Review
Biochemistry & Molecular Biology
Katarina Andelova, Barbara Szeiffova Bacova, Matus Sykora, Peter Hlivak, Miroslav Barancik, Narcis Tribulova
Summary: Oxidative stress and inflammation are detrimental to cardiovascular health and increase heart susceptibility to arrhythmias. Compounds with antiarrhythmic properties that also have antioxidant and anti-inflammatory effects may be effective in reducing arrhythmia burden by preventing or attenuating oxidative and inflammatory stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Rahmatullah Jan, Nari Kim, Seo-Ho Lee, Muhammad Aaqil Khan, Sajjad Asaf, Lubna, Jae-Ryoung Park, Saleem Asif, In-Jung Lee, Kyung-Min Kim
Summary: The study demonstrates that increased accumulation of flavonoids can enhance the tolerance of rice plants to combined salt and heat stress by regulating physiological, biochemical, and molecular mechanisms.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Abraham S. Arellano-Buendia, Juan G. Juarez-Rojas, Fernando E. Garcia-Arroyo, Raul Arguello-Garcia, Fausto Sanchez-Munoz, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: Cardiovascular diseases are a group of diseases that can be treated with allicin, a sulfur compound derived from garlic, to regulate cellular mechanisms and signaling pathways and improve cardiovascular risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jialing Gao, Xiaoxue Wu, Shuting Huang, Ziyi Zhao, Weiling He, Mei Song
Summary: This article provides an overview of copper homeostasis and its associated pathological disorders, especially copper metabolism in carcinogenesis. It summarizes the current knowledge of the tumor suppressive mechanisms of elesclomol, with emphasis on cuproptosis. Finally, strategies for better application of elesclomol in cancer therapy are discussed.
Review
Biochemistry & Molecular Biology
Dora Bianka Balogh, Laszlo Jozsef Wagner, Andrea Fekete
Summary: Metabolic diseases, especially diabetes mellitus (DM), are significant global public health concerns. Standard-of-care therapies for DM have not effectively reduced cardiovascular disease (CVD), which remains the leading cause of death among diabetic patients. Recent clinical trials have shown that SGLT2 inhibitors and GLP-1 receptor agonists can improve cardiorenal outcomes in type 2 DM patients, indicating a paradigm shift in DM management to focus on cardiovascular outcomes as well as glycemic control. The mechanisms behind the beneficial effects of these drugs, such as inflammation, oxidative stress, and fibrosis, are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min-Jin Kim, Yu-Rim Song, Young Eun Kim, Su-Jin Bae, Won-Yung Lee, Seon-Been Bak, Young Woo Kim
Summary: Recent studies have shown that Kaempferol (KP) has positive effects on inflammation and oxidative damage. This study specifically evaluated the impact of KP on liver damage induced by arachidonic acid (AA) and iron. The results suggest that KP has a hepatoprotective effect by activating autophagy and inhibiting AMP-activated protein kinase (AMPK).
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Food Science & Technology
Boshen Yang, Yuankang Zhu, Xinjie Zheng, Taixi Li, Kaifan Niu, Zhixiang Wang, Junli Duan, Chengxing Shen
Summary: This study demonstrates that amygdalin from bitter almonds has antioxidant activity and can reduce myocardial infarction damage, possibly through activating specific signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Medicine, Research & Experimental
Nyshadham S. N. Chaitanya, Arpita Devi, Sibani Sahu, Phaniendra Alugoju
Summary: This review focuses on the multifunctional roles of Trehalose in cancer treatment, highlighting its ability to target various cellular processes and proteins within the cell, with potential therapeutic value against cancer.
Review
Nutrition & Dietetics
Sen-Yuan Hong, Bao-Long Qin
Summary: Urolithiasis is a common urological disease with increasing prevalence and high recurrence rates worldwide. Reactive oxygen species (ROS) and oxidative stress (OS) play crucial roles in stone formation. Dietary polyphenols, which are natural antioxidant compounds found in plant-based foods and beverages, have been shown to be effective in preventing and treating stone formation. This review discusses the antioxidant potential of polyphenols and their mechanisms in ameliorating oxidative stress and preventing stone formation. Dietary polyphenols offer promising applications in the treatment and prevention of urolithiasis.
