Article
Pharmacology & Pharmacy
Jieming Fu, Moe H. Aung, Megan C. Prunty, Adam M. Hanif, Lauren M. Hutson, Jeffrey H. Boatright, Machelle T. Pardue
Summary: The study demonstrated that early treatment with TUDCA preserved visual and retinal function in a mouse model of early diabetic retinopathy, with better outcomes seen with early treatment compared to late treatment.
Article
Medicine, General & Internal
Pedro Romero-Aroca, Raul Navarro-Gil, Gibet Benejam, Montse Vizcarro, Marc Baget-Bernaldiz
Summary: This study compared the differences in multifocal electroretinogram between type 1 diabetes and type 2 diabetes patients. The findings suggest that the retinas of type 1 diabetes patients are more sensitive to changes in HbA1c levels, while the duration of diabetes affects both types of patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Sarah R. Sheskey, David A. Antonetti, Rene C. Renteria, Cheng-Mao Lin
Summary: Diabetic retinopathy causes vision loss and retinal thinning, with significant correlation between blood glucose levels and visual function and structure changes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Madania Amorim, Beatriz Martins, Rosa Fernandes
Summary: Diabetes is a global health issue with significant morbidity and mortality. Diabetic retinopathy (DR) is a well-known inflammatory, neurovascular complication of diabetes and a leading cause of preventable blindness in developed countries among working-age adults. However, the ocular surface components of diabetic eyes are also at risk of damage due to uncontrolled diabetes, which is often overlooked.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Suna Ye, Zhijie Wang, Jacey Hongjie Ma, Shangli Ji, Yanfang Peng, Yinhua Huang, Jiansu Chen, Shibo Tang
Summary: This study found that diabetes impairs the circadian rhythm of the transcriptomic profile in retinas, including composition, phase, and amplitude. These findings offer new perspectives on the negative effects of diabetes on the retina and may provide important information for the development of new treatments for diabetic retinopathy (DR).
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Neurosciences
Britta U. Westner, James Lubell, Mads Jensen, Sigbjorn Hokland, Sarang S. Dalal
Summary: Optically pumped magnetometers (OPMs) offer a flexible and contactless alternative for measuring brain and retinal activity without the need for cryogenic cooling. Magnetoretinographic (MRG) activity shows familiar signals similar to electroretinogram and shares a significant amount of information in both simultaneous and separate measurements.
Article
Biochemistry & Molecular Biology
Rafael Simo, Patricia Bogdanov, Hugo Ramos, Jordi Huerta, Olga Simo-Servat, Cristina Hernandez
Summary: The study found that semaglutide administered via eye drops significantly reduced retinal neuroinflammation and microvascular abnormalities in the db/db mouse model. It prevented cell apoptosis, decreased vascular leakage, and activated the AKT pathway in the retina. These beneficial effects were directly attributed to semaglutide and indicate a positive impact on the retina of subjects with diabetes.
Article
Food Science & Technology
Giulia Conversa, Anna Bonasia, Giuseppe Natrella, Corrado Lazzizera, Antonio Elia
Summary: Peeling affects the nutritional and antioxidative properties of carrots, with a greater impact on local varieties.
Article
Multidisciplinary Sciences
Muhammad Sameem Javed, Adnan Amjad, Faiz-Ul-Hassan Shah, Zulfiqar Ahmad, Aneela Hameed, Muhammad Junaid Anwar, Ammar Ahmad Khan, Muhammad Amir, Muhammad Jawad, Muhammad Abrar
Summary: Globally, the prevalence of vit-A deficiency disorders, such as xerophthalmia and nyctalopia, is increasing, particularly among teenagers due to lifestyle shifts and undernutrition. This research aims to develop carrot-supplemented tomato sauce as a solution to overcome vit-A deficiency and its related disorders. The study found that sauce containing 60% carrot pulp showed good sensory characteristics and maintained a high level of beta carotene (BC) for the entire storage period.
Article
Ophthalmology
Enrico Borrelli, Marco Battista, Maria Lucia Cascavilla, Chiara Vigano, Federico Borghesan, Nicolo Nicolini, Lidia Clemente, Riccardo Sacconi, Costanza Barresi, Alessandro Marchese, Elisabetta Miserocchi, Giulio Modorati, Francesco Bandello, Giuseppe Querques
Summary: The study found that the outer nuclear layer (ONL) in eyes screened for HCQ retinopathy was significantly thinner in the foveal, parafoveal, and perifoveal regions. Even in HCQ eyes without detectable retinopathy, there were still structural changes associated with macular function.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Medicine, General & Internal
Gerald Liew, Tania Tsang, Bridget Marshall, Mercy Saw, Levon Michael Khachigian, Stephen Ong, I-Van Ho, Vincent Wong
Summary: This study investigated the distribution of diabetic retinopathy (DR) by ethnic group in a specific region of Australia. The results showed variations in the proportion of DR among different ethnic groups, with individuals of Oceanian ethnicity having the highest proportion and those of East Asian ethnicity having the lowest proportion. The study also found that ethnicity is independently associated with DR, even after adjusting for other risk factors.
