Article
Medicine, General & Internal
Mathilde Nejrup Hemmingsen, Andreas Larsen, Tim K. Weltz, Mathias Orholt, Sebastian Wiberg, Anne Karen Bennedsen, Camilla Bille, Lena Felicia Carstensen, Lisa Toft Jensen, Rikke Bredgaard, Vibeke Koudahl, Volker Jurgen Schmidt, Peter Vester-Glowinski, Lisbet Rosenkrantz Holmich, Soren J. Sorensen, Thomas Bjarnsholt, Tine Damsgaard, Mikkel Herly
Summary: Periprosthetic infection is a serious complication of implant-based breast reconstruction. Local antibiotic treatment on breast implants is commonly used to reduce the risk of postoperative infection, but its efficacy has not been tested in randomized, placebo-controlled trials. This paper presents the BREAST-AB trial, a double-blind, randomized, placebo-controlled study investigating the use of gentamicin, vancomycin, and cefazolin for local treatment on breast implants in women undergoing implant-based breast reconstruction.
Article
Multidisciplinary Sciences
Farah Y. Eid, Walid A. El-Kenany, Mohamed I. Mowafy, Ahmed R. El-Kalza, Myriam A. Guindi
Summary: This study evaluated the effect of two low-level laser therapy protocols on canine retraction rate and found that both frequent and less frequent applications can effectively accelerate tooth movement. Additionally, the study revealed elevated IL-1 beta levels on the laser sides.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Douglas Magno Guimaraes, Tamara Melo Nunes Ota, Diego Assuncao Calixto Da Silva, Fabio De Lucas Da Silva Almeida, Tatiana Dias Schalch, Alessandro Melo Deana, Jose Miguel Alves Junior, Kristianne Porta Santos Fernandes
Summary: This study compared the efficacy of LLLT and LEDT for prevention and treatment of oral mucositis, finding that LEDT has similar effects to LLLT in reducing symptoms of oral mucositis. Therefore, LEDT could be considered as an alternative option for preventing and treating oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, General & Internal
Martin Bjorn Stausholm, Ingvill Fjell Naterstad, Patricia Pereira Alfredo, Christian Couppe, Kjartan Vibe Fersum, Ernesto Cesar Pinto Leal-Junior, Rodrigo Alvaro Brandao Lopes-Martins, Jon Joensen, Jan Magnus Bjordal
Summary: LLT combined with strength training can reduce pain and improve physical performance in patients with knee osteoarthritis. However, the improvement in joint line pain pressure threshold is less significant compared to placebo therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hahn Jin Jung, Young-Jun Chung, Young-Seok Choi, Phil Sang Chung, Ji-Hun Mo
Summary: Low-level laser therapy (LLLT) has shown significant efficacy in treating allergic rhinitis (AR) by improving symptom severity and quality of life. The clinical trial confirmed that the LLLT group performed better in reducing AR symptom severity and enhancing quality of life related to nasal symptoms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Chiung-Hui Huang, Mei-Ling Yeh, Fang-Pey Chen, Daphne Wu
Summary: This study aimed to evaluate the effect of low-level laser acupuncture on postoperative pain in older patients with knee osteoarthritis after total knee arthroplasty. The results showed that low-level laser acupuncture can gradually reduce postoperative pain intensity and morphine consumption in these patients.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Surgery
Lyly Nguyen, Ashkan Afshari, Japjit Green, Jeremy Joseph, Jun Yao, Galen Perdikis, Kent K. Higdon
Summary: The study did not find a statistically significant difference in SSI between TAS and CHG irrigation, but TAS showed a trend towards lower rates of infectious complications. An equal number of patients were enrolled in the study, with no significant differences in outcomes between the two groups.
AESTHETIC SURGERY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Amornthep Jankaew, Yu-Lin You, Tai-Hua Yang, Yu-Wei Chang, Cheng-Feng Lin
Summary: The study compared the therapeutic effects of low-level laser therapy (LLLT) with two different wavelengths (808 nm and 660 nm) on muscle strength and functional outcomes in patients with knee osteoarthritis (OA). The results showed that both intervention groups improved muscle strength and functional performance compared to the control group. The 808 nm wavelength group showed better results in knee extensor strength. Therefore, laser therapy is suggested to be integrated into rehabilitation programs for knee OA patients.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Fernanda Velluzzi, Giulia Cossu, Michele Fosci, Roberta Montisci, Rosanna Zaccheddu, Luigi Minerba, Mario Musu, Elisa Pintus, Dario Fortin, Ferdinando Romano, Cesar Ivan Aviles Gonzalez, Paola Melis, Andrea Deledda, Andrea Loviselli, Mauro Giovanni Carta
Summary: This study demonstrates that a 3-month moderate exercise program can improve or prevent dysmetabolism in older adults, especially for those who are overweight. However, prolonged combined nutritional and exercise interventions will be needed if dysmetabolism is already present.
