Article
Surgery
Xiu-Ping Zhang, Shuai Xu, Zhao-Yi Lin, Qing-Lun Gao, Kang Wang, Zi-Li Chen, Mao-Lin Yan, Fan Zhang, Yu-Fu Tang, Zhi-Ming Zhao, Cheng-Gang Li, Wan Yee Lau, Shu-Qun Cheng, Ming-Gen Hu, Rong Liu
Summary: This study aimed to evaluate the impact of anatomical resection (AR) versus nonanatomical resection (NAR) combined with resection margin (RM) on long-term prognosis in HCC patients with MVI. The results showed that AR combined with wide RM can significantly improve overall and recurrence-free survival rates for these patients.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Jianwei Liu, Guokun Zhuang, Shilei Bai, Zhiliang Hu, Yong Xia, Caixia Lu, Jie Wang, Chunyan Wang, Liu Liu, Fengwei Li, Yeye Wu, Feng Shen, Kui Wang
Summary: This study investigated the impact of surgical margin and hepatic resection on prognosis for patients with hepatocellular carcinoma (HCC). The results showed that for patients with MVI-positive HCC, wide margins and anatomical resection were protective factors for prognosis, with wide margins being more important. In clinical practice, ensuring wide margins should be prioritized.
Article
Pharmacology & Pharmacy
W. -D. Lin, L. -N. Ye, Z. -S. Song, K. -P. Wang, Y. -F. Feng, C. -Y. Pan
Summary: This study conducted a systematic review on surgical margins in HCC patients. The results showed that a wide surgical margin significantly improves patient prognosis, and predicting the progression of MVI in liver cancer can help with preoperative decision-making.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Oncology
Jiang-Min Zhou, Chen-Yang Zhou, Xiao-Ping Chen, Zhi-Wei Zhang
Summary: In patients with tumors ranging from 2-5 cm, anatomic resection (AR) can effectively remove peritumoral microvascular invasion (MVI) by obtaining a wide surgical margin, reducing postoperative recurrence, and improving prognosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Kang Wang, Yan-Jun Xiang, Hong-Ming Yu, Yu-Qiang Cheng, Ying-Yi Qin, Wei-Jun Wang, Xiu-Ping Zhang, Yi-Tao Zheng, Yun-Feng Shan, Wen-Ming Cong, Hui Dong, Wan Yee Lau, Shu-Qun Cheng
Summary: This study aimed to establish a novel classification of microvascular invasion (MVI) for predicting prognosis in hepatocellular carcinoma (HCC) patients after RO liver resection (LR). The classification, developed using multivariate cox regression analysis, included factors such as alpha-fetoprotein level, liver cirrhosis, tumor characteristics, and MVI features. The classification system categorized patients into three distinct survival groups and showed higher predictive accuracy compared to other commonly used classifications.
Article
Gastroenterology & Hepatology
Pinghua Yang, Fei Teng, Shilei Bai, Yong Xia, Zhihao Xie, Zhangjun Cheng, Jun Li, Zhengqing Lei, Kui Wang, Baohua Zhang, Tian Yang, Xuying Wan, Hao Yin, Hao Shen, Timothy M. Pawlik, Wan Yee Lau, Zhiren Fu, Feng Shen
Summary: This study compared the prognosis of hepatocellular carcinoma (HCC) patients undergoing liver resection (LR) and liver transplantation (LT) based on predicted risks of microvascular invasion (MVI). The results showed that LT had better 5-year recurrence rate and 5-year overall survival rate than LR for patients with high or low risk of MVI. However, there was no significant difference in prognosis between LT and LR for patients with low MVI risk.
GASTROENTEROLOGY REPORT
(2023)
Article
Oncology
Changying Shi, Yong Li, Li Geng, Weifeng Shen, Chengjun Sui, Binghua Dai, Jiongjiong Lu, Mianshun Pan, Jiamei Yang
Summary: This study aimed to investigate the efficacy of SBRT targeting suboptimal resection margin as adjuvant therapy in MVI-positive HCC. The results showed that SBRT group had significantly better DFS and OS compared to the surgery alone group.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Surgery
Zhen Sun, Zhe Li, Xiao-Lei Shi, Xiu-Wen He, Jian Chen, Jing-Hai Song
Summary: Anatomical resection (AR) showed higher overall survival (OS) and disease-free survival (DFS) rates compared to non-anatomical resection (NR) in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). Therefore, AR is recommended for well-presented liver function HCC patients predicted to have positive MVI.
ASIAN JOURNAL OF SURGERY
(2021)
Editorial Material
Oncology
Norihiro Kokudo, Takashi Kokudo, Kiyoshi Hasegawa
Summary: The study suggests that surgical resection may be superior to other treatments for HCC patients with macrovascular invasion, with some surgical centers reporting acceptable outcomes. This provides a new approach for hepatologists in Western countries to improve survival rates for such patients through a combination of systemic therapy and surgery.
Article
Oncology
Haoyu Hu, Shuo Qi, Silue Zeng, Peng Zhang, Linyun He, Sai Wen, Ning Zeng, Jian Yang, Weiqi Zhang, Wen Zhu, Nan Xiang, Chihua Fang
Summary: The study established a predictive model to forecast the occurrence of microvascular invasion in HCC patients, and compared the efficacy of anatomic resection and non-anatomic resection for hepatocellular carcinoma. The predictive model was found to be convenient and accurate, highlighting the importance of performing anatomic resection in patients with high risk of MVI or low risk of MVI with larger tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Kai Zhang, Changcheng Tao, Tana Siqin, Jianxiong Wu, Weiqi Rong
Summary: This study successfully developed and validated a predictive model for early relapse after R0 resection in HCC patients with MVI, incorporating preoperative blood markers, hepatitis status, tumor characteristics, and other factors, with higher predictive accuracy in the validation cohort.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Shilei Bai, Lei Hu, Jianwei Liu, Minmin Sun, Yanfu Sun, Feng Xue
Summary: This study investigated the potential effect of postoperative adjuvant therapy with lenvatinib on the long-term prognosis of hepatitis B virus-related hepatocellular carcinoma with microvascular invasion (MVI). The results showed that patients who received postoperative lenvatinib had improved recurrence rates and survival rates compared to those who did not receive the treatment. Nomograms were also used to accurately predict long-term survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Xiu-Ping Zhang, Zong-Tao Chai, Jin-Kai Feng, Hui-Min Zhu, Fan Zhang, Yi-Ren Hu, Cheng-Qian Zhong, Zhen-Hua Chen, Kang Wang, Jie Shi, Wei-Xing Guo, Chao-Shuang Chen, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
Summary: This study found that preoperative type 2 diabetes mellitus (T2DM) is an independent risk factor for the incidence of microvascular invasion (MVI) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Patients with HBV-related HCC and T2DM had worse prognosis.
Article
Oncology
Yafang Zhang, Qingyue Wei, Yini Huang, Zhao Yao, Cuiju Yan, Xuebin Zou, Jing Han, Qing Li, Rushuang Mao, Ying Liao, Lan Cao, Min Lin, Xiaoshuang Zhou, Xiaofeng Tang, Yixin Hu, Lingling Li, Yuanyuan Wang, Jinhua Yu, Jianhua Zhou
Summary: This study developed a deep convolutional neural network model based on contrast-enhanced ultrasound to predict microvascular invasion in hepatocellular carcinoma patients and thus predict prognosis. The CECL-DCNN model showed higher specificity and accuracy in predicting MVI compared to clinical models.
FRONTIERS IN ONCOLOGY
(2022)