Article
Cell Biology
Tingting Song, Wusa Qin, Zeliang Lai, Haoyu Li, Daihan Li, Baojia Wang, Wuquan Deng, Tingzhang Wang, Liming Wang, Rui Huang
Summary: In this study, the researchers found that a protein-rich diet reduced body fat storage in fruit flies by increasing the production of the neuropeptide FMRFamide. The enhanced FMRFamide activity led to increased energy expenditure, decreased food intake, and promoted lipolysis. The researchers also demonstrated that the dietary cysteine worked in a similar way in mice via neuropeptide FF signaling. Additionally, the administration of dietary cysteine or FMRFa/NPFF showed protective effects against metabolic stress without causing behavioral abnormalities.
Article
Multidisciplinary Sciences
Larissa de Brito Medeiros, Susana Paula Almeida Alves, Rui Jose Branquinho de Bessa, Juliana Kessia Barbosa Soares, Camila Neves Meireles Costa, Jailane de Souza Aquino, Gerlane Coelho Bernardo Guerra, Daline Fernandes de Souza Araujo, Lydiane Tavares Toscano, Alexandre Sergio Silva, Adriano Francisco Alves, Mateus Lacerda Pereira Lemos, Wydemberg Jose de Araujo, Ariosvaldo Nunes de Medeiros, Celso Jose Bruno de Oliveira, Rita de Cassia Ramos do Egypto Queiroga
Summary: This study demonstrates that naturally and industrially produced trans-fatty acids have distinct effects on metabolic parameters and gut microbiota of rats. Industrial trans-fatty acids intake resulted in reduced triglycerides and VLDL levels, while natural trans-fatty acids intake showed hepatoprotective effects and increased anti-inflammatory cytokine IL-10 levels. Additionally, the gut microbiota composition was significantly different among the dietary groups.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Valerie L. Darcey, Juen Guo, Amber B. Courville, Isabelle Gallagher, Jason A. Avery, W. Kyle Simmons, John E. Ingeholm, Peter Herscovitch, Alex Martin, Kevin D. Hall
Summary: This study found that reducing dietary fat, but not carbohydrates, decreased dopamine D2/3 receptor binding potential and neural activity in brain-reward regions, resulting in a shift towards high-fat high-carbohydrate food choices. These results suggest that dietary fat restriction may increase dopamine levels in reward regions, affecting diet adherence.
Article
Nutrition & Dietetics
Anja M. Sedlmeier, Sebastian E. Baumeister, Andrea Weber, Beate Fischer, Barbara Thorand, Till Ittermann, Marcus Doerr, Stephan B. Felix, Henry Voelzke, Annette Peters, Michael F. Leitzmann
Summary: The study indicates that fat mass and fat-free mass show opposing associations with mortality risk. Excess fat mass is related to increased mortality risk, while fat-free mass is protective against mortality risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Neurosciences
Kye-Yeung Park, Ga Eun Nam, Kyungdo Han, Hoon-Ki Park, Hwan-Sik Hwang
Summary: This study found that there is a positive association between waist circumference and the risk of Parkinson's disease (PD) incidence, suggesting that increased waist circumference is associated with an increased risk of PD. The risk of PD incidence also tends to elevate as waist circumference increases. Individuals with abdominal obesity were significantly associated with an increased PD risk.
NPJ PARKINSONS DISEASE
(2022)
Article
Gastroenterology & Hepatology
Priya Sumithran
Summary: Both humans and animals regulate body weight and fat through compensatory adjustments in energy intake and expenditure, implying the importance of addressing physiological changes in obesity treatments. People with obesity who have lost weight through caloric restriction and maintain a lower body weight are likely to experience lower energy expenditure, increased hunger and desire to eat, and a greater propensity to store fat. Strategies that address these physiological changes are expected to improve the long-term success of obesity treatments.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2023)
Article
Multidisciplinary Sciences
Barbara Lisowska-Myjak, Hanna Zborowska, Slawomir Bialek, Piotr Wroczynski, Marek Kuch, Ewa Skarzyzska
Summary: Investigating the association between serum thyroid hormone levels, triglyceride concentrations, and anthropometric parameters in young women, this study found that thyroid function is not related to body mass index (BMI) in healthy young women, but serum thyroid hormone levels are higher in overweight individuals. Moreover, the correlation between thyroid hormones and triglycerides differs in underweight and normal-weight women.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Ruth Owen, Emily R. Thompson, Samuel J. Tingle, Ibrahim K. Ibrahim, Derek M. Manas, Steve A. White, Colin H. Wilson
Summary: This study investigated the impact of recipient BMI on graft outcomes after pancreas transplantation. It was found that increasing recipient BMI had a significant impact on graft survival, especially for recipients on dialysis with a BMI >30 kg/m(2). However, a specific cutoff value for BMI that could predict outcomes accurately was not identified.
