Article
Oncology
J. Tang, H. Pan, W. Wang, C. Qi, C. Gu, A. Shang, J. Zhu
Summary: The study revealed that miR-143-3p and miR-495-3p target CDK1 to inhibit the occurrence and development of cervical cancer. Overexpression of miR-143-3p or miR-495-3p can down-regulate CDK1 expression in cervical cancer tissues and cells, inhibit cell proliferation, and promote apoptosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Jie Ling Zhang, Hui Fen Zheng, Kai Li, Yi Ping Zhu
Summary: This study investigates the role of miR-495-3p and HMGB1 in colorectal cancer (CRC). The findings suggest that miR-495-3p inhibits the progression of CRC by downregulating HMGB1 expression, indicating its potential as a therapeutic target for CRC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Reproductive Biology
Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wang
Summary: Embryonic mortality is a major factor contributing to reduced conception rates in the cattle industry. Insufficient endometrial receptivity is a key factor causing embryo implantation failure and losses. The study found that bta-miR-200b can influence the apoptosis of bovine endometrial epithelial cells by targeting the MYB gene.
Article
Biochemistry & Molecular Biology
Xiaomei Sun, Lingtong Hou, Chunping Qiu, Beihua Kong
Summary: miR-501 is significantly up-regulated in endometrial cancer, associated with higher pelvic lymph node metastasis and shorter overall survival in high-grade endometrial cancer. Its high expression is also found in the copy-number-high group. Furthermore, miR-501 promotes tumor progression by directly targeting HOXD10 and activating the AKT/mTOR pathway.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Cell Biology
Heqin Zhan, Feng Huang, Qian Niu, Mingli Jiao, Xumeng Han, Kaina Zhang, WenZhuo Ma, Shan Mi, Shiyu Guo, Zhenghang Zhao
Summary: Research showed that miR-128 plays a crucial role in chronic cardiac remodeling induced by Ang II, and downregulation of miR-128 can alleviate cardiac dysfunction, hypertrophy, fibrosis, apoptosis, and oxidative stress, likely through targeting PIK3R1/Akt/mTORC1 and/or SIRT1/p53 pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Agriculture, Dairy & Animal Science
Chengchuang Song, Qi Wang, Qi Qi, Xi Chen, Yanhong Wang, Chunlei Zhang, Fang Xintang
Summary: The study revealed that miR-495-3p inhibits proliferation and promotes differentiation in muscle cells by targeting CDH2. This finding sheds light on the crucial regulatory role of miR-495-3p in skeletal muscle development.
ANIMAL BIOTECHNOLOGY
(2022)
Review
Oncology
Xing Zhang, Jia-Jing Lu, Ayitila Abudukeyoumu, Ding-Yu Hou, Jing Dong, Jiang-Nan Wu, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: Glucose plays a crucial role in the metabolism of endometrial cancer cells (ECCs). Overexpressed glucose transporters (GLUTs) in ECCs not only provide abundant glucose uptake, but also participate in the activation of important signaling pathways involved in proliferation, angiogenesis, and metastasis. In addition, the overexpression of GLUTs may lead to hormone therapy resistance and resistance to radiotherapy and chemoradiotherapy in ECCs. GLUT inhibitors hold promise as sensitizers in precision-targeted therapies for endometrial cancer (EC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yani Yan, Cong Liu, Jian Zhang, Weiwei Li, Xiurong Yin, Lixia Dong, Shulan Pang, Xuefeng Li
Summary: SMC4 expression is increased in endometrial cancer and predicts poor overall survival. Silencing of SMC4 inhibits cell proliferation and promotes apoptosis, potentially through regulation of FoxO1 activity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Endocrinology & Metabolism
Chunmei Zhu, Yelin Song, Qiong Fang, Zuowei Li
Summary: This study found that inhibiting the expression of the NPAS2-ZHX3 axis can suppress cell proliferation and induce apoptosis in endometrial cancer cells, thereby attenuating tumor development.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Reproductive Biology
Haixia Wu, Youliang Yan, Jialin Yuan, Mengze Luo, Yingjian Wang
Summary: Our study found that miR-4324 inhibited FEN1 expression, suppressed cell growth, and increased apoptosis in ovarian cancer cells. Therefore, we identified miR-4324 and FEN1 as potential therapeutic targets for ovarian cancer treatment.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Cell Biology
Fan Zhang, Guoxian Wang, Wenjuan Yan, Hongmei Jiang
Summary: This study found that miR-4268 is downregulated and KRT80 is upregulated in gastric cancer tissues and cells. Interfering with KRT80 expression inhibits proliferation and migration of gastric cancer cells and promotes apoptosis. MiR-4268 targets KRT80 and negatively regulates its expression, and it may suppress gastric cancer through inhibiting the PI3K/AKT/JNK pathway by targeting KRT80.
Article
Oncology
Zhongrui Wang, Xiqian Zhou, Xiaochong Deng, Danrong Ye, Diya Liu, Baian Zhou, Wenfang Zheng, Xuehui Wang, Yuying Wang, Oyungerel Borkhuu, Lin Fang
Summary: Breast cancer is the most common cancer type in women worldwide. This study demonstrates that miR-186-5p inhibits proliferation and induces apoptosis in breast cancer cells by targeting ANXA9. These findings provide a potential therapeutic target for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Yajie Zhao, Chao Li, Yan Zhang, Zhanzhan Li
Summary: CircTMTC1 is highly expressed and miR-495 is downregulated in nasopharyngeal carcinoma (NPC), which are associated with poor prognosis. CircTMTC1 promotes NPC progression through targeting miR-495 and activating the MET-eIF4G1 translational regulation axis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Xiaodan Li, Xiaolei Yao, Kang Li, Jiahe Guo, Kaiping Deng, Zhipeng Liu, Fan Yang, Yixuan Fan, Yingnan Yang, Huabin Zhu, Feng Wang
Summary: The successful establishment of endometrial receptivity is crucial for the fertility and economic benefits of ewes. In this study, high-fertility Hu sheep were found to have higher uterine gland density, uterine coefficient, and number of uterine caruncles compared to low-fertility Hu sheep during the luteal phase. RNA sequencing (RNA-Seq) analysis identified thousands of differentially expressed genes in the endometrium of Hu sheep with different fertility potential. One of these genes, CREB1, was found to be differentially expressed in the Hu sheep endometrium during the estrous cycle. Functional analysis revealed that CREB1 significantly influenced the expression level of endometrial receptivity marker genes, promoted cell proliferation, and inhibited cell apoptosis and autophagy. Additionally, there was a negative linear correlation between miR-134-5p and CREB1 in the endometrium, and overexpression of CREB1 counteracted the negative effect of miR-134-5p on endometrial stromal cell growth.
Article
Multidisciplinary Sciences
Ramesh Chaudhari, Simran Nasra, Nikita Meghani, Ashutosh Kumar
Summary: MicroRNAs play important roles in various diseases, including cancer. They can act as tumor suppressors or oncogenes, and their expression levels vary depending on cancer subtypes and mutations. Modified metallic nanoparticles can be used for effective miRNA delivery.
SCIENTIFIC REPORTS
(2022)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)