Article
Chemistry, Multidisciplinary
Lisa Schlichter, Florian Bosse, Bonnie J. J. Tyler, Heinrich F. F. Arlinghaus, Bart Jan Ravoo
Summary: Nanoparticles with unique properties are patterned onto unmodified silicon substrates using dip pen nanolithography. Different types of nanoparticles can be used for writing nanostructures, including hydrophilic citrate and cyclodextrin functionalized gold nanoparticles and poly(acrylic) acid decorated magnetite nanoparticles. The deposition process is fast and can be done within 0.1 s. The resulting feature sizes range from 300 to 1780 nm and the heights of the deposited structures correspond to a single or double layer of nanoparticles. Dip pen nanolithography offers a versatile method for patterning nanoparticles on silicon substrates.
Article
Materials Science, Multidisciplinary
Guoqiang Liu, Mingming Rong, Hong Hu, Lina Chen, Zhuang Xie, Zijian Zheng
Summary: Dip-pen nanolithography has been developed to enable microscale 3D printing capability by designing specific ink, and can generate arbitrary 3D structures. This development will arouse interest in fundamental research and practical applications in the field.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Nanoscience & Nanotechnology
Verda Saygin, Bowen Xu, Sean B. Andersson, Keith A. Brown
Summary: This study presents a closed-loop method for patterning liquid samples at nanoscale using scanning probe lithography, achieving high accuracy and precision through the use of tipless scanning probes and a novel two-harmonic inertial sensing scheme. By combining fluid mechanics-based iterative control, real-time closed-loop control over patterning is achieved, making scanning probe lithography of liquids a promising candidate for nanoscale manipulation of liquids in high-throughput chemistry.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Verda Saygin, Sean B. Andersson, Keith A. Brown
Summary: This article introduces a novel method for programmable nanopatterning of liquid features at the fg-scale using ultrafast atomic force microscopy probes, spherical tips, and inertial mass sensing. It is found that sphere-tipped ultrafast probes can reliably pattern hundreds of features. Analysis of the changes in vibrational resonance frequency during the process reveals that drift can be removed through systematic correction. The study also shows that the mass of transferred fluid can be modulated by retraction speed and dwell time, and liquid features as small as 6 fg can be patterned and resolved.
Article
Materials Science, Multidisciplinary
Ze-Qi Li, Ping Guo, Yi-Ge Zhou
Summary: Dip-pen nanolithography is a scanning probe lithography technique that can write inks directly on a surface with high resolution. It has enabled a wide range of applications in synthesizing nanomaterials and various other fields over the past two decades.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Chemistry, Multidisciplinary
Sung-Jo Kim, Il-Hyun Lee, Won-Geun Kim, Yoon-Hwae Hwang, Jin-Woo Oh
Summary: This study demonstrates a method to control the shape and optical properties of 3D colloidal assemblies composed of nanoparticles through the evaporation of an ink solution using a nano-fountain pen. The formed assemblies exhibit different surface plasmon resonance spectra depending on the composition and mixing ratio of gold, silver, and platinum nanoparticles. This method has the potential to be a simple and flexible fabrication tool for exploring complex metamaterials.
Article
Materials Science, Ceramics
Hyun Wook Shin, Jong Yeog Son
Summary: In this study, we investigated the ferroelectric domain wall current of BaTiO3 nanodots deposited on Nb-doped SrTiO3 substrates using the dip-pen nano-lithography (DPN) method. The crystallization of deposited BTO nanodots was achieved by heat treatment at 800 degrees C. The ferroelectric domain structures and the formation of domain walls were observed through piezoresponse force microscopy studies. By using a conducting atomic force microscope, relatively large ferroelectric domain wall currents and currents corresponding to the ferroelectric polarization direction around the domain wall were observed.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Ki Hong Park, Jeong-Sik Jo, Jinho Choi, Min Jung Kim, Kwun-Bum Chung, Young Ki Hong, Dong Hyuk Park, Jae-Won Jang
Summary: With the assistance of dip-pen nanolithography (DPN), the electron donor or acceptor behavior of a concentration-adjusted AuCl3 ink on a MoS2 thin-film transistor can be altered. Low concentration AuCl3 ink increases the mobility of MoS2, while high concentration AuCl3 ink decreases the mobility.
