Article
Biochemical Research Methods
Jisun Kim, Jeha Jeon, Bin Song, Nayeon Lee, Sanghyeok Ko, Young Cha, Pierre Leblanc, Hyemyung Seo, Kwang-Soo Kim
Summary: By culturing human pluripotent stem cells in a physically confined area ('spot') and efficiently differentiating them into a highly enriched population of healthy and functional midbrain dopamine progenitors and midbrain dopamine neurons, a new potential for disease treatment and stem cell research is opened up.
Article
Biochemistry & Molecular Biology
Ziying Ye, Chuna Li, Shuqiong Liu, Hongbin Liang, Jialiang Feng, Danyu Lin, Ying Chen, Sudan Peng, Lulu Bu, Enxiang Tao, Xiuna Jing, Yanran Liang
Summary: This study demonstrated that Dl-3-n-butylphthalide (NBP) protected dopaminergic neurons in Parkinson's disease by inhibiting ferroptosis. This protective effect may be achieved by regulating ferritin expression, promoting Nrf2 nuclear translocation, and inhibiting NCOA4-mediated ferritinophagy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Tzu-Feng Wang, Shih-Ying Wu, Bo-Syong Pan, Sheng-Feng Tsai, Yu-Min Kuo
Summary: This study aimed to investigate the role of microglial activation in Parkinson's disease. The results showed that microglial activation was associated with age-related loss of dopaminergic neurons in the substantia nigra and motor deficits. Inhibiting microglial activation reduced dopaminergic neuron death. Exercise upregulated neurotrophic factor signaling and inhibited microglial activation.
Article
Cell Biology
Levi Todd, Marcus J. Hooper, Alexandra K. Haugan, Connor Finkbeiner, Nikolas Jorstad, Nicholas Radulovich, Claire K. Wong, Phoebe C. Donaldson, Wesley Jenkins, Qiang Chen, Fred Rieke, Thomas A. Reh
Summary: The combination of Ascl1 and Atoh1 transcription factors is remarkably efficient at stimulating neurogenesis in targeted Müller glia cells, even in the absence of retinal injury. Using electrophysiology and single-cell RNA sequencing, the study demonstrates that this combination can generate a diversity of retinal neuron types. The results provide proof of principle that combinations of developmental transcription factors can substantially enhance glial reprogramming to neurons and expand the variety of regenerated cell fates.
Article
Multidisciplinary Sciences
Lindsay Willmore, Courtney Cameron, John Yang, Ilana Witten, Annegret Falkner
Summary: This research reveals differences in DA neuron activity and behavior between resilient and susceptible individuals after experiencing stress. Resilient mice show more activity near the aggressor, while susceptible mice exhibit more activity at the end of attacks and the beginning of fleeing. Optogenetic stimulation of NAc-projecting DA neurons can promote resilience and alter behavior during defeat.
Article
Cell Biology
Rolando Lara-Rodarte, Daniel Cortes, Karla Soriano, Francia Carmona, Luisa Rocha, Enrique Estudillo, Adolfo Lopez-Ornelas, Ivan Velasco
Summary: This study engineered mouse ESCs to produce human GDNF, showing that overexpression of GDNF contributes to enhanced midbrain differentiation and increased survival of DaNs after grafting into the striatum.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qianqian Cao, Qiuming Zou, Xin Zhao, Yimin Zhang, Youge Qu, Nanbu Wang, Shigeo Murayama, Qi Qi, Kenji Hashimoto, Song Lin, Ji-chun Zhang
Summary: Mounting evidence suggests the key role of brain-derived neurotrophic factor (BDNF) in the dopaminergic neurotoxicity of Parkinson's disease (PD). This study revealed that Nrf2/MeCP2 coordinately regulated BDNF transcription, and activation of Nrf2 and suppression of MeCP2 could reverse the decreased levels of BDNF expression in PD models. Sulforaphane, an Nrf2 activator, attenuated dopaminergic neurotoxicity in PD models through activation of BDNF and suppression of MeCP2. These findings suggest that activating Nrf2 and/or suppressing MeCP2 to enhance BDNF transcription could be a novel therapeutic approach for PD.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Lulu Tian, Murad Al-Nusaif, Xi Chen, Song Li, Weidong Le
Summary: This review summarizes the molecular mechanism of transcription factors in the embryonic growth and maturation of meso-diencephalic dopaminergic (mdDA) neurons, as well as the progress in dopaminergic cell therapy dependent on the understanding of transcription factors in mdDA neuronal development. Researchers believe that a deeper understanding of the extrinsic and intrinsic factors that influence the fate and development of dopaminergic neurons in the midbrain could lead to a better strategy for Parkinson's disease cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Jie Li, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Shumao Cui
Summary: This study evaluated the effects of naringenin and apigenin on skin damage in mice induced by oleic acid. Both naringenin and apigenin decreased triglycerides and non-esterified fatty acids levels, with apigenin resulting in better recovery of skin lesions. They improved skin antioxidative abilities and inhibited the release of proinflammatory cytokines. Naringenin and apigenin regulated antioxidant defense and inflammatory response through specific mechanisms.
