期刊
NATURE CHEMICAL BIOLOGY
卷 15, 期 1, 页码 8-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41589-018-0171-8
关键词
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资金
- AMED [JP18gm0910007, JP18am0101079, JP18am0101070]
- JSPS KAKENHI [15J00102]
- Toray Science Foundation
- Takeda Science Foundation
- Naito Foundation
- Koyanagi Foundation
- Grants-in-Aid for Scientific Research [15J00102] Funding Source: KAKEN
Prostanoids are a series of bioactive lipid metabolites that function in an autacoid manner via activation of cognate G-protein-coupled receptors (GPCRs). Here, we report the crystal structure of human prostaglandin (PG) E receptor subtype EP3 bound to endogenous ligand PGE(2) at 2.90 angstrom resolution. The structure reveals important insights into the activation mechanism of prostanoid receptors and provides a molecular basis for the binding modes of endogenous ligands.
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