Review
Oncology
Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene, Saeed Samarghandian
Summary: Chrysin has been shown to have multiple beneficial pharmacological activities, exerting therapeutic effects on various cancers. Further studies are needed to enhance its bioavailability and evaluate its efficacy in clinical trials.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Gabriel Mendez-Valdes, Vicente Perez-Carreno, Maria Chiara Bragato, Malthe Hundahl, Silvia Chichiarelli, Luciano Saso, Ramon Rodrigo
Summary: Ischemia/reperfusion injury is a detrimental process during cardiac interventions, leading to activation of cell death pathways and increased cardiovascular risk. Multiple NADPH oxidases, activated via AT1R occupancy, contribute to the generation of ROS. In addition, ROS can induce proinflammatory responses. On the other hand, the Ang II/AT2R axis exerts cardioprotective effects. AT1R blockers may be used to inhibit the Ang II/AT1R axis and reduce ROS burst, while combination with other cardioprotective agents shows promising outcomes in experimental studies.
Article
Pharmacology & Pharmacy
Yakun Yang, Jiaying Qi, Muqing Zhang, Pingping Chen, Yanshuang Liu, Xiaorun Sun, Li Chu
Summary: In this study, the potential of naringenin in treating myocardial ischemia was systematically investigated through network pharmacology analysis and experimental validation. The results showed that naringenin could improve apoptosis, inflammation, oxidative stress, and reduce intracellular Ca2+ concentrations. The study also revealed that naringenin inhibited L-type Ca2+ currents, providing a novel cardioprotective mechanism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Mrunmai Tapadia, Stuart Johnson, Ranjeet Utikar, Philip Newsholme, Rodrigo Carlessi
Summary: The gamma-conglutin peptides showed a potential insulin-mimetic action in muscle cells by activating insulin signaling pathways and also effectively inhibited DPP4 activity, indicating their potential to prolong the half-life of incretin hormones in circulation. These results support the health benefits of consuming lupin seeds and suggest a shift in the market towards lupin-based food products for human consumption.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, Research & Experimental
Qijing Wu, Juan Chen, Xiyin Zheng, Jing Song, Lulu Yin, Hai Guo, Qian Chen, Yi Liu, Qianli Ma, Hong Zhang, Qianqian Yang
Summary: The study aimed to evaluate the protective effect of kaempferol (KPF) in doxorubicin (DOX)-induced nephrotoxicity. The results showed that KPF could alleviate DOX-induced renal injury, improve proteinuria and renal function, restore antioxidant activity in kidneys, suppress oxidative stress, and inhibit the activation of the MAPK signaling pathway. In cell experiments, KPF also inhibited DOX-induced ROS overproduction, reduced cell damage and loss of viability. Therefore, KPF may provide a viable solution to lessen renal toxicity in cancer patients receiving DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Nidhi Sharma, Subhrajit Biswas, Noura Al-Dayan, Alaa Saud Alhegaili, Maryam Sarwat
Summary: Reactive oxygen species (ROS) are harmful to cells, leading to oxidative stress and endoplasmic reticulum stress, which are key biological factors in the progression of hepatocellular carcinoma (HCC). The use of antioxidants from herbal sources can significantly reduce oxidative stress, and kaempferol may serve as a potential candidate in preventing HCC.