APPLIED SURFACE SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Haonan Li, Zhao Wang, Fengwei Huo, Shutao Wang
Summary: Dip-pen nanolithography is a surface modification technique that allows direct and controllable writing of micro/nano-array patterns on diverse substrates. It has shown high sensitivity, excellent selectivity, and fast response in target analyte detection and specific cellular recognition, making it a promising technology for fabricating versatile sensing biochips.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2021)
Article
Physics, Multidisciplinary
Yu Yi-Fei, Cao Yi
Summary: Dip-pen nanolithography (DPN) has achieved great success as a unique nanomanipulation and nanofabrication tool in the past two decades, allowing for the creation of molecular patterns with nanoscale precision on various substrates. Continuous improvements in applicable inks, fabrication throughput, and new printing chemistry have been made, along with the development of new techniques such as thermal-DPN, parallel-DPN, and polymer pen nanolithography. Advances in chemical reaction based DPN technologies, including electrochemical DPN and mechanochemical printing, have also been highlighted.
ACTA PHYSICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Eider Berganza, Mirsana P. Ebrahimkutty, Srivatsan K. Vasantham, Chunting Zhong, Alexander Wunsch, Alexander Navarrete, Milos Galic, Michael Hirtz
Summary: The study introduces a simple and low-cost platform for curvature sensitive protein screening, enabling control over lipid composition and membrane curvature, thus providing a new approach for screening curvature-dependent protein-membrane interaction studies.
Article
Chemistry, Inorganic & Nuclear
Wenjun Du, Lirong Jiang, Shan Jin, Shuang Chen, Manzhou Zhu
Summary: In this study, a chiral superatom complex nanocluster was successfully synthesized and assembled into framework materials with different topologies. These materials exhibited various structures and properties due to strong interactions, and Ag-23-dpbz showed the largest specific surface area and the strongest luminescence signal.
INORGANIC CHEMISTRY
(2022)
Article
Engineering, Environmental
Weifeng Xu, Baihui Wang, Xiaojun Zeng, Kewen Tang
Summary: In this study, four types of amorphous coordination polymers (aCPs) were synthesized using a solvothermal method. These aCPs showed significant selectivity and reusability for the adsorption of Au(III). Among them, Cr-TDBP exhibited the fastest adsorption rate and the highest adsorption capacity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Nicolas Castel, Francois-Xavier Coudert
Summary: This Perspective article reviews and compares the existing methodologies for determining microscopic models of amorphous MOFs, based on experimental data and simulation methods. Several approaches, such as Reverse Monte Carlo and Continuous Random Networks, are introduced.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Vikram V. Karve, Adriana Neves Vieira, Dragos Stoian, Olga Trukhina, Wendy L. Queen
Summary: A new solid-state method was used to incorporate a furan-thiourea polymer into the pores of a MOF, and the catalytic activity of the resulting MOF-polymer composite containing Pd was assessed in the hydrodeoxygenation of vanillin, a biomass-derived chemical.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Karl Ridier, William Nicolazzi, Lionel Salmon, Gabor Molnar, Azzedine Bousseksou
Summary: Molecular spin-crossover (SCO) compounds are a promising class of photoactive materials that exhibit efficient photoinduced phase transitions (PIPT). Through the study of the spatiotemporal dynamics of a single crystal PIPT within the thermodynamic metastability region, it was found that the PIPT occurs through the sequential activation of two switching mechanisms on sub-microsecond and millisecond timescales. The main discovery is that thermodynamic metastability has no influence on the sub-millisecond switching dynamics.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yunhui Yang, Anna Broto-Ribas, Borja Ortin-Rubio, Inhar Imaz, Felipe Gandara, Arnau Carne-Sanchez, Vincent Guillerm, Sergio Jurado, Felix Busque, Judith Juanhuix, Daniel Maspoch
Summary: The study introduces a new synthetic approach called Clip-off Chemistry, which allows for selective bond breaking in reticular materials and is effective in reactions performed in solid or liquid phases. This method opens the door to the programmed disassembly of reticular materials, leading to the design and synthesis of new molecules and materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Xiaoman Mao, Shuang Wu, Pilar Calero-Perez, Ana P. Candiota, Paula Alfonso, Jordi Bruna, Victor J. Yuste, Julia Lorenzo, Fernando Novio, Daniel Ruiz-Molina
Summary: This study reports a new approach for the treatment of glioblastoma, a highly malignant brain tumor, by using a catechol-functionalized Pt(IV) prodrug and intranasal administration. The results show promising therapeutic effects and open up new opportunities in brain tumor treatment.
