期刊
TETRAHEDRON
卷 75, 期 12, 页码 1697-1705出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2018.12.052
关键词
Bifunctional thioureas; Phosphonium salts; Mannich reaction; Asymmetric catalysis; Phase-transfer catalysis
资金
- Chinese Academy of Sciences [XDB 20020100]
- National Natural Science Foundation of China [21572247, 21871282]
A novel enantioselective Mannich reaction of gamma-malonate-substituted alpha, beta-unsaturated esters with N-protected arylaldimines was realized by using asymmetric phase-transfer catalysis (APTC). With amino acid-derived bifunctional thiourea-phosphonium salts as a catalyst, a series of enantio-enriched Mannich products could be synthesized under very mild and simple reaction conditions with high yields and enantioselectivities. (C) 2019 Elsevier Ltd. All rights reserved.
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