Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation
出版年份 2018 全文链接
标题
Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation
作者
关键词
Muscle cells, Protein expression, Inflammatory diseases, Cardiomyocytes, Guinea pigs, Heart, Action potentials, Cytokines
出版物
PLoS One
Volume 13, Issue 12, Pages e0208321
出版商
Public Library of Science (PLoS)
发表日期
2018-12-07
DOI
10.1371/journal.pone.0208321
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The role and therapeutic targeting of IL-6 in rheumatoid arthritis
- (2017) Masashi Narazaki et al. Expert Review of Clinical Immunology
- TNFα Modulates Cardiac Conduction by Altering Electrical Coupling between Myocytes
- (2017) Sharon A. George et al. Frontiers in Physiology
- High-fat diet-dependent modulation of the delayed rectifier K + current in adult guinea pig atrial myocytes
- (2016) Ademuyiwa S. Aromolaran et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial
- (2016) Ola Kleveland et al. EUROPEAN HEART JOURNAL
- Role of JAK-STAT pathway in reducing cardiomyocytes hypoxia/reoxygenation injury induced by S1P postconditioning
- (2016) Yuqing Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms
- (2016) Akil Puckerin et al. HEART RHYTHM
- Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice
- (2016) Gustavo Monnerat et al. Nature Communications
- Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England
- (2016) Mar Pujades-Rodriguez et al. PLoS One
- Pathogenesis of the Novel Autoimmune-Associated Long-QT SyndromeCLINICAL PERSPECTIVE
- (2015) Yuankun Yue et al. CIRCULATION
- The varying faces of IL-6: From cardiac protection to cardiac failure
- (2015) Jillian A. Fontes et al. CYTOKINE
- Association Between Corrected QT Interval and Inflammatory Cytokines in Rheumatoid Arthritis
- (2015) A. M. Adlan et al. JOURNAL OF RHEUMATOLOGY
- Role of pharmacotherapy in cardiac ion channelopathies
- (2015) Nabil El-Sherif et al. PHARMACOLOGY & THERAPEUTICS
- Antiarrhythmic Potential of Anticytokine Therapy in Rheumatoid Arthritis: Tocilizumab Reduces Corrected QT Interval by Controlling Systemic Inflammation
- (2015) Pietro Enea Lazzerini et al. ARTHRITIS CARE & RESEARCH
- Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative
- (2015) Rachel H. Mackey et al. Arthritis & Rheumatology
- Arrhythmic risk in rheumatoid arthritis: the driving role of systemic inflammation
- (2014) Pietro Enea Lazzerini et al. AUTOIMMUNITY REVIEWS
- Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis
- (2014) Xueli Bai et al. CANCER LETTERS
- LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms
- (2014) Ademuyiwa S. Aromolaran et al. CARDIOVASCULAR RESEARCH
- Tocilizumab, A Humanized Anti-IL-6R Antibody, as an Emerging Therapeutic Option for Rheumatoid Arthritis: Molecular and Cellular Mechanistic Insights
- (2014) Misato Hashizume et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Inflammation and Prolonged QT Time: Results from the Cardiovascular Disease, Living and Ageing in Halle (CARLA) Study
- (2014) Daniel Medenwald et al. PLoS One
- The long QT syndrome: a transatlantic clinical approach to diagnosis and therapy
- (2013) P. J. Schwartz et al. EUROPEAN HEART JOURNAL
- Association between high sensitivity C-reactive protein, heart rate variability and corrected QT interval in patients with chronic inflammatory arthritis
- (2013) Pietro Enea Lazzerini et al. European Journal of Internal Medicine
- Prolonged QTc interval predicts all-cause mortality in patients with rheumatoid arthritis: an association driven by high inflammatory burden
- (2013) V. F. Panoulas et al. RHEUMATOLOGY
- Prognostic electrocardiographic parameters in patients with suspected myocarditis
- (2011) Christian Ukena et al. EUROPEAN JOURNAL OF HEART FAILURE
- hERG potassium channel gating is mediated by N- and C-terminal region interactions
- (2011) Ahleah S. Gustina et al. JOURNAL OF GENERAL PHYSIOLOGY
- State-dependent blockade of human ether-a-go-go-related gene (hERG) K+ channels by changrolin in stably transfected HEK293 cells
- (2010) Wei-hai Chen et al. ACTA PHARMACOLOGICA SINICA
- A new regulation of IL-6 production in adult cardiomyocytes by β-adrenergic and IL-1β receptors and induction of cellular hypertrophy by IL-6 trans-signalling
- (2010) Nicolas Szabo-Fresnais et al. CELLULAR SIGNALLING
- Ventricular K+ currents are reduced in mice with elevated levels of serum TNFα
- (2009) Scott A. Grandy et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Characterization of hERG1a and hERG1b potassium channels—a possible role for hERG1b in the I Kr current
- (2008) Anders Peter Larsen et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started