Article
Computer Science, Interdisciplinary Applications
Jay Wing Wai Lee, Yeong Shiong Chiew, Xin Wang, Chee Pin Tan, Mohd Basri Mat Nor, Matthew E. Cove, Nor Salwa Damanhuri, J. Geoffrey Chase
Summary: This study proposes a model-based method (VENT) for selecting mechanical ventilation settings to aid clinical decision-making. By analyzing retrospective data from 24 patients, the study validates the effectiveness of the VENT protocol in accurately predicting pressure and volume, and shows that the protocol can prevent harmful mechanical ventilation settings.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Critical Care Medicine
Amy L. Dzierba, Anas M. Khalil, Katrina L. Derry, Purnema Madahar, Jeremy R. Beitler
Summary: The study found that sedation depth is not always indicative of respiratory drive in mechanically ventilated patients. Regardless of the level of sedation, respiratory drive can vary among patients.
CRITICAL CARE MEDICINE
(2021)
Article
Biophysics
Rosemijne R. W. P. Pigmans, Ruud W. van Leuteren, Anouk W. J. Scholten, Chiara Veneroni, Anton H. van Kaam, Jeroen Hutten, Raffaele L. Dellaca, Frans H. C. de Jongh
Summary: This study examined the effects of endotracheal tube (ETT) on respiratory reactance measured with forced oscillation technique (FOT) and developed a correction method. The results showed that the reactance of ETT can be accurately predicted by a fitted formula, with negligible effects from changes in respiratory pattern and lung volume. This study improves the potential of using FOT for lung function testing in mechanically ventilated newborns by providing ETT-independent reactance values.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Biology
Christopher Yew Shuen Ang, Yeong Shiong Chiew, Xin Wang, Mohd Basri Mat Nor, Matthew E. Cove, J. Geoffrey Chase
Summary: This research developed two stochastic models for respiratory mechanics in mechanically ventilated patients, improving prediction accuracy and range. Clinical validation showed high accuracy in predicting future respiratory elastance data. These models can potentially be used in decision support systems for guided and personalized mechanical ventilation treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Critical Care Medicine
Anne-Fleur Haudebourg, Elsa Moncomble, Arnaud Lesimple, Flora Delamaire, Bruno Louis, Armand Mekontso Dessap, Alain Mercat, Jean-Christophe Richard, Francois Beloncle, Guillaume Carteaux
Summary: This study proposes a novel method for assessing airway opening pressure (AOP) during volume assist control ventilation at a constant-flow rate of 60 L/min. The P-cond method, which compares the airway pressure waveform to detect and measure AOP, was validated and showed good respiratory and hemodynamic tolerance compared to the standard low-flow method.
Article
Critical Care Medicine
Yoann Zerbib, Alexis Lambour, Julien Maizel, Loay Kontar, Bertrand De Cagny, Thierry Soupison, Thomas Bradier, Michel Slama, Clement Brault
Summary: The study found that high recruitability patients showed a significant increase in respiratory system compliance after lung recruitment maneuvers, while low recruitability patients experienced a decrease in pulse pressure, potentially indicating a drop in cardiac output.
Article
Critical Care Medicine
Clement Brault, Jordi Mancebo, Juan-Carlos Suarez Montero, Tracey Bentall, Karen E. A. Burns, Thomas Piraino, Francois Lellouche, Pierre-Alexandre Bouchard, Emmanuel Charbonney, Guillaume Carteaux, Tommaso Maraffi, Gaetan Beduneau, Alain Mercat, Yoanna Skrobik, Fei Zuo, Myriam Lafreniere-Roula, Kevin Thorpe, Laurent Brochard, Karen J. Bosma
Summary: A simple algorithm was developed to identify patients who were ready to be liberated from mechanical ventilation but were still predicted by clinicians to require ongoing ventilation. This algorithm was successful in identifying a quarter of the enrolled patients who were ready for extubation.
Article
Critical Care Medicine
Raquel F. de Magalhaes, Daniela G. Cruz, Mariana A. Antunes, Marcos V. de S. Fernandes, Milena V. Oliveira, Cassia L. Braga, Joshua Satalin, Penny Andrews, Nader Habashi, Gary Nieman, Cassiano F. Goncalves de-Albuquerque, Adriana R. Silva, Roseli V. Ribeiro, Vera L. Capelozzi, Fernanda F. Cruz, Cynthia dos S. Samary, Patricia R. M. Rocco, Pedro L. Silva
Summary: In an animal study comparing time-controlled adaptive ventilation with volume-controlled ventilation in a Pseudomonas aeruginosa-induced pneumonia model, time-controlled adaptive ventilation showed lower lung damage, bacteremia, and reduced gene expression of inflammatory mediators compared to volume-controlled ventilation with similar mean airway pressure.
CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yuqing Chen, Yueyang Yuan, Hai Zhang, Feng Li
Summary: This study aimed to evaluate the accuracy of dynamic mechanics estimation using expiratory time constant (RCexp) calculation during noninvasive pressure support ventilation (PSV) with air leak in different lung models. The results showed that the RCexp method accurately estimated airway resistance in non-obstructive conditions, but underestimated it at V-T of 5.0 ml/kg.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Physiology
Zhimin Lin, Jing Zhou, Xiaoling Lin, Yingzhi Wang, Haichong Zheng, Weixiang Huang, Xiaoqing Liu, Yimin Li, Nanshan Zhong, Yongbo Huang, Yuanda Xu, Ling Sang
Summary: The study found a high incidence rate of RT in ventilated non-ARDS patients, with mid-cycle RT being the most common phenotype. Mean phase delay and phase angles varied between different phenotypes and patterns, and RT appeared to alter lung stress and delivered volumes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Christopher Yew Shuen Ang, Jay Wing Wai Lee, Yeong Shiong Chiew, Xin Wang, Chee Pin Tan, Matthew E. Cove, Mohd Basri Mat Nor, Cong Zhou, Thomas Desaive, J. Geoffrey Chase
Summary: This research proposes a framework for generating virtual patients to test and implement model-based decision support systems for mechanical ventilation. The framework utilizes a clinically validated respiratory mechanics model to generate virtual patients from retrospective data, and evaluates the safety and efficacy of the protocols through virtual clinical trials.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Critical Care Medicine
Francois Beloncle, Antoine Studer, Valerie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani
Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.
Article
Critical Care Medicine
Luca Bastia, Doreen Engelberts, Kohei Osada, Bhushan H. Katira, L. Felipe Damiani, Takeshi Yoshida, Lu Chen, Niall D. Ferguson, Marcelo B. P. Amato, Martin Post, Brian P. Kavanagh, Laurent Brochard
Summary: In cases of asymmetrical lung injury, pressures measured in the injured and noninjured lungs were found to be similar, with esophageal pressure serving as a reliable estimate of dorsal pleural pressure. Moderate PEEP was effective in homogenizing ventilation distribution between lungs without causing overdistension.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E. Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R. M. Rocco, Maurizio Cereda, Lucio Castellan, Nicolo Patroniti, Paolo Pelosi
Summary: This study investigated the effects of two levels of positive-end expiratory pressure (PEEP) on alveolar recruitment in critically ill patients with severe COVID-19 pneumonia. The findings showed that higher PEEP levels resulted in limited alveolar recruitment, suggesting the need to strictly limit PEEP levels to maintain oxygenation and avoid using higher PEEP levels.
Article
Critical Care Medicine
N. Segond, N. Terzi, H. Duhem, A. Bellier, M. Aygalin, L. Fuste, D. Viglino, J. Fontecave-Jallon, K. Lurie, C. Guerin, G. Debaty
Summary: This study aimed to investigate the impact of patient position on ventilatory parameters during mechanically assisted cardiopulmonary resuscitation (CPR). The results showed that positive end-expiratory pressure (PEEP) level and patient position significantly affected respiratory parameters, with lower tidal volume observed at a thorax position of 35 degrees. These findings have important implications for the implementation of mechanical ventilation during CPR.
Article
Multidisciplinary Sciences
Nigel S. Michki, Roland Ndeh, Kathryn A. Helmin, Benjamin D. Singer, Sharon A. McGrath-Morrow
Summary: Bacterial pulmonary infections are a major cause of morbidity and mortality in neonates and children. The DNA of CD4(+) T cells in the mouse lung shows differential methylation in neonates compared with juveniles. This study demonstrates that DNA methylation affects CD4(+) T cell gene expression and response to infection, and inhibition of DNA methyltransferase activity can shift the gene expression program of neonatal lung CD4(+) T cells towards a more mature profile during infection.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Sharon A. McGrath-Morrow, Jarrett Venezia, Roland Ndeh, Nigel Michki, Javier Perez, Benjamin David Singer, Raffaello Cimbro, Mark Soloski, Alan L. Scott
Summary: Bacterial pneumonia in neonates can lead to severe illness and death compared to other childhood age groups. Using a mouse model, we found differences in immune responsiveness at the cellular and molecular levels between neonates and juveniles. E. coli infection caused significant increases in certain cells and decreases in others in the lungs of both neonates and juveniles. However, there were additional cell increases in the lungs of juveniles that were not observed in neonates. These differences in immune response may contribute to the heightened susceptibility of neonates to bacterial pneumonia.
Article
Biology
Luise Hassler, Jan Wysocki, Jared T. Ahrendsen, Minghao Ye, Ian Gelarden, Vlad Nicolaescu, Anastasia Tomatsidou, Haley Gula, Cosimo Cianfarini, Peter Forster, Nigar Khurram, Benjamin D. Singer, Glenn Randall, Dominique Missiakas, Jack Henkin, Daniel Batlle
Summary: Soluble ACE2 protein (ACE2 618-DDC-ABD) administered intranasally improves survival and provides organ protection in SARS-CoV-2-inoculated mice.
