Review
Oncology
Christopher McCann, Emma M. Kerr
Summary: Tumour cell metabolism plays a crucial role in promoting cancer cell survival, evasion of cell death, and development of therapeutic resistance. Targeting therapeutically-imposed metabolic dependencies can potentially revert metabolic reprogramming and enhance treatment efficacy.
Article
Oncology
Erez Zerbib, Tasleem Arif, Anna Shteinfer-Kuzmine, Vered Chalifa-Caspi, Varda Shoshan-Barmatz
Summary: Tumors consist of proliferating cancer cells and their microenvironment, including extracellular matrix, blood vessels, and tissue cells. Understanding molecular interactions between cancer cells and the microenvironment is crucial for developing therapeutic strategies. Depleting VDAC1 in cancer cells leads to metabolic reprogramming, inhibits tumor growth, and disrupts tumor-host interactions, making it a potential therapeutic target for inhibiting cancer progression.
Review
Cardiac & Cardiovascular Systems
Xuhan Liu, Liping Zhang, Weihua Zhang
Summary: This article discusses the abnormal metabolism of pulmonary arterial hypertension (PAH) and how metabolic therapy can be used to combat remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Nunzia D'Onofrio, Elisa Martino, Anna Balestrieri, Luigi Mele, Gianluca Neglia, Maria Luisa Balestrieri, Giuseppe Campanile
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and can be prevented by modifiable risk factors such as diet. This study shows that whey from Mediterranean water buffalo milk has antiproliferative and pro-apoptotic effects on CRC cells, modulating their bioenergetic profile through SIRT3 expression. The bioactive nutrients in whey, including betaines and short-chain acylcarnitines, contribute to its anticancer, anti-inflammatory, and antioxidant properties.
Review
Oncology
Fahim Ahmad, Murali Krishna Cherukuri, Peter L. Choyke
Summary: While low-risk localized prostate cancer has a good prognosis with effective treatments, metastatic prostate cancer remains incurable and treatment resistance is a major issue. Resistance is primarily driven by tumor heterogeneity, altered genetic signatures, and metabolic reprogramming enabling tumors to adapt to drugs. Understanding prostate cancer metabolism may offer insights into therapy-induced adaptive responses and more durable therapeutic outcomes.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Merve Kulbay, Bruno Johnson, Guillaume Ricaud, Marie-Noelle Seguin-Grignon, Jacques Bernier
Summary: This study reveals that DFF40 may regulate cell metabolism and mitochondrial integrity during cell death. DFF40-deficient cells exhibit increased resistance to apoptosis and display the Warburg effect phenotype. Additionally, DFF40 can translocate to the mitochondria following apoptosis induction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Medicine, General & Internal
Juan Toro, Carlos L. Manrique-Caballero, Hernando Gomez
Summary: This article discusses the importance of tubular epithelial cell metabolic reprogramming as a defense strategy during sepsis, and how this cellular response is likely to operate through a tolerance mechanism.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Chiara Raggi, Maria Letizia Taddei, Colin Rae, Chiara Braconi, Fabio Marra
Summary: Metabolic reprogramming is a characteristic of cancer, allowing tumor cells to survive and proliferate in resource-limited conditions. Cholangiocarcinoma, the second most common form of primary liver cancer, is associated with metabolic alterations such as increased aerobic glycolysis and glutamine anaplerosis. Therapeutic interventions targeting these metabolic changes may have potential benefits for treating cholangiocarcinoma.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Jing Han, Yangfeng Zhang, Jing Xu, Tao Zhang, Hongsheng Wang, Zhuoying Wang, Yafei Jiang, Lei Zhou, Mengkai Yang, Yingqi Hua, Zhengdong Cai
Summary: This study identified a critical role of Her4 in rewiring cancer metabolism towards tumor-promoting processes, potentially through the regulation of c-Myc stability. Overexpression of Her4 was found to increase glucose uptake and promote tumor growth, shedding light on the involvement of Her4 in tumorigenesis. These findings suggest promising opportunities for targeted metabolic therapy in cancer treatment.
