期刊
TALANTA
卷 191, 期 -, 页码 133-140出版社
ELSEVIER
DOI: 10.1016/j.talanta.2018.08.036
关键词
Magnetic cyclodextrin polymer; Solid phase extraction; Gastric cancer; Biomarkers
资金
- Independent innovation fund Project of Agricultural Science and Technology of Jiangsu Province in 2017 [CX (17) 1003]
- Guizhou Provincial Science and Technology Department Joint Fund Project (Qian Kehe LH word [2016]) [7076]
- Research Project of Environment Protection Department of Jiangsu Province [2015026]
- Chinese College Students Innovation Project for the R&D of Novel Drugs [201810316242]
Analyzing of tumor markers has become an important means for cancer diagnosis and prevention. In this study, a novel solid phase extraction based on porous magnetic cyclodextrin polymer (MA-CD) was developed and used for detection of trace small molecule gastric tumor markers in urine samples. The adsorption properties of the magnetic cyclodextrin polymer were tested. Through experiments of the solid phase extraction (SPE) at the different condition, the optimal condition was selected to test the two tumor markers by High-performance liquid chromatography -Diode array detector (HPLC-DAD). The analytical performance of the method showed good accuracy (88.82%-104.34%) and precision (< 3.55%), appropriated detection limits (1.016 and 5.714 mu g L-1) and linear ranges (0.6-24.0 mu g L-1) with convenient determination coefficients (> 0.9994). The results demonstrated that the developed approach is efficient, low-cost for gastric tumor markers detection.
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