Article
Oncology
Koung Jin Suh, Min-Hee Ryu, Dae Young Zang, Woo Kyun Bae, Hye Seung Lee, Hyeon Jeong Oh, Minsu Kang, Ji-Won Kim, Bum Jun Kim, Peter G. S. Mortimer, Hee Jung Kim, Keun-Wook Lee
Summary: This study evaluated the safety and efficacy of the combination of AZD8186 and paclitaxel in patients with metastatic or recurrent gastric cancer. The results showed that although the combination treatment was well tolerated, its clinical efficacy was limited.
Article
Oncology
Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yang
Summary: This study explored the role of circ_POLA2 in glioblastoma (GBM) and found that circ_POLA2 was upregulated while PTEN was downregulated in GBM. Overexpression of circ_POLA2 in GBM cells decreased PTEN accumulation, but PTEN overexpression did not significantly affect circ_POLA2 expression. Moreover, PTEN reduced the inhibitory effects of circ_POLA2 on GBM cell apoptosis.
Article
Multidisciplinary Sciences
Romina Mehdizadeh, Alireza Madjid Ansari, Flora Forouzesh, Fatemeh Shahriari, Seyed Peyman Shariatpanahi, Ali Salaritabar, Mohammad Amin Javidi
Summary: The average survival of patients with glioblastoma is 12-15 months, making it crucial to find new treatment methods, especially for cases resistant to current therapies. This research investigates the antitumor effect of extremely low-frequency electromagnetic fields (ELF-EMF) on specific glioblastoma cell lines. The findings suggest that ELF-EMF induces apoptosis and regulates cell cycle progression, potentially offering a low-side effect cancer treatment option.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Yong Li, Yixuan Wang, Lun Gao, Yinqiu Tan, Jiayang Cai, Zhang Ye, Ann T. Chen, Yang Xu, Linyao Zhao, Shiao Tong, Qian Sun, Baohui Liu, Shenqi Zhang, Daofeng Tian, Gang Deng, Jiangbing Zhou, Qianxue Chen
Summary: This study successfully synthesized betulinic acid nanoparticles (BA NPs) that can cross the blood-brain barrier and demonstrated strong anti-tumor effects. In vitro experiments showed that BA NPs could inhibit glioma cell proliferation, induce apoptosis, and block the cell cycle. In vivo experiments in mice with intracranial GBM xenografts showed that BA NPs could effectively cross the blood-brain barrier and significantly prolong the survival time of the mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiali Shi, Shanshan Sun, Shuqiao Xing, Changgang Huang, Yuqian Huang, Qian Wang, Xiumin Xue, Zhichao Chen, Yongjie Wang, Zhihui Huang
Summary: Fraxinellone was found to inhibit the proliferation and growth of GBM cells in vitro, as well as suppress their migration and induce apoptosis. The mechanism of action involved the downregulation of SIRT3 signaling and the inhibition of GBM tumorigenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Honglan Qu, Gao-wa Hasen, Yanyan Hou, Mengwei Ren, Jun Li, Baoshong Jing, YanDan Du
Summary: TRIM37 is upregulated in T-cell acute lymphoblastic leukemia (T-ALL), and it promotes the proliferation and reduces the sensitivity of T-ALL cells to bortezomib treatment by enhancing PTEN degradation and activating PI3K/AKT signaling pathway. These findings suggest that TRIM37 could be a potential therapeutic target for T-ALL.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jian You, Bei Tao, Lilei Peng, Tangming Peng, Haiping He, Shan Zeng, Jizhong Han, Ligang Chen, Xiangguo Xia, Xiaobo Yang, Chuanhong Zhong
Summary: This study reveals that the transcription factor YY1 promotes the self-renewal of glioblastoma stem cells (GSCs) by upregulating the expression of SUMO enzyme SENP1, enhancing the methyltransferase activity of METTL3, and promoting the m6A modification and expression of MYC mRNA. This finding sheds light on the regulatory mechanism of GSC self-renewal and tumorigenicity.
CANCER GENE THERAPY
(2023)
Article
Medicine, General & Internal
Jin-Xu Zhou, Ke-Fei Chen, Shuai Hu, Ji-Rong Dong, Hong-Xiang Wang, Xin Su, Yu-Hai Wang, Jun-Sheng Chu
Summary: The study demonstrates that hsa_circ_01844 is downregulated in glioblastoma tissues, and its overexpression can induce apoptosis and inhibit proliferation, migration, and invasion of glioblastoma cells.
