Article
Plant Sciences
Aaliya Ali, Prakrati Garg, Rohit Goyal, Gurjot Kaur, Xiangkai Li, Poonam Negi, Martin Valis, Kamil Kuca, Saurabh Kulshrestha
Summary: The study evaluated the wound healing efficacy of n-hexane extract and hydrogels of Moringa oleifera seeds, demonstrating their significant effectiveness in wound healing.
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Dermatology
Andrzej Hecker, Marlies Schellnegger, Elisabeth Hofmann, Hanna Luze, Sebastian Philipp Nischwitz, Lars-Peter Kamolz, Petra Kotzbeck
Summary: Resveratrol is a powerful antioxidant that may aid in wound healing and prevent skin aging. Current research suggests that resveratrol could be a feasible treatment approach, but further studies are needed to confirm its effects.
INTERNATIONAL WOUND JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Malek Eleroui, Amal Feki, Asma Hamzaoui, Intissar Kammoun, Marwa Bouhamed, Ons Boudawara, Issam Ben Ayed, Ibtissem Ben Amara
Summary: This study aimed to prepare biodegradable and edible films from polysaccharide extracted from Hammada scoparia leaves (named PSP) and reinforced by poly (vinyl alcohol) (PVA), with the film P1 showing the highest antioxidant activity in vitro and significantly accelerating wound healing. The results demonstrated that PSP/PVA based films have potential for promoting wound healing due to their high antioxidant activities in vitro.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Shilpa Das, Tanmoy Kumar Dey, Arnab De, Anurag Banerjee, Samrat Chakraborty, Bhaskar Das, Asish Kumar Mukhopadhyay, Biswajit Mukherjee, Amalesh Samanta
Summary: The gum odina and gelatin based biomimetic scaffold showed excellent biocompatibility and the ability to promote cutaneous healing in vitro studies. Results demonstrated significant deposition of collagen and formation of intact epidermis, indicating strong potential for wound treatment applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Qijun Li, Shiqiang Gong, Weifan Yao, Ziting Yang, Renjun Wang, Zhaojin Yu, Minjie Wei
Summary: This study utilized a dual-sensitive hydrogel loaded with exosomes derived from hUCMSCs to promote wound healing and skin regeneration, showing significant improvements in wound closure, re-epithelialization rates, and collagen deposition in the wound sites. The results suggest the potential for achieving complete skin regeneration through the use of this novel approach.
Article
Dermatology
Yizhao Ma, Zhifang Liu, LinLin Miao, Xinyu Jiang, Hongyu Ruan, Rongrong Xuan, Suling Xu
Summary: Pathological scarring is caused by excessive proliferation and transdifferentiation of fibroblasts, as well as excessive deposition of extracellular matrix during wound healing. Factors that promote pathological scar formation affect the proliferation and function of fibroblasts. This study explores the microenvironment, signaling pathways, epigenetics, and autophagy related to the abnormal formation of fibroblasts in pathological scarring. Understanding the causes of abnormal fibroblast formation may lead to improved prevention and treatment strategies for pathological scarring and enhance patients' quality of life.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Ghazal Shabestani Monfared, Peter Ertl, Mario Rothbauer
Summary: Cutaneous wound healing is a complex process involving cell communication events and cell migration to achieve wound closure. Microfluidic and lab-on-a-chip technologies have improved in vitro wound healing assays to create more reliable models resembling the in vivo wound microenvironment.
Review
Biotechnology & Applied Microbiology
Jianghui Qin, Fang Chen, Pingli Wu, Guoming Sun
Summary: Wound healing is a complex biological process with bioengineered scaffolds playing a key role in regenerative therapy. Although advancements have been made, challenges remain in achieving ideal treatment for deep cutaneous injuries. Designing innovative scaffolds, precursor development, and therapeutic interventions hold promise for future wound healing strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Kehinde Ross
Summary: miRNAs play a critical role in wound healing, particularly in influencing the behavior of epidermal keratinocytes. Combining multiple miRNA mimics targeting different but complementary wound healing processes may be more effective in promoting wound repair.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biophysics
Fan Yu, Atta ur Rehman Khan, Hui Zheng, Xiaotong Li, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Jun Li, Jinglei Wu, Xiumei Mo
Summary: In this study, ddECMMA, TCS, and PCLPBA were successfully prepared and mixed to form DTP4 hydrogel with good antibacterial and antioxidant properties. The hydrogel showed good support for cell growth and exhibited excellent wound healing effects in animal experiments.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Kai-Chieh Chou, Chun-Ting Chen, Juin-Hong Cherng, Ming-Chia Li, Chia-Cheng Wen, Sheng- Hu, Yi-Wen Wang
Summary: Beta-sheet silk fibroin promotes cell migration and tissue regeneration by modulating cell adhesion molecules in dermal fibroblasts. This finding provides a basis for the clinical application of silk fibroin dressings in promoting burn wound regeneration.