Review
Food Science & Technology
Chunhua Zhang, Mingxi Li, Abdur Rauf, Anees Ahmed Khalil, Zhiguo Shan, Chuying Chen, Kannan R. R. Rengasamy, Chunpeng Wan
Summary: This review compiles the information on the potential use of alginate and alginate oligosaccharides (AOS) in different fields from 1994 to 2020. AOS, a degradation product of alginate, has gained attention for its beneficial properties in food, pharmaceutical, and agricultural industries. The review highlights the antimicrobial, antioxidant, anti-inflammatory, and other bioactive properties of AOS, and its applications in various sectors such as prebiotics, nutritional supplements, and plant growth development.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Chuqi Wang, Minhao Li, Xinyu Duan, Tareq Abu-Izneid, Abdur Rauf, Zidan Khan, Saikat Mitra, Talha Bin Emran, Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, Muthu Thiruvengadam, Hafiz A. R. Suleria
Summary: Tomatoes are widely consumed worldwide and are rich in nutritional and bioactive compounds. However, the processing of tomatoes into various products may affect the bioavailability of these compounds. This review discusses the nutritional and anti-nutritional compounds in tomatoes and their effects on human health, as well as the impact of different food processing techniques on the bioavailability of tomato antioxidants.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Prabhakar Semwal, Sakshi Painuli, Abhishek Jamloki, Abdur Rauf, Md Mominur Rahman, Ahmed Olatunde, Hassan A. Hemeg, Tareq Abu-Izneid, Saima Naz, Sneh Punia Bangar, Jose M. Lorenzo, Jesus Simal-Gandara
Summary: The Himalayan region is rich in natural resources and supports a wide diversity of flora and fauna. Wild fruits in this region have significant biologically active compounds and nutraceutical value, and show potential for various therapeutic activities. However, further research is needed to fully understand their health-promoting effects and chemical composition.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Rabia Naz, Fatima Saqib, Samir Awadallah, Muqeet Wahid, Muhammad Farhaj Latif, Iram Iqbal, Mohammad S. Mubarak
Summary: Polyphenols found in various natural products have shown potential in treating and managing type II diabetes mellitus and its complications. These compounds exhibit antidiabetic effects through different mechanisms, including protecting pancreatic beta-cells, reducing insulin resistance, modulating carbohydrate and lipid metabolism, and inhibiting digestive enzymes. They also demonstrate antioxidant and anti-inflammatory activities, regulate the intestinal microbiota, and improve adipose tissue metabolism. However, further research is needed to fully understand the effective mechanisms for managing diabetes.
Article
Crystallography
Haji Rahman, Abdur Rauf, Shahid Ali Khan, Zubair Ahmad, Abdulrahman Alshammari, Metab Alharbi, Amir Alam, Hafiz Ansar Rasul Suleria
Summary: The present study synthesized silver nanoparticles (Ag NPs) using a methanolic and aqueous extract of R. stricta. The Ag NPs were characterized using UV-visible spectroscopy, EDX, FESEM, and FTIR techniques. The Ag NPs exhibited SPR at 490-560 nm in the UV-visible spectra, and FTIR spectrum indicated the presence of various functional groups capping the nanoparticles. The Ag NPs had an average size of 20-35 nm and a spherical shape as confirmed by FESEM. The Ag NPs showed superior antioxidant, antibacterial, and antifungal activities compared to the plant extract.
Article
Engineering, Chemical
Abdur Rauf, Umer Rashid, Zafar Ali Shah, Gauhar Rehman, Kashif Bashir, Johar Jamil, Iftikhar, Abdur Rahman, Abdulrahman Alsahammari, Metab Alharbi, Abdulmajeed Al-Shahrani, Giovanni Ribaudo
Summary: This study aimed to investigate the anti-inflammatory and anti-diabetic effects of ferruginan, a compound isolated from Olea ferruginea. The results showed that ferruginan exhibited promising anti-inflammatory activity and increased glucose uptake in yeast cells, indicating its potential anti-inflammatory and anti-diabetic properties.
Article
Multidisciplinary Sciences
Abdur Rauf, Saima Naz, Naveed Muhammad, Abdul Wadood, Adnan Khan, Abdulrahman Alsahammari, Metab Alharbi, Philippe Jeandet
Summary: This study evaluated the leishmanicidal activity of two flavonoid compounds isolated from Pistacia integerrima, and found that both compounds exhibited excellent leishmanicidal effects.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Plant Sciences
Jan Sher, Gul Jan, Muhammad Israr, Muhammad Irfan, Nighat Yousuf, Fazal Ullah, Abdur Rauf, Abdulrahman Alshammari, Metab Alharbi
Summary: The present study evaluated the pharmacological, antioxidant, and phytochemical properties of Polystichum lonchitis L., a fern belonging to the family Dryopteridaceae, and conducted GC-MS screening. Various tests were conducted to assess analgesic, antipyretic, anti-inflammatory, and antispasmodic activity. The most significant effects were observed in the analgesic and anti-inflammatory activities, followed by antipyretic and antispasmodic activities. Methanolic and aqueous extracts showed the most significant antioxidant activities. GC-MS analysis detected alpha-D-Galactopyranoside, methyl, and n-hexadecanoic as the main compounds. These findings suggest that P. lonchitis has strong pharmacological potential, providing a way to isolate bioactive constituents for new medicines with reduced side effects.
