Article
Developmental Biology
Yan Qin, Peiling Ni, Qingye Zhang, Xiao Wang, Xiaoling Du, Zixi Yin, Lingling Wang, Lihong Ye, Lingyi Chen
Summary: The study reveals that Hbxip is crucial for normal development and plays a key role in the self-renewal and differentiation of embryonic stem cells (ESCs) by activating mTORC1 signaling. It also contributes to the development and differentiation of the epiblast.
Article
Biochemistry & Molecular Biology
Hsiang-Hsuan Fan, Kuo-Hong Lee, You-Tzung Chen, Li-Jyuan Lin, Tsung-Lin Yang, Shu-Wha Lin, I-Shing Yu
Summary: The study indicates that Wdhd1 plays a critical role in mouse embryonic development, with Wdhd1 homozygous null mutation resulting in reduced cell proliferation, affecting embryonic growth and viability.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Oncology
Matthew L. Fisher, Seamus Balinth, Yon Hwangbo, Caizhi Wu, Carlos Ballon, John E. Wilkinson, Gary L. Goldberg, Alea A. Mills
Summary: BRD4 plays a critical role in the regulation of cancer stem-like properties and is highly elevated in the aggressive subpopulation of cells in squamous cell carcinomas. Targeting BRD4 can effectively inhibit Delta Np63 alpha, reducing spheroid formation and inhibiting tumor growth.
Article
Developmental Biology
Akihito Morita, Yuhkoh Satouh, Hidetaka Kosako, Hisae Kobayashi, Akira Iwase, Ken Sato
Summary: During the oocyte-to-embryo transition and early embryogenesis, PKC-dependent clathrin-mediated endocytosis is essential for the selective degradation of maternal membrane proteins.
Article
Multidisciplinary Sciences
Zhenkang Chen, Bogdan Bordieanu, Rushendhiran Kesavan, Nicholas P. Lesner, Siva Sai Krishna Venigalla, Spencer D. Shelton, Ralph J. DeBerardinis, Prashant Mishra
Summary: Myopathies caused by dysfunction in the mitochondrial electron transport chain can have devastating consequences. In this study, we used a mouse model of severe mitochondrial myopathy to investigate the metabolic changes associated with the disease. We unexpectedly discovered that the dysfunction of the electron transport chain in muscle leads to a decrease in glycolytic enzymes. Instead, myopathic muscle relies on lactate import to sustain its energy metabolism.
Article
Multidisciplinary Sciences
Andres Martin Bellido, Ayelen Mariana Distefano, Nicolas Setzes, Maria Milagros Cascallares, Jana Oklestkova, Ondrej Novak, Javier Alberto Ramirez, Eduardo J. Zabaleta, Diego F. Fiol, Gabriela C. Pagnussat
Summary: This study reveals the essential role of a plant mitochondrial steroidogenic pathway in female gametogenesis and early embryogenesis through a maternal effect. Exogenous hormone application can partially rescue the mutant phenotype.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Xinwei Wang, Yaqi An, Zhi Qi, Jianwei Xiao
Summary: A novel P-type PPR protein, ECD2, plays a crucial role in early chloroplast development, affecting chloroplast gene expression and ribosome accumulation. The mutant ecd2 leads to embryo lethality and RNAi lines exhibit albino cotyledons and abnormal chloroplast development.
