Article
Microbiology
Makoto Ohashi, Mitchell Hayes, Kyle McChesney, Eric Johannsen
Summary: EBV infection can lead to specific types of lymphoma and some epithelial cancers. In vitro, EBV infection of resting B-lymphocytes drives them to proliferate as lymphoblastoid cell lines, serving as a model for studying EBV lymphomagenesis. This study reveals that interaction between EBNA3C and CtBP results in EBNA3C-mediated upregulation.
Article
Oncology
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick
Summary: The study demonstrated that the EBNA1 inhibitor VK-1727 selectively inhibited cell growth in EBV-positive gastric carcinoma and reduced tumor growth in animal models, but not in EBV-negative gastric carcinoma. Short-term treatment tended to activate viral genes, while long-term treatment resulted in significant decrease in viral gene expression.
Article
Immunology
Anders J. Svendsen, Marie Christine Wulff Westergaard, Anette Holck Draborg, Rene Holst, Kirsten O. Kyvik, Marianne A. Jakobsen, Peter Junker, Gunnar Houen
Summary: The study revealed distinct differences in EBNA1 antibody levels between patients with RA and healthy individuals, as well as between relatives predisposed to RA and healthy subjects. The levels of EBNA1 antibodies associated with RA and family predisposition to RA are influenced by both genetics (including the shared epitope) and environmental factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jayaraju Dheekollu, Andreas Wiedmer, Samantha S. Soldan, Leonardo Josue Castro-Munoz, Christopher Chen, Hsin-Yao Tang, David W. Speicher, Paul M. Lieberman
Summary: EBV is associated with various malignancies and autoimmune disease. EBNA1 is essential for viral episome maintenance and DNA replication. PLOD1 interacts with EBNA1, regulates its protein stability, and plays a role in viral persistence and DNA replication.
Article
Immunology
Yiran Qu, Bingyang Zhang, Yingli Wang, Shuang Yin, Jordan L. Pederick, John B. Bruning, Yan Sun, Anton Middelberg, Jingxiu Bi
Summary: The study investigated the relationship between insertion sites in ferritin (N-terminus and C-terminus) and immune responses, finding that C-terminus insertion resulted in a stronger cell-mediated immune response than N-terminus insertion. This research provides new insights into the development of ferritin nanoparticle vaccines.
Article
Virology
Samires Avelino de Souza Franca, Julimar Benedita Gomes de Oliveira Viana, Hilda Carla Azevedo Goes, Ricardo Roberto de Souza Fonseca, Rogerio Valois Laurentino, Igor Brasil Costa, Aldemir Branco Oliveira-Filho, Luiz Fernando Almeida Machado
Summary: This study aimed to describe the seroprevalence infection of Epstein-Barr virus (EBV) and its genotypes in patients with AIRD. The results indicated a higher lytic infection of EBV in SLE patients compared to other autoimmune diseases, and corticosteroid therapy may increase the risk of EBV activity.
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Article
Microbiology
Archana Panikkar, Katie E. Lineburg, Jyothy Raju, Keng Yih Chew, George R. Ambalathingal, Sweera Rehan, Srividhya Swaminathan, Pauline Crooks, Laetitia Le Texier, Leone Beagley, Shannon Best, Matthew Solomon, Katherine K. Matthews, Sriganesh Srihari, Michelle A. Neller, Kirsty R. Short, Rajiv Khanna, Corey Smith
Summary: Adoptive T-cell immunotherapy has shown promising results in treating viral complications, especially in immunocompromised patients. Expanding T cells from healthy individuals provides a new approach to antiviral immunotherapy with rapid and customized treatment options. Recent research indicates that SARS-CoV-2-specific T cells play a crucial role in protecting against COVID-19, suggesting the potential of using HLA-matched virus-specific T cells for treating active COVID-19 or at-risk patients.
Article
Immunology
Sukayna Fadlallah, Hadi Hussein, Mary-Ann Jallad, Marwa Shehab, Abdo R. Jurjus, Ghassan M. Matar, Elias A. Rahal
Summary: EBV DNA increases the incidence and severity of arthritis in a RA mouse model. Targeting mediators triggered by viral DNA may be a potential therapeutic avenue.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Khalid Ahmed, Alisalman Sheikh, Saira Fatima, Ghulam Haider, Kulsoom Ghias, Farhat Abbas, Nouman Mughal, Syed Hani Abidi
Summary: This study identified the presence of Epstein-Barr virus (EBV) in prostate cancer and benign prostatic hyperplasia (BPH) samples, with a higher prevalence in prostate cancer samples. The EBV-positive samples exhibited higher Gleason scores, suggesting a potential link between EBV and the onset/progression of prostate cancer. The study also found variable expression patterns of latency-associated genes in EBV-positive samples.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Bin Zhao, Lingting Zeng, Danyang Chen, Songqing Xie, Zhaokui Jin, Guanglin Li, Wei Tang, Qianjun He
Summary: This study proposes a concept of photocatalytic regulation of the synovial microenvironment (SME) for arthritis treatment. Monodispersive hydrogen-doped titanium dioxide nanorods with a rutile single-crystal structure are developed to achieve near infrared-photocatalytic generation of hydrogen molecules and depletion of lactic acid (LA) in a collagen-induced mouse model of rheumatoid arthritis. The results show that locally produced hydrogen molecules scavenge reactive oxygen species and regulate the synovial microenvironment, thereby preventing synovial pannus formation and cartilage destruction.
Article
Gastroenterology & Hepatology
Hui Song, Yan Zhang, Juanjuan Liu, Wen Liu, Bing Luo
Summary: The study revealed a new mechanism of EBV in regulating the expression of DNMT3a in EBV-associated gastric carcinoma. Targeting the EBNA1/E2F1/DNMT3a axis could be a potential therapeutic strategy for EBVaGC with high DNMT3a expression.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Multidisciplinary Sciences
Julia Su Zhou Li, Ammal Abbasi, Dong Hyun Kim, Scott M. Lippman, Ludmil B. Alexandrov, Don W. Cleveland
Summary: Epstein-Barr virus (EBV) is an oncogenic herpesvirus associated with various cancers. In this study, researchers found that the EBNA1 protein of EBV binds to a repetitive copy of an 18-base-pair imperfect palindromic sequence on human chromosome 11q23, leading to chromosome breakage. Increasing levels of EBNA1 binding trigger chromosome breakage and acquisition of structural variations in chromosome 11, which is associated with cancer development. The presence of EBV is also associated with chromosome rearrangements in various cancer types.
Article
Microbiology
Danijela Miljanovic, Andja Cirkovic, Ivica Jermic, Milica Basaric, Ivana Lazarevic, Milka Grk, Rada Miskovic, Aleksa Despotovic, Ana Banko
Summary: The study aimed to analyze the association between EBV and RA by examining antibody titers, DNA viremia, infection status and EBNA1 variants in RA patients. The results showed a higher prevalence of active/recent EBV infection in RA patients compared to controls, along with elevated levels of specific antibodies. The findings suggest the need for further research to understand the causal relationship between EBV and RA. Evaluation: 8/10.
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.