Article
Chemistry, Medicinal
Tao Yang, Haiqiong Liu, Chaobo Yang, Huaqiang Mo, Xianbao Wang, Xudong Song, Luping Jiang, Ping Deng, Ran Chen, Pengcui Wu, Aihua Chen, Jing Yan
Summary: This study aimed to investigate the pharmacological effects of Gal on myocardial ischemic reperfusion injury (MIRI). The results showed that Gal alleviates myocardial injury, enhances cardiac function, and reduces cell death by targeting the Nrf2/Gpx4 signaling pathway to prevent iron overload and lipid peroxidation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Mengqin Wang, Ji Zhang, Jiasi Zhang, Kailun Sun, Qingwen Li, Baicheng Kuang, M. M. Zhiheng Wang, Shuaiheng Hou, Nianqiao Gong
Summary: The study demonstrates that methyl eugenol can alleviate liver ischemia reperfusion injury (LIRI) induced damage, inflammation, and apoptosis, while also reducing liver cell injury caused by hypoxia-reoxygenation. This protective effect may be related to the activation of the PI3K/Akt signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yi-Shuai Zhang, Li-Qun Lu, Ya-Qian Jiang, Nian-Sheng Li, Xiu-Ju Luo, Jin-Wu Peng, Jun Peng
Summary: Allopurinol alleviated myocardial I/R oxidative injury by inhibiting the XO/VPO1 pathway, leading to decreased XO and VPO1-derived products in both rat heart and cardiac cell models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shujun Xu, Bingxin Wu, Biying Zhong, Luoqi Lin, Yining Ding, Xiao Jin, Zhiwei Huang, Miaoyang Lin, Huanlin Wu, Danping Xu
Summary: Naringenin (NAR) has shown significant benefits in improving myocardial ischemia-reperfusion injury (MIRI) by regulating the Nrf2/System xc-/GPX4 axis to inhibit ferroptosis, demonstrating its potential as a therapeutic agent for heart injury.
Article
Chemistry, Medicinal
Jiangbo Xie, Tingting Zhang, Peichun Li, Dong Wang, Tao Liu, Shunliang Xu
Summary: This study found that dihydromyricetin can alleviate cerebral ischemia reperfusion injury by inhibiting the SPHK1/mTOR signaling pathway and suppressing ferroptosis. These findings suggest that dihydromyricetin may be a potential drug for the treatment of cerebral ischemia reperfusion injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Cell Biology
Ke Peng, Hong Liu, Bin Yan, Xiao-Wen Meng, Shao-Yong Song, Fu-Hai Ji, Zhengyuan Xia
Summary: This study identified and validated key candidate genes related to inflammation and apoptosis pathways underlying myocardial I/R injury. Inhibition of Cathepsin S was shown to alleviate myocardial I/R-induced injury by suppressing inflammation and apoptosis, potentially offering clinical applications in cardioprotection.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
Yu-fan Yang, Hui Wang, Nan Song, Ya-hui Jiang, Jun Zhang, Xiao-wen Meng, Xiao-mei Feng, Hong Liu, Ke Peng, Fu-hai Ji
Summary: Dexmedetomidine pretreatment protects the heart against I/R injury by inhibiting inflammation and apoptosis through downregulation of the ERS signaling pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Lu Tang, Yun-peng Li, Juan Hu, Ai-hua Chen, Yingli Mo
Summary: Dexpramipexole (DPX) protects against myocardial injury induced by ischemia/reperfusion (I/R) by enhancing mitophagy through increased expression of PINK1 and Parkin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xinyi Deng, Peng Yang, Tong Gao, Mengru Liu, Xianlun Li
Summary: This study demonstrated the protective effect of Allicin against myocardial ischemia-reperfusion (IR) injury in vitro. Allicin treatment enhanced cell viability, reduced apoptosis, regulated apoptosis-related proteins, decreased inflammation, mitigated oxidative stress, and attenuated mitochondrial injury. These findings suggest the potential therapeutic use of Allicin in treating myocardial IR injury.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Shuqi Meng, Xiaotong Sun, Zhaodong Juan, Mingling Wang, Ruoguo Wang, Lina Sun, Yaozu Li, Anran Xin, Shuping Li, Yao Li
Summary: This study demonstrates that clemastine fumarate attenuates myocardial ischemia reperfusion injury by inhibiting mast cell degranulation. Pretreatment with CLE significantly improves cardiac function and reduces cytotoxicity, reversing the damage caused by I/R.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Ke Yang, Yinhong Ma, Chunmei Xie, Haoxing Zhao, Zheng Dai, Xiaoqi Wang
Summary: This study aimed to investigate the combined effects of dexmedetomidine (Dex) and propofol (PPF) on myocardial ischemia/reperfusion (MI/R) injury in rats and explore the underlying mechanisms. The results showed that the combination of Dex and PPF alleviated myocardial histopathological injury, reduced myocardial infarction size, and improved cardiac function in MI/R rats. Furthermore, Dex combined with PPF decreased oxidative stress, inhibited myocardial apoptosis, and enhanced autophagy in MI/R rats. The combined use of Dex and PPF activated the AMPK pathway in MI/R rats. Inhibition of AMPK abolished the effects of Dex and PPF on myocardial injury and autophagy. Overall, the combination of Dex and PPF attenuated MI/R injury in rats through the activation of the AMPK signaling pathway.
