Article
Medicine, Research & Experimental
Eiji Yuba, Munenobu Takashima, Takaaki Hayashi, Daisuke Kokuryo, Ichio Aoki, Atsushi Harada, Sadahito Aoshima, Uma Maheswari Krishnan, Kenji Kono
Summary: This study aims to enhance the therapeutic effect of liposomes by accumulating doxorubicin-loaded liposomes at high concentrations in and around the tumor, followed by heat trigger drug release to facilitate low-molecular-weight drug penetration throughout the tumor. The targeted thermosensitive liposomes successfully inhibited tumor growth and achieved tumor remission through multiple administrations and heat treatments. Combining tumor neovascular targeting and heat-triggered drug release, these liposomes offer high potential for minimally invasive and effective cancer chemotherapy.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Mohammad Reza Malekpour, Saereh Hosseindoost, Fatemeh Madani, Morteza Kamali, Masood Khosravani, Mahdi Adabi
Summary: This study explores the use of Poly(lactic co-glycolic acid) nanoparticles loaded with Paclitaxel (PTX) and Doxorubicin (DOX) to improve the treatment of glioblastoma tumors. The results show that these nanoparticles enhance cytotoxicity and decrease tumor size. MRI results also demonstrate a longer median survival rate for the combination therapy. Additionally, the combination therapy has a positive effect on rat movement, as indicated by behavioral tests.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Shujing Yue, Yifan Zhang, Yaohua Wei, Rainer Haag, Huanli Sun, Zhiyuan Zhong
Summary: A novel and robust targeted nanodrug, C-P-DM1, was developed for highly potent and stable therapy of EGFR-positive solid tumors. The drug demonstrated strong cytotoxicity in various cancer cell lines and effectively suppressed tumor growth in animal models without toxic effects, showing promising potential for targeted treatment of solid malignancies.
Article
Chemistry, Analytical
Emmanuel Douez, Valentina D'Atri, Davy Guillarme, Daniel Antier, Mathieu Guerriaud, Alain Beck, Herve Watier, Laura Foucault-Fruchard
Summary: Monoclonal antibody (mAb)-based therapies have revolutionized oncology patient care, but their high cost prompted the development of biosimilars as more affordable alternatives. This article focuses on Erbitux® (cetuximab), a monoclonal antibody used for colorectal cancer and head and neck cancer. Despite its patent expiration and profitable sales, Erbitux® has not faced any biosimilar challenges in the US or Europe. The article discusses the complex structure of Erbitux® and the risks associated with demonstrating biosimilarity, as well as the potential of developing Erbitux® biobetters.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Applied
Yue Sun, Ning Zhang, Chang Han, Zhiyang Chen, Xiaodong Zhai, Zhihua Li, Kaiyi Zheng, Jianfei Zhu, Xin Wang, Xiaobo Zou, Xiaowei Huang, Jiyong Shi
Summary: A nitrile-mediated SERS immunosensor was developed for sensitive and optical anti-interference determination of imidacloprid in complex environments. Specific recognition between antigen and antibody enabled the competitive system for imidacloprid detection with high recoveries in real samples.
Article
Engineering, Electrical & Electronic
Amruta D. Bang, Monika Ghalawat, Pankaj Poddar, Sulabha K. Kulkarni, Parag V. Adhyapak
Summary: Breathing is essential for living beings, and the gases in breath can act as biomarkers for health conditions. Therefore, the development of breath sensors is necessary for early and noninvasive disease detection. In this study, a breath sensor using Au nanorods and a nanocomposite with reduced graphene oxide and polyvinylidene fluoride was reported. The nanocomposite system was designed to optimize breath sensing by taking advantage of the humidity sensitivity of Au nanorods, the ferroelectric properties of PVDF, and the high conductivity of rGO. The synthesized materials were characterized using various physiochemical techniques, and the nanocomposite showed high sensitivity towards breath with voltage generation within a short time.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Zongqiang Li, Jingjing Li, Xu Wang, Qianru Li, Jingru Zhu, Yuying Yao, Zhiqiang Guo, Yu Wang, Su Liu, Jiadong Huang
Summary: This study proposes a colorimetric assay method based on DNAzyme-powered AuNR-DNA walker for ultrasensitive detection of E. coli. The method features a target-triggered DNAzyme activation, efficient DNA walking machine, peroxidase-mimicking enzyme formation, and visual color change for E. coli detection. The proposed strategy shows improved sensitivity compared to previous methods and has potential applications in food safety analysis and clinical diagnosis.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Memona Khan, Sarah Boumati, Celia Arib, Amadou Thierno Diallo, Nadia Djaker, Bich-thuy Doan, Jolanda Spadavecchia
