Article
Pharmacology & Pharmacy
Jiabin Zhou, Tao Yu, Gujie Wu, Peng Xu, Chen Wang, Yiling Su, Li Wang, Qi Lu
Summary: This study demonstrates that PQQ can regulate the pathogenesis of myocardial hypertrophy through the induction of YAP-related anti-ferroptotic activity, highlighting its potential as a therapeutic agent for the treatment of myocardial hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qin Zou, Mei Zhang, Rong Yuan, Yifei Wang, Zhengyin Gong, Rui Shi, Yujing Li, Kaixin Fei, Chenggang Luo, Ying Xiong, Ting Zheng, Li Zhu, Guoqing Tang, Mingzhou Li, Xuewei Li, Yanzhi Jiang
Summary: In this study, the effects of CH-SEVs and LW-SEVs on DFs and skin tissue were compared. The results showed that CH-SEVs promoted fibroblast activity, skin thickness, and collagen synthesis more effectively. miRNA-218 and ITGBL1 protein were found to play important roles in promoting fibroblast activity. These findings suggest that CH-SEVs have the potential to promote skin development and repair skin damage.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Jian Zhang, Shen Hu, Rui Ding, Jinghong Yuan, Jingyu Jia, Tianlong Wu, Xigao Cheng
Summary: The study revealed a novel circSNHG5-miR-495-3p axis involved in IDD progression, with circSNHG5 regulating cell proliferation and extracellular matrix degradation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shalakha Sharma, Witty Tyagi, Rohini Tamang, Sanjeev Das
Summary: This study reveals that HDAC5 interacts with and deacetylates SATB1, with the acetylation of SATB1 at lysine 411 regulated by TIP60 acetyltransferase. HDAC5-mediated deacetylation is critical for the downregulation of key tumor suppressor genes by SATB1 and the repression of SDHA-induced epigenetic remodeling and anti-proliferative transcriptional program. These findings shed light on the molecular mechanisms underlying SATB1-promoted tumor growth and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Engineering, Biomedical
Xue Bai, Hongyan Sun, Lina Jia, Junjie Xu, Peng Zhang, Deyuan Zhang, Yu Gu, Bo Chen, Lin Feng
Summary: This study found that gold nanoparticles (AuNPs) can partially protect children's cartilage from inflammatory damage. In a model of LPS-induced cartilage damage, AuNPs inhibited chondrocyte apoptosis and extracellular matrix degradation, resulting in reduced release of inflammatory cytokines and degradation factors. This leads to a decrease in cartilage destruction.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Smitha Sivapragasam, Bastian Stark, Amanda Albrecht, Kaitlynne A. Bohm, Peng Mao, Raymond G. Emehiser, Steven A. Roberts, Patrick J. Hrdlicka, Gregory M. K. Poon, John J. Wyrick
Summary: Somatic mutations in DNA-binding sites for CTCF are elevated in many cancers, possibly due to its role in inhibiting repair of UV damage and modulating the formation of UV-induced DNA damage, leading to mutation hot spots. Analysis demonstrates that CTCF interacts with damaged DNA and hinders repair, providing insights into the molecular mechanisms of how CTCF binding influences CPD formation.
Article
Chemistry, Multidisciplinary
Michele Anselmi, Adina Borbely, Eduard Figueras, Carmela Michalek, Isabell Kemker, Luca Gentilucci, Norbert Sewald
Summary: The study utilized a hydrophilic beta-glucuronidase-cleavable linker to connect an anticancer drug with a target protein, demonstrating the potential of hydrophilic sugar linkers in reducing cytotoxicity and providing guidance for the development of therapies containing hydrophobic anticancer drugs.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Naoki Sugimura, Qing Li, Eagle Siu Hong Chu, Harry Cheuk Hay Lau, Winnie Fong, Weixin Liu, Cong Liang, Geicho Nakatsu, Anthony Chin Yang Su, Olabisi Oluwabukola Coker, William Ka Kei Wu, Francis Ka Leung Chan, Jun Yu
Summary: In this study, we found that L. gallinarum significantly reduced intestinal tumor number and size in murine models, by producing protective metabolites that promote apoptosis of colorectal cancer cells, thus protecting against intestinal tumorigenesis.
