Article
Plant Sciences
Salek Ahmed Sajib, Bjorn Gruebler, Cylia Oukacine, Etienne Delannoy, Florence Courtois, Caroline Mauve, Claire Lurin, Bertrand Gakiere, Thomas Pfannschmidt, Livia Merendino
Summary: Seedling development in darkness is regulated by both plastids and mitochondria, with inhibition of plastid gene expression leading to an exaggerated apical hook bending. Dysfunction of plastid gene expression also results in perturbation of mitochondrial metabolism and increased oxygen consumption. Signaling between plastids and mitochondria plays a crucial role in seedling architecture reprogramming.
Article
Pharmacology & Pharmacy
Da Eun Lee, Hyeon Woong Kang, So Yi Kim, Myeong Jin Kim, Jae Woong Jeong, Woosol Chris Hong, Sungsoon Fang, Hyung Sun Kim, Yun Sun Lee, Hyo Jung Kim, Joon Seong Park
Summary: This study demonstrates that the combination of ivermectin and gemcitabine effectively suppresses pancreatic cancer by inhibiting cell proliferation and inducing cell apoptosis through cell cycle arrest and mitochondrial dysfunction. In vivo experiments also support the tumor-inhibiting effect of this combination treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tingting Zhao, Delphine Arbelet-Bonnin, Daniel Tran, Emanuela Monetti, Arnaud Lehner, Patrice Meimoun, Takashi Kadono, Aurelien Dauphin, Rafik Errakhi, David Reboutier, Sylvie Cangemi, Tomonori Kawano, Stefano Mancuso, Hayat El-Maarouf-Bouteau, Patrick Laurenti, Francois Bouteau
Summary: Using Arabidopsis thaliana cultured cells, this study analyzed early cellular responses to sorbitol-induced hyperosmotic stress, revealing biphasic and dual responses in the cells. These responses included survival adaptation through signaling and osmotic adjustment, as well as programmed cell death in part of the cell population, raising questions about the induction of different behaviors in response to the same hyperosmotic condition.
Article
Neurosciences
Andrey Y. Y. Vinokurov, Vladislav O. O. Soldatov, Evgenia S. S. Seregina, Angelina I. I. Dolgikh, Pavel A. A. Tagunov, Andrey V. V. Dunaev, Marina Y. Y. Skorkina, Alexey V. V. Deykin, Andrey Y. Y. Abramov
Summary: Alterations in function of HPRT lead to overproduction of uric acid and symptoms of LNS. HPRT1 deficiency inhibits mitochondrial respiration and increases ROS production, but does not induce oxidative stress or decrease the level of antioxidant glutathione.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lichao Huang, Yijing Liu, Xiaqin Wang, Cheng Jiang, Yanqiu Zhao, Mengzhu Lu, Jin Zhang
Summary: This article summarizes the generation and scavenging pathways of peroxisomal ROS and explains how peroxisome-derived ROS participate in cellular PCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ying Guo, Teng Guan, Kashfia Shafiq, Qiang Yu, Xin Jiao, Donghui Na, Meiyu Li, Guohui Zhang, Jiming Kong
Summary: Aging is a complex process involving functional decline in multiple organelles. The role of mitochondrial quality control (MQC) in aging is still poorly understood, although mitochondrial dysfunction is suggested to be a determining factor. Evidence suggests that reactive oxygen species (ROS) stimulate changes in mitochondrial dynamics and contribute to the accumulation of oxidized by-products through mitochondrial proteases and mitochondrial unfolded protein response (UPRmt). MQC mechanisms such as mitochondrial-derived vesicles (MDVs) and mitophagy play crucial roles in maintaining mitochondrial homeostasis and preventing cellular senescence and aging. However, imbalanced MQC interventions may accelerate abnormal energy metabolism and senescence. Appropriate interventions on MQC may delay the aging process and extend lifespan.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Massimo Malerba, Raffaella Cerana
Summary: Programmed cell death (PCD) is a genetically controlled suicide process present in all living beings, playing a crucial role in plant development and stress responses. Studying PCD in whole plants or complex tissues is challenging due to its occurrence in a small group of inaccessible cells. Cultured cells provide a useful tool with their uniformity, accessibility, and reproducibility for investigating various aspects of plant PCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jielin Deng, Yunqiu Jiang, Zhen Bouman Chen, June-Wha Rhee, Yingfeng Deng, Zhao V. Wang
Summary: Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to mitochondrial dysfunction. Mitochondria are responsible for producing ATP, which is essential for the continuous electrical activity in the heart. Impaired supply-demand relationship and progressive mitochondrial dysfunction in arrhythmias result in reduced ATP production and increased reactive oxidative species generation. Pathological changes in gap junctions and inflammatory signaling disrupt ion homeostasis, membrane excitability, and cardiac structure, leading to impaired cardiac electrical homeostasis. This review focuses on the electrical and molecular mechanisms of cardiac arrhythmias, highlighting the role of mitochondrial dysfunction in ionic regulation and gap junction action. The article explores inherited and acquired mitochondrial dysfunction and its impact on different types of arrhythmias, as well as the involvement of mitochondria in bradyarrhythmia and tachyarrhythmia caused by factors like aging, gut microbiome, cardiac reperfusion injury, and electrical stimulation.
