Article
Geriatrics & Gerontology
Min Lei, Xiying Guo, Yue Yao, Ting Shu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Qingjie Chen, Chao Liu, Xiufen Liu
Summary: This study found that Trelagliptin can improve diabetes-related cognitive impairment. The experimental results showed that Trelagliptin can reduce the expression of inflammatory factors, promote the protection and restoration of neurons, and activate pathways that are beneficial to cognitive function.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiying Guo, Min Lei, Jiangyan Zhao, Min Wu, Zhanhong Ren, Xiaosong Yang, Changhan Ouyang, Xiufen Liu, Chao Liu, Qingjie Chen
Summary: The GLP-1/GIP dual agonist tirzepatide has a protective effect against spatial learning and memory impairment in diabetic rats, possibly through regulating insulin resistance and inflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amrita Singh, Surendra H. Bodakhe
Summary: This study demonstrated that resveratrol improved hyperglycemia and learning-memory impairments in T2DM animals by modulating the SIRT1-TGF-beta 1 signaling pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Ruijuan Chen, Yi Zeng, Wenbiao Xiao, Le Zhang, Yi Shu
Summary: Diabetes in elderly individuals can lead to cognitive impairment, and the mechanisms behind this are still not fully understood. Through non-targeted metabolomics using LC-MS, serum biomarkers for diabetic mild cognitive impairment in rats were identified. The study showed that Type 2 diabetes can affect various metabolic pathways, especially lipid metabolism, leading to cognitive dysfunction. Serum PE, PC, L-Trp, and S1P were identified as potential critical biomarkers for early diagnosis of DMMCI.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francesca Chiara Pignalosa, Antonella Desiderio, Paola Mirra, Cecilia Nigro, Giuseppe Perruolo, Luca Ulianich, Pietro Formisano, Francesco Beguinot, Claudia Miele, Raffaele Napoli, Francesca Fiory
Summary: Diabetes mellitus can lead to cognitive dysfunction, with alterations in the dopaminergic system playing a role. Research suggests that advanced glycation end products may be associated with cognitive impairment and changes in the dopaminergic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Sweta Priyadarshini Pradhan, Sonali Sahoo, Anindita Behera, Rajesh Sahoo, Pratap Kumar Sahu
Summary: The present study aimed to investigate the potential and efficacy of hesperidin gold nanoparticles (HSP-AuNPs) for memory enhancement in a diabetes-induced cognitive impairment model. The results showed that HSP-AuNPs exhibited significant antioxidant activity and protective effects, and increased the availability of hesperidin in the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Geriatrics & Gerontology
Dihe Cheng, Xue Zhao, Shuo Yang, Guixia Wang, Guang Ning
Summary: Diabetic retinopathy is associated with cognitive impairment, with proliferative DR showing a stronger association. Screening for DR can aid in early identification of individuals with cognitive impairment. Further studies are needed to confirm the relationship between proliferative DR and cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Li-zhen Cheng, Wei Li, Yi-xin Chen, Yi-jia Lin, Ya Miao
Summary: The review discusses the evidence of autophagy dysfunction in diabetic encephalopathy, provides insights into the potential biological mechanisms linking autophagy impairment to the disease, and explores autophagy-targeted therapies as possible treatments for diabetic encephalopathy.
