期刊
POLYHEDRON
卷 161, 期 -, 页码 126-131出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2019.01.005
关键词
N-allylimidazol complexes; Zinc; Cobalt; X-ray diffraction; Antihypoxic activity
Zinc(II) and cobalt(II) complexes of N-allylimidazole, bis(N-allylimidazole)zinc diacetate (1) and bis(N-allylimidazole)cobalt dichloride (2), have been prepared and characterized by X-ray crystallography, NMR, FTIR spectroscopy, microanalysis and melting point. The single crystal X-ray diffraction analysis confirms that compounds 1 and 2 are monomeric with tetra-coordinate zinc and cobalt centers. Complexes 1 and 2 have been tested using four in vivo models of acute hypoxia of different genesis (hypobaric, hemic, histotoxic, hypoxia with hypercapnia). Complex 1 reveals a moderate effect against the hemic and histotoxic hypoxia, and a high effect against the hypobaric hypoxia and hypoxia with hypercapnia, while complex 2 demonstrates a high antihypoxic activity in all the studied models. (C) 2019 Elsevier Ltd. All rights reserved.
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