期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 5, 页码 1489-1494出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1811722116
关键词
collective behavior; swarming; cell-cell interactions; microbiology; biofilm
资金
- Max Planck Society
- Human Frontier Science Program [CDA00084/2015-C]
- Deutsche Forschungsgemeinschaft [SFB 987]
- European Research Council [StG-716734]
- James S. McDonnell Foundation Complex Systems Scholar Award
- Edmund F. Kelly Research Award
- Massachusetts Institute of Technology (MIT) International Science and Technology Initiatives Germany
Coordinated dynamics of individual components in active matter are an essential aspect of life on all scales. Establishing a comprehensive, causal connection between intracellular, intercellular, and macroscopic behaviors has remained a major challenge due to limitations in data acquisition and analysis techniques suitable for multiscale dynamics. Here, we combine a high-throughput adaptive microscopy approach with machine learning, to identify key biological and physical mechanisms that determine distinct microscopic and macroscopic collective behavior phases which develop as Bacillus subtilis swarms expand over five orders of magnitude in space. Our experiments, continuum modeling, and particle-based simulations reveal that macroscopic swarm expansion is primarily driven by cellular growth kinetics, whereas the microscopic swarming motility phases are dominated by physical cell-cell interactions. These results provide a unified understanding of bacterial multiscale behavioral complexity in swarms.
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