Article
Ophthalmology
Malena Daich Varela, Yannik Laich, Shaima Awadh Hashem, Omar A. Mahroo, Andrew R. Webster, Michel Michaelides
Summary: The purpose of this study was to explore the use of fundus autofluorescence (FAF) imaging as a noninvasive method for predicting disease progression in Stargardt disease (STGD). The study found that FAF imaging can effectively determine the extent of retinal involvement and showed concordance with electroretinography (ERG). However, in certain patient populations, FAF imaging may not accurately predict the extent of retinal involvement.
Article
Multidisciplinary Sciences
Sepalika Bandara, Srinivasagan Ramkumar, Sanae Imanishi, Linda D. Thomas, Onkar B. Sawant, Yoshikazu Imanishi, Johannes von Lintig
Summary: This study unravels the biochemical basis for intracellular carotenoid transport and implicates Aster-B in the pathway for macula pigment concentration in the human retina.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Sajjad Haider, Rasiah Thayakaran, Anuradha Subramanian, Konstantinos A. Toulis, David Moore, Malcolm James Price, Krishnarajah Nirantharakumar
Summary: The study estimated the disease burden, trends, and future projections for diabetes mellitus (DM) and diabetic retinopathy (DR) in the IQVIA Medical Research Data (IMRD). The results showed increasing trends in the prevalence of DM, DR, and sight-threatening retinopathy (STR), with differential rising trends in the prevalence of DM and DR. Preventive strategies and treatment services planning can be based on these projected prevalence estimates.
Article
Biochemistry & Molecular Biology
Sandrine Joly, Lea Rodriguez, Vincent Pernet
Summary: The study found that in aging mice, the amyloidogenic and nonamyloidogenic pathways are not involved in visual function decline, and retinal neurons do not have the capacity to secrete A beta like other cortical and hippocampal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ye (Flora) Wang, Nick Bellissimo, David D. Kitts, Huguette Turgeon O'Brien, W. L. David Ma, Miyoung Suh, Bohdan Luhovyy, Chiara DiAngelo, Laura Pasut, Sandra Marsden, Mei Chung, Anil Gurcan
Summary: The study found that Canadian nutrition-major undergraduates performed better than elective nutrition students in carbohydrate knowledge, but there was no significant difference in sugars-related knowledge. Internet was the main source of nutrition information for students, with a majority coming from online sources with no qualifiers, and a quarter from social media.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2021)
Article
Cell Biology
Simone C. da Silva Rosa, Matthew D. Martens, Jared T. Field, Lucas Nguyen, Stephanie M. Kereliuk, Yan Hai, Donald Chapman, William Diehl-Jones, Michel Aliani, Adrian R. West, James Thliveris, Saeid Ghavami, Christof Rampitsch, Vernon W. Dolinsky, Joseph W. Gordon
Summary: Lipotoxicity causes cellular stress, mitochondrial dysfunction, and insulin resistance; a high-fat diet leads to reduced expression of autophagy-related genes and altered fatty acyl composition; BNIP3L-induced mitophagy and impaired glucose uptake can be reversed by direct phosphorylation of BNIP3L by PRKA/PKA.
Article
Neurosciences
Shoug Alashmali, Chelsey Walchuk, Chris Cadonic, Benedict C. Albensi, Michel Aliani, Miyoung Suh
Summary: Choline supplementation during gestation has benefits for spatial memory but minor contributions to retina function. Larger sample size studies are needed to confirm the essentiality of choline for retina development.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Erin Goldberg, Shiva Ievari-Shariati, Biniam Kidane, Julian Kim, Shantanu Banerji, Gefei Qing, Sadeesh Srinathan, Leigh Murphy, Michel Aliani
Summary: Metabolomics analysis was conducted on blood samples from 42 patients undergoing surgery for suspected lung cancer, revealing the impact of collection tube, sex, and blood location on 96 metabolites. It is recommended to collect replicate blood samples in different types of collection tubes for a broader analysis of the metabolome. Several metabolites were found at higher concentrations in cancer patients, which could potentially be used for early detection and monitoring of the disease.
