期刊
出版社
ROYAL SOC
DOI: 10.1098/rspa.2018.0409
关键词
scanning electrochemical microscopy microelectrodes; nanoelectrodes; chemical imaging; bio-SECM; microelectrochemistry
资金
- Thailand Research Fund (TRF) [BRG 568000013]
- Deutsche Forschungsgemeinschaft (DFG) [EXC 1069]
- Deutsch-Israelische Projektkooperation (DIP) in the framework of the project 'Nanoengineered Optobioelectronics with Biomaterials and Bioinspired Assemblies'
- Suranaree University of Technology in Nakhon Ratchsima [BRG 568000013]
Scanning electrochemical microscopy (SECM) is a powerful and versatile technique for visualizing the local electrochemical activity of a surface as an ultramicroelectrode tip is moved towards or over a sample of interest using precise positioning systems. In comparison with other scanning probe techniques, SECM not only enables topographical surface mapping but also gathers chemical information with high spatial resolution. Considerable progress has been made in the analysis of biological samples, including living cells and immobilized biomacromolecules such as enzymes, antibodies and DNA fragments. Moreover, combinations of SECM with complementary analytical tools broadened its applicability and facilitated multi-functional analysis with extended life science capabilities. The aim of this review is to present a brief topical overview on recent applications of biological SECM, with particular emphasis on important technical improvements of this surface imaging technique, recommended applications and future trends.
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