Article
Plant Sciences
Min Si, Zheng Ma, Jie Zhang, Xinwei Li, Rui Li, Chao Wang, Huiyu Jia, Shengyong Luo
Summary: The study showed that QLY granules have significant therapeutic effects on adjuvant arthritis rats, which may be associated with downregulating the CXCL12/CXCR4-NF-kappa B signaling pathway. Further research on the use of QLY granules as a potential treatment for rheumatoid arthritis is warranted.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Cell Biology
Susu Guo, Yuxin Chen, Yueyue Yang, Xiao Zhang, Lifang Ma, Xiangfei Xue, Yongxia Qiao, Jiayi Wang
Summary: This study demonstrates that TRIB2 reduces Ub levels by stimulating proteasome degradation and interacts with PCBP2 to modulate PSMB5 activity, which is crucial for liver cancer cell viability and tumor growth. The interaction between TRIB2 and PCBP2 also protects liver cancer cells from oxidative damage through the function of glutathione peroxidase 4. Targeting TRIB2 may enhance the effectiveness of therapeutic agents for liver cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yingdong Lu, Mi Xiang, Laiyun Xin, Yang Zhang, Yuling Wang, Zihuan Shen, Li Li, Xiangning Cui
Summary: This study aimed to investigate the therapeutic effect of Qiliqiangxin on rats with heart failure, and found that QL treatment improved cardiac function, LV remodeling, gut microbial composition, and inhibited the expression levels of inflammatory proteins.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Lintao Li, Bing Zheng, Fan Zhang, Xi Luo, Fudong Li, Tao Xu, Hong Zhao, Guodong Shi, Yongfei Guo, Jiangang Shi, Jingchuan Sun
Summary: The study showed that LINC00370 promotes the osteogenic differentiation of adipose-derived stem cells through the miR-222-3p/RGS4 axis, as well as protects against osteoporosis induced by ovariectomy.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Multidisciplinary Sciences
Kazim Sahin, Osman Kucuk, Cemal Orhan, Mehmet Tuzcu, Ali Said Durmus, Ibrahim Hanifi Ozercan, Nurhan Sahin, Vijaya Juturu
Summary: Oral supplementation of niacinamide and undenatured type II collagen (UCII) can reduce inflammation and joint pain in rats with osteoarthritis, improving related symptoms.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Majd Mohammad, Manli Na, Zhicheng Hu, Minh-Thu Nguyen, Pradeep Kumar Kopparapu, Anders Jarneborn, Anna Karlsson, Abukar Ali, Rille Pullerits, Friedrich Goetz, Tao Jin
Summary: The study demonstrates that subcutaneous injection of Staphylococcus aureus lipoproteins (Lpp) leads to the infiltration of neutrophils and monocytes/macrophages, inducing skin lesions. Lpp-deficient strains exhibit smaller lesion size and reduced bacterial loads in skin infections, indicating the crucial role of Lpp in promoting lesions and bacterial burden.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rizwana Begum Syed Nabi, Raheem Shahzad, Rupesh Tayade, Muhammad Shahid, Adil Hussain, Muhammad Waqas Ali, Byung-Wook Yun
Summary: This study evaluated the ability of a plant growth-promoting rhizobacterium to control tomato wilt disease caused by Fusarium oxysporum and promote plant growth. The results showed significant inhibition of fungal growth, protection of susceptible tomato cultivars, and promotion of plant growth and biomass production in both susceptible and tolerant cultivars. Further analysis revealed higher amino acid production and alterations in plant defense hormone levels, suggesting that the rhizobacterium reduces the effects of Fusarium wilt disease by modulating endogenous phytohormones and amino acid levels.
Article
Biochemistry & Molecular Biology
Dong Gil Jang, Keun Yeong Kwon, Eun Kyung Song, Tae Joo Park
Summary: ITGBL1 facilitates directional cell migration by inhibiting integrin activity at the trailing edges. Depletion of ITGBL1 leads to increased focal adhesions at the trailing edges, preventing retraction. Overexpression of ITGBL1 promotes directional cell migration by promoting disassembly of the focal adhesion complex at the trailing edges.
Article
Cell Biology
Sang Kwon Lee, Yeong Cheon Kweon, Ah Reum Lee, Yoon Young Lee, Chan Young Park
Summary: This article investigates the role of PGRMC1 in regulating Ca2+ signaling in breast cancer cells, and finds that PGRMC1 can promote the generation of SOCE, affecting various cellular processes.
Article
Multidisciplinary Sciences
Hyo Jung Sim, Chanmi Cho, Ha Eun Kim, Ju Yeon Hong, Eun Kyung Song, Keun Yeong Kwon, Dong Gil Jang, Seok-Jung Kim, Hyun-Shik Lee, Changwook Lee, Taejoon Kwon, Siyoung Yang, Tae Joo Park
Summary: The ERAD complex plays a crucial role in cartilage formation and maintenance, and disruption of its function can lead to chondrodysplasia and cartilage destruction. Decreased ERAD gene expression is observed in damaged cartilage from OA patients.