Article
Cell Biology
Catherine A. Bellissimo, Madison C. Garibotti, Christopher G. R. Perry
Summary: Mitochondrial stress may play a secondary role in muscle weakness in inherited muscular dystrophies, such as Duchenne muscular dystrophy. The degree and direction of mitochondrial stress responses depend on various factors, including disease progression, muscle type, mouse models used, metabolic pathways, and in vitro techniques. Future research should consider these factors to better understand the heterogeneous nature of mitochondrial stress in Duchenne muscular dystrophy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jiaxin Li, Xiaoxuan Zhai, Xiao Sun, Shengchuan Cao, Qiuhuan Yuan, Jiali Wang
Summary: This review summarizes recent findings on metabolic reprogramming occurring in different cell types during pulmonary fibrosis, especially those related to glucose, lipid, and amino acid metabolism, with the aim of identifying novel treatment targets for pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mai M. Alzaydi, Vahitha B. Abdul-Salam, Harry J. Whitwell, Giusy Russomanno, Angelos Glynos, Daria Capece, Gyorgy Szabadkai, Martin R. Wilkins, Beata Wojciak-Stothard
Summary: Mitochondrial fission and metabolic switch contribute to vascular pathology in pulmonary arterial hypertension. In this study, the researchers found that the intracellular chloride channel proteins CLIC1 and CLIC4 play a key role in mitochondrial dysfunction and energy metabolism in PAH endothelium.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Samik Chakraborty, Murugabaskar Balan, Akash Sabarwal, Toni K. Choueiri, Soumitro Pal
Summary: Tumors can reprogram pathways to withstand the altered requirements of cancer cells, with VHL gene inactivation and Ras-PI3K-AKT-mTOR pathway activation being key factors in metabolic reprogramming in renal cell carcinoma. Understanding these modifications offers opportunities for new therapeutic targets, biomarker discovery, and effective tumor detection methods.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Biochemistry & Molecular Biology
Liufeng Zhang, Yuancheng Wei, Shengtao Yuan, Li Sun
Summary: Abnormal energy metabolism is a characteristic of tumor cells, and mitochondria are important components of tumor metabolic reprogramming. Based on the concept of reprogramming mitochondrial metabolism, we discuss the current progress in mitochondrial metabolic reprogramming and summarized the corresponding treatment options. Finally, we propose mitochondrial inner membrane transporters as new and feasible therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rui Sun, Chao Lei, Liang Chen, Liqing He, Haixun Guo, Xiang Zhang, Wenke Feng, Jun Yan, Craig J. McClain, Zhongbin Deng
Summary: ROR gamma t is a master regulator of Th17 cells, but its role in lymphoma metabolism is unclear. This study found that alcohol consumption accelerates lymphomagenesis caused by ROR gamma t deficiency and promotes a shift from aerobic glycolysis to glutaminolysis. These metabolic alterations, induced by both ROR gamma t deficiency and alcohol, are mediated by c-Myc. The ethanol-mediated c-Myc activation coupled with increased glutaminolysis highlights the critical role of ROR gamma t-Myc signaling in lymphoma.
Article
Biochemistry & Molecular Biology
Anna Rolicka, Yuan Guo, Antoni Ganez Zapater, Kanwal Tariq, Jaclyn Quin, Anna Vintermist, Fatemeh Sadeghifar, Marie Arsenian-Henriksson, Ann-Kristin Ostlund Farrants
Article
Multidisciplinary Sciences
Muhammad Mushtaq, Larysa Kovalevska, Suhas Darekar, Alexandra Abramsson, Henrik Zetterberg, Vladimir Kashuba, George Klein, Marie Arsenian-Henriksson, Elena Kashuba
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Maria Victoria Ruiz-Perez, Lourdes Sainero-Alcolado, Ganna Oliynyk, Isabell Matuschek, Nicola Balboni, S. J. Kumari A. Ubhayasekera, Marteinn Thor Snaebjornsson, Kamil Makowski, Kristina Aaltonen, Daniel Bexell, Dolors Serra, Roland Nilsson, Jonas Bergquist, Almut Schulze, Marie Arsenian-Henriksson
Summary: Metabolic pathways, especially lipid metabolism, are rewired in tumors to support their growth and adaptation to stressful environments. In neuroblastoma, inhibition of fatty acid synthesis led to increased neural differentiation and reduced tumor burden independently of MYCN-status, showing promise as a pharmacological intervention strategy.