Article
Chemistry, Physical
Mario Piedrahita-Bello, Yue Zan, Alejandro Enriquez-Cabrera, Gabor Molnar, Bertrand Tondu, Lionel Salmon, Azzedine Bousseksou
Summary: Macroscopic, soft bilayer spin crossover@polymer actuators were fabricated by embedding [Fe(NH(2)trz)(3)]SO4 spin crossover particles in a P(VDF-TrFE) matrix and incorporating silver flakes for electro-thermal actuation. The speed and amplitude of the actuator bending movement, as well as its charge capacity and ability to follow a sinusoidal position, were investigated.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Xiaoman Mao, Pilar Calero-Perez, David Montpeyo, Jordi Bruna, Victor J. Yuste, Ana Paula Candiota, Julia Lorenzo, Fernando Novio, Daniel Ruiz-Molina
Summary: Versatile nanoparticles based on coordination chemistry were developed, which exhibited dual pH- and redox-sensitivity, controlled release, and comparable cytotoxicity to cisplatin. In vivo intranasal administration of these nanoparticles led to increased accumulation of platinum in glioblastoma tumors, resulting in complete cure and prolonged survival in some cases.
Article
Chemistry, Medicinal
Adria Sanchez-Morales, Atilla Bicer, Vasilis Panagiotopoulos, Selma Crecente-Garcia, Cristina Benaiges, Sergi Bayod, Jose Luis Hernandez, Felix Busque, Minos-Timotheos Matsoukas, Merce Perez-Riba, Ramon Alibes
Summary: The Ca2+/calmodulin-mediated phosphatase activity of calcineurin integrates calcium signaling with gene expression programs. In this study, new synthetic compounds were designed and synthesized to inhibit NFATc activity without interfering with CN phosphatase activity. These compounds also showed potential in inhibiting cancer progression.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Gabor Molnar, Azzedine Bousseksou, Damian Paliwoda, Laure Vendier, William Nicolazz
Summary: This study investigated the high-spin to low-spin transitions in two transition metal complexes using high-pressure and low-temperature single-crystal X-ray diffraction, revealing that external pressure can tune the coupling between the two phenomena and change the sequence of transitions. The correlation between spontaneous strain and order parameter behaviors highlights the interconnected nature of separated transitions and the partial split in simultaneous transitions.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sergio Jurado, Beatriz Dominguez-Perez, Ona Illa, Jan Balzarini, Felix Busque, Ramon Alibes
Summary: The enantioselective preparation of the two isomers of 4-hydroxy-2-cyclohexanone derivatives was achieved through asymmetric transfer hydrogenation reactions. A stereoselective route to a cytosine analogue was described, showing selectivity for herpes simplex virus TKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Organic
Sergio Jurado, Ona Illa, Angel Alvarez-Larena, Christophe Pannecouque, Felix Busque, Ramon Alibes
Summary: A synthetic approach for the enantioselective synthesis of carbocyclic nucleoside analogues has been established, resulting in the synthesis of two new families of compounds. These compounds have been tested as antiviral agents and have shown moderate activity against coxsackie B4 virus.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Oncology
Daniel Ruiz-Molina, Xiaoman Mao, Paula Alfonso-Triguero, Julia Lorenzo, Jordi Bruna, Victor J. Yuste, Ana Paula Candiota, Fernando Novio
Summary: Glioblastoma treatment is challenging due to resistance mechanisms and limited drug entry into the central nervous system. Nanoconstructs are being proposed as a promising approach to overcome these obstacles and improve therapeutic outcomes.