Article
Oncology
Mikael Eriksson, Martin Eklund, Signe Borgquist, Roxanna Hellgren, Sara Margolin, Linda Thoren, Ann Rosendahl, Kristina Lang, Jose Tapia, Magnus Backlund, Andrea Discacciati, Alessio Crippa, Marike Gabrielson, Mattias Hammarstrom, Yvonne Wengstrom, Kamila Czene, And Per Hall
Summary: Pre-menopausal women showed noninferior reduction in breast density with 2.5 mg of tamoxifen, and experienced fewer side effects compared to the standard dose of 20 mg.Future studies are needed to investigate whether 2.5 mg of tamoxifen can reduce the risk of primary breast cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jae-Hong Kim, Chang-Su Na, Myoung-Rae Cho, Gwang-Cheon Park, Jeong-Soon Lee
Summary: This study aimed to investigate the efficacy of invasive laser acupuncture for chronic non-specific low back pain. The results showed that both 650 nm-wavelength and 830 nm-wavelength ILA significantly reduced pain intensity and improved functional disability.
Article
Chemistry, Medicinal
Mengyue Fu, Shi Chen, Rui Xu, Jie Chen, Xuehan Chen, Wanxia Gan, He Huang, Guangyou Duan
Summary: This study aimed to explore the effects of intravenous analgesia using tramadol on postoperative depression, anxiety, and sleep in women undergoing abdominal endoscopic surgery. The results showed that intravenous analgesia with tramadol can effectively improve postoperative depression and sleep, with no impact on anxiety state.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Nutrition & Dietetics
Oliwia Gawlik-Kotelnicka, Aleksandra Margulska, Anna Skowronska, Dominik Strzelecki
Summary: Finding new treatment options for depression and its comorbidities is crucial. Microbiota interventions, such as probiotics, may be a safe and easy-to-use adjunctive therapy for patients who are partially responsive to pharmacologic treatment. The study discussed the feasibility and pilot findings of a randomized controlled trial on the effect of probiotic supplementation on depressive disorders in patients with metabolic syndrome.
Article
Health Care Sciences & Services
S. Silviya, C. M. Anitha, P. S. G. Prakash, Sarah Ahmed Bahammam, Maha A. Bahammam, Ammar Almarghlani, Mohammad Assaggaf, Mona Awad Kamil, Sangeetha Subramanian, Thodur Madapusi Balaji, Shankargouda Patil
Summary: This study assessed the clinical outcomes of combining the Single Flap Approach (SFA) with Low-level laser therapy (LLLT). The results showed that LLLT can increase clinical attachment levels (CAL) and decrease probing pocket depth (PPD), enhancing wound healing.