Article
Neurosciences
Xiying Guo, Min Lei, Guandi Ma, Changhan Ouyang, Xiaosong Yang, Chao Liu, Qingjie Chen, Xiufen Liu
Summary: Clinical and epidemiological research shows that Schisandrin A (SchA), a compound found in Schisandra chinensis, can improve spatial learning and memory impairment in diabetic rats. SchA therapy effectively improves glucose tolerance, blood glucose level, and serum insulin level in diabetic rats. It also reduces hippocampus damage and increases synaptic protein production in diabetic rats.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Plant Sciences
Busra Ertas, Ayse Nur Hazar-Yavuz, Fadime Topal, Rumeysa Keles-Kaya, Ozge Karakus, Gul Sinemcan Ozcan, Turgut Taskin, Muhammet Emin Cam
Summary: Recent studies have found that Rosa canina L. (R. canina) can improve cognitive decline and memory impairment in patients with Type-2 diabetes mellitus (T2DM), possibly through modulation of the insulin pathway, prevention of amyloid deposition, and increased cholinergic transmission.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhigao Xu, Lili Zhao, Lei Yin, Yan Liu, Ying Ren, Guoqiang Yang, Jinlong Wu, Feng Gu, Xuesong Sun, Hui Yang, Taisong Peng, Jinfeng Hu, Xiaogeng Wang, Minghao Pang, Qiong Dai, Guojiang Zhang
Summary: The study aimed to develop an MRI-based machine learning model and found that the LR algorithm performed the best in predicting cognitive dysfunction in patients with type 2 diabetes, showing potential for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Anja Baric, Marina Dobrivojevic Radmilovic
Summary: Stroke is a major cause of mortality and disability globally. Recent studies have shown evidence of diabetes involvement in producing a chronic neuroinflammatory state, affecting recovery of function and cognition after stroke.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Environmental Sciences
Ruike Wang, Zuntao Wu, Lin Bai, Rundong Liu, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huang
Summary: The study confirmed the protective effects of resveratrol against hippocampal neurogenesis impairments induced by lead exposure in male rats, and demonstrated that resveratrol can alleviate cognitive damage and promote neurogenesis through regulation of the SIRT1 pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hanan Ehtewish, Abdelilah Arredouani, Omar El-Agnaf
Summary: The underlying mechanisms linking type 2 diabetes to cognitive dysfunction are still unclear, but may include factors such as hyperglycemia, insulin resistance, and neuroinflammation. Risk factors for dementia in diabetes patients include aging, poor glycemic control, hypoglycemic and hyperglycemic episodes, depression, and vascular complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jiawei Zhang, Lan Liu, Yaxuan Zhang, Yuan Yuan, Zhijuan Miao, Kaili Lu, Xiaojie Zhang, Ruiqing Ni, Haibing Zhang, Yuwu Zhao, Xiuzhe Wang
Summary: This study explored the role of ChemR23 in diabetes-associated cognitive impairment and found that abnormal ChemR23 signaling may be involved in this cognitive impairment. Treatment with ChemR23 agonists could alleviate cognitive impairment in diabetic mice, while depletion of ChemR23 exacerbated cognitive impairment. ChemR23 signaling may have a crucial role in regulating oxidative stress and NLRP3 inflammasome. Therefore, targeting ChemR23 could be a promising strategy for the treatment of diabetes-associated cognitive impairment.
Article
Andrology
Osman Can, Lutfi Canat, Fatma Ceyla Eraldemir, Esra Acar, Funda Yildirim, Kivilcim Sonmez, Alper Otunctemur, Fatih Altunrende
Summary: The study evaluated the protective effect of oltipraz in testicular ischaemia/reperfusion damage, showing a significant decrease in TGF-β1, GSH, and MDA values in the oltipraz treatment groups. Oltipraz treatment has a significant protective effect against testicular ischaemia/reperfusion damage.