Article
Polymer Science
Hongyan Xue, Meng Sun, Xiaoliang Zhao, Yonggang Wang, Jinxin Yan, Weijie Zhang
Summary: Hydrogels prepared by cross-linking plant polysaccharides and chitosan show promising potential for wound healing, with good swelling, water-retention ability, blood coagulation, cytocompatibility, and low cytotoxicity.
Article
Dermatology
Yi-Kai Hong, Yi-Han Chang, Yu-Chen Lin, Brandon Chen, Bryan Edgar K. Guevara, Chao-Kai Hsu
Summary: This review provides a summary of the current knowledge on the immunopathogenesis and treatment options for pathological scars. Pathological scars, such as hypertrophic scars and keloids, result from abnormal inflammation during wound healing and have negative impacts on patients' quality of life due to their disfiguring appearance and symptoms of itch and pain.
ADVANCES IN WOUND CARE
(2023)
Article
Instruments & Instrumentation
Majid Salehi, Arian Ehterami, Saeed Farzamfar, Ahmad Vaez, Somayeh Ebrahimi-Barough
Summary: The alginate/naringenin hydrogel developed in this study showed positive effects on wound healing process, with appropriate porosity and biodegradability, as well as no toxicity to cells. In the rat experiment, the hydrogel containing 20% naringenin demonstrated the best wound closure among other groups.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Dermatology
Xin Huang, Shuchen Gu, Caiyue Liu, Liang Zhang, Zewei Zhang, Yixuan Zhao, Yimin Khoong, Haizhou Li, Yashan Gao, Yunhan Liu, Zi Wang, Danyang Zhao, Qingfeng Li, Tao Zan
Summary: This study revealed an increased fraction of CD39(+) fibroblasts in hypertrophic scars (HTSs) and their positive correlation with scar severity. CD39(+) fibroblasts expressed higher levels of IL-11 and TGF beta 1 induced the expression of CD39, mediating the maintenance of the CD39(+) phenotype. Furthermore, IL-11 facilitated myofibroblast activation and extracellular matrix production in both CD39(+) and CD39(-) fibroblasts.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Oncology
Chuanqi Liu, Ming Pei, Qingfeng Li, Yuanyuan Zhang
Summary: ECM constituents play crucial roles in organ formation and tissue regeneration by providing structural integrity and cellular-function regulation. Further research and development are needed to apply ECM more specifically in 3D cultures for different cell types.
FRONTIERS OF MEDICINE
(2022)
Article
Surgery
Zhihua Qiao, Xiancheng Wang, Yiwen Deng, Qingfeng Li, Tao Zan, Yang Sun, Xiang Xiong, Xianxi Meng, Wenbo Li, Zhongjie Yi, Xiaofang Li, Borong Fang
Summary: This study suggests that combining tissue expansion with a perforator flap for large tissue reconstruction can be successful with limited complications.
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ming Li, Yongbo Liu, Chengxian Xu, Qun Zhao, Jianling Liu, Mingyan Xing, Xiaoming Li, Haiwei Zhang, Xiaoxia Wu, Lingxia Wang, Yangjing Ou, Xuanhui Wu, Xiaoming Zhao, Han Liu, Lin Qiu, Fang Li, Jinbao Li, Wuwei Rong, Yan Luo, Jiangshan Deng, Xiuzhe Wang, Zhichao Wang, Yuwu Zhao, Ankang Lv, Qingfeng Li, Haibing Zhang
Summary: This study reveals the importance of the ABIN1 UBD domain in regulating cell death during embryonic development. The loss of ABIN1 protein results in increased cell death and inflammatory response, while the ABIN1-A20 axis can limit cell death. Additionally, a previously unknown ubiquitin pathway that regulates RIPK1 ubiquitination through FADD/Casp8 to suppress cell activation is discovered.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biotechnology & Applied Microbiology
Qingxiong Yu, Hainan Zhu, Huijing Wang, Rehanguli Aimaier, Manhon Chung, Zhichao Wang, Qingfeng Li
Summary: By analyzing gene expression levels of 25 m6A genes in CMM patients, we were able to divide them into two clusters and identified ELAVL1, ABCF1, and IGF2BP1 as the genes with the highest scores for predicting prognosis. CNV mutations in m6A genes had a negative impact on patient survival, and the mRNA expression levels of m6A genes were correlated with CNV. The selected m6A regulators were closely associated with inflammation and immune pathways, and m6A gene expressions were negatively correlated with immune cell infiltration.
Article
Cell Biology
Yixuan Zhao, Xin Huang, Zewei Zhang, Haizhou Li, Tao Zan
Summary: In this study, a novel long noncoding RNA (lncRNA) called HNSCAT1 was identified to have a tumor inhibitory role in head and neck squamous carcinoma (HNSC) by regulating the tumor suppressor gene KRT80. Additionally, it was found that miR-1245 plays a regulatory role between KRT80 and HNSCAT1.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Orthopedics
Xiaoxue Chen, Baofu Yu, Zi Wang, Qingfeng Li, Chuanchang Dai, Jiao Wei
Summary: This article reviews the research progress in repairing large segment bone defects. It introduces bone tissue prefabrication and other bone reconstruction strategies, while emphasizing the critical role of periosteum in osteogenesis.
