期刊
PEDIATRIC BLOOD & CANCER
卷 66, 期 5, 页码 -出版社
WILEY
DOI: 10.1002/pbc.27595
关键词
circulating tumor DNA; pediatric cancer; next-generation sequencing; digital PCR; liquid biopsy
资金
- Nuovo-Soldati Fundation
- NCI [K08CA188073-03]
Circulating tumor DNA can be detected in the blood and body fluids of patients using ultrasensitive technologies, which have the potential to improve cancer diagnosis, risk stratification, noninvasive tumor profiling, and tracking of treatment response and disease recurrence. As we begin to apply liquid biopsy strategies in children with cancer, it is important to tailor our efforts to the unique genomic features of these tumors and address the technical and logistical challenges of integrating biomarker testing. This article reviews the literature demonstrating the feasibility of applying liquid biopsy to pediatric solid malignancies and suggests new directions for future studies.
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