Article
Ophthalmology
Sebnem Kaya Ergen, Sevgi Subasi, Selenay Furat Rencber, Gokhan Duruksu, Yusufhan Yazir
Summary: In a rabbit model of corneal alkali burn, treatment with KGF-2 and NGF effectively promoted corneal healing and reduced inflammation, opacity, and neovascularization.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Gozde Bicaklioglu, Dilara Pirhan, Yusufhan Yazir, Gokhan Duruksu, Selenay Furat Rencber, Nursen Yuksel
Summary: This study aimed to investigate the efficacy of nintedanib in reducing postoperative inflammation and fibrosis, compared to triamcinolone acetonide. The results showed that nintedanib can attenuate postoperative inflammation and fibrosis after extraocular muscle surgery, suggesting it may be a safer and stronger alternative agent in this type of surgery.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Behavioral Sciences
Gulcin Gacar, Semil Selcen Gocmez, Zehra Seda Halbutogullari, Kamil Can Kilic, Aysenur Kaya, Yusufhan Yazir, Tijen Utkan
Summary: This study investigated the effects of resveratrol on vascular function in a rat model of chronic psychological stress and explored its possible mechanisms. The results showed that resveratrol improved depressive-like behavior, ameliorated vascular dysfunction, and reduced stress-induced inflammation. Therefore, resveratrol may be a therapeutic option with vasculoprotective effects in depression induced by chronic stress.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Ophthalmology
Kuebra Demirci Kucuk, Ecem Onder Tokuc, Aysegul Aciksari, Gokhan Duruksu, Yusufhan Yazir, Veysel Levent Karabas
Summary: The study investigated the anti-apoptotic and antioxidant effects of crocetin on an oxidative damage model of ARPE-19 cells. It was found that a dose of 10 mu M crocetin had the most effective impact on cell viability. This dose of crocetin improved the activities of SOD and GSH, reduced MDA level, and downregulated the expression of Bax1 and Nrf2 while upregulating Bcl-2 expression.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Biochemical Research Methods
Eser Oz Oyar, Aysegul Aciksari, Burcu Azak Pazarlar, Cansu Bilister Egilmez, Gokhan Duruksu, Selenay Furat Rencber, Melda Yardimoglu Yilmaz, Ahmet Ozturk, Yusufhan Yazir
Summary: The study shows that induced exosomes can improve the therapeutic effect in cell-free regenerative medicine, which is significant for the treatment of cisplatin-induced tissue damage.
MOLECULAR AND CELLULAR PROBES
(2022)
Article
Pharmacology & Pharmacy
Ece Guler, Ayse Nur Hazar-Yavuz, Esra Tatar, Mohammad Morid Haidari, Gul Sinemcan Ozcan, Gokhan Duruksu, Manuel Pedro F. Graca, Deepak M. Kalaskar, Oguzhan Gunduz, Muhammet Emin Cam
Summary: Empagliflozin (EM) was successfully loaded in PCL/PLA/PMMA fibers and showed improved insulin expression and glucose control in BRIN-BD11 cells. In vitro release testing demonstrated controlled drug release from the fibers, and pharmacokinetic analysis revealed enhanced bioavailability and sustained antidiabetic activity in rats. EMF treatment also increased GLP-1, PPAR-gamma, and insulin levels, while decreasing SGLT-2 and TNF-alpha levels. Histopathological changes were reversed and pancreatic beta-cells were protected in T2DM rats treated with EMF. Overall, EMF represents a novel and effective treatment approach for T2DM.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Anatomy & Morphology
Alparslan Okcu, Yusufhan Yazir, Turgay Simsek, Serap Mert, Gokhan Duruksu, Ahmet Ozturk, Kamil Can Kilic, Gurler Akpinar, Murat Kasap
Summary: The study aimed to develop a therapeutic approach for T1DM by encapsulating pancreatic islets with mesenchymal stem cells and decellularized pancreatic extracellular matrix. The decellularized matrix was proven to be free of cells and genetic material, and supported the growth and maintenance of the islet cells. The encapsulated cells demonstrated improved insulin expression compared to non-encapsulated islets, but the efficiency of insulin secretion did not meet expectations.
