Article
Oncology
Sean Li, Roger McLendon, Eric Sankey, Reb Kornahrens, Anne-Marie Lyne, Florence Marie Geraldine Cavalli, Zachary McKay, James Emmett Herndon, Marc Remke, Daniel Picard, Matthias Gromeier, Michael Brown, Eric Michael Thompson
Summary: This study found that CD155 is widely expressed in medulloblastoma and blocking CD155 can lead to cell death and reduced cellular invasion. This provides rationale for CD155-targeting agents including PVSRIPO and antibody-mediated blockade of CD155.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Sara Badodi, Nicola Pomella, Yau Mun Lim, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Xinyu Zhang, Nicolae Radu Zabet, Silvia Marino
Summary: This study identifies the therapeutic potential of a combination treatment with BMI1 and MAPK/ERK inhibitors in BMI1(High);CHD7(Low) MB cells, and elucidates the role of the CHD7-BMI1-MAPK regulatory axis in the pathogenesis of MB.
Article
Oncology
Cara E. Shields, Sindhu Potlapalli, Selma M. Cuya-Smith, Sarah K. Chappell, Dongdong Chen, Daniel Martinez, Jennifer Pogoriler, Komal S. Rathi, Shiv A. Patel, Kristianne M. Oristian, Corinne M. Linardic, John M. Maris, Karmella A. Haynes, Robert W. Schnepp
Summary: Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma with two main subtypes, alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma. There are no targeted therapies for ARMS, but recent studies have shown a potential cooperation between epigenetic proteins and PAX3-FOXO1 fusion, suggesting epigenetic proteins as targets in ARMS. In this study, BMI1 was identified as a potential therapeutic vulnerability in ARMS, with inhibition activating the Hippo pathway and reducing tumor growth.
MOLECULAR ONCOLOGY
(2021)
Article
Immunology
Huangyi Fang, Yusong Zhang, Chengyin Lin, Zhenkai Sun, Wei Wen, Hansong Sheng, Jian Lin
Summary: Non-WNT/non-SHH medulloblastoma (MB) is a subtype with high genetic heterogeneity, and current treatment strategies have poor efficacy and significant side effects. CENPE, a member of the CENP family, is upregulated in MB but its role in MB development is unknown.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Duygu Kuzuoglu-Ozturk, Ozlem Aksoy, Christin Schmidt, Robin Lea, Jon D. Larson, Ryan R. L. Phelps, Nicole Nasholm, Megan Holt, Adrian Contreras, Miller Huang, Shannon Wong-Michalak, Hao Shao, Robert Wechsler-Reya, Joanna J. Phillips, Jason E. Gestwicki, Davide Ruggero, William A. Weiss
Summary: Deregulation of N-myc is a major cause of malignant brain tumors in children. This study characterizes the translatome of medulloblastoma and reveals that N-myc drives selective translation of transcripts promoting protein homeostasis. These findings identify a hidden molecular program promoting medulloblastoma formation and suggest potential new therapies for clinical use.
Article
Oncology
Avik Dutta, Dipmoy Nath, Yue Yang, Bao T. Le, Golam Mohi
Summary: The CDK4/6 inhibitor palbociclib, alone or in combination with ruxolitinib, shows significant efficacy in reducing leukocytosis, splenomegaly, and bone marrow fibrosis in murine models of myelofibrosis, especially in inhibiting Jak2V617F mutant hematopoietic progenitors. This drug combination could have therapeutic potential for the treatment of myelofibrosis and warrants further clinical investigation.