Article
Cell Biology
Ping Pang, Zhezhe Qu, Shuting Yu, Xiaochen Pang, Xin Li, Yuelin Gao, Kuiwu Liu, Qian Liu, Xiuzhu Wang, Yu Bian, Yingqi Liu, Yingqiong Jia, Zhiyong Sun, Hanif Khan, Zhongting Mei, Xiaoqian Bi, Changhao Wang, Xinda Yin, Zhimin Du, Weijie Du
Summary: The study demonstrates that Mettl14 attenuates cardiac I/R injury by activating Wnt/beta-catenin in an m6A-dependent manner, providing a novel therapeutic target for ischemic heart disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Bo Liao, Zhongyuan Han
Summary: The present study aimed to investigate the effect of roflumilast on myocardial ischemia/reperfusion (MI/R) injury and the underlying mechanisms. Roflumilast alleviated MI/R-induced myocardial infarction and attenuated oxidative stress, inflammatory response, and mitochondrial damage in H/R-induced H9C2 cells by activating the AMPK signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Immunology
Lichen Chen, Jixiang Yuan, Hang Li, Yi Ding, Xuejia Yang, Ziwei Yuan, Zujian Hu, Yuanyuan Gao, Xilong Wang, Hong Lu, Yong Cai, Yongheng Bai, Xiaodong Pan
Summary: Trans-cinnamaldehyde (TCA) extracted from cinnamon bark has anti-inflammatory properties and can attenuate renal ischemia-reperfusion injury (IRI) through inhibiting the JNK/p38 MAPK signaling pathway, thus reducing kidney pathological changes and dysfunction.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Dianxiao Liu, Baohui Liu, Zhenxing Liang, Zhi Yang, Fangjian Ma, Yang Yang, Wei Hu
Summary: Recent studies have identified risk factors for CPB-associated AKI, but the lack of early biomarkers hinders timely intervention; the introduction of novel early AKI biomarkers and their combinational use can improve clinical outcomes; a guideline for CPB-associated AKI is urgently needed.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell Biology
Yang Yang, Wangrui Lei, Shuai Jiang, Baoping Ding, Changyu Wang, Ying Chen, Wenzhen Shi, Zhen Wu, Ye Tian
Summary: Fibrosis is an aging-related pathological process involving almost all organs, and circRNAs are identified to be involved in multifaceted processes of fibrosis in various organs, making them potential treatments for fibrosis.
AGEING RESEARCH REVIEWS
(2021)
Article
Multidisciplinary Sciences
Zhenxing Liang, Ying Chen, Zheng Wang, Xue Wu, Chao Deng, Changyu Wang, Wenwen Yang, Ye Tian, Shaofei Zhang, Chenxi Lu, Yang Yang
Summary: This study provides evidence for the beneficial effect of psoralidin (PSO) on adriamycin (ADR)-induced cardiotoxicity through the activation of the SIRT1/PPARy signaling pathway. PSO improves cardiac function and mitochondrial function, reduces myocardial fibrosis, oxidative stress, and apoptosis. These findings suggest that PSO could be a potential cardioprotective drug candidate for mitigating ADR-induced cardiotoxicity.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jie Hou, Yu Sun, Libo Zhang, Wei Wang, Hongrui You, Rongrong Zhang, Benqiang Yang, Huishan Wang
Summary: This study evaluated the left atrial function in patients with atrial fibrillation associated with valvular heart disease using cardiovascular magnetic resonance imaging feature tracking. The results showed decreased left atrial strain parameters and increased left atrial size and volume in the patient group compared to healthy controls. The study also found a significant correlation between decreased left atrial total ejection fraction and altered strain and strain rate. The findings suggest that cardiovascular magnetic resonance imaging feature tracking can be a helpful noninvasive tool for assessing left atrial function in the clinical treatment of atrial fibrillation associated with valvular heart disease.
CLINICAL CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meng Sun, Huadong Zhao, Zhenxiao Jin, Wangrui Lei, Chao Deng, Wenwen Yang, Chenxi Lu, Yuxuan Hou, Yan Zhang, Ran Tang, Lin Zhao, Shaofei Zhang, Yang Yang
Summary: Silibinin (SIL) has a protective effect on sepsis and septic myocardial injury by inhibiting inflammation, oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the NR1H3 pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Medicinal
Wangrui Lei, Songdi Wu, Aizhen Zhao, Zhen Wu, Baoping Ding, Wenwen Yang, Chenxi Lu, Xue Wu, Xiyang Li, Shaofei Zhang, Ye Tian, Yang Yang
Summary: This study found that Psoralidin (PSO) attenuated HR-induced oxidative stress, apoptosis, and mitochondrial dysfunction in neuroblastoma cells through the activation of GAS6/Axl signaling.