Article
Biology
Ekhlaque A. Khan, Hamdino M. Ahmed, Meena Misra, Pallavi Sharma, Amarendra N. Misra, Mirza Hasanuzzaman
Summary: Cadmium stress has negative effects on pea plants, including disruption of antioxidant defense system and oxidative damage. The application of exogenous nitric oxide (NO) can alleviate the damage caused by cadmium and promote plant growth and development.
Article
Biochemistry & Molecular Biology
Tongtong Zhang, Lina Feng, Jie Cui, Weiwei Tong, Han Zhao, Tingchao Wu, Pu Zhang, Xianjun Wang, Yingjun Gao, Jing Su, Xiaoyan Fu
Summary: This study found that hexavalent chromium can cause neurotoxicity in rat primary hippocampal neurons, and its mechanism involves mitochondrial dysfunction, ROS-mediated oxidative damage, and MAPKs activation. By inhibiting the production of ROS, the expression of Bcl-2 family can be balanced, DNA damage and MAPKs activation can be attenuated, and the viability of neurons can be improved.
NEUROCHEMICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Wanessa M. C. Awata, Juliano V. Alves, Rafael M. Costa, Ariane Bruder-Nascimento, Shubhnita Singh, Gabriela S. Barbosa, Carlos Renato Tirapelli, Thiago Bruder-Nascimento
Summary: This study found that ethanol-induced vascular dysfunction may be mediated by RAAS activation, mitochondrial dysfunction, and mitochondrial reactive oxygen species (mtROS). Inhibition of the AT(1) receptor can prevent vascular hypercontractility, mitochondrial dysfunction, and mtROS production, as well as restore the bioavailability of nitric oxide and hydrogen peroxide.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Tingting Yan, Yan Zhao, Zhongyu Jiang, Jiyang Chen
Summary: This study investigated the role of mitophagy in cytotoxicity induced by acetaldehyde, a toxic metabolite of ethanol. The findings showed that acetaldehyde treatment induced mitophagy and cytotoxicity in SH-SY5Y cells. The overactive mitophagy and oxidative stress were identified as important mechanisms contributing to acetaldehyde-induced cytotoxicity. Autophagy inhibitors and an antioxidant could alleviate the cytotoxic effects.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Haiyan Chen, Wendan Pu, Xiankang Hu, Cheng Yang, Guanli Zhao, Houyuan Hu, Jianxiang Zhang
Summary: This article reports a mitochondrial-mimetic therapy for dilated cardiomyopathy (DCM) that efficiently targets the heart, cardiomyocytes, and myocardial mitochondria, effectively regulating mitochondrial homeostasis. By synthesizing a bioactive conjugate TPT and delivering it intravenously, TPTN can accumulate in the heart and primarily localize in the cardiomyocytes and myocardial mitochondria, alleviating DCM. By packaging TPTN into outer mitochondrial membrane-derived vesicles, a mitochondrial-mimetic therapy with enhanced targeting capability is created, providing notable therapeutic effects in DCM mice.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Plant Sciences
Chien-Liang Lin, Chung- Yu, Tzong-Huei Lee, Jimmy Ming -Jung Chuang, Kuang-Fen Han, Chang-Shen Lin, Wan-Ping Huang, Jeff Yi-Fu Chen, Chung-Yi Chen, Mei-Ying Lin, Chien-Hsing Lee
Summary: This study demonstrated that plumbagin (PG), a natural compound isolated from Plumbago zeylanica L, exhibits anticancer effects against drug-resistant oral cancer cells by reducing cell viability, inducing apoptosis, and triggering intracellular and mitochondrial ROS generation, leading to mitochondrial dysfunction and endoplasmic reticulum stress. In addition, the inhibition of ROS abolished the effects of PG on cell viability, apoptosis, and ER stress.