CHINESE MEDICAL JOURNAL
(2021)
Article
Oncology
Shanshan Sun, Jiali Shi, Xin Wang, Changgang Huang, Yuqian Huang, Jiayun Xu, Yuanyuan Jiang, Liying Cao, Tian Xie, Yongjie Wang, Zhihui Huang
Summary: Atractylon can inhibit proliferation and migration, as well as induce apoptosis in GBM cells by up-regulating SIRT3, suggesting it as a potential strategy for the treatment of GBM.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Oncology
Jiajia Chen, Yuecan Zeng, Rong Wu, Ying Xuan, Min Jiang, Hao Teng
Summary: The study found that DUSP26 is down-regulated in high-grade gliomas and GBM compared to normal brain tissues. At the cellular level, DUSP26 overexpression resulted in decreased cell proliferation, migration, and senescence in U251 and U87 cells, with increased apoptosis. Additionally, the biological effects of DUSP26 overexpression were associated with the dephosphorylation of proteins in the MAPK and Akt signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lanwei Ouyang, Min Yang, Xiaolin Wang, Jidan Fan, Xing Liu, Yong Zhang, Yusheng Shu
Summary: The study revealed that FER1L4 is significantly downregulated in NSCLC plasma, tissues, and lung cancer cell lines. Overexpression of FER1L4 led to a decrease in cell proliferation, migration, and invasion. FER1L4 promoted PTEN and p53 expression, inhibited AKT phosphorylation, and increased the proportion of apoptotic cells, suggesting it may serve as a novel potential therapeutic target for NSCLC.
Article
Oncology
Hao Zhang, Huajun Sheng, Zhen Guo, Yu Xing, Qian Liu, Ziling Cai, Zihao Shen, Qingqian Xia, Shujuan Zhu
Summary: According to the study, AQP8 plays a significant role in the proliferation and growth of gliomas. Overexpression of AQP8 promotes cell proliferation, invasion, and migration, inhibits apoptosis, and affects the ROS/PTEN/AKT signaling pathway. Therefore, AQP8 may serve as a potential therapeutic target in gliomas.
Article
Cell Biology
Lianjie Hou, Xiong Tong, Shuyun Lin, Mingfang Yu, Wen-Chu Ye, Meiying Xie
Summary: The study showed that Deoxynivalenol (Don) downregulated miR-221/222 in intestinal epithelial cells, leading to apoptosis and proliferation inhibition. Exosome treatment reversed the effect and targeted Phosphatase and tensin homolog (PTEN) to alleviate Don-induced damage in intestinal epithelial cells. This research expands the understanding of how miR-221/222 and PTEN regulate intestinal epithelial cells defending against Don-induced damage and offers a new approach to protect intestinal development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Correction
Behavioral Sciences
Pian Gong, Zhan Zhang, Changlin Zou, Qi Tian, Xuemei Chen, Michael Hong, Xi Liu, Qianxue Chen, Zhou Xu, Mingchang Li, Jian Wang
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Fanen Yuan, Qian Sun, Si Zhang, Liguo Ye, Yang Xu, Zhou Xu, Baohui Liu, Shenqi Zhang, Qianxue Chen
Summary: This study unveils novel molecular mechanisms of ferroptosis in glioma and identifies HSP27 as a negative regulator of ferroptosis and a potential target for the treatment of glioma.
Article
Oncology
Tengfeng Yan, Daofeng Tian, Junhui Chen, Yinqiu Tan, Yue Cheng, Liguo Ye, Gang Deng, Baohui Liu, Fanen Yuan, Shenqi Zhang, Linzhi Cai, Qianxue Chen
Summary: The Fc Fragment of IgG Binding Protein (FCGBP) is highly expressed in glioma and is associated with poor prognosis. It plays a role in regulating immune response and is positively correlated with immune cell infiltration and immune marker expression levels in glioma. These findings reveal a new mechanism by which FCGBP participates in immune tolerance in glioma and suggest its potential as a therapeutic target or predictive marker.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Fanen Yuan, Si Zhang, Qian Sun, Liguo Ye, Yang Xu, Zhou Xu, Gang Deng, Shenqi Zhang, Baohui Liu, Qianxue Chen
Summary: The study demonstrated that hsa_circ_0072309 promotes autophagy through the p53 signaling pathway and enhances sensitivity to temozolomide in GBM. It may serve as a potential and promising target in designing treatment strategies for GBM.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Oncology
Yixuan Wang, Yuntao Li, Qian Sun, Fanen Yuan, Yang Xu, Shiao Tong, Yong Li, Shangfeng Yi, Tengfeng Yan, Qianxue Chen, Baohui Liu
