Article
Biochemistry & Molecular Biology
Guanghui Yang, Jiufeng Wang, Shenghua Wang, Yaohong Zhu
Summary: This study investigated the effects of Forsythoside A (FTA) on Bovine Viral Diarrhea Virus (BVDV) and its underlying mechanisms. The results showed that FTA could directly inhibit the replication of BVDV, reduce inflammatory response, and increase the expression of type I interferon (IFN-I) to clear the virus. Animal experiments demonstrated that FTA could alleviate pathological damage, decrease viral load, enhance body defense, and delay BVDV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Lauren Crawford, Shollie Falkenberg, Ellie Jordan Putz, Steven Olsen, Paola M. Boggiatto
Summary: Brucella abortus is a zoonotic pathogen that can cause abortions and stillbirths in cattle. Cell mediated immunity plays a crucial role in protection against this pathogen. In this study, PBMCs from vaccinated and non-vaccinated cattle were analyzed. Results showed that simultaneous administration of RB51 and a viral modified live vaccine did not interfere with immune responses, suggesting that potential vaccine combinations should be evaluated for biological effects.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Virology
Ahlam Chaqroun, Cedric Hartard, Evelyne Schvoerer
Summary: The genetically variable SARS-CoV-2 virus has led to the emergence of different variants that affect transmissibility and immune escape. Further research is needed to develop effective preventive and therapeutic control strategies.
Article
Multidisciplinary Sciences
Kristan Alexander Schneider, Henri Christian Junior Tsoungui Obama, Nessma Adil Mahmoud Yousif
Summary: After the approval of COVID-19 vaccines, vaccination campaigns were launched globally. These campaigns initially prioritized specific risk groups due to a vaccine shortage. However, as vaccine supply increased, the focus shifted to anti-vaxxers, under-aged population, and regions with low coverage. This study introduces a predictive model to assess the impact of vaccination campaigns on the spread of SARS-CoV-2 viral variants.
Review
Biochemistry & Molecular Biology
Ioannis P. Trougakos, Evangelos Terpos, Harry Alexopoulos, Marianna Politou, Dimitrios Paraskevis, Andreas Scorilas, Efstathios Kastritis, Evangelos Andreakos, Meletios A. Dimopoulos
Summary: Vaccination is crucial in controlling the COVID-19 pandemic, and mRNA vaccines are particularly effective. However, adverse effects following vaccination have been observed, which may be related to the vaccine formulation and the inflammatory effects of the antigens produced. It is important to conduct further research on the cellular and molecular basis of these adverse effects to ensure vaccine safety.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Sachin Kumar
Summary: The article by Abdalla et al. highlighted the significance of the SARS-CoV-2 spike protein in COVID-19 vaccines and the reported mutations across the globe. Studying the protein's biochemistry and immunology will contribute to our understanding of the biology of SARS-CoV-2 variants.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Mateus da Silva Matias Antunes, Fabricia Heloisa Cavicchioli Sugiyama, Humberto Doriguetto Gravina, Ricardo Cardoso Castro, Francisco Javier Romero Mercado, Julia Oliveira de Lima, Caroline Fontanari, Fabiani Gai Frantz
Summary: This study aimed to investigate the immunophenotyping, cytokine, and metabolic profile of monocytes from individuals who were vaccinated with inactivated COVID-19 vaccine or non-replicating viral vector vaccine. The results showed that vaccination reduced the inflammatory response of monocytes to unrelated stimuli, indicating the induction of trained immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Carlos U. Torres-Estrella, Maria del Rocio Reyes-Montes, Esperanza Duarte-Escalante, Monica Sierra Martinez, Maria Guadalupe Frias-De-Leon, Gustavo Acosta-Altamirano
Summary: This paper describes the current status of COVID-19 vaccine development and production, and proposes ideas for future research. The paper also discusses the immune effects of vaccination in different populations and the role of Mexico in managing the vaccination process.
Review
Immunology
Naina McCann, Daniel O'Connor, Teresa Lambe, Andrew J. Pollard
Summary: Viral vector vaccines, utilizing recombinant viruses to deliver immunogens, have shown significant impact and efficacy in the response to the SARS-CoV-2 pandemic. Adenoviral vector vaccines, in particular, have demonstrated strong immune responses and hold promise in the fight against infectious diseases.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Review
Virology
Maireid B. Bull, Carolyn A. Cohen, Nancy H. L. Leung, Sophie A. Valkenburg
Summary: Next generation influenza vaccines targeting conserved epitopes are considered vital tools, but face challenges including immune escape. Vaccine strategies include HA-stem and T cell activating vaccines, but may need mosaic approaches.