ORTHOPAEDIC SURGERY
(2022)
Article
Dermatology
Boxuan Wei, Jieyu Gu, Bowen Gao, Yongyang Bao, Ran Duan, Qingfeng Li, Feng Xie
Summary: This study discovered an association between dMMR and LGCMN. Diagnostic IHC showed that dMMR was present in 37% of giant CMNs, 23% of large CMNs, and 7% of medium CMNs. Regression analyses revealed significant associations between MMR status and CMN size and the presence of satellites. Whole-exome sequencing detected rare deleterious germline mutations in DNA repair genes.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemical Research Methods
Shan Wu, Caixia Wang, Min Yao, Dong Han, Qingfeng Li
Summary: Noninvasive photothermal treatment can tighten the skin and subcutaneous tissue, but the mechanism is not well understood. This study found that thermal injury to adipocytes increases ALOX15 in macrophages, which stimulates the production of extracellular matrix (ECM) in fibroblasts. The ALOX15 metabolite 12(S)-HETE activates the p38 MAPK signaling pathway and mediates ECM production in fibroblasts.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Pathology
Yuehua Li, Chengjiang Wei, Wei Wang, Qingfeng Li, Zhi-Chao Wang
Summary: Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein encoded by the NTRK2 gene, plays a crucial role in neural development. Abnormal activation of TrkB caused by NTRK2 overexpression or fusion contributes to tumour initiation, progression, and therapeutic resistance in neurogenic tumours. Targeted therapies, including selective TrkB inhibitors and pan-TRK inhibitors, have been developed to target this mechanism in preclinical and clinical studies. This review provides an overview of the gene structure, biological function, abnormal TrkB activation mechanism, and current targeted therapies in neurogenic tumours.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Yangdan Liu, Dongsheng Wen, Chiakang Ho, Li Yu, Danning Zheng, Steven O'Reilly, Ya Gao, Qingfeng Li, Yifan Zhang
Summary: Fibrosis, caused by excessive deposition of extracellular matrix, is a common and serious condition leading to organ failure and death. Recent advances in epigenetics have provided new insights into the mechanism of fibrogenesis and potential therapeutic strategies for organ fibrosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Man-Hon Chung, Rehanguli Aimaier, Qingxiong Yu, Haibo Li, Yuehua Li, Chengjiang Wei, Yihui Gu, Wei Wang, Zizhen Guo, Manmei Long, Qingfeng Li, Zhichao Wang
Summary: RRM2 expression is significantly elevated in NF1-associated MPNST and high RRM2 expression correlates with poorer outcomes. Inhibition of RRM2 can suppress NF1-associated MPNST cell proliferation and promote apoptosis and S-phase arrest. Therefore, inhibiting RRM2 may be an effective strategy for treating NF1-associated MPNST.
Review
Biochemistry & Molecular Biology
Shengzhou Shan, Qingfeng Li, Tracy Criswell, Anthony Atala, Yuanyuan Zhang
Summary: Sphincter dysfunction is a common consequence of neuromuscular impairment in tubule organs, resulting from trauma, inflammation, and aging. Conventional pharmacological treatments have limited success, prompting the exploration of cell- or growth factor-based therapies. However, challenges such as poor cell retention and viability, and the short half-life of growth factors have hindered clinical translation. Natural biomaterials offer a promising solution for controlled growth factor delivery, which has shown improved outcomes in sphincter function recovery. This review provides insights into the potential therapeutic role of stem cells combined with controlled release of growth factors, highlighting their use in preclinical studies as a new strategy to treat incontinence or sphincter dysfunction.
CELL AND BIOSCIENCE
(2023)
Article
Immunology
Meixia Wang, Hongfei Mi, Na Li, Qingfeng Shi, Wei Sun, Tingjuan He, Jiabing Lin, Wenting Jin, Xiaodong Gao, Bijie Hu, Chenghao Su, Jue Pan
Summary: This study investigated the associations between overall comorbidity burden, inflammatory indicators in plasma, and Ct values in elderly COVID-19 patients. The results showed that patients with a high comorbidity burden had lower Ct values and higher inflammatory responses. Inflammation mediated the association between comorbidity burden and Ct values.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kang Wang, Dongsheng Wen, Xuewen Xu, Rui Zhao, Feipeng Jiang, Shengqin Yuan, Yifan Zhang, Ya Gao, Qingfeng Li
Summary: Skin fibrosis is characterized by excessive deposition of extracellular matrix (ECM), which plays a central role in providing structural support and creating a microenvironment for cellular activities. Recent studies have focused on the relationship between mechanical properties of ECM and the development of skin fibrosis, involving complex signaling pathways, activation of mechanosensitive proteins, and changes in immune regulation and metabolism. The stiffening of ECM during fibrosis disturbs mechanical and humoral homeostasis, forming a pro-fibrotic positive feedback loop. This review highlights the importance of ECM and its dynamic changes in skin fibrosis, particularly the role of mechanical cues in ECM remodeling. Various interventions targeting ECM are also discussed to provide new strategies for fibrotic diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