Summary: The study indicates that BCAS3 is up-regulated in GBM, and its high expression predicts poor prognosis. BCAS3 significantly regulates GBM cell proliferation and cell cycle, and is associated with the p53/GADD45α pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Tengfeng Yan, Yinqiu Tan, Gang Deng, Zhiqiang Sun, Baohui Liu, Yixuan Wang, Fanen Yuan, Qian Sun, Ping Hu, Lun Gao, Daofeng Tian, Qianxue Chen
Summary: The abnormal expression of CLDN4 is closely related to tumor progression in glioblastoma, and inhibiting CLDN4 expression can weaken the invasion and migration ability of glioma cells. The TGF-beta signal pathway upregulates the expression of CLDN4 and promotes the invasion ability of glioma cells, while TGF-beta signal pathway inhibitors downregulate the expression of CLDN4 and inhibit the invasion ability of glioma cells. TGF-beta can also promote the nuclear translocation of CLDN4.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Fanen Yuan, Qian Sun, Si Zhang, Liguo Ye, Yang Xu, Gang Deng, Zhou Xu, Shenqi Zhang, Baohui Liu, Qianxue Chen
Summary: This study reveals a dual role of p62 in regulating ferroptosis in glioblastoma (GBM) depending on the status of p53. P62 overexpression promotes ferroptosis and inhibits SLC7A11 expression in p53 mutant GBM, while attenuates ferroptosis and promotes SLC7A11 expression in p53 wild-type GBM. The mutation status of p53 is a crucial factor in determining the therapeutic response to p62-mediated ferroptosis-targeted therapies in GBM.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yang Xu, Fanen Yuan, Qian Sun, Linyao Zhao, Yu Hong, Shiao Tong, Yangzhi Qi, Liguo Ye, Ping Hu, Zhang Ye, Si Zhang, Baohui Liu, Qianxue Chen
Summary: RNA-binding protein CSTF2 is upregulated in human glioblastoma (GBM) and promotes GBM cell survival by binding to the mRNA of the BAD protein to shorten its 3' UTR, resulting in the destabilization of BAD mRNA and inhibition of BAD-mediated apoptosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Correction
Oncology
Yangzhi Qi, Gang Deng, Pengfei Xu, Huikai Zhang, Fanen Yuan, Rongxin Geng, Hongxiang Jiang, Baohui Liu, Qianxue Chen
Article
Biotechnology & Applied Microbiology
Linyao Zhao, Congkuan Song, Yong Li, Fanen Yuan, Qingyu Zhao, Huimin Dong, Baohui Liu
Summary: This study investigated the expression of BZW1 in glioma and its relationship with clinicopathological features and prognosis. It was found that BZW1 was highly expressed in glioma and correlated with poor prognosis. BZW1 promoted glioma proliferation and progression, and was also associated with the tumor immune microenvironment.
Article
Medicine, Research & Experimental
Shiao Tong, Minqi Xia, Yang Xu, Qian Sun, Liguo Ye, Fanen Yuan, Yixuan Wang, Jiayang Cai, Zhang Ye, Daofeng Tian
Summary: This study constructed a risk model to predict the prognosis and therapeutic targets for glioblastoma (GBM) patients by analyzing mitochondria and oxidative stress-related genes from public databases. The model demonstrated strong prediction accuracy and correlation with immune cell infiltration and mutation status, providing potential targeted therapeutic drugs for GBM. Further experiments validated that elevated NUDT1 gene in GBM promoted cell proliferation and inhibited apoptosis, while damaging mitochondrial homeostasis and inducing oxidative stress.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Huairui Yuan, Xujia Wu, Qiulian Wu, Adam Chatoff, Emily Megill, Jinjun Gao, Tengfei Huang, Tingting Duan, Kailin Yang, Chunyu Jin, Fanen Yuan, Shuai Wang, Linjie Zhao, Pascal O. Zinn, Kalil G. Abdullah, Yingming Zhao, Nathaniel W. Snyder, Jeremy N. Rich
Summary: Cancer cells reprogram lysine metabolism to accumulate intracellular crotonyl-CoA and histone H4 lysine crotonylation, promoting tumorigenic potential. Histone lysine crotonylation promotes immunogenic cytosolic dsRNA and dsDNA generation, leading to enhanced immune response and compromised tumor growth. Lysine-restricted diet synergizes with MYC inhibition or anti-PD-1 therapy to slow tumor growth.
Article
Neurosciences
Yonggang Zhang, Peng Ye, Hua Zhu, Lijuan Gu, Yuntao Li, Shi Feng, Zhi Zeng, Qianxue Chen, Benhong Zhou, Xiaoxing Xiong
Summary: This study investigated the potential effects of Neutral polysaccharide from Gastrodia elata (NPGE) on cerebral ischemia-reperfusion injury (CIRI) neuropathology. The results showed that NPGE treatment could alleviate neurological deficits, reduce infarct volume, and promote cell survival. Mechanistically, NPGE could regulate the expression of various signaling molecules, alleviating neuroinflammation and ferroptosis.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