Review
Immunology
Pascal Rainard, Florence B. Gilbert, Rodrigo P. Martins, Pierre Germon, Gilles Foucras
Summary: Mastitis is a major problem in dairy farming, and the current vaccines are not effective. To address this issue, research should focus on the immunobiology of the mammary gland and the pathogens adapted to it. Vaccines need to elicit immune mechanisms different from those induced by infection, in order to be more effective.
Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Naila Qamar, Gul Rukh, Sadiq N. Khan
Summary: This review article discusses the effectiveness and efficacy of different Covid-19 vaccines, as well as explores strategies to improve their effectiveness and efficacy, reduce side effects, and determine the required vaccine doses for enhanced surveillance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Cristina Bayo, Gerhard Jung, Marta Espanol-Rego, Francesc Balaguer, Daniel Benitez-Ribas
Summary: Cancer vaccines aim to modulate the immune system to induce protective immune responses against cancer-related antigens. Administering cancer-preventive vaccination at early stages is seen as a potential way to increase clinical efficacy, as research begins to focus on these approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Immunology
Camila Robles-Oteiza, Catherine J. Wu
Summary: Lessons learned from the rapid deployment of vaccines during the COVID-19 pandemic are reinvigorating the cancer vaccine field, with recent clinical trials demonstrating the safety and feasibility of cancer vaccines using delivery platforms such as mRNA and synthetic long peptides. However, fundamental questions remain regarding the optimal delivery platforms and antigen targets to use in cancer vaccines.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mehdi Mahmudpour, Katayoun Vahdat, Mohsen Keshavarz, Iraj Nabipour
Summary: This study suggests that insulin resistance, rather than direct damage to beta-cells, is the main cause of rapid metabolic deterioration in diabetes patients with COVID-19. A proposed molecular tetrahedron highlights the complex interactions between COVID-19 and diabetes, involving the entry of SARS-CoV-2, viral replication, inflammatory responses, and resulting insulin resistance.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Cell Biology
Ali Karimi Sisakht, Mohammad Malekan, Farbod Ghobadinezhad, Seyedeh Negar Mousavi Firouzabadi, Ameneh Jafari, Seyed Mohammad Ali Mirazimi, Banafshe Abadi, Rana Shafabakhsh, Hamed Mirzaei
Summary: Glioblastoma (GBM) is a highly malignant brain tumor with poor prognosis. The communication between glioblastoma cells and their microenvironment plays a critical role in tumor progression, angiogenesis, metastasis, immune suppression, and treatment resistance. Understanding these communication routes could lead to the development of novel therapeutic strategies against GBM.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Nader Molavi, Morad Rasouli-Azad, Hamed Mirzaei, Amir Hassan Matini, Hamid Reza Banafshe, Marjan Valiollahzadeh, Majid Hassanzadeh, Ahmad Reza Saghazade, Samira Abbaszadeh-Mashkani, Peyman Mamsharifi, Amir Ghaderi
Summary: The study showed that probiotic treatment in patients receiving MMTPs significantly improved symptoms of depression, reduced blood glucose, cholesterol, and LDL cholesterol levels, as well as decreased inflammation. Probiotics also increased total antioxidant capacity and total glutathione levels.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Genetics & Heredity
Sara Ahmadpour, Tarannomsadat Taghavi, Amirhossein Sheida, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Hamed Mirzaei
Summary: Glioma is a common invasive primary tumor of the central nervous system, and treatment resistance remains a problem. Non-coding RNAs play a role in the mechanisms of treatment resistance. This review discusses the pathways by which microRNAs and long non-coding RNAs affect resistance to chemotherapy and radiotherapy, and offers potential therapeutic options for future glioma treatment.