Editorial Material
Cell Biology
Natalia Jimenez-Moreno, Jon D. Lane
Summary: Parkinson's disease is caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. In our recent study, we found that the transcription factors LMX1A and LMX1B play crucial roles in autophagy gene expression for stress protection in the developed brain. We propose a novel role for ATG8 proteins as transcriptional co-factors for autophagy genes in protecting dopaminergic neurons in Parkinson's disease.
Article
Biochemistry & Molecular Biology
Uttam Ojha, Shristi Khanal, Pil-Hoon Park, Jin Tae Hong, Dong-Young Choi
Summary: This study investigated the neuroprotective effects of fasting in a mouse model of Parkinson's disease. The findings showed that alternate-day fasting attenuated dopaminergic neuronal loss and astroglial activation in the brain, reduced depletion of striatal dopamine, improved motor impairment caused by MPTP, and increased the phosphorylation of signaling molecules involved in neurotrophic factors.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Kuo-Jen Wu, Tsai-Wei Hung, Yu-Syuan Wang, Yun-Hsiang Chen, Eun-Kyung Bae, Seong-Jin Yu
Summary: Saposin and its precursor prosaposin are endogenous proteins with neurotrophic and anti-apoptotic properties. This study found that PS18 has neuroprotective effects in cellular and animal models of Parkinson's disease, possibly through anti-endoplasmic reticulum stress mechanisms.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Xiaolin Tian
Summary: The study shows that overexpression of Mask protein in DANs can extend lifespan and maintain locomotor and fecundity in old flies. Additionally, independent activation of G alpha(s) in DANs also extends fly lifespan, indicating a connection between specific DANs and aging control. The function of Mask in regulating microtubule stability appears to be crucial for the lifespan extension.
Article
Endocrinology & Metabolism
Bing Feng, Jerney Harms, Nirali Patel, Hui Ye, Pei Luo, Valeria Torres Irizarry, Jacob Vidrine, Ann Coulter, Candida J. Rebello, Sangho Yu, Jia Fan, Hans-Rudolf Berthoud, Frank Greenway, Heike Munzberg, Christopher Morrison, Pingwen Xu, Yanlin He
Summary: The study identified the crucial role of Cav3.2 expressed by VgatARH neurons in regulating food intake and energy balance, affecting body weight and fat mass in mice. Naringenin extract was found to decrease firing activity of VgatARH neurons by acting on Cav3.2, leading to reduced food intake and body weight.
MOLECULAR METABOLISM
(2021)
Article
Biochemical Research Methods
Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Xiaolei Miao, Jinxia Wan, John T. Williams, Malcolm G. Campbell, Ruyi Cai, Tongrui Qian, Fengling Li, Sophia J. Weber, Lei Wang, Bozhi Li, Yu Wei, Guochuan Li, Huan Wang, Yu Zheng, Yulin Zhao, Marina E. Wolf, Yingjie Zhu, Mitsuko Watabe-Uchida, Yulong Li
Summary: Researchers have developed a series of fluorescent dopamine sensors with high sensitivity and selectivity, which can detect the spatiotemporal dynamics of dopamine release and measure neurochemical signaling in multiple brain regions. These sensors provide important tools for studying dopamine activity.
