期刊
ORGANIC LETTERS
卷 20, 期 24, 页码 7982-7986出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b03553
关键词
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资金
- Programs for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]
- National Science Fund for Distinguished Young Scholars [81725021]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- National Natural Science Foundation of China [21702067, 81573316, 31870326, 81703580]
- China Postdoctoral Science Foundation [2017M610479, 2018T110777]
Alterbrassicicene A (1), a fusicoccane-derived diterpenoid with an unprecedented framework, together with two known biosynthetic intermediates (2 and 3), were characterized from Alternaria brassicicola. The absolute structure of 1 was assigned by extensive spectroscopic analyses and quantum chemical calculations. Compound 1 represents a newly transformed monocyclic carbon skeleton of a highly functionalized diterpenoid bearing unique dihydro-2(3H)-furanone and 2-cyclopenten1-one motifs. Compound 1 was the first fusicoccane-derived diterpenoid functioning as a potent PPAR-gamma agonist (EC50 = 744.1 nM).
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