Article
Food Science & Technology
Afaf Ejaz, Muhmmad Afzaal, Farhan Saeed, Sadaf Waliat, Yasir Abbas Shah, Ali Imran, Noor Akram, Aasma Asghar, Huda Ateeq, Suliman Yousef Alomar, Asad Nawaz, Degnet Teferi Asres
Summary: This research investigates the impact of introducing different kinds of onion peel extract on the survival and sustainability of Lactobacillus rhamnosus probiotic. The study finds that including onion peel extract in microcapsules enhances probiotic survival. The structure, distribution, and encapsulation efficacy of probiotics and substances in the extract are evaluated, along with the probiotics' capability to persist under simulated gastrointestinal conditions.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Food Science & Technology
Afza Farooq, Bushra Niaz, Farhan Saeed, Muhammad Afzaal, Muhammad Armghan Khalid, Muhammad Ahtisham Raza, Entessar Al Jbawi
Summary: This study investigated the impact of aloe vera gel-based edible coating on the post-harvest quality of tomatoes. The results showed that the tomatoes with aloe vera-based coating exhibited better preservation effects, including reduced weight loss, maintained soluble solids content and acidity, inhibited microbial growth, and preserved firmness and color during storage.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Biochemistry & Molecular Biology
Mehedi Hasan Bappi, Abdullah Al Shamsh Prottay, Hossam Kamli, Fatema Akter Sonia, Md. Nayem Mia, Md. Showkoth Akbor, Md. Munnaf Hossen, Samir Awadallah, Mohammad S. S. Mubarak, Muhammad Torequl Islam
Summary: Sedatives are used for calmness or sleepiness in surgery or severe stress. Depression negatively affects emotional well-being and can be treated with anti-depressants. This study evaluated the effects of quercetin and linalool on sleeping mice induced by thiopental sodium and investigated their combined effects using in silico studies.
Review
Biochemistry & Molecular Biology
Md. Shimul Bhuia, Polrat Wilairatana, Jannatul Ferdous, Raihan Chowdhury, Mehedi Hasan Bappi, Md Anisur Rahman, Mohammad S. Mubarak, Muhammad Torequl Islam
Summary: Fruits and vegetables not only provide nutrition, but also have therapeutic effects against various diseases. Hirsutine (HSN), a natural indole alkaloid found in Uncaria species, has multiple therapeutic benefits and can be found in various foods. This study summarizes the pharmacological activities and mechanisms of HSN against different diseases, and emphasizes its potential as a promising therapeutic agent for cancer treatment.
Article
Food Science & Technology
Noor Akram, Muhammad Afzaal, Farhan Saeed, Adnan Ahmad, Ali Imran, Aftab Ahmed, Yasir Abbas Shah, Fakhar Islam, Suliman Yousef Alomar, Salim Manoharadas, Asad Nawaz
Summary: In this study, whey protein-based nanofibers were fabricated to encapsulate Lactobacillus rhamnosus. The nanofibers were blended using different ratios of PVA and WPI, and characterized for various properties. SEM and FTIR analysis showed successful loading of probiotics within the nanofibers, with strong bonding between the encapsulating materials. In vitro and thermal analyses demonstrated significant improvement in the survival of the encapsulated probiotics.
Editorial Material
Nutrition & Dietetics
Farhan Saeed, Muhammad Imran, Ghulam Hussain, Hafiz A. R. Suleria, Ali Imran
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Ayesha Talib, Shafiq Ali Shah, Muhammad Saeed Jan, Muhammad Zaeem Ahsan, Abubakr Munir, Ishfaq A. Bukhari, Halima Sadia, Taghrid S. Alomar, Najla Almasoud, Abdur Rauf
Summary: Diabetes mellitus is a challenging and life-threatening disease. Research has found that certain succinimides with ketone functionalities exhibit excellent inhibitory activity against alpha-glucosidase and alpha-amylase in vitro. These compounds demonstrate potential for anti-diabetic effects in in vivo experiments.
GREEN PROCESSING AND SYNTHESIS
(2023)
