Article
Pharmacology & Pharmacy
Kamran Hidayat Ullah, Faisal Rasheed, Iffat Naz, Naveed Ul Haq, Humaira Fatima, Nosheen Kanwal, Tofeeq Ur-Rehman
Summary: The study developed chitosan nanoparticles loaded poloxamer 407 gel formulation for transungual delivery of terbinafine HCl. The optimized formulation exhibited spherical shape, high entrapment efficiency, and potential therapeutic effect against onychomycosis.
Article
Polymer Science
Qian Li, Ruiqi Wang, Jun Lee, Joana S. Correia, Anna P. Constantinou, Jonathan Krell, Theoni K. Georgiou
Summary: A series of biocompatible thermoresponsive copolymers were synthesised using GTP from MEGMA and OEGMA. The copolymers displayed thermoresponsive behavior and self-assembly properties. Diblock copolymers with higher MEGMA content were able to form gels at low concentrations and showed a transition from spherical to wormlike micelles. Additionally, mixing the synthesised copolymers with Pluronic & REG; F127 broadened the gelation area and formed a stable gel within a desirable temperature range. Cell viability experiments confirmed the non-toxicity of the copolymers.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Mahboobeh Zare, Malihe Norouzi Sarkati, Hamed Tashakkorian, Somayeh Rahaiee
Summary: Quercetin, a bioactive flavonoid, shows anti-cancer effects by inhibiting the proliferation of cancer cells. A novel functionalized Fe3O4 nanoparticle was developed for quercetin delivery, which exhibited greater toxicity against MCF-7 cells compared to free quercetin nanoparticles. The cytotoxicity of quercetin loaded MNPs against cancer cells makes them promising candidates for further study in cancer treatment.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Zikai Xu, Liangyu Zou, Feng Xie, Xi Zhang, Xiaolan Ou, Guanghui Gao
Summary: A hemostatic sponge based on modified graphene oxide (GO) and carboxymethyl chitosan (CMCS) is successfully prepared, which exhibits excellent water absorption ability, mechanical strength, hemostatic efficiency, antibacterial effects, and cell proliferation promotion. This graphene-based sponge holds broad prospects in the hemostatic field.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Fushi Wang, Weiwei Qiao, Weiting Guo, Zhiwen Li, Xinjie Cai
Summary: Peri-implant surgical site infection is a challenge in oral implant surgery. This study investigated the use of negatively charged carboxymethyl chitosan/gelatin composite membranes fabricated via anodic electrophoretic deposition to prevent peri-implantitis.
Article
Polymer Science
Karol K. Klosinski, Radoslaw A. Wach, Malgorzata K. Girek-Bak, Bozena Rokita, Damian Kolat, Zaneta Kaluzinska-Kolat, Barbara Klosinska, Lukasz Duda, Zbigniew W. Pasieka
Summary: Hydrogels formed from CMCS and crosslinking agent via electron beam irradiation showed potential as wound dressings. The gel's elasticity was influenced by component concentrations and irradiation dose. The hydrogels exhibited biocompatibility and could stimulate cell growth. Ionizing radiation proved to be a suitable tool for synthesis and sterilization of CMCS hydrogels.
Article
Pharmacology & Pharmacy
Kummara Madhusudana Rao, Kannan Badri Narayanan, Uluvangada Thammaiah Uthappa, Pil-Hoon Park, Inho Choi, Sung Soo Han
Summary: In this study, multifunctional fungal mushroom-derived hydrogels were developed for wound dressing applications, with tissue adhesive, hemostasis, self-healing, and antibacterial properties. The hydrogels exhibited good swelling ratio, biodegradability, mechanical properties, and high adhesion strength to porcine skin. Additionally, they showed excellent antibacterial properties and promoted cell viability and attachment, making them a promising material for wound healing.
Article
Crystallography
Narayanasamy Duraisamy, Sangeetha Dhayalan, Mohammed Rafi Shaik, Althaf Hussain Shaik, Jilani P. Shaik, Baji Shaik
Summary: This study characterized the green synthesized Martynia annua mediated Chitosan nanoparticles (MAL-CNPs) using various characterization techniques. The MAL-CNPs showed antioxidant, cytotoxicity, a-amylase, and alpha-glucosidase inhibitory activities. The nanoparticles were non-toxic and demonstrated potential for biomedical applications.
