Article
Engineering, Biomedical
Chunli Zhang, Gang Xu, Liwei Han, Xiantong Hu, Yantao Zhao, Zhonghai Li
Summary: The study demonstrated that the combination of TBC with rhBMP-2 and Sr had good bioactivity, significant bone conduction, and excellent bone defect repair performance, potentially paving the way for clinical applications.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Yi-ding Zhang, Ao-bo Ma, Lu Sun, Jun-duo Chen, Guang Hong, Hong-kun Wu
Summary: This study explores an easy and sound way to modify the biological behavior of microspheres for bone tissue regeneration. Nanoclay can successfully sediment on the surface of microspheres, binding with either positively or negatively charged proteins. These properties facilitate cell proliferation and minimize the use of BMP-2.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Narae Jung, Jaehan Park, Sang-Hyun Park, Seunghan Oh, Sungtae Kim, Sung-Won Cho, Jong-Eun Kim, Hong Seok Moon, Young-Bum Park
Summary: This study examines the reinforcement effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) applied to collagen membranes in guided bone regeneration. Results show that the combination of collagen membranes with rhBMP-2 and biphasic calcium phosphate (BCP) significantly enhances bone formation rates. The 2-week healing period yields lower bone formation compared to 4 and 8 weeks.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ho-Kyung Lim, Ik-Jae Kwon, Sung-Woon On, Seok-Jin Hong, Byoung-Eun Yang, Soung-Min Kim, Jong-Ho Lee, Soo-Hwan Byun
Summary: The study investigated the bone regeneration capacity of BCP powder, BCP block, and BCP collagen with different concentrations of rhBMP-2 in an animal model. Results showed that increasing rhBMP-2 concentration did not significantly enhance osteogenesis, while collagen-added material may help mediate rapid bone formation in initial stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Xinye Chen, Shuang Wang, Xiaohui Zhang, Yuanman Yu, Jing Wang, Changsheng Liu
Summary: Bone fractures in aging patients often have slow healing rates and high complication rates. Injecting a fibrin gel with sulfated chitosan nanoparticles can improve bone regeneration and reduce inflammation at the fracture site. This gel also regulates macrophage function and effectively treats fractures in postmenopausal mice.
APPLIED MATERIALS TODAY
(2022)
Article
Biochemistry & Molecular Biology
Leticia Ferreira Montarele, Dimitrius Leonardo Pitol, Bruno Fiorelini Pereira, Sara Feldman, Valeria Paula Sassoli Fazan, Joao Paulo Mardegan Issa
Summary: This study investigated the effects of topical melatonin treatment and its association with rhBMP-2 on bone repair. The results showed a positive effect of the combination treatment on bone repair, suggesting its potential as a new safe alternative technique.
Article
Cell & Tissue Engineering
E. Ling-Ling, Rong Zhang, Chuan-Jie Li, Shuo Zhang, Xiao-Cao Ma, Rui Xiao, Hong-Chen Liu
Summary: The study demonstrated that dental follicle cells exhibit superior proliferation and osteogenic differentiation potential in vitro, and form higher quantity and quality bones in vivo. This suggests that dental stem/progenitor cells may be alternative sources for alveolar bone engineering in regenerative medicine, with developing dental tissue potentially providing a better source for stem/progenitor cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yueh-Ling Chao, Tong-Mei Wang, Hao-Hueng Chang, Li-Deh Lin
Summary: The study investigated the potential of low-dose rhBMP-2 combined with a composite material in repairing peri-implant critical size defects, with results showing that HAp/TCP/Col +0.2 mg/ml rhBMP-2 demonstrated strong osteogenic potential and improved implant stability.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Chemistry, Physical
Tianyi Bao, Zheng Zhou, Peng Gao, Xiaohan Dong, Jian Chen, Shujie Zhao, Pingsheng Liu, Guoyong Yin
Summary: This study designed a multilayer polyelectrolyte coating that can promote the integration of metallic implants with bone and possess antibacterial properties. Stable coatings were constructed on titanium alloy substrates using a layer-by-layer technology, allowing for the sustained release of bone morphogenetic protein 2 and promotion of cell differentiation. Additionally, the polycationic component in the coating significantly improved the antibacterial properties of the titanium alloy surface.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ji-In Ryu, Byoung-Eun Yang, Sang-Min Yi, Hyo-Geun Choi, Sung-Woon On, Seok-Jin Hong, Ho-Kyung Lim, Soo-Hwan Byun