Article
Multidisciplinary Sciences
Saumil Sethna, Patrick A. Scott, Arnaud P. J. Giese, Todd Duncan, Xiaoying Jian, Sheikh Riazuddin, Paul A. Randazzo, T. Michael Redmond, Steven L. Bernstein, Saima Riazuddin, Zubair M. Ahmed
Summary: The research demonstrates the role of CIB2 in regulating the Rheb-mTORC1 signaling axis and autophagy in AMD. Molecular deficits and pathologies related to AMD were observed in Cib2 mutant mice and dry-AMD patient samples.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Regina Putri Virgirinia, Makoto Nakamura, Kimiko Takebayashi-Suzuki, Fatchiyah Fatchiyah, Atsushi Suzuki
Summary: In addition to Clk2, Clk1 and Clk3 also play a role in the formation of neural tissue in Xenopus. Clk3 is essential for promoting neural development during early embryogenesis in Xenopus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hanuman T. Kale, Rajendra Singh Rajpurohit, Debabrata Jana, Vijay V. Vishnu, Mansi Srivastava, Preeti R. Mourya, Gunda Srinivas, P. Chandra Shekar
Summary: In this study, it was found that NANOG induces the expression of Fgfbp1 and Fgfr2 to activate ERK signaling, triggering autorepression in Nanog-high cells. Phosphorylated ERK recruits NONO to the Nanog locus to repress transcription, establishing a reciprocal NANOG-pERK regulatory circuit. This circuit regulates ERK signaling dynamics and Nanog autoregulation in pluripotent cells.
Article
Biochemistry & Molecular Biology
Daria D. Korotkova, Elena A. Gantsova, Alexander S. Goryashchenko, Fedor M. Eroshkin, Oxana V. Serova, Alexey S. Sokolov, Fedor Sharko, Svetlana V. Zhenilo, Natalia Y. Martynova, Alexander G. Petrenko, Andrey G. Zaraisky, Igor E. Deyev
Summary: This study investigated the function of insrr in early development of Xenopus laevis and found that its downregulation led to developmental retardation, which could be partially restored by alkaline treatment. The results demonstrate the critical role of insrr in regulating early development rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Meenalakshmi Chinnam, Chao Xu, Rati Lama, Xiaojing Zhang, Carlos D. Cedeno, Yanqing Wang, Aimee B. Stablewski, David W. Goodrich, Xinjiang Wang
Summary: MDM2 and MDM4 are essential regulators of p53, playing a role in its transcriptional activation and stability. This study shows that the E3 ligase activity of MDM2 is crucial for p53 regulation in vivo and also plays a p53-independent role in cell cycle regulation and genome integrity.
Article
Plant Sciences
Sofia Shevtsov-Tal, Corinne Best, Roei Matan, Sam A. Chandran, Gregory G. Brown, Oren Ostersetzer-Biran
Summary: Plant organellar introns have degenerated during evolution, relying on host-acting protein cofactors for splicing, which may link cellular signals with respiratory functions.
Article
Oncology
Yong Xia, Xing Wang, Yan Liu, Ellen Shapiro, Herbert Lepor, Moon-shong Tang, Tung-Tien Sun, Xue-Ru Wu
Summary: PKM2 plays an essential role in promoting tumor growth and maintenance by enhancing angiogenesis and metabolic addiction, although it is not required for tumor initiation. The PKM2-STAT3-HIF1 alpha/VEGF signaling axis may be critical in bladder cancer and could be a potential therapeutic target.
Article
Developmental Biology
Xue Zhang, Bo-Yin Tan, Shuang Zhang, Qian Feng, Ying Bai, Shi-Quan Xiao, Xue-Mei Chen, Jun-Lin He, Xue-Qing Liu, Ying-Xiong Wang, Yu-Bin Ding, Fang-Fang Li
Summary: Decidualization is an essential process for a successful pregnancy. Acyl-CoA binding protein (Acbp) has been found to play a critical role in cellular functions such as proliferation, differentiation, and autophagy. In this study, we investigated the expression and function of Acbp during decidualization in mice. We found that the expression of Acbp increased during decidualization and was not induced by embryonic signaling. Furthermore, interfering with Acbp attenuated decidualization, possibly due to mitochondrial dysfunctions and inhibition of fatty acid oxidation. Our results suggest that Acbp regulates stromal cell proliferation and differentiation during decidualization through modulation of mitochondria functions, fatty acid oxidation, and autophagy.
