Article
Food Science & Technology
Joseph Festa, Aamir Hussain, Amon Hackney, Unmesh Desai, Tarsem S. Sahota, Harprit Singh, Mariasole Da Boit
Summary: Endothelial dysfunction (ED), secondary to reduced nitric oxide (NO) production and oxidative stress, is an early marker of atherosclerosis. Elderberry extract (EB) with high anthocyanin content has vascular protective effects and can prevent monocyte adhesion and inflammatory response. EB upregulates key markers of endothelial function and ameliorates ED, suggesting its potential use in preventing atherosclerosis progression.
FOOD SCIENCE & NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Kyung Ha Ku, Michelle K. Dubinsky, Aravin N. Sukumar, Noeline Subramaniam, Manon Y. M. Feasson, Ranju Nair, Eileen Tran, Brent M. Steer, Britta J. Knight, Philip A. Marsden
Summary: The study reveals that the SSRE and KLF elements in the eNOS promoter play critical roles in endothelial cells, providing new mechanistic insights into the transcription of the eNOS gene under chronic shear stress in vivo.
Article
Nutrition & Dietetics
Jia-Ning Syu, Hung-Yu Lin, Tun Yu Huang, Der-Yen Lee, En-Pei Isabel Chiang, Feng-Yao Tang
Summary: In this study, it was found that trimethylamine-N-oxide (TMAO) has detrimental effects on the neovascularization of human endothelial progenitor cells (hEPCs), while docosahexaenoic acid (DHA) could alleviate these effects. The mechanism involves upregulation of miR-221 level, inactivation of Akt/eNOS and MAPK/ERK signaling cascades, suppression of ?-GCS protein, and decreased levels of glutathione (GSH) and GSH/GSSG ratio. DHA reverses these effects by suppressing miR-221 level, activating Akt/eNOS and MAPK/ERK signaling cascades, increasing expression of ?-GCS protein, and increasing cellular GSH level and GSH/GSSG ratio in hEPCs.
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Pharmacology & Pharmacy
Xiaowan Han, Tong Li, Tieshan Wang, Baofu Wang, Yang Li, Lei Wang, Ziwen Lu, Aiming Wu, Lisong Liu, Guozhong Pan, Mingjing Zhao
Summary: This study evaluated the correlation between different microparticle phenotypes and plaque burden, and investigated the role of microparticles in atherosclerosis. The results showed that CD11a(+) LMP and CD11a(+)/CD45(+) LMP may be potential biomarkers for predicting carotid atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tian-tian Liu, Huan-huan Xu, Ze-juan Liu, He-ping Zhang, Hai-tao Zhou, Zhi-xiang Zhu, Zhi-qiang Wang, Jing-yi Xue, Qiang Li, Yi Ma, Hong-jie You, Da-li Luo
Summary: Endothelial dysfunction is a central characteristic of cardiovascular pathogenesis in diabetes mellitus, characterized by impaired eNOS and NO bioavailability. This study identified the role of CaM in the dysfunction of eNOS in diabetes. Downregulated CaM expression was found to be responsible for endothelial injury and impaired angiogenesis in diabetes. The findings provide a novel mechanism and target for protecting against diabetic endothelial injury.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Shumpei Fujie, Natsuki Hasegawa, Naoki Horii, Kenichiro Inoue, Masataka Uchida, Motoyuki Iemitsu
Summary: The study found that chronic Chlorella intake combined with aerobic exercise training can enhance endothelial vasorelaxation in aged mice by increasing arterial NO production.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Chemistry, Medicinal
Chin-Feng Hsuan, Thung-Lip Lee, Wei-Kung Tseng, Chau-Chung Wu, Chi-Chang Chang, Tsui-Ling Ko, Ya-Ling Chen, Jer-Yiing Houng
Summary: The study demonstrated that extracts from Glossogyne tenuifolia (GT) can significantly increase nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs), with the root methanol extract showing the most potent effect. The root methanol extract increased NO production by increasing eNOS expression and activating eNOS phosphorylation at serine(1177).