Review
Biochemistry & Molecular Biology
Anwar Zaiter, Zahraa F. Audi, Fatima Shawraba, Zahraa Saker, Hisham F. Bahmad, Rami H. Nabha, Hayat Harati, Sanaa M. Nabha
Summary: Medulloblastoma is the most common malignant brain tumor of childhood, with improved overall survival rate but still lacking efficient and reliable therapeutic approaches. Understanding the role of signal transducer and activator of transcription 3 in medulloblastoma tumorigenesis is crucial for the development of effective therapies.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Flora Cimmino, Annalaura Montella, Matilde Tirelli, Marianna Avitabile, Vito Alessandro Lasorsa, Feliciano Visconte, Sueva Cantalupo, Teresa Maiorino, Biagio De Angelis, Martina Morini, Aurora Castellano, Franco Locatelli, Mario Capasso, Achille Iolascon
Summary: FGFR1 is an actionable driver oncogene in neuroblastoma (NB), and targeting FGFR1 mutations may be a promising therapy for patients with therapy-resistant NB.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Anbukkarasi Muniyandi, Matthew Martin, Kamakshi Sishtla, Aishat Motolani, Mengyao Sun, Nathan R. Jensen, Xiaoping Qi, Michael E. Boulton, Lakshmi Prabhu, Tao Lu, Timothy W. Corson
Summary: PRMT5 has been identified as a novel therapeutic target for nvAMD, and its inhibitor PR5-LL-CM01 can reduce angiogenesis and activation of NF-kappa B.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Pureun-Haneul Lee, Seon Muk Choi, Min Hyeok An, Da Yeon Hwang, Shinhee Park, Ae Rin Baek, An-Soo Jang
Summary: This study discovered that Nectin4 levels in the blood of asthmatic patients were significantly increased and correlated with clinical variables. The experimental results indicated that Nectin4 is involved in airway inflammation and may serve as a therapeutic target in patients with asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Ling
Summary: We have shown that ADCK1, a mitochondrial protein, is upregulated in human osteosarcoma tissues and cells. ADCK1 plays a crucial role in cell viability, proliferation, migration, apoptosis, and mitochondrial functions. Inhibition of ADCK1 enhances doxorubicin-induced apoptosis and decreases cell growth. The mTOR pathway is important for ADCK1 expression. ADCK1 is a novel therapeutic target for osteosarcoma.
CELL DEATH & DISEASE
(2022)
Editorial Material
Immunology
Zulekha A. Qadeer, William A. Weiss
Summary: The study reveals that bone morphogenetic proteins and Sox9 promote the transdifferentiation of tumor cells into tumor-derived astrocytes, which can be targeted by BMP inhibitors.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Yuhao Deng, Huantao Wen, Hanjie Yang, Zhengqiang Zhu, Qiongzhen Huang, Yuewei Bi, Pengfei Wang, Ming Zhou, Jianwei Guan, Wangming Zhang, Min Li
Summary: Medulloblastoma (MB) is the most common malignant brain tumor in pediatrics. Current standard treatment often results in high morbidity, so there is a need for more effective and less toxic therapies. This study identified an upregulated gene (PDZ binding kinase) in MB and found its aberrant expression to be associated with poor clinical outcomes. Targeting this gene with an inhibitor impaired MB cell proliferation and induced apoptosis.
Review
Endocrinology & Metabolism
Yunyu Du, Tieying Li, Muqing Yi
Summary: MG53 protein plays a crucial role in the occurrence, progression, and drug resistance of tumors, showing potential in cancer therapy. Its membrane repair function and anti-inflammatory capacity are beneficial for cancer prevention and treatment. However, MG53's involvement in glucose metabolism and muscle regeneration may have a negative impact on cancer treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Junjie Gao, Dandan Yang, Zheng Huang, Xueshan Pan, Ruoxue Cao, Chaoqun Lian, Jia Ma, Yuyun Li, Zhiwei Wang, Jun Xia
Summary: Nitric oxide synthase-interacting protein (Nosip) interacts with nitric oxide synthase (NOS) and regulates NO synthesis and release, participating in various physiological and pathological processes. Nosip was found to be elevated in hepatocellular carcinoma (HCC) tissues and cells. Silencing Nosip inhibited HCC cell proliferation and motility, and promoted apoptosis, while overexpression of Nosip had the opposite effects. Quercetin, a natural compound, inhibited the proliferation and motility of HCC cells possibly by repressing Nosip expression. Our findings suggest that Nosip acts as an oncogene in HCC progression and quercetin may be a potential natural compound for treating HCC by targeting Nosip expression.
