: This study demonstrates the translational applicability of a novel class of COX inhibitors containing Selenium for efficiently managing inflammatory disorders such as Ulcerative Colitis (UC). Selenocoxib-3 shows promising pharmacokinetics, therapeutic potential, and safety margins compared to its parent NSAID Celecoxib. It effectively resolves the symptoms of DSS-induced colitis and mitigates inflammation and colon damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Immunology
Heba M. Hafez, Mohamed A. Ibrahim, Walaa Yehia Abdelzaher, Alyaa A. Gad, Sara Mohammed Naguib Abdel Hafez, Seham A. Abdel-Gaber
Summary: The study found that MRT has a protective effect against UC by reducing colonic damage and oxidative stress, as well as modulating the NLRP3/caspase-1 inflammatory pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pramod Kumar, Gajanand Sharma, Varun Gupta, Ramanpreet Kaur, Kanika Thakur, Ruchi Malik, Anil Kumar, Naveen Kaushal, Kaisar Raza
ACS CHEMICAL NEUROSCIENCE
(2018)
Article
Hematology
Pulkit Rastogi, Prashant Sharma, Neelam Varma, Dmitry Sukhachev, Naveen Kaushal, Ishwar Bihana, Man Updesh Singh Sachdeva, Shano Naseem, Pankaj Malhotra
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2018)
Review
Pharmacology & Pharmacy
Jagdish Rai, Kuldeep Kaushik
SAUDI PHARMACEUTICAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Rankaljeet Kaur, Preety Ghanghas, Pulkit Rastogi, Naveen Kaushal
BIOLOGICAL TRACE ELEMENT RESEARCH
(2019)
Article
Multidisciplinary Sciences
Ramanpreet Kaur, Shivani Thakur, Pulkit Rastogi, Naveen Kaushal
Article
Pharmacology & Pharmacy
Pramod Kumar, Gajanand Sharma, Varun Gupta, Ramanpreet Kaur, Kanika Thakur, Ruchi Malik, Anil Kumar, Naveen Kaushal, Om Prakash Katare, Kaisar Raza
Article
Cardiac & Cardiovascular Systems
Naveen Kaushal, Shallu Dhadwal, Parminder Kaur
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Roobee Garla, Nikita Sharma, Shamli, Naveen Kaushal, Mohan Lal Garg
Summary: Exposure to arsenic results in elevated accumulation of arsenic in liver and kidney tissues, leading to oxidative stress, impaired liver and kidney function, and histological abnormalities. Zinc supplementation can ameliorate these toxic effects by restoring the antioxidant defense system and improving liver and kidney function.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Preety Ghanghas, Monika Sharma, Dhimant Desai, Kaisar Raza, Aman Bhalla, Pramod Kumar, Dipika Narula, Shantu Amin, Sankar Nath Sanyal, Naveen Kaushal
Summary: The study revealed that Se-substituted SAHA (SelSA-1) has higher anti-carcinogenic potential and wider safety profiles in treating colorectal cancer, with better pharmacokinetic data and enhanced chemotherapeutic effects compared to the traditional HDAC inhibitor SAHA.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Cell Biology
Ramanpreet Kaur, Dhimant Desai, Shantu Amin, Kaisar Raza, Aman Bhalla, Pooja Yadav, Naveen Kaushal
Summary: This study demonstrates the translational applicability of a novel class of COX inhibitors containing Selenium for efficiently managing inflammatory disorders such as Ulcerative Colitis (UC). Selenocoxib-3 shows promising pharmacokinetics, therapeutic potential, and safety margins compared to its parent NSAID Celecoxib. It effectively resolves the symptoms of DSS-induced colitis and mitigates inflammation and colon damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Rajbinder K. Virk, Roobee Garla, Naveen Kaushal, Mohinder P. Bansal, Mohan L. Garg, Biraja P. Mohanty
Summary: Long term exposure to arsenic through consumption of contaminated groundwater is a global issue, but arsenic compounds are also emerging as potential chemotherapeutic drugs. Arsenic speciation studies have significantly contributed to our understanding of the biological behavior of arsenic in humans, but there are limitations and challenges in interpreting arsenic metabolism. Various technologies have identified hundreds of metabolic arsenic conjugates, but the relationship between these species and the metabolic pathway of arsenic remains unclear. New experimental methodologies have revealed novel biorelevant arsenic species, but there is still a need to focus on identifying and characterizing different types of arsenicals in a comprehensive manner.
Article
Multidisciplinary Sciences
Naveen Kaushal, Megha Gupta, Era Kulshreshtha
Article
Obstetrics & Gynecology
Kuldeep Kaushik, Naveen Kaushal, Natwar Raj Kalla
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE
(2018)