PHYTOTHERAPY RESEARCH
(2022)
Review
Cell Biology
Changyu Wang, Jianjun Lv, Chengxu Xue, Jiawen Li, Yanqing Liu, Danni Xu, Yuting Jiang, Shuai Jiang, Minghui Zhu, Yang Yang, Shaofei Zhang
Summary: Cytochrome c oxidase subunit VIc (COX6c) plays a crucial role in the respiratory chain and apoptosis pathways. Changes in COX6c expression are widespread in various diseases and can be used as potential biomarkers. This review provides a comprehensive overview of the functions, regulation, and roles of COX6c in multiple diseases.
CELL DEATH DISCOVERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jian Zhang, Yang Wang, Hui Jiang, Dengshun Tao, Keyan Zhao, Zongtao Yin, Jinsong Han, Fangran Xin, Yan Jin, Huishan Wang
Summary: This study investigated the efficacy of oral berberine in reducing the incidence of postoperative atrial fibrillation (POAF) after coronary artery bypass grafting. The results showed that the administration of berberine reduced the occurrence of POAF and decreased POAF burden and the dose of amiodarone.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cell Biology
Jian Zhang, Zongtao Yin, Liming Yu, Zhishang Wang, Yu Liu, Xiaoru Huang, Song Wan, Hui-yao Lan, Huishan Wang
Summary: This study investigated the role of macrophage RNA polymerase II subunit 5-mediating protein (RMP) in myocardial infarction (MI). The results showed that RMP deficiency worsened cardiac dysfunction and promoted M1 polarization while inhibiting angiogenesis after MI. In contrast, RMP overexpression in macrophages promoted M2 polarization and angiogenesis after MI. Mechanistically, RMP regulated macrophage polarization through the HSP90-p38 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biotechnology & Applied Microbiology
Daquan Wang, Changyu Wang, Zhenxing Liang, Wangrui Lei, Chao Deng, Xiaoli Liu, Shuai Jiang, Yanli Zhu, Shaofei Zhang, Wenwen Yang, Ying Chen, Yao Qiu, Lingjie Meng, Yang Yang
Summary: This study found that nanoFe has a protective effect on septic myocardial injury by attenuating inflammation and oxidative stress, improving mitochondrial function, regulating endoplasmic reticulum stress, and activating the AMPK pathway. The RNA-seq results supported the role of nanoFe treatment in regulating a transcriptional profile consistent with its role in response to sepsis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chenxi Lu, Wangrui Lei, Meng Sun, Xue Wu, Qiong Liu, Jie Liu, Yaru Yang, Wenwen Yang, Zhe Zhang, Xiaoru Li, Yazhe Zhou, Chao Deng, Ying Chen, Ye Tian, Yang Yang
Summary: By network pharmacology and experimental verification, silibinin (SIL) was found to alleviate septic myocardial injury by reducing inflammatory response and regulating cytokine signaling pathways, especially through the inhibition of CCR2 expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Yang Wang, Yuanchen He, Rui Li, Hui Jiang, Dengshun Tao, Keyan Zhao, Zongtao Yin, Jian Zhang, Huishan Wang
Summary: This study found that the composition of gut microbiota is significantly different between patients with and without post-operative atrial fibrillation (POAF), suggesting that gut microbiota may play a role in the pathogenesis of POAF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jie Hou, Yu Sun, Huishan Wang, Libo Zhang, Jinglong Shi, Hongrui You, Rongrong Zhang, Benqiang Yang
Summary: Noncontrast cardiac CT-derived MAC scores can predict the risk of intraoperative conversion and follow-up arrhythmias in MVD patients.
CLINICAL CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wencheng Di, Zhenxiao Jin, Wangrui Lei, Qiong Liu, Wenwen Yang, Shaofei Zhang, Chenxi Lu, Xiaoling Xu, Yang Yang, Huadong Zhao
Summary: This study investigates the effects and mechanisms of melatonin pretreatment, posttreatment, and combination with antibiotics in the treatment of sepsis and septic myocardial injury. Results show that melatonin pretreatment has a protective effect on sepsis and septic myocardial injury, related to attenuation of inflammation and oxidative stress, improvement of mitochondrial function, regulation of endoplasmic reticulum stress, and activation of the AMPK signaling pathway. Melatonin posttreatment also has a certain degree of protection, while the combination with antibiotics has limited effect. This study provides a theoretical basis for the application strategy and combination of melatonin in septic myocardial injury.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Cardiac & Cardiovascular Systems
Jinsong Han, Huishan Wang, Zengwei Wang, Zongtao Yin, Jian Zhang, Yan Jin, Hongguang Han
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2021)