Article
Polymer Science
Namon Hirun, Pakorn Kraisit, Vimon Tantishaiyakul
Summary: In this study, a thermosensitive gel with good adhesion and rheological properties was developed using a mixture of poloxamer and polycarbophil, which could serve as a viable platform for mucoadhesive in situ gelling drug delivery.
Article
Biochemistry & Molecular Biology
Aakriti Singh, Ganesh Yadagiri, Manorma Negi, Anurag Kumar Kushwaha, Om Prakash Singh, Shyam Sundar, Shyam Lal Mudavath
Summary: In this study, carboxymethyl chitosan (CMC) grafted lipid nanoformulations were prepared as an efficient carrier for amphotericin B (AmB) to treat leishmaniasis. The nanoformulations showed good physicochemical characteristics, controlled drug release, and high antileishmanial activity without causing toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mandeep Dahiya, Rajendra Awasthi, Jaya Parkash Yadav, Shammi Sharma, Kamal Dua, Harish Dureja
Summary: This study developed magnetic nanoparticles by embedding magnetite particles in the drug-loaded, crosslinked matrix of chitosan. Sorafenib tosylate-loaded magnetic nanoparticles were prepared and showed superparamagnetic nature. The IC50 value of the nanoparticles in HepG2 cells was 54.75 mu g/mL.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Suresh Naveenkumar, Narayanan Venkateshan, K. Kaviyarasu, Johnson Retnaraj Samuel Selvan Christyraj, Azhaguchamy Muthukumaran
Summary: This study developed a novel Alginate-Pectin selenium nanoparticles (AP-SeNPs) scaffold, which demonstrated high antioxidative potential, mechanical strength, and performance in cardiac tissue engineering applications. The scaffold showed good stability and antioxidative activity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biology
Abdullah S. Alshetaili
Summary: In this study, gefitinib loaded PLGA nanoparticles and chitosan coated PLGA nanoparticles were synthesized to investigate the role of surface charge on drug delivery for non-small-cell lung cancer. The chitosan-coated nanoparticles showed more sustained release of gefitinib and demonstrated significant anti-cancer activity in A549 lung cancer cells. This research indicates that the developed nanoparticles could be efficient carriers for delivering gefitinib with enhanced efficacy against NSCLC.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Instruments & Instrumentation
Sagar R. Pardeshi, Mahesh P. More, Pritam B. Patil, Arun Mujumdar, Jitendra B. Naik
Summary: The study developed novel voriconazole loaded nanoparticles for ocular diseases, which were incorporated into carboxymethyl chitosan and poloxamer to prepare in situ ophthalmic gel. The nanoparticles showed good encapsulation efficiency and particle size, and the gel containing CMCh demonstrated enhanced antifungal activity against Candida albicans.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Materials Science, Paper & Wood
Mahmoud H. Abu Elella, Heba M. Abdallah, Heba Gamal, Essam B. Moustafa, Emad S. Goda
Summary: Antimicrobial hydrogels are a major focus for repairing soft tissues and preventing bacterial infections, with new hydrogels designed in this study showing high biocompatibility through physical crosslinking reactions. The hydrogels exhibit significant antibacterial activity against Staphylococcus aureus and Escherichia coli, with those containing high TMC content showing superior inhibition zones compared to pure TMC. Additionally, the cytotoxicity testing on normal cell lines VERO and lung (Wi38) cells demonstrates high cell viability at lower concentrations.
Article
Computer Science, Information Systems
Nayyer Aafaq, Ajmal Mian, Naveed Akhtar, Wei Liu, Mubarak Shah
Summary: Dense captioning methods detect events in videos and generate captions, but lack explicit modeling of linguistic information and context. In this paper, a Visual-Semantic Embedding (ViSE) Framework is proposed to model word(s)-context distributional properties and compute weights for informative n-grams. Visual-Semantic Joint Modeling Network (VSJM-Net) is designed for supervised contextualization. The effectiveness of the method is demonstrated on ActivityNet Captions and YouCook-II datasets.