Article
Clinical Neurology
Radwan Takroni, Nirmeen Zagzoog, Nimita Patel, Amanda Martyniuk, Sheila Singh, Forough Farrokhyar, Arunachala Trivedi, Mazen Alotaibi, Almunder Algird
Summary: This study retrospectively analyzed data from 172 patients with chronic subdural hematoma (CSDH) and compared the effect of two drainage systems on the recurrence rate of CSDH. The results showed no significant difference in the recurrence rate between the use of a pediatric size nasogastric tube and an external ventricular drainage catheter.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Editorial Material
Oncology
Beth Frenkel, Elena Gerasimov, Allen Gustafson, Patti Gustafson, Ginny McLean, Aloysius Ochasi, Angela Waanders, Vijay Ramaswamy
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Leonard H. H. Verhey, Arjuna Maharaj, Nikunj Patel, Branavan Manoranjan, Olufemi Ajani, Adam Fleming, Forough Farrokhyar, Sheila K. K. Singh, Blake Yarascavitch, Pediat Brain Tumor Study Grp
Summary: The purpose of this study was to determine whether intraoperative adjunctive EVD placement in patients with a posterior fossa tumor (PFT) led to improved surgical, radiographic, and clinical outcomes. The results showed that the routine use of EVD as an intraoperative adjunct in clinically stable pediatric patients with posterior fossa tumors and hydrocephalus may not be associated with improved radiological or clinical outcomes.
CHILDS NERVOUS SYSTEM
(2023)
Correction
Multidisciplinary Sciences
Michelle M. Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G. Fox, Ashley A. Adile, David Bakhshinyan, Kevin Brown, William D. Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam Fleming, Kristin Hope, John P. Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jueri Reimand, Robert J. Wechsler-Reya, Gene W. Yeo, Sheila K. Singh
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Ieta Shams, Branavan Manoranjan, Rebecca Voth, Malavan Ragulojan, Olufemi Ajani, Blake Yarascavitch, Sheila K. Singh, Adam J. Fleming
Summary: This study retrospectively analyzed 40 cases of progressive juvenile pilocytic astrocytoma (JPA) treated at a single center over an 18-year period (1998-2016). The findings showed that the treatment of progressive JPA is variable and may require numerous surgeries and adjuvant therapies.
JOURNAL OF NEUROSURGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Blessing Iquo Bassey- Archibong, Chirayu Rajendra Chokshi, Nikoo Aghaei, Agata Monika Kieliszek, Nazanin Tatari, Dillon McKenna, Mohini Singh, Minomi Kalpana Subapanditha, Arun Parmar, Daniel Mobilio, Neil Savage, Fred Lam, Tomas Tokar, John Provias, Yu Lu, Shawn Christopher Chafe, Charles Swanton, Robert Edward Hynds, Chitra Venugopal, Sheila Kumari Singh
Summary: Brain metastases (BM) are the most common brain neoplasm in adults, but current therapies have limited efficacy. This study analyzed the transcriptional profile of brain metastasis initiating cells (BMICs) at two distinct stages of the metastatic cascade. The researchers found that premetastatic BMICs exhibited increased expression of HLA-G, which plays a role in promoting brain metastatic lesions. Understanding the molecular landscape of premetastatic BMICs could lead to the development of more effective therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Obstetrics & Gynecology
Shikha Singh, Praveen Kumar, Saurabh Singh Rathore, Yashasvi Singh, Neha Garg
Summary: Uterine fibroids, the most common benign solid tumors in females, are associated with poor quality of life. Current treatment mainly involves surgical interventions, but they have complications and are not ideal for preserving fertility. Therefore, there is a need to develop or repurpose non-surgical pharmacological agents for the management of uterine fibroids.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Parasitology
Sunidhi Sharma, Vanshita Goel, Pawandeep Kaur, Kundlik Gadhave, Neha Garg, Lachhman Das Singla, Diptiman Choudhury
Summary: Targeted delivery for anthelmintic treatment has not been achieved, resulting in the need for excessive drug dose and leading to side effects and therapeutic resistance. This study developed biocompatible albendazole-loaded solid lipid nanoparticles with sustained-release properties, which enhanced the bioavailability of the drug and showed potential as an effective anthelmintic drug delivery vehicle.