Article
Obstetrics & Gynecology
Burak Un, Busra Cetinkaya-Un, Meryem Akpolat, Fundagul Andic, Yusufhan Yazir
Summary: This study explores the effects of mesenchymal stem cell conditioned medium (hAMSCs-CM) derived from the amniotic membrane of human placenta on premature ovarian failure (POF) caused by ionizing radiation. The findings indicate that hAMSCs-CM can promote follicle regeneration and reduce cell stress and apoptosis caused by radiation. These results suggest a potential therapeutic role for hAMSCs-CM in the treatment of radiation-induced POF.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Reyhan Koyuncu, Gokhan Duruksu, Beraat Ozcelik, Serap Mert, Yusufhan Yazir
Summary: In this study, complexes generated by combining α-lactalbumin and hydrolyzed α-lactalbumin with oleic acid, called BAMLET and HBAMLET, respectively, were prepared as nanoparticles using PLGA polymer as a carrier. The tumoricidal activity of HBAMLET was found to be more effective than BAMLET, while BAMLET showed cytotoxicity on fibroblasts at higher concentrations. Encapsulated BAMLET and HBAMLET exhibited promising encapsulation efficiency in the nanoparticles.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Servan Veysanoglu, Busra Ertas, Ece Guler, Fadime Topal, Gul Sinemcan Ozcan, Gokhan Duruksu, Burak Ece, Cansun Sahin Cam, Oguzhan Aydemir, Muhammet Emin Cam
Summary: In this study, polyvinyl alcohol/polyvinylpyrrolidone nanofibers loaded with rivastigmine, memantine, and Gingko biloba extract were developed and investigated for their anti-Alzheimer's effects. The nanofibers showed good compatibility and rapid disintegration, making them suitable for sublingual application. They were found to be safe and promising candidates, significantly improving learning and memory impairment in an Alzheimer's disease model and reducing the levels of key proteins associated with the disease.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gulsen Celebi, Semil Selcen Gocmez, Cuneyt Ozer, Gokhan Duruksu, Yusufhan Yazir, Tijen Utkan
Summary: This study evaluated the effects of propolis on depression and vascular endothelial function induced by chronic stress. The results showed that propolis improved depression-like behavior and vascular function, and protected vascular endothelial function through its anti-inflammatory and antioxidant effects.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Kamil Can Kilic, Yusufhan Yazir, Ahmet Ozturk, Zehra Seda Halbutogullari, Serap Mert, Gulcin Gacar, Gokhan Duruksu
Summary: In this study, the effect of decellularized heart extracellular matrix and VEGF on cardiomyogenic differentiation of rBM-MSCs was investigated. The results showed that both the heart extracellular matrix and VEGF had an impact on the differentiation of stem cells into cardiomyocytes.
Article
Oncology
Eldar Sovunjov, Zehra Seda Halbutogullari, Gulcin Gacar, Ahmet Ozturk, Goekhan Duruksu, Yusufhan Yazir
Summary: Lung cancer is a major global health problem with various physical, psychological, social, and economic consequences. Activated cytotoxic T cells (ACTC) have been found to improve cancer patient prognosis by positively influencing the tumor microenvironment (TME). Recent studies suggest that ACTC-derived exosomes (ACTC-dExo) inhibit the spread of mesenchymal stem cells in the TME, potentially combating metastasis. Exosomes, which resemble natural liposomes in their characteristics, size, and stability, hold promise as a targeted drug delivery system for cancer cells. This study aimed to investigate the cytotoxic and metastatic inhibitory effects of ACTC-dExo on A549 cells in vitro, demonstrating their ability to reduce cancer cell proliferation and metastatic properties.
Article
Materials Science, Biomaterials
Fadime Topal, Busra Ertas, Ece Guler, Fatmanur Gurbuz, Gul Sinemcan Ozcan, Oguzhan Aydemir, Veysel Gokhan Bocekci, Gokhan Duruksu, Cansun Sahin Cam, Yusufhan Yazir, Oguzhan Gunduz, Muhammet Emin Cam
Summary: Drug delivery systems that can deliver multiple therapeutic agents effectively, facilitate patient drug administration, and have high bioavailability show promise in the treatment of Alzheimer's disease. In this study, electrospun nanofibers loaded with donepezil/memantine/curcumin were developed for sublingual delivery. These nanofibers demonstrated good drug incorporation, rapid disintegration, and dissolution properties suitable for sublingual application. The in vitro and in vivo studies showed that the loaded nanofibers enhanced the expression of neurotrophic factors and improved memory and learning abilities in icv-STZ treated rats. Furthermore, the treatment with loaded nanofibers resulted in reduced levels of pathological markers and prevented the formation of neurofibrillary tangles and plaques. Overall, these findings suggest the potential clinical application of sublingually delivered nanofibers for the treatment of Alzheimer's disease.
BIOMATERIALS ADVANCES
(2022)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)