期刊
PROGRESS IN LIPID RESEARCH
卷 73, 期 -, 页码 92-100出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2019.01.001
关键词
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资金
- 973-Program [2015CB856304]
- National Natural Science Foundation of China [11772054, 11772055, 11532009]
- National Institutes of Health (NIH) [R35GM128837]
To study membrane fusion mediated by synaptic proteins, proteoliposomes have been widely used for in vitro ensemble measurements with limited insights into the fusion mechanism. Single-particle techniques have proven to be powerful in overcoming the limitations of traditional ensemble methods. Here, we summarize current single-particle methods in biophysical and biochemical studies of fusion mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and other synaptic proteins, together with their advantages and limitations.
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