Review
Cell Biology
Maria A. Yapryntseva, Polina V. Maximchik, Boris Zhivotovsky, Vladimir Gogvadze
Summary: Sirtuin-3 is a key regulator in cells, involved in the regulation of oxidative stress, reprogramming of tumor cell energy pathways, and metabolic homeostasis. It plays a crucial role in regulating mitochondrial outer membrane permeabilization, a key step in apoptosis initiation and progression. Additionally, Sirtuin-3 is involved in the execution of various cell death modalities, indicating its potential role as a regulator of crosstalk between different forms of cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agronomy
M. Iftikhar Hussain, Yedra Vieites-Alvarez, Paz Otero, Miguel A. Prieto, Jesus Simal-Gandara, Manuel J. Reigosa, Adela M. Sanchez-Moreiras
Summary: The study showed that the wheat accession 'Ursita' exhibits allelopathic activity, which can be used in breeding programs to enhance its allelopathic properties. Furthermore, there is potential to explore the allelopathic effects of wheat cultivars for controlling Portulaca oleracea and Lolium rigidum in field conditions.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Federico Colombo, Andrea Pagano, Stefano Sangiorgio, Anca Macovei, Alma Balestrazzi, Fabrizio Araniti, Roberto Pilu
Summary: This study found that low phytic acid (lpa) mutants aged faster and had reduced germination compared to wildtype seeds. Two possible solutions were proposed: building synthetic populations using classical breeding and seed priming, both of which showed potential to improve germination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
David Lopez-Gonzalez, Elisa Grana, Marta Teijeira, Mercedes Verdeguer, Manuel J. Reigosa, Adela M. Sanchez-Moreiras, Fabrizio Araniti
Summary: Experimental and metabolomic analyses have shown that the phytotoxic compounds farnesene and citral have similar effects on photosynthesis but different mechanisms of action, potentially due to oxidative stress-induced side effects.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Plant Sciences
Marco Landi, Biswapriya B. Misra, Fabio Francesco Nocito, Giorgio Lucchini, Leonardo Bruno, Angela Malara, Maria Rosa Abenavoli, Fabrizio Araniti
Summary: Parasitisation by C. campestris enhances internal host defences but reduces environmentally directed defences, limiting the plant's ability to defend against parasitisation. The parasitisation alters plant water status, amino acid and sugar metabolism, and VOC levels, ultimately affecting the efficiency of photosynthesis and plant defence mechanisms. Overall, C. campestris parasitisation leads to an increase in osmoprotectants and changes in plant volatile compounds, impacting the host's ability to defend against parasitic invasion.
Article
Agronomy
Antonio Calvi, Meriem Miyassa Aci, Antonio Lupini, Giovanni Preiti
Summary: This study investigated the morphological traits and genetic diversity of wild hops in the Calabria region of South Italy. Cone length showed significant variation among different populations, while cone shape was the most discriminant trait. Genetic diversity analysis using eight SSR markers revealed high genetic variability in Calabria, and genetic structure analysis identified two distinct groups regardless of the sampling sites. Further research will be conducted to explore other wild hops populations in Calabria and identify specific alleles for new breeding programs.
Review
Plant Sciences
Martina Ghidoli, Elena Ponzoni, Fabrizio Araniti, Daniela Miglio, Roberto Pilu
Summary: In recent years, there has been a growing interest in novel crops due to environmental issues in agriculture. One such crop, Camelina sativa (L.) Crantz, is attracting attention for its desirable features. It can grow in marginal lands with little inputs and is resistant to important pathogens. This review summarizes the main works on genetic improvement of Camelina, particularly in terms of yield, seed oil content and quality, and reduction in anti-nutritional substances.
