Article
Chemistry, Multidisciplinary
Shannon E. Creegan, Matthias Zeller, Edward F. C. Byrd, Davin G. Piercey
Summary: 3,5-Diamino-6-nitro-1,2,4-triazine (DANT) was identified as a potentially insensitive energetic material with high symmetry and planar geometry. The generation of this energetic material was achieved by reduction and oxidation reactions. DANT and DANTX were characterized using various analytical methods, and their structures and properties were determined.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Neurosciences
Paul S. Buckmaster, Bianca Reyes, Tahsin Kahn, Megan Wyeth
Summary: This study evaluated seizure initiation zones in rats with temporal lobe epilepsy and found that the ventral hippocampal formation is the primary bilateral epileptogenic zone, while the dorsal hippocampus is a secondary epileptogenic zone. These findings are consistent with human patients and validate the use of LFP (local field potential) method for identifying seizure onset zones.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Silvia Regina Bica Kohek, Maira Licia Foresti, Miriam Marcela Blanco, Clarissa Fantin Cavarsan, Clivandir Severino da Silva, Luiz E. Mello
Summary: Anxiety and epilepsy have a complex bidirectional relationship, where a depressive/anxious condition can trigger seizures and vice versa. Different anxious profiles may influence epileptogenesis, with differences in anxiety interfering with findings in some brain regions. Additionally, animals that do not develop status epilepticus after pilocarpine injection show behavioral and neuroanatomical alterations, indicating its importance in studying the heterogeneity of epileptogenic response.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Julia Taube, Gulsah Aydin, Inja Ilic, Matthias Schneider, Patrick Schuss, Erdem Guresir, Albert Becker, Christoph Helmstaedter, Christian E. Elger, Hartmut Vatter
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy, and about 30% of patients have drug-resistant seizures. This study evaluated the seizure outcomes of patients with drug-refractory TLE who underwent resective temporal lobe surgery (rTLS), finding that the lack of MRI lesions and placement of depth electrodes before surgery were associated with unfavorable postsurgical seizure outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Article
Chemistry, Organic
Yushi Tan, Wu Xuekun, Ya-Ping Han, Yuecheng Zhang, Hong-Yu Zhang, Jiquan Zhao
Summary: An efficient and convenient method for synthesizing 6-oxyalkylated 1,2,4-triazine-3,5(2H, 4H)-diones has been developed using a visible-light-induced cross-dehydrogenative coupling reaction. This reaction allows for a wide range of functional groups and uses a cheap and low-toxic photocatalyst and air as an oxidant. Additionally, the reaction can be driven by sunlight as a clean energy resource and has demonstrated utility in gram-scale reactions and the synthesis of key intermediates for bioactive molecules.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Geriatrics & Gerontology
Yilin Wang, Penghu Wei, Feng Yan, Yumin Luo, Guoguang Zhao
Summary: Epilepsy is a serious neurological disorder that can cause brain damage, and animal models help understand the mechanisms of epilepsy and select treatment drugs.
Review
Clinical Neurology
Carmen Barba, Sabrina Giometto, Ersilia Lucenteforte, Simona Pellacani, Giulia Matta, Alessandra Bettiol, Sara Minghetti, Lavinia Falorni, Federico Melani, Gianpiero Di Giacomo, Flavio Giordano, Salvatore De Masi, Renzo Guerrini
Summary: The efficacy of temporal lobe epilepsy (TLE) surgery varies between children and adults, with higher seizure freedom rates observed in children. Histopathology and surgical approach have an impact on seizure outcome, with age being an important variable.
Review
Clinical Neurology
Ali A. Asadi-Pooya, Amir Tajbakhsh, Amir Savardashtaki
Summary: This review systematically examined the potential applications of microRNAs as biomarkers in drug-resistant temporal lobe epilepsy. While three studies provided some evidence, challenges remain before microRNAs can be translated into clinical practice for the diagnosis of drug-resistant TLE.
NEUROLOGICAL SCIENCES
(2021)
Article
Thermodynamics
Andrey Kustov, Nataliya L. Smirnova, Tatyana Kustova
Summary: This paper focuses on the thermodynamics of transfer of DAPT from water to liquid 1-octanol, examining the enthalpic and entropic contributions to the process. The calculated results accurately predict the behavior of 1,2,4-triazole derivatives within the physiological temperature range.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Medicine, General & Internal
Sung-Min You, Baek-Hwan Cho, Hyo-Eun Bae, Young-Kyun Kim, Jae-Rim Kim, Soo-Ryun Park, Young-Min Shon, Dae-Won Seo, In-Young Kim
Summary: The impact of epilepsy on cardiovascular function and autonomic regulation, particularly heart-rate variability (HRV), is complex and may contribute to sudden unexpected death in epilepsy (SUDEP). A retrospective study analyzed data from 75 patients with temporal lobe epilepsy to investigate the influence of various factors on HRV indices during different seizure intervals. Significant differences in HRV indices were observed based on hemispheric laterality, language dominancy, hippocampal atrophy, amygdala enlargement, sustained theta activity, and seizure frequency. This study suggests a potential relationship between HRV and the risk of SUDEP.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Michael Moir, Samuel Lane, Andrew P. Montgomery, David Hibbs, Mark Connor, Michael Kassiou
Summary: The development of selective CB2 receptor agonists is a promising therapeutic approach for inflammatory diseases. Through structure-activity relationship studies, a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine agonist has been discovered, with key structural features of the linkage group being important for its activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Clinical Neurology
Austin Gamblin, Vance L. Fredrickson, Todd C. Hollon, Karen L. Salzman, William T. Couldwell
Summary: Herniation of the parahippocampal gyrus is rare without known risk factors and is usually caused by intracranial pressure differentials. This case report discusses a patient with a long history of seizures who was found to have chronic mesial temporal lobe herniation on MRI, despite lacking risk factors for cerebral herniation. Accurate radiographic identification of the condition likely prevented unnecessary surgery or biopsy, allowing the patient to receive appropriate conservative care.