Summary: The study demonstrated that 3D-printed custom HA/TCP graft with rhBMP-2 showed bone regeneration effects similar to that of particulate Bio-Oss with rhBMP-2, suggesting its potential application in various fields of bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ronald E. Jung, Marionna N. Kovacs, Daniel S. Thoma, Christoph H. F. Hammerle
Summary: The long-term outcomes of implants placed in conjunction with guided bone regeneration (GBR) with or without recombinant human bone morphogenetic protein-2 (rhBMP-2) were assessed. The study showed that after at least 17 years, the implant survival rate was 100% and the clinical and radiographic results were excellent.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ho-Kyung Lim, Yeh-Jin Kwon, Seok-Jin Hong, Hyo-Geun Choi, Sung-Min Chung, Byoung-Eun Yang, Jong-Ho Lee, Soo-Hwan Byun
Summary: The study evaluated the effects of different concentrations of PDRN and rhBMP-2 on bone regeneration and mechanical properties of HA/TCP scaffolds. Results showed that rhBMP-2 significantly increased bone formation, while PDRN showed no significant effect; when used at optimal concentrations, HA/TCP scaffolds demonstrated sufficient bone regeneration capacity and mechanical strength.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Dominik Spahr, Jannes Koenig, Lkhamsuren Bayarjargal, Victor Milman, Alexander Perlov, Hanns-Peter Liermann, Bjoern Winkler
Summary: Researchers have synthesized a novel inorganic pyrocarbonate salt, Sr[C2O5], which contains isolated [C2O5](2-) groups. This discovery significantly expands the crystal chemistry of inorganic carbonates. Through experimental and theoretical calculations, it is shown that Sr[C2O5] is a pyrocarbonate salt and it is predicted that more inorganic pyrocarbonates can be obtained. These findings are relevant to geoscience and provide insights into the conversion of CO2 into useful inorganic compounds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ryu Jaeyoung, Hyo-Sun Kang, Byung-Hun Kang, Seunggon Jung, Min-Suk Kook, Oh Hee-Kyun, Ji-Yeon Jung, Hong-Ju Park
Summary: This study compared the biocompatibility of 3D-printed titanium implants with conventional machined titanium products, with results showing better cell response in the 3D-printed specimens and enhanced new bone formation with the application of rhBMP-2.
JOURNAL OF APPLIED ORAL SCIENCE
(2021)
Article
Chemistry, Physical
Yulong Ling, Kun Li, Mi Wang, Junfeng Lu, Chenlu Wang, Yanlei Wang, Hongyan He
Summary: The deep learning force field (DPFF) can accurately describe the force and energy of ionic liquids, and reasonably predict the coupling nature between coulombic and hydrogen bonding interactions.
JOURNAL OF POWER SOURCES
(2023)
Article
Biochemistry & Molecular Biology
Chenmin Luo, Shengyang Liu, Wei Luo, Jing Wang, Hongyan He, Can Chen, Lan Xiao, Changsheng Liu, Yulin Li
Summary: In this study, well-defined poly(L-lactide-b-caprolactone) block copolymers (bPLCL) were synthesized through a pre-polymerization method with precise control over their composition and structure. These materials exhibit better mechanical properties and biodegradability control compared to randomly copolymerized poly(L-lactide-co-caprolactone) (rPLCL). Introduction of 10 mol% caprolactone results in an elastic polymer with elongation at break of 286.15% +/- 55.23%. The unique crystalline structure of the soft and hard segments in bPLCL contributes to its more sustainable biodegradability. The pre-polymerization technique shows promise for scalable production of PLCL materials for biomedical applications.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Junjie Pan, Chi-ling Chiang, Xinyu Wang, Paul Bertani, Yifan Ma, Junao Cheng, Vishank Talesara, Ly James Lee, Wu Lu
Summary: Nanochannel electroporation (NEP) is a new technology for cell transfection that offers improved gene delivery and cell viability compared to conventional bulk electroporation (BEP). NEP uses an asymmetric electric field to induce asymmetric membrane poration of cells laid on a porous substrate. This study systematically investigates the transfection window of NEP for different sized molecules and shows that small molecules can be delivered with minimal impact on the non-transfection membrane, while larger molecules require higher voltages but can result in lower cell viability. Numerical analysis of transmembrane potential allows for prediction of membrane damage and cargo delivery in NEP, providing a comprehensive understanding of the process.