LIFE SCIENCE ALLIANCE
(2023)
Article
Medicine, General & Internal
D. Clark Files
Summary: An adaptive platform design was used to rapidly evaluate potential therapeutics for severe COVID-19. The study included hospitalized patients with severe COVID-19 and compared the outcomes of different treatment regimens. The results showed that none of the evaluated agents met the pre-specified efficacy criteria.
Editorial Material
Critical Care Medicine
Chiagozie I. Pickens, Benjamin D. Singer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Chiagozie Pickens, Catherine A. Gao, Justin Bodner, James M. Walter, Jacqueline M. Kruser, Helen K. Donnelly, Alvaro Donayre, Katie Clepp, Nicole Borkowski, Richard G. Wunderink, Benjamin D. Singer, N. U. S. C. R. I. P. T. Study Investigators NU SCRIPT Study Investigators
Summary: This study aimed to develop an adjudication protocol for severe bacterial and/or viral pneumonia and evaluate its effectiveness. The results showed that achieving clinical cure by day 7-8 was associated with more favorable hospital discharge dispositions. However, the interobserver agreement among the adjudicators was only moderate.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Milica Jovisic, Nurbek Mambetsariev, Benjamin D. Singer, Luisa Morales-Nebreda
Summary: Acute respiratory infections trigger an immune response that can lead to tissue damage and impaired pulmonary function. CD4+FOXP3+ regulatory T cells (Tregs) play a critical role in limiting inflammation and promoting lung tissue repair. This review explores the mechanisms by which Tregs promote resolution of inflammation and repair of acute lung injury, and discusses the potential use of Tregs as cellular therapy for severe acute respiratory infections.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Catherine A. Gao, Nikolay S. Markov, Thomas Stoeger, Anna Pawlowski, Mengjia Kang, Prasanth Nannapaneni, Rogan A. Grant, Chiagozie Pickens, James M. Walter, Jacqueline M. Kruser, Luke Rasmussen, Daniel Schneider, Justin Starren, Helen K. Donnelly, Alvaro Donayre, Yuan Luo, G. R. Scott Budinger, Richard G. Wunderink, Alexander V. Misharin, Benjamin D. Singer
Summary: This study aimed to determine the contribution of unsuccessful treatment of ventilator-associated pneumonia (VAP) to mortality for patients with severe pneumonia. By observing 585 mechanically ventilated patients with severe pneumonia and respiratory failure, it was found that the unsuccessful treatment of VAP was associated with higher mortality.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Respiratory System
Carmen Mikacenic, Lynn A. Fussner, Jasmine Bell, Ellen L. Burnham, Linda L. Chlan, Sarah K. Cook, Robert P. Dickson, Francis Almonor, Fengming Luo, Karan Madan, Luisa Morales-Nebreda, Kara J. Mould, A. John Simpson, Benjamin D. Singer, Renee D. Stapleton, Chris H. Wendt, D. Clark Files
Summary: Bronchoscopy for research purposes is a valuable tool to understand lung-specific biology in humans. This study provides recommendations for patient selection, hospital staff protection, sample procurement, and sample preparation. The committee concludes that research bronchoscopy is valuable and safe in appropriately selected patients.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Cell Biology
Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie-Pimentel, Kishore R. Anekalla, Sophia S. Liu, Heliodoro Tejedor-Navarro, Benjamin D. Singer, Hiam Abdala-Valencia, Michael Schwake, Marie-Pier Tetreault, Harris Perlman, William E. Balch, Navdeep S. Chandel, Karen M. Ridge, Jacob Sznajder, Richard Morimoto, Alexander Misharin, G. R. Scott Budinger, Luis A. Nunes Amaral
Summary: The length of transcripts explains the majority of transcriptional changes observed during aging in mice and humans. The relative abundance of long transcripts is lower in aging, and antiaging interventions can counter this length association. Genes with the longest transcripts are associated with lifespan extension, while genes with the shortest transcripts are associated with lifespan shortening.
Meeting Abstract
Critical Care Medicine
P. H. Sporn, A. Mahmoud, M. Kang, A. Pawlowski, S. M. Casalino-Matsuda, R. Kalhan, B. D. Singer, G. R. S. Budinger, R. G. Wunderink
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
E. E. Rabin, M. Kang, C. Gao, C. Qi, B. D. Singer, R. G. Wunderink, C. Pickens, J. M. Walter
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
E. E. Rabin, M. Kang, J. M. Walter, C. Qi, C. Gao, B. D. Singer, R. G. Wunderink, C. Pickens
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
A. M. Joudi, K. Helmin, L. Morales-Nebreda, M. A. Torres Acosta, C. Reyes Flores, S. E. Weinberg, B. D. Singer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
C. Gao, A. Pawlowski, P. Nannapaneni, M. Kang, M. J. Cuttica, S. B. Smith, G. Budinger, B. D. Singer, R. G. Wunderink
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
