Effect of panaxytriol on cytochrome P450 3A4 via the pregnane X receptor regulatory pathway

Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro

(2018) Guncha Taneja et al.   DRUG METABOLISM AND DISPOSITION

A current structural perspective on PXR and CAR in drug metabolism

(2018) Cameron D. Buchman et al.   Expert Opinion on Drug Metabolism & Toxicology

Semi-quantitative profiling of bile acids in serum and liver reveals the dosage-related effects of dexamethasone on bile acid metabolism in mice

(2018) Xue Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A Transcriptional Regulatory Network Containing Nuclear Receptors and Long Noncoding RNAs Controls Basal and Drug-Induced Expression of Cytochrome P450s in HepaRG Cells

(2018) Liming Chen et al.   MOLECULAR PHARMACOLOGY

Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug–Drug Interactions with Moderate CYP3A4 Inhibitors or Inducers

(2017) Aiqun Li et al.   PEDIATRIC DRUGS

Mechanism of Action of Panaxytriol on Midazolam 1′-Hydroxylation and 4-Hydroxylation Mediated by CYP3A in Liver Microsomes and Rat Primary Hepatocytes

(2015) Fang He et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Targeting xenobiotic receptors PXR and CAR in human diseases

(2015) Monimoy Banerjee et al.   DRUG DISCOVERY TODAY

Transcriptional regulation of human paraoxonase 1 by PXR and GR in human hepatoma cells

(2015) N. Ponce-Ruiz et al.   TOXICOLOGY IN VITRO

Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists

(2014) Giuseppina Chianese et al.   STEROIDS

Structure–activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: Core region

(2013) Hongtao Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A mechanism-based pharmacokinetic/pharmacodynamic model for CYP3A1/2 induction by dexamethasone in rats

(2012) Liang Li et al.   ACTA PHARMACOLOGICA SINICA

Fucoxanthin Attenuates Rifampin-Induced Cytochrome P450 3A4 (CYP3A4) and Multiple Drug Resistance 1 (MDR1) Gene Expression Through Pregnane X Receptor (PXR)-Mediated Pathways in Human Hepatoma HepG2 and Colon Adenocarcinoma LS174T Cells

(2012) Cheng-Ling Liu et al.   Marine Drugs

Pregnane X Receptor and Yin Yang 1 Contribute to the Differential Tissue Expression and Induction of CYP3A5 and CYP3A4

(2012) Dieudonné Nem et al.   PLoS One

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes

(2010) Jian Yang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The challenge of modeling nuclear receptor regulatory networks in mammalian cells

(2010) Vidhya Jagannathan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1′-hydroxylation and 4-hydroxylation of midazolam

(2009) Chunhua Xia et al.   CHEMICO-BIOLOGICAL INTERACTIONS

(3R,9R,10R)-Panaxytriol: a molecular-based nutraceutical with possible application to cancer prevention and treatment

(2008) Fay Ng et al.   TETRAHEDRON LETTERS