Article
Chemistry, Multidisciplinary
Ziyang Wu, Ting Liao, Sen Wang, Wei Li, Binodhya Wijerathne, Wanping Hu, Anthony P. O'Mullane, Yuantong Gu, Ziqi Sun
Summary: In this study, Fe-doped MFe-LDHs (M = Co, Ni, Cu, Mn) were synthesized to investigate the influence of Fe on their electrocatalytic activity for the oxygen evolution reaction (OER). It was found that the Fe content had a significant impact on the catalytic performance, with an optimal Fe content resulting in the highest OER activity. Excess Fe, however, compromised the activity. Additionally, a volcano relationship was observed between the intermediate adsorption and Fe content, and intermediate adsorption capacitance was identified as a new activity descriptor for electrocatalysts.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Weizhen Meng, Xiaoming Zhang, Ying Liu, Xuefang Dai, Guodong Liu, Yuantong Gu, E. P. Kenny, Liangzhi Kou
Summary: Topological materials with surface metallic states and high carrier mobility have been considered as ideal catalysts for heterogeneous reactions. The relationship between their catalytic performance and topological states is still under debate. Through studies on the hydrogen evolution process under different doping and strain conditions, it has been demonstrated that the excellent catalytic performance indeed originates from the topological properties. A linear relationship between the length of Fermi arcs and Gibbs free energy (Delta G(H*)) has been found, providing direct evidence linking enhanced catalytic performance and surface Fermi arc states, and clarifying the fundamental mechanism in topological catalysis.
Article
Agricultural Engineering
Chanaka P. Batuwatta-Gamage, Charith Rathnayaka, Helambage C. P. Karunasena, Hyogu Jeong, Azharul Karim, Yuan Tong Gu
Summary: This study investigates the feasibility of using Physics-Informed Neural Networks with Automatic Differentiation to predict mass transfer and moisture variations during food drying. The proposed approach, called PINN-MT, incorporates convective mass transfer equation and Fick's law of diffusion into the loss function. Adaptive Activation and Transfer Learning are used to improve computational efficiency and prediction accuracy.
BIOSYSTEMS ENGINEERING
(2023)
Article
Engineering, Civil
Hyogu Jeong, Jinshuai Bai, C. P. Batuwatta-Gamage, Charith Rathnayaka, Ying Zhou, YuanTong Gu
Summary: This paper proposes a novel topology optimization framework called PINNTO, which uses a energy-based PINN to determine deformation states in structural topology optimization. It trains a supervised neural network to respect governing physical laws defined via partial differential equations. The results show that PINNTO can achieve optimized topologies without labeled data or FEA, and can generate comparable designs to SIMP. The framework demonstrates promising capabilities to solve problems when the usage of FEA is challenging or impossible.
ENGINEERING STRUCTURES
(2023)
Article
Chemistry, Multidisciplinary
Kun Li, Yanlei Wang, Junfeng Lu, Weilu Ding, Feng Huo, Hongyan He, Suojiang Zhang
Summary: Electrocatalytic conversion of dinitrogen and carbon dioxide directly to urea by C-N coupling is a promising eco-friendly alternative to the current ammonia-based synthetic route. This study investigates the catalytic performance of bimetallic catalysts anchored on N-doped graphene. A TiCo@NC catalyst is found to exhibit an ultra-low onset potential of 0.23 V, efficiently catalyzing the reaction. The results provide insights into C-N coupling in urea electrosynthesis and inspire rational catalyst design.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Genetics & Heredity
Xingfei Fu, Guiping Li, Faguang Hu, Jiaxiong Huang, Yuqiang Lou, Yaqi Li, Yanan Li, Hongyan He, YuLan Lv, Jinhuan Cheng
Summary: This study performed a transcriptome analysis to investigate the genetic differences between peaberry and regular coffee beans, and identified 139 differentially expressed genes. These genes were mainly associated with functional annotation related to cell wall modification, lipid binding, protein binding, oxidoreductase activity, and transmembrane transportation. The findings provide molecular insights into the formation of peaberry.
Article
Engineering, Chemical
Mi Wang, Yanlei Wang, Tao Zhang, Yu Xia, Hongyan He
Summary: In this study, the regulating mechanism of structural, thermodynamical, and diffusive properties of 18 imidazole ionic liquids (ILs) with different anions was investigated using molecular dynamics simulations and theoretical analysis. It was found that the radial distribution function and coordinate number of these ILs were similar, while the vibrational spectrum and diffusive property varied greatly with the anion structure, resulting in a significant change in the self-diffusive coefficient (SDC). Moreover, the SDC was found to have an exponential relationship with free energy and entropy, suggesting that these can be key indicators in designing high-performance ILs for practical chemical engineering applications.