Article
Plant Sciences
David Lopez-Gonzalez, Leonardo Bruno, Carla Diaz-Tielas, Antonio Lupini, Meriem Miyassa Aci, Emanuela Talarico, Maria Letizia Madeo, Antonella Muto, Adela M. Sanchez-Moreiras, Fabrizio Araniti
Summary: This study analyzed the short-term effect of trans-cinnamic acid on the morphology and metabolism of maize roots. The results showed that there was a reduction in the content of many amino acids at short times, which may be associated with altered nitrogen uptake. Additionally, the compound caused an alteration of the vascular bundles and changed the root metabolism to favor lignin and galactose synthesis. These findings demonstrate that trans-cinnamic acid can trigger stress-coping processes in the treated plants in the short term.
Article
Agriculture, Multidisciplinary
Sara Alvarez-Rodriguez, Carla M. Alvite, Manuel J. Reigosa, Adela M. Sanchez-Moreiras, Fabrizio Araniti
Summary: Finding herbicides with new and multiple modes of action is crucial for preventing the increase in resistant weed species. In this study, harmaline, a natural alkaloid, was tested on Arabidopsis plants and found to significantly affect photosynthetic parameters and induce metabolic alterations. The results suggest that harmaline has the potential to be a new and interesting phytotoxic molecule for further investigation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Yedra Vieites-Alvarez, Paz Otero, Miguel Angel Prieto, Jesus Simal-Gandara, Manuel J. Reigosa, Adela M. Sanchez-Moreiras, M. Iftikhar Hussain
Summary: This study reveals that Maurizio is a promising wheat cultivar for sustainable weed control, with the ability to outcompete weeds and exude large amounts of benzoxazinones. Screening crop varieties with allelopathic potential is an immediate solution for ecological and sustainable agriculture.
PEST MANAGEMENT SCIENCE
(2023)
Article
Plant Sciences
David Lopez-Gonzalez, Yolanda Ferradas, Fabrizio Araniti, Elisa Grana, Jose M. Hermida-Ramon, Maria Victoria Gonzalez, Marta Teijeira, Manuel Rey, Manuel J. Reigosa, Adela M. Sanchez-Moreiras
Summary: This study investigated the phytotoxic effects of trans-cinnamaldehyde on Arabidopsis thaliana seedlings. The compound inhibited root growth and induced the formation of adventitious roots. It also caused alterations to the mitochondria, hormonal mismatch, and oxidative stress in the treated seedlings.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Anna Taglienti, Livia Donati, Immacolata Dragone, Luca Ferretti, Andrea Gentili, Fabrizio Araniti, Filippo Sapienza, Roberta Astolfi, Simona Fiorentino, Valerio Vecchiarelli, Claudia Papalini, Rino Ragno, Sabrina Bertin
Summary: This study evaluated the biological activity of essential oils and hydrosols obtained from Mentha suaveolens and Foeniculum vulgare in controlling zucchini yellow mosaic virus and its vector, Aphis gossypii. The treatments were found to decrease virus titer and effectively repel aphids.
Article
Agricultural Engineering
Sara Alvarez-Rodriguez, Eleonora Spinozzi, Adela M. Sanchez-Moreiras, David Lopez-Gonzalez, Marta Ferrati, Giorgio Lucchini, Filippo Maggi, Riccardo Petrelli, Fabrizio Araniti
Summary: In this study, the phytotoxic potential of essential oil (EO) extracted from Carlina acaulis L. roots was tested against the weed Bidens pilosa L. The EO showed strong toxic effects on the plant metabolism, causing leaf necrosis, reduction in water content and leaf area, and an increase in dry weight/fresh weight ratio. It also damaged the photosynthetic machinery and altered the concentration of certain metabolites, indicating a reduction in photosynthetic efficiency. These findings suggest that C. acaulis EO has potential as a natural herbicide against weeds and requires further investigation.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Tiziana Maria Sirangelo, Ivano Forgione, Samanta Zelasco, Cinzia Benincasa, Enzo Perri, Elisa Vendramin, Federica Angile, Francesco Paolo Fanizzi, Francesco Sunseri, Amelia Salimonti, Fabrizio Carbone
Summary: Olive has excellent nutritional and economic values, with high content of antioxidant compounds in its main healthy products. Our study reveals the variability of antioxidant content in olive due to genetic and environmental factors during the ripening process. Furthermore, it highlights the crucial role of light quality and quantity in the synthesis of metabolites in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)