Article
Biochemistry & Molecular Biology
Petri Kresanov, Juha Mykkanen, Markku Ahotupa, Mika Ala-Korpela, Markus Juonala, Jari Kaikkonen, Mika Kahonen, Terho Lehtimaki, Tommi Vasankari, Jorma Viikari, Olli T. Raitakari
Summary: The study found that oxidized HDL lipids were not significantly associated with lipoprotein subclass lipid concentrations and composition after adjusting for certain factors, while oxidized LDL lipids were associated with multiple markers of lipoprotein subclass lipid concentrations and composition. Additionally, HDL and LDL subclass measures, such as phospholipid and triglyceride composition, were directly associated with oxidized LDL lipids, while cholesterol ester and free cholesterol composition in HDL and LDL were inversely associated. These results suggest that LDL oxidation may play a role in atherogenesis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Emilie Westerlin Kjeldsen, Jesper Qvist Thomassen, Ruth Frikke-Schmidt
Summary: Over the past seven decades, studies have observed an inverse association between HDL cholesterol concentrations and atherosclerotic cardiovascular disease (ASCVD) risk. However, recent evidence from human genetics and randomized clinical trials suggest that targeting HDL cholesterol concentrations may not be a viable approach for preventing ASCVD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Cardiac & Cardiovascular Systems
Luca Liberale, Fabrizio Montecucco, Lena Schwarz, Thomas F. Luscher, Giovanni G. Camici
Summary: Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) and Colchicine Cardiovascular Outcomes Trial (COLCOT) were the first two randomized clinical trials to demonstrate the effectiveness of specific anti-inflammatory treatments in cardiovascular prevention, confirming the involvement of specific inflammatory pathways in atherosclerotic cardiovascular disease. Other trials targeting multiple inflammasome-independent pathways failed to show benefit, highlighting the significance of balancing the risk of impaired host defense and infections with the prevention of major adverse cardiovascular events in patients with residual inflammatory risk.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Heinz Drexel, Basil S. Lewis, Giuseppe M. C. Rosano, Christoph H. Saely, Gerda Tautermann, Kurt Huber, Joern F. Dopheide, Juan Carlos Kaski, Arthur Mader, Alexander Niessner, Gianluigi Savarese, Thomas A. Schmidt, AnneGrete Semb, Juan Tamargo, Sven Wassmann, Keld Per Kjeldsen, Stefan Agewall, Stuart J. Pocock
Summary: This review article discusses the important issues that data safety monitoring boards face when considering early termination of a trial, focusing on efficacy, futility, and harm reasons for stopping trials. It also covers statistical essentials and regulatory aspects, with examples from lipid and antithrombotic trials, to provide insights into the decision-making process for stopping a randomized clinical trial.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Surojit Banerjee, Abhijit De
Summary: This article discusses the role of CETP inhibitors in reducing 'bad' cholesterol and preventing cardiovascular disease, including the current status of trials with different drugs, their adverse effects and limitations, as well as the pathophysiology of CETP.
DRUG DISCOVERY TODAY
(2021)
Article
Multidisciplinary Sciences
Akira Umeda, Kazuya Miyagawa, Atsumi Mochida, Hiroshi Takeda, Yoshiyuki Ohira, Toru Kato, Yasumasa Okada, Kazuhiko Kotani
Summary: This study investigated the effects of smoking cessation with varenicline on the levels of oxidized high-density lipoprotein (oxHDL) in the serum. The study found that smoking cessation decreased oxHDL levels and increased high-density lipoprotein cholesterol (HDL-C) levels.
