期刊
NATURE REVIEWS MICROBIOLOGY
卷 17, 期 3, 页码 131-139出版社
NATURE PORTFOLIO
DOI: 10.1038/s41579-018-0134-9
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资金
- National Key Research and Development Project of China [2016YFD0500304, 2018ZX09711003, 2017FYC1200800, 2017ZX10104001-006]
- National Natural Science Foundation of China [31770190, U1702282, 81661148054, 81621005, 81522025]
- Newton Advanced Fellowship from the UK Academy of Medical Sciences
- Taishan Scholar programme of Shandong province [ts201511056]
Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic, with mild and self-limiting symptoms. The large-scale ZIKV epidemics in the Americas and the unexpected uncovering of a link to congenital birth defects escalated ZIKV infections to the status of a global public health emergency. Recent studies that combined reverse genetics with modelling in multiple systems have provided evidence that ZIKV has acquired additional amino acid substitutions at the same time as congenital Zika syndrome and other birth defects were detected. In this Progress article, we summarize the evolution of ZIKV during its spread from Asia to the Americas and discuss potential links to pathogenesis.
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