Article
Nanoscience & Nanotechnology
Junda Zhang, Daniel Ruiz-Molina, Fernando Novio, Claudio Roscini
Summary: This study introduces a method of photon upconversion (UC) using UC coordination polymer nanoparticles (CPNs) with alkyl spacers to promote amorphous character. The CPNs exhibit high dye density and flexible ratio tunability, leading to highly photostable UC in two different visible spectral regions. The CPNs also show good chemical/colloidal stability in water and have potential applications in anticounterfeiting patterns and luminescent solar concentrators.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Medicinal
Francisca Pinheiro, Irantzu Pallares, Francesca Peccati, Adria Sanchez-Morales, Nathalia Varejao, Filipa Bezerra, David Ortega-Alarcon, Danilo Gonzalez, Marcelo Osorio, Susanna Navarro, Adrian Velazquez-Campoy, Maria Rosario Almeida, David Reverter, Felix Busque, Ramon Alibes, Mariona Sodupe, Salvador Ventura
Summary: This study discovered a series of novel halogenated kinetic stabilizers for transthyretin (TTR) through rational design and molecular dynamics (MD) simulations. Among them, M-23 displayed high affinity for TTR and demonstrated enhanced tetramer stability. The crystal structure confirmed the unprecedented protein-ligand contacts predicted by MD simulations.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Gianni Ciofani, Marco Campisi, Clara Mattu, Roger D. Kamm, Valeria Chiono, Aji Alex Moothedathu Raynold, Joao S. Freitas, Eugenio Redolfi Riva, Silvestro Micera, Carlotta Pucci, Fernando Novio, Julia Lorenzo, Daniel Ruiz-Molina, Giulia Sierri, Francesca Re, Hannah Wunderlich, Prachi Kumari, Kristen L. Kozielski, Mounia Chami, Attilio Marino, Lino Ferreira
Summary: In recent years, significant efforts have been made to address the challenges of treating pathologies in the central nervous system (CNS), due to the presence of the blood-brain barrier. This article presents a roadmap of the latest developments, challenges, and opportunities in this field. The format of the roadmap encourages collaboration among experts across disciplines, emphasizing that it is a forward-looking summary rather than a comprehensive review.
JOURNAL OF PHYSICS-MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Damian Paliwoda, Laure Vendier, Livia Getzner, Frederico Alabarse, Davide Comboni, Baptiste Martin, Seyed Ehsan Alavi, Mario Piedrahita Bello, Lionel Salmon, William Nicolazzi, Gabor Molnar, Azzedine Bousseksou
Summary: Two benchmark Fe(II)-triazole spin-crossover compounds, [Fe(Htrz)2trz]BF4 (1) and [Fe(NH2trz)3]SO4 (2), were investigated using various techniques to evaluate their transformation strain, compressibility, and anisotropy. Elastic softening and mechanical damping were observed during the spin-crossover process in both compounds, suggesting a coupling between spin state and lattice strain. The elastic potential energy, stored elastic work, and frictional work were assessed, providing important insights for understanding the behavior of this compound family and guiding their technological applications.
CRYSTAL GROWTH & DESIGN
(2023)
Review
Chemistry, Multidisciplinary
Paula Alfonso-Triguero, Julia Lorenzo, Ana Paula Candiota, Carles Arus, Daniel Ruiz-Molina, Fernando Novio
Summary: Current therapies for glioblastoma and brain tumours are inefficient and face numerous challenges. Chemotherapy and radiotherapy, along with surgical resection, are currently used as standard treatments. However, these treatments have limited efficacy and patients still face a poor prognosis. To overcome these challenges, researchers have developed and tested various platinum complexes, particularly platinum (IV)-based prodrugs, with the aim of improving anticancer activity. Nanomedicines that encapsulate these platinum-based drugs, cross the blood-brain barrier, and specifically target cancer cells show promise in increasing therapeutic effectiveness and reducing side effects.