期刊
PSYCHIATRY RESEARCH
卷 271, 期 -, 页码 328-334出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2018.12.015
关键词
Scopolamine; Depression; Serotonin transporter (5-HTT); Brain-derived neurotrophic factor (BDNF); Tryptophan hydroxylase 1 (TPH1)
类别
资金
- National Natural Science Foundation of China [81671337, 81201050]
- Natural Science Foundation of Zhejiang province [LQ12H09001]
- Natural Science Foundation of Ningbo [2017A610212, 2016A610156]
- Ningbo Municipal Innovation Team of Life Science and Health [2015C110026]
- Xinmiao Talents Program of Zhejiang [2018R405052]
- Student Research and Innovation Program (SIRP)
- K.C. Wong Magna funded in Ningbo University
Reserpine treatment in rodents has been shown to induce depression-like behaviors that mimic monoamine dysfunction implicated in the development of depression. Herein, we aimed to demonstrate the antidepressant like activities of scopolamine, the muscarinic receptor antagonist, in a reserpine-induced mouse model. Mice were injected with 1.5 mg/kg (i.p.) of reserpine for 10 days, and the depression-like state was confirmed via the open field test (OFT) and forced swimming test (FST). Then, the mice were treated with scopolamine (25 mu g/kg, i.p.) or saline for 3 days. Ten days of reserpine treatment resulted in a significant decrease in locomotor activity and an increase in immobility time in the OFT and FST, respectively, indicating that ten days of reserpine administration significantly induced depression-like behaviors in mice. However, scopolamine rapidly ameliorated the increase in immobility time in the FST and had no effect on locomotor activity in the OFT. In addition, the reserpine-induced decreases in serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF) and tryptophan hydroxylase 1 (TPH1) in mouse hippocampus and prefrontal cortex (PFC) were significantly reversed by scopolamine. Our study provides evidence that scopolamine rapidly attenuates reserpine-induced depression in mice partially by regulating 5-HTT, BDNF and TPH1 in the hippocampus and PFC of mice.
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