Article
Computer Science, Artificial Intelligence
Yanyan Tan, Bin Wang, Zeyuan Yan, Haoran Liu, Huaxiang Zhang
Summary: This paper proposes a deep spatio-temporal residual network model based on Region-reConStruction algorithm to predict the usage of shared bikes in the bike-sharing system. Experiments show that the prediction accuracy of our model is significantly better than that of previous models.
COMPLEX & INTELLIGENT SYSTEMS
(2023)
Article
Chemistry, Physical
Tianzhao Li, Xuelei Pan, Zhongzhuo Yang, Fang Liu, Kesong Yu, Lin Xu, Liqiang Mai
Summary: In this study, a patternable lithium-ion polymer electrolyte was successfully prepared by modifying SU-8 material. The modified sample exhibited higher ionic conductivity, good thermal stability, and mechanical properties, as well as a larger electrochemical window. Through the fabrication and testing of half-cell and microdevices, the feasibility of integrating batteries on microchips was verified.
Letter
Critical Care Medicine
Shoujin Dong, Wenting Lu, Yongsheng Wang
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Oncology
Senbo Liu, Yan Zhang, Yang Liu, Wenkang Wang, Shuochen Gao, Weitang Yuan, Zhenqiang Sun, Lin Liu, Chengzeng Wang
Summary: Cancer immunotherapy has made promising progress, but its therapeutic efficacy needs to be improved. Ultrasound-targeted microbubble destruction is an emerging technology that can remodel the tumor microenvironment and enhance the effectiveness of immunotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Linhua Xu, Qishuai Li, Dongwei Li, Xin Zhou, Ni Song, Peng Wang, Ming Li
Summary: A direct oxidative radical decarboxylative cyanomethylation of carboxylic acids using 3-azido-2-methylbut-3-en-2-ol as the carbon-centered radical acceptor is described. The method is applicable to various α-amino acids, α-oxy acids, α-keto acids, pentofuranuronic acids, and hexopyranuronic acids. Mechanistic investigations suggest the involvement of a radical process. This work provides a potential approach to synthesize biologically relevant β-amino acids, 5-deoxy-hexofuranose, and 6-deoxy-heptose constructs.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yu-Shi Shen, Xing Zhou, Shuai You, Lu-Chan Gong, Jun Wang, Tao Chen, Wei-Guo Zhao, Xiao-Hui Yao, Dong-Yang Zhang
Summary: Inspired by the structure of natural wood, a cellulose-based bionic microfluidic biocatalytic reactor was developed for the continuous fluid catalytic conversion of polydatin to resveratrol. The reactor, with vertically aligned channels and a porous inner wall, showed high catalytic activity (98.69% treatment efficiency) and excellent stability (maintain a conversion rate of more than 90% within 15 days) due to the unidirectionally aligned channels and porous inner wall. The reactor has great potential for simplifying industrial production and has broad application prospects for catalytic reactions.
Article
Infectious Diseases
Huiyong Xuan, Lining Xia, Stefan Schwarz, Haiyan Jia, Xiaohui Yao, Shufeng Wang, Ruichao Li, Jianchao Wei, Zongjie Li, Donghua Shao, Ke Liu, Yafeng Qiu, Zhiyong Ma, Beibei Li
Summary: This study analyzed the distribution of the optrA gene and the mobile genetic elements involved in its dissemination among enterococcal isolates from a swine farm. The results showed that optrA was present in enterococcal isolates from different stages of pig production, and horizontal transfer played a key role in its dissemination.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Correction
Oncology
Lin Xu, Xuejun Jiang, Fang Wei, Hongling Zhu
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Shan Wei, Chaojiang Hu, Yige Zhang, Yangyong Lv, Shuaibing Zhang, Huanchen Zhai, Yuansen Hu
Summary: Aspergillus niger produces ochratoxin A (OTA), which is genotoxic and carcinogenic. In this study, a gene encoding the transcription factor Azf1 was deleted in A. niger, resulting in complete blockage of OTA production. The deletion of Azf1 also led to decreased levels of reactive oxygen species (ROS) and impaired oxidative phosphorylation, which ultimately prevented OTA biosynthesis.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Guangwei Yang, Qiao Cheng, Jianying Li, Shuai Zhang, Steven Gao, Xiaodong Chen