Article
Chemistry, Multidisciplinary
Chanmi Cho, Jin Sil Lee, Hyeryeon Oh, Li-Jung Kang, Yiseul Hwang, Sunyoung Chae, In-Jeong Lee, Seok Jung Kim, Hyunmin Woo, Seong-il Eyun, Ho Chul Kang, Won Il Choi, Siyoung Yang
Summary: Biocompatible self-assembled levan nanoparticles (LevNPs) that specifically bind to CD44 receptors have been developed and show potential in treating osteoarthritis.
Article
Environmental Sciences
Tayaba Ismail, Hongchan Lee, Youni Kim, Hong-Yeoul Ryu, Dong-Hyung Cho, Zae Young Ryoo, Dong-Seok Lee, Taeg Kyu Kwon, Tae Joo Park, Taejoon Kwon, Hyun-Shik Lee
Summary: This study evaluated the developmental toxicity and teratogenicity of PCNB and found that it affects organogenesis and gene expression in frog embryos. The teratogenic potential of PCNB not only affects the phenotype of developing embryos, but also poses a hazard to normal embryonic growth through oxidative stress mechanism.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Keun Yeong Kwon, Hyeongsun Jeong, Dong Gil Jang, Taejoon Kwon, Tae Joo Park
Summary: This study found that Ckb and Ybx2 are involved in the interaction with Ribc2 and are necessary for the ciliary beating of multi-cilia.
Article
Engineering, Biomedical
Chanmi Cho, Hyeryeon Oh, Jin Sil Lee, Li-Jung Kang, Eun-Jeong Oh, Yiseul Hwang, Seok Jung Kim, Yong-Soo Bae, Eun-Jeong Kim, Ho Chul Kang, Won Il Choi, Siyoung Yang
Summary: This study describes the efficacy and mechanisms of action of Prussian blue nanozymes coated with Pluronic (PPBzymes) as a new therapy for osteoarthritis. PPBzymes are stable, promote cartilage generation, and reduce cartilage degradation. Intra-articular injections of PPBzymes in mice show long-term stability, effective uptake, and attenuated cartilage degradation without cytotoxic effects. Furthermore, PPBzymes specifically block JNK phosphorylation, suggesting their potential as a biocompatible nanotherapeutic for inflammatory osteoarthritis.
Article
Chemistry, Multidisciplinary
Jimin Jeon, Hyemi Lee, Min-Seung Jeon, Seok-Jung Kim, Cham Choi, Ki Woo Kim, Dong Joo Yang, Sangho Lee, Yong-Soo Bae, Won Il Choi, Juyeon Jung, Seong-il Eyun, Siyoung Yang
Summary: The upregulation of ACVR2B and its assembly play a role in osteoarthritic cartilage destruction. Activin A, the ligand for ACVR2B, regulates catabolic factor expression in OA development. The ACVR2B assembly, consisting of Activin A, ACVR2B, ACVR1B, Nox4, and AP-1-induced HIF-2 alpha, accelerates OA development.
Article
Chemistry, Multidisciplinary
Ah Reum Lee, Chan Young Park
Summary: Intracellular calcium signaling regulates entosis through the SEPTIN-Orai1-Ca2+/CaM-MLCK-actomyosin axis. Orai1 calcium channels mediate intracellular calcium oscillations in entotic cells, and SEPTIN controls the polarized distribution of Orai1 for MLCK activation, resulting in actomyosin contraction and internalization of invasive cells. Calcium chelators and inhibitors of SEPTIN, Orai1, and MLCK can suppress entosis.
Article
Multidisciplinary Sciences
Julie Lee, Andreas Fonss Moller, Shinhyeok Chae, Alexandra Bussek, Tae Joo Park, Youni Kim, Hyun-Shik Lee, Tune H. Pers, Taejoon Kwon, Jakub Sedzinski, Kedar Nath Natarajan
Summary: This study investigates the development of the mucociliary epithelium in the respiratory tract using single-cell transcriptomics. They identify multipotent early epithelial progenitors that differentiate into specialized cell types through multilineage cues. Comparative analysis of different species reveals conserved transcriptional modules in ciliated cells and distinct function-specific programs in secretory and basal cells.
Article
Medicine, Research & Experimental
Hyemi Lee, Jiho Nam, Hahyeong Jang, Young-Sik Park, Min-Hee Son, In-Hyun Lee, Seong-Il Eyun, Jimin Jeon, Siyoung Yang
Summary: BBC0901, as a BRD4 inhibitor, can prevent the development of osteoarthritis (OA) by inhibiting the expression of catabolic factors and blocking related signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