IEEE TRANSACTIONS ON MULTIMEDIA
(2023)
Article
Polymer Science
Huma Butt, Muhammad Usman Minhas, Kifayat Ullah Khan, Muhammad Sohail, Ikrima Khalid, Sehrish Rehmani, Muhammad Suhail
Summary: In this study, beta-cyclodextrin-based pH-responsive hydrogels were prepared by grafting 2-acrylamido-2-methylpropane sulphonic acid (AMPS) and methacrylic acid (MAA) using the free radical polymerization technique. Captopril was loaded as a model drug. The properties of the hydrogels were influenced by the acrylamide sulphonate and methacrylate-modified beta-cyclodextrin. The swelling dynamics and drug release of the hydrogels were pH-responsive, with the highest swelling and drug release observed at pH 7.4. The addition of beta-cyclodextrin, AMPS, and MAA increased the gel fraction of the hydrogels.
Article
Computer Science, Information Systems
Uno Fang, Jianxin Li, Naveed Akhtar, Man Li, Yan Jia
Summary: This article proposes a self-supervised multi-view image clustering technique based on contrastive heterogeneous graph learning. It computes a heterogeneous affinity graph and conducts local feature propagation and influence-aware feature propagation to learn the clustering intention. Experimental results show that the proposed method outperforms existing methods on benchmark datasets.
WORLD WIDE WEB-INTERNET AND WEB INFORMATION SYSTEMS
(2023)
Meeting Abstract
Clinical Neurology
Naveed Akhtar, Rajvir Singh, Saadat I. Kamran, Sujatha Joseph, Deborah Morgan, Ryan T. Uy, Sarah Treit, Ashfaq Shuaib
Meeting Abstract
Clinical Neurology
Hiba Naveed, Muna Almasri, Bahram Kazani, Areej Nauman, Rajvir Singh, Salman Aljerdi, Naveed Akhtar, Ashfaq Shuaib
Article
Dermatology
Muhammad Shahzad Khan, Qazi Adnan, Naveed Akhtar
Summary: A stable emulgel containing wild Alpinia galanga extract was prepared and characterized. The emulgel showed significant improvement in skin physiological parameters such as sebum, erythema, moisturizing, melanin, and pores.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Plant Sciences
Muhammad Zafar, Siraj Ahmed, Muhammad Kashif Munir, Nawal Zafar, Muhammad Saqib, Muhammad Aleem Sarwar, Saba Iqbal, Baber Ali, Naveed Akhtar, Basharat Ali, Sadam Hussain, Muhammad Saeed, Mohammad Khalid Al-Sadoon, Aneela Gulnaz
Summary: Deficiencies in essential vitamins, iron, and zinc affect more than half of the global population. Agronomic biofortification of pulses with these nutrients offers a pragmatic solution to combat hidden hunger and improve crop production. This study conducted three field experiments to evaluate the impact of soil and foliar application of these nutrients on mungbean yield and seed biofortification. The results showed that soil application enhanced the yield performance of mungbean, while foliar application significantly increased the contents of zinc, iron, and boron in the seeds.
PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Mathematics
Muhammad Afzal, Naveed Akhtar, Mohammed Omar Alkinidri, Meshal Shutaywi
Summary: The current study focuses on the modeling and analysis of acoustic scattering from an elastic membrane disc located in a cylindrical waveguide that may involve structural discontinuities. The physical problem is governed by Helmholtz's equation and involves higher order boundary conditions at the interfaces. The Mode-Matching (MM) method in conjunction with Galerkin formulation is developed to solve the governing boundary value problems. The solution procedure is first applied on two prototype problems to formulate the theoretical frame work, which is then used to analyze the structural response of the elastic membranes attached at the mouth of the cylindrical expansion chamber. The aforementioned solution method yields the linear algebraic systems containing infinite equations. These systems are truncated first and then are numerically solved. From the numerical experiments, it is found that geometrical and material properties of the structure significantly affect the transmission loss as well as the scattering energies.