Article
Chemistry, Physical
Kilian Colas, Susanne Doloczki, Aikaterina Kesidou, Lourdes Sainero-Alcolado, Aida Rodriguez-Garcia, Marie Arsenian-Henriksson, Christine Dyrager
Summary: A series of solvatochromic phenylbenzothiadiazoles with dual emission properties were studied, showing sensitivity to polarity changes and potential applications in staining intracellular lipid droplets as well as fluorescence in hypoxic cancer cells. The compounds demonstrate differences in emission efficiency, spectral shifts, and ratios of locally excited and intramolecular charge transfer states.
Article
Biology
Luana Naia, Catarina M. Pinho, Giacomo Dentoni, Jianping Liu, Nuno Santos Leal, Duarte M. S. Ferreira, Bernadette Schreiner, Riccardo Filadi, Ligia Fao, Niamh M. C. Connolly, Pontus Forsell, Gunnar Nordvall, Makoto Shimozawa, Elisa Greotti, Emy Basso, Pierre Theurey, Anna Gioran, Alvin Joselin, Marie Arsenian-Henriksson, Per Nilsson, A. Cristina Rego, Jorge L. Ruas, David Park, Daniele Bano, Paola Pizzo, Jochen H. M. Prehn, Maria Ankarcrona
Summary: This study established a large-scale screening platform for mitochondrial-based modulators and identified luteolin as a compound with potential therapeutic validity for various human diseases by increasing mitochondrial activity through enhancing interactions between mitochondria and endoplasmic reticulum. The findings suggest a novel mechanism for luteolin's modulation of mitochondrial function in neuronal models and potential therapeutic applications.
Article
Multidisciplinary Sciences
Juan Zhang, Graciela Teran, Mihaela Popa, Harsha Madapura, Marcus James Graeme Watson Ladds, Danai Lianoudaki, Jacob Grunler, Marie Arsenian-Henriksson, Emmet McCormack, Martin Enrique Rottenberg, Sergiu-Bogdan Catrina, Sonia Lain, Suhas Darekar
Summary: Pharmacological inhibition of DHODH reduces mitochondrial respiration, promotes glycolysis, enhances GLUT4 translocation, increases expression of GDF15 through p53 activation, and leads to reduced appetite and prolonged lifespan. DHODH inhibitors also elevate levels of circulating GDF15 and improve metabolic balance in obesity-induced diabetes models.
Review
Oncology
Judit Liano-Pons, Marie Arsenian-Henriksson, Javier Leon
Summary: The MYC oncoprotein is deregulated in a large percentage of human tumors and plays a crucial role in tumorigenesis. The MYC modulator MNT is an important member of the MXD family with diverse functions that can either enhance or inhibit MYC-driven tumorigenesis. Understanding the complex interactions of MNT with other proteins in the MYC network may provide alternative strategies for targeting MYC in cancer therapy.
Article
Multidisciplinary Sciences
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang
Summary: By investigating inflammatory signaling pathways in neuroblastoma, researchers have identified heterogeneity in dsRNA sensing and intratumoral inflammatory signaling, which has significant implications for immunotherapeutic strategies in this aggressive childhood cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physics, Multidisciplinary
Kian Shaker, Ilian Haggmark, Jakob Reichmann, Marie Arsenian-Henriksson, Hans M. Hertz
Summary: Research has shown that in laboratory settings, X-ray imaging can be performed through free breathing without mechanical ventilation, achieving intrapulmonary spatial resolution in the 30-micron range, and successfully distinguishing terminal bronchioles in the 60-micron range from surrounding lung tissue. This method facilitates non-invasive longitudinal studies of animal airways for respiratory research.