Article
Rheumatology
Anne Grete Semb, Silvia Rollefstad, Eirik Ikdahl, Grunde Wibetoe, Joseph Sexton, Cindy Crowson, Piet van Riel, George Kitas, Ian Graham, Solbritt Rantapaa-Dahlqvist, George Athanasios Karpouzas, Elena Myasoedova, Miguel A. Gonzalez-Gay, Petros P. Sfikakis, Maria G. Tektonidou, Argyro Lazarini, Dimitrios Vassilopoulos, Bindee Kuriya, Carol Hitchon, Maria Simona Stoenoiu, Patrick Durez, Virginia Pascual-Ramos, Dionicio Angel Galarza-Delgado, Pompilio Faggiano, Durga Prasanna Misra, Andrew A. Borg, Rong Mu, Erkin M. Mirrakhimov, Diane Gheta, Karen Douglas, Vikas Agarwal, Svetlana Myasoedova, Lev Krougly, Tatiana Valentinovna Popkova, Alena Tuchynova, Michal Tomcik, Michal Vrablik, Jiri Lastuvka, Pavel Horak, Helena Kaspar Medkova, Anne M. Kerola
Summary: The prevalence of ASCVD was higher in RA-DM compared to RAwoDM, and lipid goals were more frequently obtained in RA-DM. Lessons from CVD prevention programs in diabetes mellitus could benefit patients with rheumatoid arthritis.
Article
Cardiac & Cardiovascular Systems
Mie Balling, Shoaib Afzal, George Davey Smith, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Borge G. Nordestgaard
Summary: Elevated LDL triglycerides are associated with an increased risk of ASCVD and its individual components, as shown in two prospective cohort studies and meta-analyses.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An, Yongting Luo
Summary: The supplementation of casein hydrolysate can effectively reduce blood pressure without affecting blood lipids or glycemic status.
Article
Rheumatology
George C. Drosos, George Konstantonis, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study examined the eligibility for lipid-lowering therapy (LLT) in SLE patients according to SCORE, with the addition of vascular ultrasound and disease-related features. The results showed that disease-related and ultrasound features can help improve LLT decision making in SLE.
Article
Nutrition & Dietetics
Yueyue Wang, Jose Lara Gallegos, Crystal Haskell-Ramsay, John K. Lodge
Summary: This study compared the effects of fresh blueberries, freeze-dried blueberry powder, and a control group on cardiovascular health. The results showed that supplementation with blueberries and blueberry powder had a positive impact on plasma nitrite levels, but did not significantly affect other indicators such as blood pressure, cholesterol, and glucose.
Article
Medicine, General & Internal
Reed Mszar, Gayley B. Webb, Vivek T. Kulkarni, Zahid Ahmad, Daniel Soffer
Summary: Genetic lipid disorders, including common dyslipidemias such as familial hypercholesterolemia and familial combined hyperlipidemia, affect millions of individuals and often go undiagnosed in the general population. Clinicians should consider the potential of inherited lipid disorders or syndromes when severe derangements in lipid parameters are observed.
MEDICAL CLINICS OF NORTH AMERICA
(2022)
Review
Cardiac & Cardiovascular Systems
Lucia Scisciola, Vittoria Cataldo, Fatemeh Taktaz, Rosaria Anna Fontanella, Ada Pesapane, Puja Ghosh, Martina Franzese, Armando Puocci, Antonella De Angelis, Liberata Sportiello, Raffaele Marfella, Michelangela Barbieri
Summary: Atherosclerosis is an inflammatory disease that leads to cardiovascular mortality and morbidity. Type 2 diabetes mellitus is a known risk factor for atherosclerosis. Sodium-glucose co-transporter 2 inhibitors have been found to have anti-inflammatory effects and can potentially slow down the progression of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Hematology
Christian M. Madsen, Anette Varbo, Borge G. Nordestgaard
Summary: Recent studies have suggested that extremely high levels of HDL cholesterol are associated with increased mortality, indicating that HDL may have harmful effects in some instances. Furthermore, observational and genetic studies have shown that HDL might be linked to the development of major noncardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
