Standard dosing of piperacillin and meropenem fail to achieve adequate plasma concentrations in ICU patients

Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis. A Meta-analysis of Individual Patient Data from Randomized Trials

(2016) Jason A. Roberts et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis

(2016) Mohd H. Abdul-Aziz et al.   INTENSIVE CARE MEDICINE

Effect of obesity on the pharmacokinetics of antimicrobials in critically ill patients: A structured review

(2016) Abdulaziz S. Alobaid et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current  -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

(2014) J. A. Roberts et al.   CLINICAL INFECTIOUS DISEASES

Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour

(2014) Ricard Ferrer et al.   CRITICAL CARE MEDICINE

Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients

(2014) Jan J. De Waele et al.   INTENSIVE CARE MEDICINE

Prolonged infusion versus intermittent boluses of β-lactam antibiotics for treatment of acute infections: a meta-analysis

(2014) Jocelyn Teo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versusserum creatinine

(2014) Pierre Delanaye et al.   BMC Nephrology

Augmented Renal Clearance in the ICU

(2013) Andrew A. Udy et al.   CRITICAL CARE MEDICINE

Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial

(2013) Jan J. De Waele et al.   INTENSIVE CARE MEDICINE

β-Lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: A structured review

(2012) Mahipal G Sinnollareddy et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Continuous beta-lactam infusion in critically ill patients: the clinical evidence

(2012) Mohd H Abdul-Aziz et al.   Annals of Intensive Care

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

(2011) Andrew A. Udy et al.   CHEST

Rapid detection of acute kidney injury by plasma cystatin C in the intensive care unit

(2010) M. Nejat et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

(2009) Anand Kumar et al.   CHEST

Piperacillin penetration into tissue of critically ill patients with sepsis—Bolus versus continuous administration?

(2009) Jason A. Roberts et al.   CRITICAL CARE MEDICINE

Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion

(2009) Leonardo Lorente et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

(2009) Jason A. Roberts et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

(2008) Peggy S. McKinnon et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS