Article
Biochemistry & Molecular Biology
Marcin Gierach, Roman Junik
Summary: This study aimed to investigate the metabolic parameter changes in females newly diagnosed with Hashimoto's thyroiditis who were practicing triathlon before treatment with L-thyroxine and after 3 and 6 months of treatment. The results showed significant reductions in body fat percentage and visceral adipose tissue, lower BMI levels, and significant differences in thyroid function tests (TSH and fT4) after L-thyroxine treatment.
Article
Physiology
Tomasz Kowalski, Przemyslaw Seweryn Kasiak, Kinga Rebis, Andrzej Klusiewicz, Dominika Granda, Szczepan Wiecha
Summary: This study assessed the additional load induced by RMT in well-trained triathletes and found that the changes in monitored variables depend on sex and training method. VIH significantly increased the subjective training load measures, while IPTL was associated with imbalances in blood gas analysis, increased lactate levels, and reports of headaches and dizziness. Both methods should be used with consideration in high-performance settings.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Environmental Sciences
Jing Wang, Chen Liu, Shu-Ping Wang, Tian-Xu Zhang, Jing-Yi Chen, Quan Zhou, Yin Hou, Zhen-Guang Yan
Summary: This study investigated the toxic effects and underlying mechanisms of decabromodiphenyl ether (BDE-209) exposure on the intestinal tract using adult male zebrafish as a model. The results showed that BDE-209 exposure caused damage to intestinal structure and barrier function, and promoted oxidative stress, inflammatory response, apoptosis, and disorders in steroid and lipid metabolism. Mechanistically, BDE-209 induced intestinal inflammation through the NF kappa B signaling pathway, and might induce apoptosis through the p53-Bax/Bcl2-Caspase3 pathway. BDE-209 also disrupted cholesterol synthesis and caused lipid metabolism disorders. Furthermore, BDE-209 stress reduced the richness and diversity of intestinal microbiota and decreased the abundance of probiotics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Holly E. Szczepanski, Kyle L. Flannigan, Barbara Mainoli, Laurie Alston, Grace M. Baruta, Joshua W. Lee, Vivek Krishna Pulakazhi Venu, Jane Shearer, Antoine Dufour, Simon A. Hirota
Summary: Stricture formation is a common complication of Crohn's disease, and the orphan nuclear receptor NR4A1 plays a role in regulating intestinal smooth muscle cell proliferation and muscle thickening. Loss of NR4A1 leads to increased proliferation and alterations in cellular metabolism, while activation of NR4A1 attenuates proliferation. By targeting NR4A1, it may be possible to regulate intestinal smooth muscle phenotype and limit excessive proliferation contributing to stricture development in Crohn's disease.
Article
Physiology
Cesar Augustus Zocoler de Sousa, Ana Paula Renno Sierra, Bryan Steve Martinez Galan, Jaqueline Fernanda de Sousa Maciel, Richelieau Manoel, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Maria Fernanda Cury-Boaventura
Summary: Endurance exercise increases the expression of exercise-induced peptides that aid in muscle repair and regeneration. A study on marathon runners showed an increase in various exercise-induced cytokines immediately after the race, including IL-6, IL-8, TNF-alpha, IL-10, decorin, GDF-15, BDNF, follistatin, and FGF-21. The decrease in myostatin, IL-15, musclin, and apelin levels post-race suggested muscle regeneration.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Rehabilitation
J. A. Stewart, E. K. Merritt, D. E. Lidstone, J. M. McBride, K. A. Zwetsloot
Summary: The purpose of this study was to determine the impact of performing cycling before running in collegiate triathletes. It was found that mechanical efficiency of running was decreased and anaerobic energy expenditure was increased when a 40-km bout of cycling was performed immediately before running.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2022)
Article
Biochemistry & Molecular Biology
Maria-Theodora Melissari, Ana Henriques, Christos Tzaferis, Alejandro Prados, Michalis E. Sarris, Niki Chalkidi, Dimitra Mavroeidi, Panagiotis Chouvardas, Sofia Grammenoudi, George Kollias, Vasiliki Koliaraki