Article
Engineering, Multidisciplinary
Jinshuai Bai, Gui-Rong Liu, Ashish Gupta, Laith Alzubaidi, Xi-Qiao Feng, YuanTong Gu
Summary: Our study reveals that physics-informed neural networks (PINN) are often local approximators after training. This led to the development of a novel physics-informed radial basis network (PIRBN), which maintains the local approximating property throughout the training process. Unlike deep neural networks, PIRBN consists of only one hidden layer and a radial basis activation function. Under appropriate conditions, we demonstrated that PIRBNs can converge to Gaussian processes using gradient descent methods. Furthermore, we investigated the training dynamics of PIRBN using the neural tangent kernel (NTK) theory and explored various initialization strategies. Numerical examples showed that PIRBN is more effective than PINN in solving nonlinear partial differential equations with high-frequency features and ill-posed computational domains. Moreover, existing PINN numerical techniques such as adaptive learning, decomposition, and different loss functions can be applied to PIRBN. The reproducible code for all numerical results is available at https://github.com/JinshuaiBai/PIRBN.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
N. Mai-Duy, Y. T. Gu
Summary: This paper presents a new high-order embedded-/immersed-boundary method based on point collocation and integrated radial basis functions (IRBFs) for solving an elliptic partial differential equation (PDE) in a domain with holes. The proposed scheme achieves high sparseness of the system matrix and high accuracy of the solution by incorporating nodal values of high-order derivatives and constructing a globally smooth solution. Numerical verification shows highly accurate results even with relatively coarse grids.
ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS
(2023)
Article
Chemistry, Multidisciplinary
Yifan Ma, Lili Sun, Jingjing Zhang, Chi-ling Chiang, Junjie Pan, Xinyu Wang, Kwang Joo Kwak, Hong Li, Renliang Zhao, Xilal Y. Rima, Chi Zhang, Anan Zhang, Yutong Liu, Zirui He, Derek Hansford, Eduardo Reategui, Changsheng Liu, Andrew S. Lee, Yuan Yuan, Ly James Lee
Summary: This study introduces a method of using therapeutic small extracellular vesicles (t-sEVs) for bone regeneration in rats with challenging femur critical-size defects. Abundant t-sEVs carrying therapeutic mRNAs are produced through a simple cellular nanoelectroporation system, which enhance angiogenesis and osteogenesis. Controlled release of t-sEVs within a customized hydrogel cage leads to highly efficient bone regeneration.
Article
Cell Biology
Jingjing Zhang, Xilal Y. Rima, Xinyu Wang, Luong T. H. Nguyen, Kristin Huntoon, Yifan Ma, Paola Loreto Palacio, Kim Truc Nguyen, Karunya Albert, Minh-Dao Duong-Thi, Nicole Walters, Kwang Joo Kwak, Min Jin Yoon, Hong Li, Jacob Doon-Ralls, Colin L. Hisey, Daeyong Lee, Yifan Wang, Jonghoon Ha, Kelsey Scherler, Shannon Fallen, Inyoul Lee, Andre F. Palmer, Wen Jiang, Setty M. Magana, Kai Wang, Betty Y. S. Kim, L. James Lee, Eduardo Reategui
Summary: This study presents a method for simultaneous detection of RNA and proteins in extracellular vesicles and lipoproteins. The method immobilizes particles onto micropatterns and focuses signals in situ, achieving high sensitivity for RNA and protein detection in EVs.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Engineering, Biomedical
Min Zhou, Ruxin Cui, Zhengjie Luo, Zihao Cong, Ning Shao, Ling Yuan, Jiawei Gu, Hongyan He, Runhui Liu
Summary: Polyethylene glycol (PEG)-doxorubicin (DOX) conjugation is an important strategy to improve toxicity and enhance clinically therapeutic efficacy. However, the accumulation of anti-PEG antibodies has become a tough issue, which limits the application of PEG-drug conjugation. As an alternative solution, poly(2-oxazoline) (POX)-DOX conjugation has shown great potential in the anti-tumor field, but the reported conjugation process of POX with DOX has drawbacks such as complex synthetic steps and purification.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