Summary: A novel synthesis of doxorubicin loaded bimetallic gold nanorods was designed and formulated in this study. The bimetallic nanoparticles showed high stability, biocompatibility, photothermal abilities, and magnetic features. Cytotoxicity studies demonstrated that DOX IN-Gd-AuNRs had significantly higher efficiency in killing tumor cells compared to free doxorubicin.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Environmental
Dabum Kim, Goomin Gwon, Gangyoon Lee, Youngho Jeon, Ung-Jin Kim, Zeid A. Alothman, Jungmok You
Summary: The study presents a surface-enhanced Raman scattering (SERS)-active array film based on regenerated cellulose hydrogels and gold nanorods, which can efficiently detect multiple analytes with high reproducibility. By controlling the number density and interparticle nanogap, the SERS enhancement effect was achieved, showing great potential for practical applications.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Multidisciplinary Sciences
Christoph Mamot, Andreas Wicki, Ursula Hasler-Strub, Salome Riniker, Qiyu Li, Lisa Holer, Daniela Bartschi, Khalil Zaman, Roger von Moos, Konstantin J. Dedes, Laura A. Boos, Urban Novak, Alexandre Bodmer, Reto Ritschard, Ellen C. Obermann, Alexandar Tzankov, Christoph Ackermann, Veronique Membrez-Antonioli, Ursina Zurrer-Hardi, Clemens B. Caspar, Stefanie Deuster, Martin Senn, Ralph Winterhalder, Christoph Rochlitz
Summary: The study developed a targeted nanocontainer drug for EGFR, which showed some efficacy in treating triple negative breast cancer, but did not significantly improve survival rates for advanced stage patients.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Peter Lin, Terenz Escartin, Melissa Larsen, Matthew Ng, Mengyuan Li, Jennifer Barry, Idan Roifman, Mihaela Pop
Summary: In this study, a novel animal protocol was developed using magnetic resonance imaging and electrophysiology tests to detect subtle structural and functional changes associated with myocardial damage in the early months following chemotherapy. The results revealed key signs of potentially-irreversible tissue changes, including an increase in collagen density, a decline in left ventricle function, and an increased risk of arrhythmia. This study provides important insights for understanding the cardiotoxic effects of chemotherapy and lays the foundation for testing cardioprotective strategies.
APPLIED SCIENCES-BASEL
(2022)
Article
Materials Science, Multidisciplinary
Jiaqi Chen, Xi Lu, Yejun Chen, Jintao Shuai, Jian Gao, Xiaoyang Liu, Wei Feng
Summary: This work regulated the upconversion luminescence performance of UCNPs by coupling with Au nanorod-silicon core-shell nanostructures. The influence of the thickness and surface charge of the silica shell on the energy transfer of UCNPs was explored.
Article
Engineering, Biomedical
Jiaojiao Li, Jihua Wang, Jianye Li, Xin Yang, Jiangling Wan, Chuansheng Zheng, Qing Du, Guofeng Zhou, Xiangliang Yang
Summary: This study developed a novel method for fabricating PVA microspheres encapsulated with in situ synthesized Fe3O4 nanoparticles, which were used as contrast agents for MRI and cross-linkers for PVA matrixes. In vivo evaluations showed that Fe3O4@PVA microspheres had good embolic effect and enhanced MRI capability, with favorable biocompatibility. The DOX-loaded Fe3O4@PVA microspheres demonstrated a sustained drug release profile, indicating their potential for MRI, embolotherapy, and chemotherapy.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
L. Z. Liu, X. Y. Sun, Z. Y. Yan, B. F. Ye
Summary: In this study, a new drug delivery system composed of gold nanorods has been developed for near-infrared light activation, utilizing photothermal heating effect and thermo responsive volume transition for controlled drug release with real-time color indication.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemical Research Methods
Rachel M. Lieser, Emily J. Hartzell, Daniel Yur, Millicent O. Sullivan, Wilfred Chen
Summary: In this study, SpyTag peptide was fused to the surface of engineered E2 nanocages to enable tunable nanocage decoration and effective E2 cell targeting using a variety of SpyCatcher fusion proteins. The core of the E2 nanocage incorporated four phenylalanine mutations for hydrophobic drug loading and pH-responsive release. By functionalizing the nanocage surface with a highly cell-specific EGFR-targeting protein conjugate, efficient drug loading and targeted cell death in inflammatory breast cancer cells were achieved. This engineered protein nanocage construct demonstrates versatility for cargo delivery.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)