Summary: This study investigates the various subsets of intestinal mesenchymal cells and their roles in intestinal morphogenesis and pathophysiology. The results show that Col6a1(Cre) mouse targets fibroblast subsets and perivascular cells, as well as mesenchymal aggregates crucial for intestinal development. In adulthood, Col6a1(+)/CD201(+) mesenchymal cells regulate enteroendocrine cell differentiation and epithelial proliferation. During acute colitis, they exhibit an inflammatory and extracellular matrix remodelling gene signature. However, these cells are dispensable for normal organ architecture in both homeostasis and tissue regeneration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Almira Zada, Yuying Zhao, Danny Halim, Jonathan Windster, Herma C. van der Linde, Jackleen Glodener, Sander Overkleeft, Bianca M. de Graaf, Robert M. Verdijk, Alice S. Brooks, Iain Shepherd, Ya Gao, Alan J. Burns, Robert M. W. Hofstra, Maria M. Alves
Summary: Long FLNA isoform plays a crucial role in intestinal development and function, and its loss may result in myopathic form of CIPO.
HUMAN MOLECULAR GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Marcio Vinicius Damico, Cristiane Damas Gil, Rosely Oliveira Godinho, Enio Setsuo Arakaki Pacini, Consuelo Latorre Fortes -Dias, Vanessa Moreira
Summary: The inhibition of 5-LOX and 12-LOX pathways can promote the regeneration of skeletal muscle fibers. Oral treatment with 5-LOX inhibitor MK886 or 12-LOX inhibitor baicalein can reduce inflammation and facilitate the healing process of muscle injury. Inhibition of the 5-LOX pathway enhances muscle resistance, while inhibition of the 12-LOX pathway promotes early recovery of muscle fiber activity and function.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Cuiyu Zhang, Yuping Zhou, Junjie Zheng, Nannan Ning, Haining Liu, Wenyang Jiang, Xin Yu, Kun Mu, Yan Li, Wei Guo, Huili Hu, Jingxin Li, Dawei Chen
Summary: This study demonstrates that GABA regulates intestinal stem cell apoptosis through its A receptor in chemoradiotherapy-induced intestinal injury. FDA-approved GABA(A)R antagonist flumazenil may be a promising drug for reducing the gastrointestinal side effects brought by chemoradiotherapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Jingxia Gao, Guanzhong Song, Haibo Shen, Yiming Wu, Chongqi Zhao, Zhuo Zhang, Qian Jiang, Xilong Li, Xiaokang Ma, Bie Tan, Yulong Yin
Summary: This study found that allicin improves intestinal barrier function and prevents damage caused by bacteria. It increases cell viability and enhances the integrity of cell monolayers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dongxiao Zhang, Danni Zhong, Jiang Ouyang, Jian He, Yuchen Qi, Wei Chen, Xingcai Zhang, Wei Tao, Min Zhou
Summary: In this study, researchers have successfully developed an oral delivery system using Spirulina platensis as a microcarrier to protect the whole small intestine from radiation-induced injury during radiotherapy. The system accumulates the drug effectively and provides superior radioprotection compared to free drug and enteric capsules, preventing radiation-induced intestinal injury without affecting tumor regression. It also has benefits on gut microbiota homeostasis and long-term safety.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Xiaobin Wen, Lixin Tang, Ruqing Zhong, Lei Liu, Liang Chen, Hongfu Zhang
Summary: The mitochondrion plays a major role in maintaining redox homeostasis and is both a source and target of reactive oxygen species (ROS). Oxidative stress, resulting from an imbalance between ROS and the antioxidative system, is linked to inflammatory bowel disease and gastrointestinal mucosal diseases. Mitophagy, the selective autophagic degradation of damaged mitochondria, can significantly alleviate oxidative damage. This review aims to explore the molecular mechanisms of mitophagy and oxidative stress regulation and their relationship in intestinal diseases, providing new insights for antioxidant research and preventing oxidative damage-related diseases.
Article
Endocrinology & Metabolism
Tom S. O. Jameson, Sean P. Kilroe, Jonathan Fulford, Doaa R. Abdelrahman, Andrew J. Murton, Marlou L. Dirks, Francis B. Stephens, Benjamin T. Wall
Summary: This study investigated the impact of prior muscle-damaging eccentric exercise on disuse-induced muscle deconditioning. The results showed that prior exercise can prevent the decline in muscle volume after 2 days and attenuate the decline in MyoPS after 2 and 7 days.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
Qianqian Wang, Jiafang Wang, Elmira Tokhtaeva, Zhen Li, Martin G. Martin, Xuefeng B. Ling, James C. Y. Dunn
Summary: The study presents the development of a living intestinal muscle patch capable of generating different motility patterns and multiple digesta manipulations. It is shown that the successful generation of the contracting muscle patch requires both biological factors and cues from the scaffold. The findings highlight the importance of combining biomolecular and biomaterial approaches for tissue engineering, providing a more physiological model for studying gastrointestinal motility and drug discovery.
ADVANCED MATERIALS
(2023)
Article
Oncology
Wanda Pilch, Marta Szarek, Czerwinska-Ledwig Olga, Piotrowska Anna, Malgorzata Zychowska, Sadowska-Krepa Ewa, Stefania Andrascikova, Tomasz Palka
Summary: The aim of this study was to investigate the effect of a Finnish sauna on the immune status parameters. The study found that sauna bathing as a series of treatments can improve the immune response. Trained and untrained subjects had different responses to sauna baths in terms of white blood cells, lymphocyte subpopulations, and immunoglobulins. The study also found positive correlations between cortisol and internal temperature, IL-6 and cortisol concentrations, and IL-6 and IL-10 concentrations after sauna bathing.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Rydzik, Tadeusz Ambrozy, Tomasz Palka, Wojciech Wasacz, Michal Spieszny, Jacek Perlinski, Pawel Krol, Marta Kopanska
Summary: The aim of this study was to develop a brainwave model using quantitative electroencephalography to assess the brain function of competitive K1 kickboxers. The results showed that the level of brain activity significantly differentiated the kickboxers from the control group in selected measurement areas, particularly in the frontal lobe where the activity of Delta waves was significantly higher than normal values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Lukasz Rydzik, Tomasz Palka, Ewa Sobilo-Rydzik, Lukasz Tota, Dorota Ambrozy, Tadeusz Ambrozy, Pavel Ruzbarsky, Wojciech Czarny, Marta Kopanska
Summary: Brain injuries are common in combat sports, and particularly in disciplines like kickboxing. This study examined the brainwave activity of 18 high-level K-1 kickboxing athletes and found that high activity in certain brainwave frequencies may have a negative effect on athletic performance. It is therefore important for athletes to monitor their brainwave activity and use appropriate training strategies to achieve optimal results.
Article
Biochemistry & Molecular Biology
Tomasz Palka, Piotr Michal Koteja, Lukasz Tota, Lukasz Rydzik, Alejandro Leiva-Arcas, Anna Kaluza, Wojciech Czarny, Tadeusz Ambrozy
Summary: This study aimed to examine the effectiveness of different hydration strategies in young men during prolonged exercise at elevated ambient temperatures on levels of oxidative stress, antioxidant status, muscle cell damage, and inflammatory status. The results showed that using isotonic drinks instead of water or no hydration effectively protected muscle cells from the negative effects of exercise.
Article
Biology
Tomasz Palka, Piotr Michal Koteja, Lukasz Tota, Lukasz Rydzik, Marta Kopanska, Izabela Kaczorowska, Norollah Javdaneh, Wioletta Mikulakova, Hubert Wolski, Tadeusz Ambrozy
Summary: Engaging in physical exertion in a high temperature environment can disrupt water-electrolyte balance and thermal homeostasis, leading to physiological and biochemical changes. It is crucial to hydrate the body and provide adequate carbohydrates to maintain exercise capacity. Different hydration strategies have varying effects on hematological indicators and blood lactate levels during prolonged physical exercise in a high ambient temperature.