H. W. Grievink, V. Smit, B. W. Huisman, P. Gal, Y. Yavuz, C. Klerks, C. J. Binder, I. Bot, J. Kuiper, A. C. Foks, M. Moerland
Summary: This study investigated the effects of key risk factors for atherosclerosis development, aging and smoking, on the immune system. The results showed that aging and heavy smoking are associated with an inflammatory immunophenotype, and heavy smokers or elderly individuals may be potential populations for future clinical trials investigating immunomodulatory drugs for cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Daisuke Shishikura, Yu Kataoka, Satoshi Honda, Kohei Takata, Susan W. Kim, Jordan Andrews, Peter J. Psaltis, Michael Sweeney, Ewelina Kulikowski, Jan Johansson, Norman C. W. Wong, Stephen J. Nicholls
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2019)
Review
Cardiac & Cardiovascular Systems
Kohei Takata, Stephen J. Nicholls
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2019)
Article
Cardiac & Cardiovascular Systems
Stephen J. Nicholls, Adam J. Nelson
AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
(2019)
Article
Medicine, General & Internal
Brian A. Ference, Kausik K. Ray, Alberico L. Catapano, Thatcher B. Ference, Stephen Burgess, David R. Neff, Clare Oliver-Williams, Angela M. Wood, Adam S. Butterworth, Emanuele Di Angelantonio, John Danesh, John J. P. Kastelein, Stephen J. Nicholls
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Multidisciplinary Sciences
Achini K. Vidanapathirana, Benjamin J. Pullen, Run Zhang, MyNgan Duong, Jarrad M. Goyne, Xiaozhou Zhang, Claudine S. Bonder, Andrew D. Abell, Christina A. Bursill, Stephen J. Nicholls, Peter J. Psaltis
SCIENTIFIC REPORTS
(2019)
Review
Cardiac & Cardiovascular Systems
Stephen J. Nicholls
CURRENT CARDIOLOGY REPORTS
(2019)
Editorial Material
Respiratory System
Stephen J. Nicholls, Adam J. Nelson
JOURNAL OF THORACIC DISEASE
(2019)
Article
Cardiac & Cardiovascular Systems
Preethi Mani, Rishi Puri, Gregory G. Schwartz, Steven E. Nissen, Mingyuan Shao, John J. P. Kastelein, Venu Menon, A. Michael Lincoff, Stephen J. Nicholls
Article
Cardiac & Cardiovascular Systems
Andrew Lin, Nitesh Nerlekar, Ashray Rajagopalan, Jeremy Yuvaraj, Rohan Modi, Sam Mirzaee, Ravi Kiran Munnur, Michelle Seckington, James C. G. Doery, Sujith Seneviratne, Stephen J. Nicholls, Dennis T. L. Wong
Article
Endocrinology & Metabolism
Anirudh Kumar, Divyang R. Patel, Kathy E. Wolski, A. Michael Lincoff, Sangeeta R. Kashyap, Giacomo Ruotolo, Ellen McErlean, Govinda Weerakkody, Jeffrey S. Riesmeyer, Stephen J. Nicholls, Steven E. Nissen, Venu Menon
DIABETES & VASCULAR DISEASE RESEARCH
(2019)
Article
Cardiac & Cardiovascular Systems
Carolyn M. Astley, Derek P. Chew, Wendy Keech, Stephen Nicholls, John Beltrame, Matthew Horsfall, Rosanna Tavella, Rosy Tirimacco, Robyn A. Clark
HEART LUNG AND CIRCULATION
(2020)
Review
Cardiac & Cardiovascular Systems
Daniel J. Scherer, Adam J. Nelson, Richard O'Brien, Karam M. Kostner, David L. Hare, David M. Colquhoun, Philip J. Barter, Philip Aylward, Stephen J. Nicholls, Gerald F. Watts
HEART LUNG AND CIRCULATION
(2019)
Article
Multidisciplinary Sciences
Deborah Toledo-Flores, Anna Williamson, Nisha Schwarz, Sanuja Fernando, Catherine Dimasi, Tyra A. Witt, Thao M. Nguyen, Amrutesh S. Puranik, Colin D. Chue, Sinny Delacroix, Daniel B. Spoon, Claudine S. Bonder, Christina A. Bursill, Belinda A. Di Bartolo, Stephen J. Nicholls, Robert D. Simari, Peter J. Psaltis
SCIENTIFIC REPORTS
(2019)
Review
Cardiac & Cardiovascular Systems
Kyle B. Franke, Dennis T. L. Wong, Angus Baumann, Stephen J. Nicholls, Rajiv Gulati, Peter J. Psaltis
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2019)