Article
Nutrition & Dietetics
Le Wang, Erin M. Goldberg, Carla G. Taylor, Peter Zahradka, Michel Aliani
Summary: In this study, a metabolomics approach was used to investigate the impact of consuming bean-rich diets on individuals with PAD. The results showed significant changes in the metabolomic profile, particularly in the levels of prostaglandins and glutathione. The study also revealed potential diet-drug interactions, as the consumption of beans modified the metabolism of metoprolol and metformin.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Neurosciences
Yidi Wang, Bradley A. Feltham, Xavier L. Louis, Michael N. A. Eskin, Miyoung Suh
Summary: This study examines the impact of maternal nutrition on Ceramide concentrations in the brain of rat pups exposed to ethanol during gestation. The results show that a formulated semi-purified energy dense diet can decrease Cer concentrations in the hippocampus of pups born to dams fed a standard chow, indicating the potential of maternal nutrition to prevent the adverse effects of prenatal ethanol exposure.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Food Science & Technology
Chelsey Walchuk, James D. House, Michel Aliani, Miyoung Suh
Summary: The study aimed to investigate the effects of consuming lutein and DHA enriched eggs on visual function in older adults at risk of age-related eye disease. The results showed that daily consumption of these enriched eggs significantly improved retinal function and increased plasma DHA levels. Plasma lipids and lipoprotein subfractions remained unchanged, except for an increase in large HDL particles and a decrease in intermediate sized HDL particles.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Arun Surendran, Negar Atefi, Hannah Zhang, Michel Aliani, Amir Ravandi
Summary: Metabolomics as an emerging platform technology offers new insights into the pathomechanisms of complex diseases like cardiovascular diseases, and holds immense potential for biomarker discovery and understanding disease progression. In the context of ACS, metabolomics studies have identified metabolomic signatures associated with disease progression, providing valuable mechanistic insights and potential biomarkers.
Article
Multidisciplinary Sciences
Glen Lester Sequiera, Abhay Srivastava, Niketa Sareen, Weiang Yan, Keshav Narayan Alagarsamy, Elika Verma, Mohamad Reza Aghanoori, Michel Aliani, Ashok Kumar, Paul Fernyhough, Cheryl Rockman-Greenberg, Sanjiv Dhingra
Summary: This study reports the use of an iPSC-based platform to assess drug efficacy and validate personalized treatments for a patient with an ultrarare disease. The results demonstrate the potential of this platform in aiding decision-making for future clinical trials.
Article
Oncology
Naseer Ahmed, Biniam Kidane, Le Wang, Zoann Nugent, Nataliya Moldovan, April McElrea, Shiva Shariati-Ievari, Gefei Qing, Lawrence Tan, Gordon Buduhan, Sadeesh K. Srinathan, Renelle Meyers, Michel Aliani
Summary: In this pilot study, metabolic alterations in sputum and breath condensate of early-stage lung cancer patients before and after surgery were analyzed. The results suggest that these metabolic changes could serve as noninvasive diagnostic tools for early detection of lung cancer and potential targets for treatment response and drug discovery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Food Science & Technology
Ronak Fahmi, Heather Blewett, Jo-Ann Stebbing, Nancy Olson, Donna Ryland, Michel Aliani
Summary: This study found that fortifying white pan bread with split yellow pea flour can improve postprandial glucose response and increase satiety. The heat processing of pea flour did not significantly affect the postprandial effects. The addition of pea flour can enhance fullness and reduce hunger, desire to eat, and prospective food consumption ratings without affecting the overall acceptability of the bread.
Article
Biochemistry & Molecular Biology
Danielle Defries, Kayla Curtis, Jay C. Petkau, Shiva Shariati-Ievari, Heather Blewett, Michel Aliani
Summary: After treatment with ALA, the incorporation of ALA into phospholipids is selective, with certain molecular species of phospholipids increasing almost immediately while others only increasing after several hours.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Oncology
Julian O. Kim, Robert Balshaw, Connel Trevena, Shantanu Banerji, Leigh Murphy, David Dawe, Lawrence Tan, Sadeesh Srinathan, Gordon Buduhan, Biniam Kidane, Gefei Qing, Michael Domaratzki, Michel Aliani
Summary: This study explored the potential of metabolomics for biofluid-based lung cancer detection. Plasma samples from early-stage non-small cell lung cancer (ES-NSCLC) cases and cancer-free controls (CFC) were analyzed using ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. The study identified clusters of metabolites that effectively classified cases from controls and identified several metabolites of interest for further analysis. Plasma-based metabolomics shows promise for the noninvasive detection of early-stage NSCLC, with further research needed to develop targeted detection methods.
CANCER & METABOLISM
(2022)
Article
Plant Sciences
Pankaj Bhowmik, Wei Yan, Connor Hodgins, Brittany Polley, Tom Warkentin, Michael Nickerson, Dae-Kyun Ro, Frederic Marsolais, Claire Domoney, Shiva Shariati-Ievari, Michel Aliani
Summary: Although pulses are nutritious, their consumption and use in the food industry have been limited due to the formation of unappealing flavors/aromas. This study focused on the role of lipoxygenase (LOX) enzymes in pulse seeds, which can lead to the formation of specific volatile organic compounds (VOCs). The results demonstrate the potential of CRISPR-mediated gene editing to improve the aroma and fatty acid profiles of pulse seeds.
FRONTIERS IN PLANT SCIENCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Arun Surendran, Umar Ismail, Negar Atefi, Ashim Bagchi, Pawan Singal, Ashish H. Shah, Michel Aliani, Amir Ravandi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)