Article
Biochemistry & Molecular Biology
Martyna Guzik, Olga Czerwinska-Ledwig, Anna Piotrowska
Summary: Microplastics are commonly used as abrasive components in facial peelings. Although they are not the main cause of environmental microplastic contamination, they can pose a significant threat to the environment and people. Manufacturers are increasingly replacing microplastics with alternatives due to legal requirements.
Article
Chemistry, Multidisciplinary
Marcin Maciejczyk, Tomasz Palka, Magdalena Wiecek, Jadwiga Szymura, Justyna Kusmierczyk, Marek Bawelski, Sebastian Masel, Zbigniew Szygula
Summary: The aim of this study was to evaluate the effects of interval training performed in hypoxia on aerobic capacity and second ventilatory threshold in young, untrained men. The results showed that compared to training in normoxia, interval training in hypoxia significantly improved maximum oxygen uptake and power output at the second ventilatory threshold.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, General & Internal
Tomasz Palka, Marcin Maciejczyk, Olga Czerwinska-Ledwig, Lukasz Tota, Marek Bawelski, Alejandro Leiva-Arcas, Rafal Stabrawa, Przemyslaw Bujas, Dawid Mucha, Andrzej Wisniewski, Anna Piotrowska
Summary: The aim of this project was to determine the optimal parameters for vibrotherapy as a recovery modality after physical exercise. Sixteen healthy male volunteers were involved in the study, performing intensive exercises followed by vibrotherapy treatment. The study found that lower frequency values (2-52 Hz) and a raised feet position were more beneficial. A 45-minute treatment was also more efficient in improving work capacity and reducing biochemical markers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anna Grodecka, Olga Czerwinska-Ledwig, Adrianna Dzidek, Wiktoria Lis, Dorota Cwalinska, Weronika Koziol, Aneta Teleglow, Tomasz Palka, Anna Piotrowska
Summary: This study evaluated the effects of a series of workouts in a hypoxic chamber on skin characteristics in overweight and obese women. The results showed that the workouts did not affect skin firmness or transepidermal water loss, but led to increased skin hydration on the hand. Additionally, a reduction in body weight, BMI, and total body water was observed in the study group, while the control group showed an increase in BMI and visceral fat accumulation.
Review
Biochemistry & Molecular Biology
Aleksandra Krawiec, Olga Czerwinska-Ledwig, Bartlomiej Kita, Anna Piotrowska
Summary: Diabetic foot syndrome is the leading cause of limb loss due to non-healing ulcers. Vigilant observation and regular care can reduce wound size and prevent new wounds. The application of natural ingredients, nanomaterials, ozone and stem cells in diabetic foot care were discussed.
Article
Chemistry, Multidisciplinary
Tomasz Palka, Tadeusz Ambrozy, Ewa Sadowska-Krepa, Lukasz Rydzik, Szczepan Wiecha, Marcin Maciejczyk, Peter Kacur, Piotr Michal Koteja, Bibiana Vadasova, Kazimierz Witkowski, Lukasz Tota
Summary: This study investigates the impact of anaerobic interval exercises involving both upper and lower limbs at different temperatures on physiological indicators. The results show that muscle cell damage is evident under both temperature conditions, providing insights into training strategies and highlighting the physiological responses observed in combat sports athletes.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Adrianna Dzidek, Olga Czerwinska-Ledwig, Malgorzata Zychowska, Wanda Pilch, Anna Piotrowska
Summary: SIRT6 is an enzyme involved in protein modification and is considered a longevity protein. It affects various molecular pathways related to aging and is influenced by factors such as diet, weight loss, and exercise. SIRT6 plays a role in wound healing and has different effects on inflammation. It is also affected by exogenous substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)