Article
Dentistry, Oral Surgery & Medicine
Mahta Fazlyab, Sepideh Esmaeili Shahmirzadi, Ehsan Esnaashari, Arash Azizi, Amir Abbas Moshari
Summary: The study revealed that low-level laser therapy significantly reduced postoperative pain after single-visit root canal retreatment of mandibular molars, especially showing noticeable effects four hours after the procedure.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Oncology
Alexander C. J. van Akkooi, Tina J. Hieken, Elizabeth M. Burton, Charlotte Ariyan, Paolo A. Ascierto, Salvatore V. M. A. Asero, Christian U. Blank, Matthew S. Block, Genevieve M. Boland, Corrado Caraco, Sydney Chng, B. Scott Davidson, Joao Pedreira Duprat Neto, Mark B. Faries, Jeffrey E. Gershenwald, Dirk J. Grunhagen, David E. Gyorki, Dale Han, Andrew J. Hayes, Winan J. van Houdt, George C. Karakousis, Willem M. C. Klop, Georgina Long, Michael C. Lowe, Alexander M. Menzies, Roger Olofsson Bagge, Thomas E. Pennington, Piotr Rutkowski, Robyn P. M. Saw, Richard A. Scolyer, Kerwin F. Shannon, Vernon K. Sondak, Hussein Tawbi, Alessandro A. E. Testori, Mike T. Tetzlaff, John F. Thompson, Jonathan S. Zager, Charlotte L. Zuur, Jennifer A. Wargo, Andrew J. Spillane, Merrick Ross
Summary: Exciting advances in melanoma systemic therapies have provided opportunities for neoadjuvant systemic treatment in high-risk, resectable metastatic melanomas. This article presents the current state of neoadjuvant systemic therapy for melanoma, focusing on the surgical aspects and the role of surgical oncologists. It summarizes past developments in melanoma treatment and the evidence for neoadjuvant systemic therapy in stage III melanoma, discussing surgical issues, technical aspects, and other important considerations.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Felicity Newell, Ines Pires da Silva, Peter A. Johansson, Alexander M. Menzies, James S. Wilmott, Venkateswar Addala, Matteo S. Carlino, Helen Rizos, Katia Nones, Jarem J. Edwards, Vanessa Lakis, Stephen H. Kazakoff, Pamela Mukhopadhyay, Peter M. Ferguson, Conrad Leonard, Lambros T. Koufariotis, Scott Wood, Christian U. Blank, John F. Thompson, Andrew J. Spillane, Robyn P. M. Saw, Kerwin F. Shannon, John Pearson, Graham J. Mann, Nicholas K. Hayward, Richard A. Scolyer, Nicola Waddell, Georgina Long
Summary: This study examines the relationship between various factors and the response to immunotherapy in patients with advanced cutaneous melanoma. The results identify several factors associated with response and develop a multivariable model for predicting response. However, the study also indicates the presence of intratumor and intertumor heterogeneity in response to immunotherapy and the lack of clear biological mechanisms explaining non-predicted responses.
Article
Oncology
Mary-Ann El Sharouni, Richard A. Scolyer, Carla H. van Gils, Sydney Ch'ng, Omgo E. Nieweg, Thomas E. Pennington, Robyn PM. Saw, Kerwin Shannon, Andrew Spillane, Jonathan Stretch, Arjen J. Witkamp, Vigfus Sigurdsson, John F. Thompson, Paul J. van Diest
Summary: This study examined whether the interval between diagnostic excision-biopsy and definitive wide excision with sentinel node biopsy (SNB) affected the size of SN metastatic deposits. The results showed that patients who underwent SNB later after diagnosis had significantly larger SN metastasis diameters. This finding has implications for management and prognosis.
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
R. C. Simpson, M. Batten, E. R. Shanahan, I. Pires Da Silva, J. M. Versluis, I. L. M. Reijers, A. M. Menzies, R. P. M. Saw, M. Gonzalez, K. F. Shannon, A. J. Spillane, C. U. Blank, R. A. Scolyer, G. V. Long
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
G. V. Long, A. J. Spillane, T. E. Pennington, K. F. Shannon, J. Stretch, M. Gonzalez, R. P. M. Saw, S. N. Lo, R. A. Scolyer, A. M. Menzies
ANNALS OF ONCOLOGY
(2022)
Editorial Material
Oncology
Anna K. Lawless, David J. Coker, Serigne N. Lo, Tasnia Ahmed, Richard A. Scolyer, Sydney Ch'ng, Omgo E. Nieweg, Kerwin Shannon, Andrew Spillane, Jonathan R. Stretch, John F. Thompson, Robyn P. M. Saw
ANNALS OF SURGICAL ONCOLOGY
(2022)
Letter
Pathology
Elizabeth Paver, Karina Aivazian, Fiona Maclean, Georgina Long, Andrew J. Spillane, James S. Wilmott, Richard A. Scolyer
Editorial Material
Oncology
Trine Schoenfeldt, John F. Thompson, Serigne Lo, Krzysztof T. Drzewiecki, Jonathan Stretch, Robyn P. M. Saw, Andrew Spillane, Kerwin Shannon, Roger F. Uren, Annette H. Chakera, Omgo E. Nieweg
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Trine Schoenfeldt, John F. Thompson, Serigne Lo, Krzysztof T. Drzewiecki, Jonathan Stretch, Robyn P. M. Saw, Andrew Spillane, Kerwin Shannon, Roger F. Uren, Annette H. Chakera, Omgo E. Nieweg
Summary: This study aimed to determine the clinical significance of sentinel nodes (SNs) in the triangular intermuscular space (TIS) in patients with melanoma. It found that 11% of patients with melanomas on their upper back had TIS SNs, and retrieval of these SNs was important for accurate staging and to minimize the risk of recurrence in the TIS.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Nirmal Dayaratna, Chu Luan Nguyen, Andrew Spillane, Cindy Mak, Sanjay Kumar Warrier, Joseph R. Dusseldorp
Summary: The breast reconstruction rate in Australia has increased over the past decade, but significant variations still exist between different states. Reconstruction surgery is less common in older women and those living in remote areas. While the steady increase in reconstruction uptake is encouraging, existing barriers to equitable provision of reconstructive surgical services for all women with breast cancer still need to be addressed.