COMMUNICATIONS PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Margit Kaldmae, Thibault Vosselman, Xueying Zhong, Dilraj Lama, Gefei Chen, Mihkel Saluri, Nina Kronqvist, Jia Wei Siau, Aik Seng Ng, Farid J. Ghadessy, Pierre Sabatier, Borivoj Vojtesek, Medoune Sarr, Cagla Sahin, Nicklas Osterlund, Leopold L. Ilag, Venla A. Vaananen, Saikiran Sedimbi, Marie Arsenian-Henriksson, Roman A. Zubarev, Lennart Nilsson, Philip J. B. Koeck, Anna Rising, Axel Abelein, Nicolas Fritz, Jan Johansson, David P. Lane, Michael Landreh
Summary: Disordered proteins pose challenges to structural biology. Researchers have found that fusing the protein with a highly soluble spider silk domain can modulate its characteristics and enhance translation efficiency. This mechanism is of great significance for cancer treatment.
Review
Biochemistry & Molecular Biology
Lourdes Sainero-Alcolado, Judit Liano-Pons, Maria Victoria Ruiz-Perez, Marie Arsenian-Henriksson
Summary: The research field of cancer metabolism has been based on the Warburg effect for decades, but recently the key role of mitochondria in cancer development has been demonstrated. Mutations in oncogenes, tumor suppressor genes, and metabolic enzymes alter various mitochondrial pathways in tumors, leading to metabolic reprogramming that sustains rapid cell proliferation and the utilization of reactive oxygen species by cancer cells. The knowledge acquired on mitochondrial cancer metabolism is now being translated into clinical practice, where detailed analysis of tumors is necessary to develop more precise treatments. Drugs targeting metabolic mitochondrial enzymes have shown potential in precision medicine, but efficient personalized drugs remain challenging to develop and may require combination with other strategies.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Oncology
Lourdes Sainero-Alcolado, Muhammad Mushtaq, Judit Liano-Pons, Aida Rodriguez-Garcia, Ye Yuan, Tong Liu, Maria Victoria Ruiz-Perez, Susanne Schlisio, Oscar Bedoya-Reina, Marie Arsenian-Henriksson
Summary: This study demonstrates that the simultaneous activation of glucocorticoid receptor (GR) and estrogen receptor alpha (ER alpha) promotes neuronal differentiation, reduces cell viability, and decreases tumor burden in neuroblastoma. This combination therapy leads to metabolic reprogramming and lipid droplet accumulation. Additionally, the sequential expression of ER alpha, GR, and retinoic acid receptor alpha (RAR alpha) during adrenal gland development is observed. Patients with higher combined expression of GR, ER alpha, and RAR alpha mRNA have elevated expression of neuronal differentiation markers and a favorable outcome.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mihkel Saluri, Axel Leppert, Genis Valentin Gese, Cagla Sahin, Dilraj Lama, Margit Kaldmae, Gefei Chen, Arne Elofsson, Timothy M. Allison, Marie Arsenian-Henriksson, Jan Johansson, David P. Lane, B. Martin Hallberg, Michael Landreh
Summary: This study examines the relationship between the self-assembly and chaperone activity of nucleophosmin 1 (NPM1). The results show that oligomerization of NPM1 modulates its ability to prevent amyloid formation, and fuzzy interactions between different regions of NPM1 contribute to its partially disordered oligomerization. Additionally, nucleolar proteins and RNAs regulate the association strength and chaperone activity of NPM1.
Correction
Endocrinology & Metabolism
Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sorensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao, Susanne Schlisio
Article
Endocrinology & Metabolism
Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sorensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao, Susanne Schlisio
Summary: This study reveals the oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcription and replication, and its connection to tumorigenesis in von Hippel-Lindau syndrome. The findings suggest that impaired mitochondrial biogenesis is linked to VHL tumorigenesis, and targeting mitochondria could sensitize therapy-resistant VHL tumors.