Review
Biochemistry & Molecular Biology
Ze Wang, Chunyang He, Jing-Shan Shi
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Guo-Qing Wang, Xue-Mei He, Guo-Fu Zhu, Jing-Shan Shi, Feng Zhang
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Yong Zheng, Yan Deng, Jian-mei Gao, Chun Lv, Ling-hu Lang, Jing-shan Shi, Chang-yin Yu, Qi-hai Gong
ACTA PHARMACOLOGICA SINICA
(2020)
Article
Biochemistry & Molecular Biology
Surendra Sarsaiya, Archana Jain, Qi Jia, Xiaokuan Fan, Fuxing Shu, Zhongwen Chen, Qinian Zhou, Jingshan Shi, Jishuang Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Jinjiao Hu, Hongwei Zhang, Jie Li, Xiuxing Jiang, Yanhao Zhang, Qin Wu, Liwen Shen, Jingshan Shi, Ning Gao
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Jianmei Gao, Nana Chen, Na Li, Fan Xu, Wei Wang, Yaying Lei, Jingshan Shi, Qihai Gong
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Article
Microbiology
Surendra Sarsaiya, Archana Jain, Xiaokuan Fan, Qi Jia, Quan Xu, Fuxing Shu, Qinian Zhou, Jingshan Shi, Jishuang Chen
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Neurosciences
Bo Liu, Bo Huang, Jie Liu, Jing-Shan Shi
Article
Neurosciences
Ling-Li Lv, Bo Liu, Jing Liu, Li-Sheng Li, Feng Jin, Yun-Yan Xu, Qin Wu, Jie Liu, Jing-Shan Shi
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Review
Biotechnology & Applied Microbiology
Archana Jain, Surendra Sarsaiya, Jishuang Chen, Qin Wu, Yuanfu Lu, Jingshan Shi
Summary: This article critically analyzes the threats, disease patterns, and challenges facing Orchidaceae species, highlighting the impact of microbial diseases on their growth and development. It provides comprehensive data for evaluating the identification and detection of diseases, which is a crucial challenge for sustainable cultivation of Orchidaceae diversity.
Article
Clinical Neurology
Tingting Pi, Shenjiao Wei, Yongxuan Jiang, Jing-Shan Shi
Summary: Feeding high methionine diets to mice caused weight loss, impaired learning, memory, and motor abilities, damaged hippocampal and cortical neurons, and increased levels of amyloid-beta and 5-methylcytosine.
BEHAVIOURAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xianyu Huang, Shan Yang, Jian Sun, Xia Li, Shao-Yu Zhou, Jing-Shan Shi, Jie Liu, Qin Wu
Summary: Dendrobium nobile Lindl. alkaloids (DNLA) have protective effects against chronic alcoholic liver injury by decreasing triglyceride levels, ameliorating hepatocyte degeneration and steatosis, restoring the aberrant gene expression pattern induced by alcohol, and alleviating oxidative stress and xenobiotic metabolism disruption.
Review
Medicine, Research & Experimental
Xi He, Jiaojiao Liu, Bo Liu, Jingshan Shi
Summary: DNA methylation clocks are accurate biomarkers of biological age, measuring the rate of aging and the effects of anti-aging interventions, and are important for assessing individual health status.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Toxicology
Ru Zeng, Qian Zhou, Wei Zhang, Xiaolong Fu, Qin Wu, Yuanfu Lu, Jingshan Shi, Shaoyu Zhou
TOXICOLOGY REPORTS
(2019)
Review
Biotechnology & Applied Microbiology
Archana Jain, Surendra Sarsaiya, Qin Wu, Jingshan Shi, Yuanfu Lu