Summary: In this work, an innovative method is investigated to control the current distribution of the radiating patch by adjusting the input phase, resulting in both pattern and polarization reconfigurable characteristics. A compact and low-profile antenna with four fed ports is designed to implement this method, allowing for linear, RHCP, and LHCP polarization with different beam directions. A passive planar array is also designed and fabricated based on this antenna element, which can scan a coverage of +/- 70 degrees with low gain fluctuation and low sidelobe. The proposed antenna is a good solution for wireless communication systems due to its simple configuration, multifunction, and beamforming capability.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Chemistry, Multidisciplinary
Hongyan Ji, Xiao Wang, Xiaoxu Wei, Yuxuan Peng, Shuaishuai Zhang, Shuyan Song, Hongjie Zhang
Summary: Hydrogenolysis is an effective method for converting polyolefins into high-value chemicals. In this study, the activity of CeO2-supported Ru single atoms, nanoclusters, and nanoparticles in LDPE hydrogenolysis showed a volcanic trend. Metal-support interactions and hydrogen spillover effect were identified as the two key factors in the reaction. Only when the balance between these two effects is achieved, as in CeO2-supported Ru nanoclusters, can the hydrogenolysis activity be promoted.
Article
Clinical Neurology
Jian Chen, Cheng-Gang Li, Li-Xuan Yang, Yi Qian, Li-Wen Zhu, Pin-Yi Liu, Xiang Cao, Ye Wang, Min-Sheng Zhu, Yun Xu
Summary: This study utilized MYPT1(SMKO) mice as a novel animal model of cerebral small vessel disease (CSVD). These mice exhibited neurobehavioral and pathological features similar to human CSVD, including decreased motion speed, anxiety, cognitive decline, white matter injury, small vessel impairment, inflammatory microenvironment, and blood-brain barrier disruption. This study provides an important animal model for investigating the pathophysiological mechanisms of CSVD.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Energy & Fuels
Qingchun Yang, Jinliang Zhang, Jianlong Zhou, Lei Zhao, Dawei Zhang
Summary: Gasification technology can effectively improve the utilization efficiency of coal and biomass resources. This study developed a hybrid data-driven machine learning framework for predicting the performance of coal and biomass gasification processes. The artificial neural network (ANN) model showed the best prediction performance with a coefficient of determination of 0.9242. The optimized ANN model, achieved through investigations into the number of hidden layers and neurons, and the application of a genetic algorithm, demonstrated improved prediction accuracy.
Article
Engineering, Electrical & Electronic
Xiaozhu Wen, Haodong Yang, Zixian Wu, Yang Yu, Guanghua Shi, Zhen Wang, Xubo Song, Shixiong Liang, Guodong Gu, Yuanjie Lv, Zhihong Feng, Yu Zheng, Anxue Zhang, Cheng Guo
Summary: This article presents a wideband coaxial D-band frequency tripler fabricated by copper additive manufacturing (AM). The tripler consists of waveguide-coaxial transitions, a coaxial low-pass filter, a Schottky diode chip, and an output impedance matching network. The diode chip is specially designed for thermal performance and power handling. Measurements show the tripler's output power, bandwidth, and return loss performance.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2023)
Article
Materials Science, Multidisciplinary
Jinliang Zhang, Jianbao Gao, Shenglan Yang, Bo Song, Lijun Zhang, Jian Lu, Yusheng Shi
Summary: This paper proposes a novel duplex nucleation mechanism to control the grain structure of additively manufactured AlCuMgTi-TiB2 composites for achieving a homogeneous equiaxed grain structure and breaking the strength-ductility trade-off. The results show that the proposed alloy design approach and duplex nucleation mechanism can guide the tailoring of the microstructure and mechanical properties of additively manufactured aluminum parts.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)