期刊
NEURON
卷 101, 期 4, 页码 738-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2018.12.022
关键词
-
资金
- Bloomington Drosophila Stock Center (NIH grant) [P40OD018537]
- National Institute of General Medicine [F32 GM113318]
- National Institute of Neurological Disorders and Strokes [T32-NS007292]
- National Institute on Deafness and Other Communication Disorders [F31 DC015155]
- Swiss National Science Foundation [P2FRP3_168480]
- European Research Council [205202, 615094]
- National Institute of General Medical Sciences [R01 GM083122, P01 GM103770]
- National Institute of Allergy and Infectious Diseases [R01 AI122802]
- Swiss National Science Foundation (SNF) [P2FRP3_168480] Funding Source: Swiss National Science Foundation (SNF)
Thermosensation is critical for avoiding thermal extremes and regulating body temperature. While thermosensors activated by noxious temperatures respond to hot or cold, many innocuous thermosensors exhibit robust baseline activity and lack discrete temperature thresholds, suggesting they are not simply warm and cool detectors. Here, we investigate how the aristal Cold Cells encode innocuous temperatures in Drosophila. We find they are not cold sensors but cooling-activated and warming-inhibited phasic thermosensors that operate similarly at warm and cool temperatures; we propose renaming them Cooling Cells.'' Unexpectedly, Cooling Cell thermosensing does not require the previously reported Brivido Transient Receptor Potential (TRP) channels. Instead, three Ionotropic Receptors (IRs), IR21a, IR25a, and IR93a, specify both the unique structure of Cooling Cell cilia endings and their thermosensitivity. Behaviorally, Cooling Cells promote both warm and cool avoidance. These findings reveal a morphogenetic role for IRs and demonstrate the central role of phasic thermosensing in innocuous thermosensation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据