EXPERIMENTAL PARASITOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vipendra Kumar Singh, D. C. Thakur, Naina Rajak, Anand Mishra, Ankur Kumar, Rajanish Giri, Neha Garg
Summary: The study demonstrates the multi-protein targeting potential of bioactive glycoside syringin in inflammatory diseases, as confirmed by molecular dynamic simulation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Anna S. Kolodziejczak, Lea Guerrini-Rousseau, Julien Masliah Planchon, Jonas Ecker, Florian Selt, Martin Mynarek, Denise Obrecht, Martin Sill, Robert J. Autry, Eric Stutheit-Zhao, Steffen Hirsch, Elsa Amouyal, Christelle Dufour, Olivier Ayrault, Jacob Torrejon, Sebastian M. Waszak, Vijay Ramaswamy, Virve Pentikainen, Haci Ahmet Demir, Steven C. Clifford, Ed C. Schwalbe, Luca Massimi, Matija Snuderl, Kristyn Galbraith, Matthias A. Karajannis, Katherine Hill, Bryan K. Li, Mike Walsh, Christine L. White, Shelagh Redmond, Loizou Loizos, Marcus Jakob, Uwe R. Kordes, Irene Schmid, Julia Hauer, Claudia Blattmann, Maria Filippidou, Gianluca Piccolo, Wolfram Scheurlen, Ahmed Farrag, Kerstin Grund, Christian Sutter, Torsten Pietsch, Stephan Frank, Denis M. Schewe, David Malkin, Myriam Ben-Arush, Astrid Sehested, Tai-Tong Wong, Kuo-Sheng Wu, Yen-Lin Liu, Fernando Carceller, Sabine Mueller, Schuyler Stoller, Michael D. Taylor, Uri Tabori, Eric Bouffet, Marcel Kool, Felix Sahm, Andreas von Deimling, Andrey Korshunov, Katja von Hoff, Christian P. Kratz, Dominik Sturm, David T. W. Jones, Stefan Rutkowski, Cornelis M. van Tilburg, Olaf Witt, Gaelle Bougeard, Kristian W. Pajtler, Stefan M. Pfister, Franck Bourdeaut, Till Milde
Summary: This retrospective cohort study investigated medulloblastoma in Li-Fraumeni syndrome (LFS) patients and found poor prognosis. The results showed that patients who received radiotherapy and chemotherapy had better clinical outcomes, while chemotherapy intensity did not affect their prognosis.
Review
Oncology
Thais Baccili Cury Megid, Abdul Rehman Farooq, Xin Wang, Elena Elimova
Summary: Gastric cancer is a global health concern, ranking fifth in cancer diagnoses and fourth in cancer-related deaths worldwide. Recent breakthroughs in genome analysis have identified biomarkers with positive clinical significance for GC treatment, offering the potential for more precise diagnostic and therapeutic approaches. This review explores the classification and molecular pathways in GC, highlighting potential biomarkers that have emerged in recent studies, including targeted therapies and immunotherapies. These advancements provide a promising direction for improving the management of GC.
Article
Statistics & Probability
Ranjana Janbandhu, Neha Garg, Rajesh Tailor
Summary: This paper proposes a new chain ratio type exponential estimator for finite population mean in double sampling, extending the Chand (1975) chain ratio estimator using exponential strategy. The bias and mean squared error of the developed estimator are derived up to the first degree of approximation. The properties of the estimator are examined and compared with other estimators through theoretical and empirical analysis using simulation study.
THAILAND STATISTICIAN
(2023)
Article
Chemistry, Multidisciplinary
Mayank, Ashutosh Singh, Kumar Udit Saumya, Mayank Joshi, Navneet Kaur, Neha Garg, Narinder Singh
Summary: 4H-Chromene derivatives are potential anticancer compounds that bind to the colchicine binding site of tubulin protein. The 2-amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile-based 4H-chromenes scaffold has a significant impact on tubulin proteins. Understanding the interaction pattern of these compounds against various tubulin isoforms is important for selective targeting of cancer cells. Structural modification can potentially enhance the selective targeting ability of these molecules.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Arpna Tamrakar, Praveen Kumar, Neha Garg, Santiago V. Luis, Mrituanjay D. Pandey
Summary: A C-2 symmetric l-phenylalanine-derived pseudopeptide has been synthesized for selective and sensitive recognition of Zn(ii) ions in aqueous-organic media. The pseudopeptidic probes exhibit intracellular Zn(ii) ion-sensing capabilities as demonstrated via live-cell fluorescence studies on RAW264.7 cells. Therefore, this study presents a bioinspired pseudopeptide for potential biological applications involving intracellular Zn(ii) ion detection.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Neha Garg, Pooja Choudhari, Abha Choudhary
HORMONE RESEARCH IN PAEDIATRICS
(2023)