ACTA NEUROCHIRURGICA
(2021)
Article
Behavioral Sciences
Ali A. Asadi-Pooya, Mohsen Farazdaghi
Summary: By applying Two-Step cluster analysis on a cohort of patients with temporal lobe epilepsy, it was found that there are two distinct clusters of patients with different seizure outcomes based on their clinical characteristics. These findings can be used to develop a practical outcome prediction tool for patients with temporal lobe epilepsy.
EPILEPSY & BEHAVIOR
(2022)
Article
Health Care Sciences & Services
Sung Chul Lim, Juhee Oh, Bo Young Hong, Seong Hoon Lim
Summary: Temporal lobe epilepsy (TLE) is a network disorder of the brain, characterized by hippocampal dysfunction. This study found significant changes in the volumes of the amygdala, hippocampus, and thalamus in patients with left TLE and hippocampal sclerosis (HS), while no abnormal diffusion properties associated with volume reduction were found in specific brain regions of patients with right TLE and HS.
Article
Chemistry, Physical
Rohit Pal, Md Jawaid Akhtar, Khadga Raj, Shamsher Singh, Priyanka Sharma, Sourav Kalra, Pooja A. Chawla, Bhupinder Kumar
Summary: A new series of N-(5,6-diphenyl-1,2,4-triazin-3-yl)-2-(4-substituted piperazin-1-yl) acetamide (RP1-5) and 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-1-(4-substituted piperazin1-yl)-ethan-1-one (RP6-10) derivatives were designed and synthesized. Two compounds (RP4 and RP5) exhibited the most potent anticonvulsant activity and significant antidepressant activity in mice models.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Critical Care Medicine
Martin Pohland, Robert Glumm, Luminita Stoenica, Markus Hoeltje, Juergen Kiwit, Gudrun Ahnert-Hilger, Ulf Strauss, Anja U. Braeuer, Friedemann Paul, Jana Glumm
JOURNAL OF NEUROTRAUMA
(2015)
Article
Biochemistry & Molecular Biology
S. Schuster, M. Rivalan, U. Strauss, L. Stoenica, T. Trimbuch, N. Rademacher, S. Parthasarathy, D. Lajko, C. Rosenmund, S. A. Shoichet, Y. Winter, V. Tarabykin, M. Rosario
MOLECULAR PSYCHIATRY
(2015)
Article
Cell Biology
Lennart Barthel, Olivia Reetz, Ulf Strauss
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2016)
Article
Neurosciences
Johannes Vogt, Sergei Kirischuk, Petr Unichenko, Leslie Schlueter, Assunta Pelosi, Heiko Endle, Jenq-Wei Yang, Nikolai Schmarowski, Jin Cheng, Carine Thalman, Ulf Strauss, Alexey Prokudin, B. Suman Bharati, Junken Aoki, Jerold Chun, Beat Lutz, Heiko J. Luhmann, Robert Nitsch
Article
Neurosciences
Tanja Velmans, Arne Battefeld, Beate Geist, Anna Soriguera Farres, Ulf Strauss, Anja U. Braeuer
Article
Cell Biology
Olivia Reetz, Ulf Strauss
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2013)
Article
Neurosciences
Konstantin Stadler, Claudia Bierwirth, Luminita Stoenica, Arne Battefeld, Olivia Reetz, Eilhard Mix, Sebastian Schuchmann, Tanja Velmans, Karen Rosenberger, Anja U. Braeuer, Seija Lehnardt, Robert Nitsch, Matthias Budt, Thorsten Wolff, Maarten H. P. Kole, Ulf Strauss
Article
Developmental Biology
Luminita Stoenica, Wiebke Wilkars, Arne Battefeld, Konstantin Stadler, Roland Bender, Ulf Strauss
DEVELOPMENTAL NEUROBIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Pierluca Coiro, Luminita Stoenica, Ulf Strauss, Anja Ursula Braeuer
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Immunology
Olivia Reetz, Konstantin Stadler, Ulf Strauss
JOURNAL OF NEUROINFLAMMATION
(2014)
Article
Neurosciences
Sami Zaqout, Kathrin Blaesius, Yuan-Ju Wu, Stefanie Ott, Nadine Kraemer, Lena-Luise Becker, Marta Rosario, Christian Rosenmund, Ulf Strauss, Angela M. Kaindl
NEUROBIOLOGY OF DISEASE
(2019)
Article
Immunology
Gabriel M. S. Janach, Olivia Reetz, Noah Doehne, Konstantin Stadler, Sabine Grosser, Egor Byvaltcev, Anja U. Braeuer, Ulf Strauss
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Multidisciplinary Sciences
Peter Wust, Benedikt Kortuem, Ulf Strauss, Jacek Nadobny, Sebastian Zschaeck, Marcus Beck, Ulrike Stein, Pirus Ghadjar
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Gabriel M. S. Janach, Maximilian Boehm, Noah Doehne, Ha-Rang Kim, Marta Rosario, Ulf Strauss
Summary: IFN-gamma plays an important role in the central nervous system, enhancing the regulation of GABA(A)R and impacting neocortical function and behavior.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.