Article
Computer Science, Software Engineering
Muhammad Bilal Shaikh, Douglas Chai, Syed Mohammed Shamsul Islam, Naveed Akhtar
Summary: PyMAiVAR is a versatile toolbox that generates image representations for audio data, including wave plots, spectral centroids, spectral roll offs, Mel Frequency Cepstral Coefficients (MFCC), MFCC feature scaling, and chromagrams. This toolkit plays a pivotal role in reshaping human action recognition by fully exploiting the latent potential of audio data. Implemented in Python, PyMAiVAR can be used across different operating systems.
Article
Zoology
Ikram Ullah, Zaib Ullah, Junaid Khan, Sajid Mahmood, Zafar Iqbal, Naveed Akhtar
Summary: The Asiatic black bear (Ursus thibetanus) in the northern mountainous areas of Pakistan is threatened by human conflict. This study aimed to gather information on human-black bear conflicts and potential mitigation measures in the Siran and Kaghan valleys of District Mansehra from April 2018 to April 2019. Interviews and questionnaires from 100 inhabitants and 32 villages revealed that agriculture crops destruction, livestock predation, and human casualties were common conflicts. The most effective mitigation strategies were compensation for losses and involving the local community in conservation programs.
PAKISTAN JOURNAL OF ZOOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Huan Lei, Naveed Akhtar, Mubarak Shah, Ajmal Mian
Summary: This article proposes a series of modular operations for effective geometric feature learning from 3-D triangle meshes. These operations include novel mesh convolutions, efficient mesh decimation, and associated mesh (un)poolings. These operations have important applications in computer graphics and 3-D vision.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Clinical Neurology
Ioannis N. Petropoulos, Fatima Al-Shibani, Gulfidan Bitirgen, Georgios Ponirakis, Adnan Khan, Hoda Gad, Ziyad R. Mahfoud, Heba Altarawneh, Muhammad Hassan Rehman, Karen John, Dhabia Al-Merekhi, Pooja George, Ali Ulvi Uca, Ahmet Ozkagnici, Faiza Ibrahim, Reny Francis, Beatriz Canibano, Dirk Deleu, Ahmed El-Sotouhy, Surjith Vattoth, Ahmed Own, Ashfaq Shuaib, Naveed Akhtar, Saadat Kamran, Rayaz A. Malik
Summary: Corneal confocal microscopy (CCM) can be used to detect axonal loss in multiple sclerosis (MS) patients. This study found progressive corneal and retinal axonal loss over a 2-year follow-up period, especially in patients with more active disease. CCM may serve as an imaging biomarker of axonal loss in MS.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: Transient ischemic attack (TIA) is a temporary neurologic deficit caused by ischemic insult to the brain, spinal cord, or retina. TIA is associated with a high risk of impending acute ischemic stroke (AIS), a condition characterized by focal infarction in the brain, spinal cord, or retina. This study investigated the differences in circulating microRNA profiles between AIS and TIA patients and identified a panel of differentially regulated microRNAs. Furthermore, a multivariate classifier was developed that could potentially be used as a biomarker to distinguish AIS and TIA patients. Understanding the molecular pathways in AIS compared to TIA may have important implications for therapeutic targeting in clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Samiullah Khan, Muhammad Usman Minhas
Summary: This study reports the combined technique of microneedle array patches and thermoresponsive gels for sustained drug delivery. The optimized formulations loaded with Ibuprofen sodium showed longer permeation time through the prepared microneedle array patches. Confocal study confirmed the diffusion of drug loaded formulations in deeper tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Proceedings Paper
Automation & Control Systems
Muhammad Ibrahim, Naveed Akhtar, Saeed Anwar, Michael Wise, Ajmal Mian
Summary: This paper presents a self-supervised learning method for precise outdoor localization using LiDAR data. The proposed method reorganizes the slices of a LiDAR scan and utilizes a transformer model with multi-head attention for localization. The efficacy of the proposed method is evaluated on the Perth-WA dataset and validated for object classification tasks. The research demonstrates the effectiveness of the approach for outdoor localization and object classification.
2023 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA 2023)
(2023)