ANZ JOURNAL OF SURGERY
(2023)
Article
Immunology
Irene L. M. Reijers, Disha Rao, Judith M. Versluis, Alexander M. Menzies, Petros Dimitriadis, Michel W. Wouters, Andrew J. Spillane, Willem M. C. Klop, Annegien Broeks, Linda J. W. Bosch, Marta Lopez-Yurda, Winan J. van Houdt, Robert V. Rawson, Lindsay G. Grijpink-Ongering, Maria Gonzalez, Sten Cornelissen, Jasper Bouwman, Joyce Sanders, Elsemieke Plasmeijer, Yannick S. Elshot, Richard A. Scolyer, Bart A. van de Wiel, Daniel S. Peeper, Alexander C. J. van Akkooi, Georgina V. Long, Christian U. Blank
Summary: The baseline IFN-gamma signature can be used to select patients who can benefit from anti-PD-1 monotherapy in the DONIMI trial. However, the addition of domatinostat, a class I HDAC inhibitor, does not provide additional benefits in patients receiving neoadjuvant anti-PD-1 +/- anti-CTLA-4. Neoadjuvant ipilimumab + nivolumab shows high pathologic response rates in stage III melanoma, but patients with low intra-tumoral IFN-gamma signatures are less likely to benefit.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Lodewijka H. J. Holtkamp, Serigne N. Lo, John F. Thompson, Andrew J. Spillane, Jonathan R. Stretch, Robyn P. M. Saw, Kerwin F. Shannon, Omgo E. Nieweg, Angela M. Hong
Summary: This study evaluated the long-term node field control and survival of melanoma patients with node field recurrence following prior node dissection who underwent salvage surgery with adjuvant radiotherapy. The results showed that while adjuvant radiotherapy achieved control of the node field, disease progression at distant sites was common and the survival outcomes were poor.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Brooke Nickel, Kirsten McCaffery, Jesse Jansen, Alexandra Barratt, Nehmat Houssami, Christobel Saunders, Andrew Spillane, Claudia Rutherford, Kirsty Stuart, Geraldine Robertson, Ann Dixon, Jolyn Hersch
Summary: Management of low-risk ductal carcinoma in situ (DCIS) is controversial, with clinical trials currently assessing the safety of active monitoring amidst concern about overtreatment. Women's understanding and views about low-risk DCIS and its management were explored through qualitative focus groups and brief quantitative questionnaires. The findings revealed limited prior awareness of DCIS, but substantial support for active monitoring as a management approach for low-risk DCIS, indicating the need for well-informed patient choice and potential future trials.
Review
Public, Environmental & Occupational Health
Matthew N. Berger, Ellen S. Mowbray, Marian W. A. Farag, Erin Mathieu, Cristyn Davies, Claire Thomas, Robert Booy, Angus H. Forster, S. Rachel Skinner
Summary: Microarray patches (MAPs) show potential as a safe and effective method for vaccine delivery. They have been found to be well tolerated, with similar or enhanced immunogenicity compared to needle and syringe. Further research is needed to explore their full potential.
Article
Public, Environmental & Occupational Health
Erin Mathieu, Anne C. Grunseit, Bridget C. Foley, Lindsey J. Reece
Summary: The junior parkrun pilot in Australia has shown promise in encouraging children to engage in physical activity in a fun and inclusive way, with majority of parents acknowledging the benefits and enjoyment it brings to their children.
HEALTH PROMOTION JOURNAL OF AUSTRALIA
(2023)