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Julia C. Benincasa, Luiz H. de Freitas Filho, Giane D. Carneiro, Micheli S. Sielski, Selma Giorgio, Claudio C. Werneck, Cristina P. Vicente
CELL BIOLOGY INTERNATIONAL
(2019)
Article
Cell Biology
Leticia D. Lucke, Fernanda O. Bortolazzo, Viviane Theodoro, Lucas Fujii, Andre L. Bombeiro, Maira Felonato, Rodrigo A. Dalia, Giane D. Carneiro, Luciana P. Cartarozzi, Cristina Pontes Vicente, Alexandre L. R. Oliveira, Fernanda A. S. Mendonca, Marcelo A. M. Esquisatto, Edson R. Pimentel, Andrea A. de Aro
CELL PROLIFERATION
(2019)
Article
Cell & Tissue Engineering
Giane D. Carneiro, Micheli S. Sielski, Cristiano Pedroso Vieira, Fabio Trindade Maranhao Costa, Claudio C. Werneck, Cristina P. Vicente
Article
Hematology
Nadine Mueller-Calleja, Anne Hollerbach, Svenja Ritter, Denise G. Pedrosa, Dennis Strand, Claudine Graf, Christoph Reinhardt, Susanne Strand, Philippe Poncelet, John H. Griffin, Karl J. Lackner, Wolfram Ruf
Article
Pharmacology & Pharmacy
Caroline Honaiser Lescano, Guilherme Leonardi, Pedro Henrique Portugal Torres, Tiago Nardi Amaral, Luiz Henrique de Freitas Filho, Edson Antunes, Cristina Pontes Vicente, Gabriel Forato Anhe, Fabiola Zakia Monica
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Nadine Mueller-Calleja, Anne Hollerbach, Jennifer Royce, Svenja Ritter, Denise Pedrosa, Thati Madhusudhan, Sina Teifel, Myriam Meineck, Friederike Haeuser, Antje Canisius, T. Son Nguyen, Johannes Braun, Kai Bruns, Anna Etzold, Ulrich Zechner, Susanne Strand, Markus Radsak, Dennis Strand, Jian-Ming Gu, Julia Weinmann-Menke, Charles T. Esmon, Luc Teyton, Karl J. Lackner, Wolfram Ruf
Summary: The study revealed that antiphospholipid antibodies (aPLs) recognize endosomal lysobisphosphatidic acid (LBPA) presented by the endothelial protein C receptor (EPCR), leading to thrombosis induction and inflammatory signaling, contributing to autoimmune pathologies and autoantibody production. Pharmacological intervention targeting the EPCR-LBPA signaling pathway can attenuate these pathologies.
Review
Nutrition & Dietetics
Joao V. S. Guerra, Marieli M. G. Dias, Anna J. V. C. Brilhante, Maiara F. Terra, Marta Garcia-Arevalo, Ana Carolina M. Figueira
Summary: The incidence of NCDs is increasing globally, with changes in dietary and physical activity patterns, as well as genetic factors, being main contributors. Understanding the molecular mechanisms of these diseases can help in developing more effective treatments. NCDs play a crucial role globally and have an impact on the progression and severity of COVID-19.
Article
Hematology
Caroline Fernanda Sanches Dal Pozzo, Micheli Severo Sielski, Benedicto de Campos Vidal, Claudio C. Werneck, Cristina Pontes Vicente
Summary: The peptide p1158/59 was found to increase thrombus size and gelatinase activity, exacerbate vascular lesion, and not recover endothelial loss. It also promoted neointima growth and collagen birefringence, indicating collagen fibers reorganization. After 14 days, the peptide promoted increased re-endothelization and decreased gelatinase activity.
THROMBOSIS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Viviane Theodoro, Lucas de Oliveira Fujii, Leticia Dudri Lucke, Fernanda Oriani Bortolazzo, Daniela Fernanda Dezotti Silva, Giane Daniela Carneiro, Maria Esmeria Corezola Amaral, Camila Andrea de Oliveira, Thiago Antonio Moretti de Andrade, Andre Luis Bombeiro, Cristina Pontes Vicente, Fernando Russo Costa Bomfim, Alexandre Leite Rodrigues de Oliveira, Vanderlei Salvador Bagnato, Marcelo Augusto Marretto Esquisatto, Fernanda Aparecida Sampaio Mendonca, Glaucia Maria Tech dos Santos, Andrea Aparecida de Aro
Article
Parasitology
Marcele F. Bastos, Letusa Albrecht, Angelica M. Gomes, Stefanie C. P. Lopes, Cristina P. Vicente, Rodrigo P. M. de Almeida, Gustavo C. Cassiano, Roberto J. C. Fonseca, Claudio C. Werneck, Mauro S. G. Pavao, Fabio T. M. Costa
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2019)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)