Article
Endocrinology & Metabolism
Yuyan Zhu, Sora Q. Kim, Yuan Zhang, Qing Liu, Kee-Hong Kim
Summary: The study demonstrated that the ACAT inhibitor avasimibe significantly reduced body weight, body fat content, and food intake, while increasing energy expenditure in obese mice. Avasimibe also improved glucose tolerance and insulin levels, and the weight loss effect was mainly attributed to the reduction of food intake.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Nutrition & Dietetics
Elena Lopez-Gonzales, Lisa Lehmann, Francisco Javier Ruiz-Ojeda, Rene Hernandez-Bautista, Irem Altun, Yasuhiro Onogi, Ahmed Elagamy Khalil, Xue Liu, Andreas Israel, Siegfried Ussar
Summary: Weight regain after fasting is a common issue in obesity treatment. Supplementing with L-serine can reduce weight regain and increase energy expenditure, which addresses a major problem in current obesity therapies.
Review
Food Science & Technology
Chandana Deekshith, Markandeya Jois, Jessica Radcliffe, Jency Thomas
Summary: This article systematically reviewed literature on the effects of culinary herbs and spices on obesity in adults, finding eight herbs/spices to be beneficial in regards to obesity, with significant improvements in BMI, weight, and waist circumference.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Endocrinology & Metabolism
Manuel Delpero, Danny Arends, Maximilian Sprechert, Florian Krause, Oliver Kluth, Annette Schuermann, Gudrun A. Brockmann, Deike Hesse
Summary: The study aimed to identify genetic variants associated with impaired glucose metabolism using obese lines BFMI861-S1 and BFMI861-S2. QTL mapping revealed overlapping QTL for gonadal adipose tissue weight and blood glucose concentration on Chr 3 and Chr 17, with additional QTL detected on Chr 15 and Chr 16. The study provided evidence for direct and indirect genetic effects on blood glucose concentration in the insulin-resistant mouse line BFMI861-S1.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Endocrinology & Metabolism
Xinru Huang, Mingjie Li, Yefei Shi, Hongyun Yao, Zhijun Lei, Wenxin Kou, Bo Li, Jiayun Shi, Weiwei Zhang, Weixia Jian
Summary: During the COVID-19 pandemic, there was a significant increase in the number of individuals participating in self-monitored weight loss, with women being the majority. Many overweight and obese individuals achieved their weight loss goals using smart body fat scales. The effectiveness of weight loss and fat loss was greater in the obese population compared to the overweight population.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Farah J. Alsharif, Yara A. Almuhtadi
Summary: With the global prevalence of obesity increasing dramatically, it has become a serious public health threat associated with comorbid conditions and psychological disorders. While lifestyle interventions and dietary adjustments may help with weight loss, maintaining these changes long-term can be challenging. Spices like turmeric, ginger, and pepper have shown promise in obesity management, with curcumin in particular gaining interest for its health benefits. Studies have shown potential favorable effects of curcumin supplementation on anthropometric indices, warranting further investigation for overweight or obese adults.
Article
Clinical Neurology
Antonia M. Werner, Mareike Ernst, Elmar Braehler, Ana N. Tibubos, Danielle Otten, Iris Reiner, Joerg Wiltink, Matthias Michal, Andreas Schulz, Philipp S. Wild, Thomas Muenzel, Jochem Koenig, Karl J. Lackner, Norbert Pfeiffer, Manfred E. Beutel
Summary: This study aimed to investigate the impact of depressive symptoms on bodyweight change in adults and its association with other psychosocial and biomedical factors. The results showed that depressive symptoms were associated with weight gain, while factors such as female gender, younger age, lower socioeconomic status, and smoking cessation were also associated with weight gain. In terms of weight loss, depressive symptoms did not have a significant effect, but factors such as female gender, diabetes, less physical activity, and higher BMI at baseline were associated with weight loss.
JOURNAL OF AFFECTIVE DISORDERS
(2023)