Article
Immunology
Mohsen Keshavarz, Seyed Mohammad Miri, Emad Behboudi, Yaser Arjeini, Hassan Dianat-Moghadam, Amir Ghaemi
Summary: This paper summarizes the latest advancements in the use of chemical and biological compounds for safe and efficient delivery of oncolytic viruses to target tissues or tumor deposits.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Correction
Neurosciences
Amir Hossein Mohammadi, Seyedvahid Seyedmoalemi, Mahsa Moghanlou, Seyed Amirreza Akhlagh, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Ameneh Jafari, Hamed Mirzaei
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Amir Hossein Mohammadi, Seyedvahid Seyedmoalemi, Mahsa Moghanlou, Seyed Amirreza Akhlagh, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Ameneh Jafari, Hamed Mirzaei
Summary: Synaptic plasticity refers to the ability of synapses to weaken or strengthen over time, with miRNAs playing crucial roles in regulating this process. Dysregulation of miRNAs may be associated with pathological alterations in synaptic plasticity, leading to diseases. Understanding the impact of miRNAs on synaptic plasticity provides insights for the diagnosis and treatment of related diseases and drug addiction.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Virology
Seyed Mohammad Miri, Behzad Pourhossein, Seyed Younes Hosseini, Mohsen Keshavarz, Shohreh Shahmahmoodi, Mohammad Reza Zolfaghari, Seyed Reza Mohebbi, Ali Gorji, Amir Ghaemi
Summary: The study found a significant synergistic effect between the E7 DNA vaccine and MDA-7/IL-24 cytokine against HPV-16+ cervical cancer models, demonstrating superior efficacy of the adjuvant vaccine compared to individual administration. The adjuvant vaccine led to increased proliferation of lymphocytes, cytotoxicity of CD8+ T cells, levels of Th1 cytokines, apoptotic markers, and decreased immunosuppressive IL-10, while also controlling tumor growth and inducing tumor regression.
Article
Chemistry, Analytical
Hamed Mirzaei, Milad Ramezankhani, Emily Earl, Nishat Tasnim, Abbas S. Milani, Mina Hoorfar
Summary: In this study, a Sparse Autoencoder-based Transfer Learning (SAE-TL) framework was proposed to estimate the hydrogen gas concentration in HENG mixtures. By combining limited datasets from a 3D printed microfluidic detector and commercial MOS sensors, accurate detection of simulated HENG concentrations can be achieved.
Article
Oncology
Hassan Dianat-Moghadam, Mohammadreza Sharifi, Rasoul Salehi, Mohsen Keshavarz, Mehdi Shahgolzari, Zohreh Amoozgar
Summary: Intra-tumoral immune cells promote the stemness of cancer stem cells (CSCs) in the tumor microenvironment, which can play a role in tumor progression, relapse, and resistance to immunotherapy. Stem-like T cells and stem cell-derived NK cells show promising potential in improving the therapeutic efficacy of immunotherapy.
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Virology
Mohsen Keshavarz, Somayeh Ghasemi, Yaser Arjeini, Haideh Namdari, Hassan Maleki, Neda Mousavi, Talat Mokhtari-Azad, Farhad Rezaei
Summary: Skin rash is a common complication in childhood, often caused by viral infections. This study aimed to investigate the prevalence and genetic variability of Human Herpesvirus 6 and 7 in children with skin rash. The results showed that a significant number of cases had HHV-6 and HHV-7 infections, with certain genetic variations found in HHV-6 strains. These findings highlight the importance of evaluating the frequency and distribution of HHV6/7 in children with skin rash and the potential impact on vaccine research and antiviral drug development.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Medicinal
Mohammad Jaber MasodKhooy, Massoumeh Farasat, Mohamadreza Salehi Salmi, Hamed Mirzaei
Summary: This study evaluated the antitumor effect of a combination of Silybum marianum essential oils and 5-fluorouracil (5-FU) on hepatocellular carcinoma. The combination treatment significantly reduced migration, invasion, and angiogenesis, while also modulating apoptosis, autophagy, and NF-kappa B and Wnt pathway-related proteins. In vivo experiments showed that the combined treatment prolonged survival in a mouse model of hepatocellular carcinoma compared to either treatment alone.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Hamed Mirzaei, Jack McClelland, Devansh Sharma, Mohammad Arjmand, Mohammad H. H. Zarifi
Summary: This study focuses on investigating the real-time resonant microwave behavior of two polydimethylsiloxane (PDMS) structures in interaction with tetrahydrofuran (THF) and acetone, which are primary swelling agents. The interaction of the PDMS structures with target gases alters their structure, resulting in changes in the dielectric properties of the PDMS/gas system. Microwave resonators show substantial potential as versatile tools for investigating the physical changes in polymers during their interaction with gases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Microbiology
Mohsen Keshavarz, Nahid Janati-Namin, Yaser Arjeini, Talat Mokhtari-Azad, Farhad Rezaei
Summary: This study investigated the prevalence and characteristics of B19V infection in hemophilia patients. The results showed a higher level of B19V seropositivity, DNA detection, and viral load in the case group compared to the control group.
IRANIAN JOURNAL OF MICROBIOLOGY
(2022)