期刊
ACS NANO
卷 10, 期 8, 页码 7362-7369出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b07950
关键词
protein nanocapsule; degradable polymer; controlled release; bone regeneration; inflammation
类别
资金
- National Nature Science Foundation of China [81402229]
- International Science and Technology Cooperation Program of China [2012DFA51690]
Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules.
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