Article
Dermatology
Aditya K. Gupta, Helen J. Renaud, Emma M. Quinlan, Neil H. Shear, Vincent Piguet
Summary: Superficial mycoses are increasingly developing resistance to current antifungal medications, particularly to terbinafine. Mix infections and single-point mutations are major factors contributing to this resistance.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Article
Veterinary Sciences
Donya Nikaein, Pegah Yaghuti, Aghil Sharifzadeh, Alireza Khosravi, Asad Balal
Summary: This study investigates the incidence of dermatophytosis among rodents referred to a mycology laboratory during 2019-2021. The results show that 37.4% of rodents were affected by dermatophytosis, with rabbits having the highest prevalence. Microsporum canis was the most commonly isolated agent. Female rabbits were more susceptible, while male guinea pigs and hamsters were more likely to be infected with dermatophytosis. Rodents less than 6 months old were more susceptible to dermatophytosis.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Dermatology
Jason B. B. Pieper, Daniel G. G. Bowden, Darren J. J. Berger, James O. O. Noxon, Sandra L. L. Grable, Karen L. L. Campbell
Summary: This study evaluated the breed prevalence, lesion distribution, and seasonality of the T. mentagrophytes complex in dogs from the central United States. It also assessed the clinical response to newer systemic antifungal drugs. The results showed a higher incidence of infection in the American Kennel Club Sporting and Terrier groups, with clinical signs being most prevalent in October. Muzzle and head were the most commonly affected areas, and ketoconazole, itraconazole, and terbinafine were identified as effective treatment options.
VETERINARY DERMATOLOGY
(2023)
Article
Microbiology
Marina Fratti, Olympia Bontems, Karine Salamin, Emmanuella Guenova, Michel Monod
Summary: Most inflammatory dermatophytoses in humans are caused by zoophilic and geophilic dermatophytes. Knowledge of the epidemiology of these fungi in animals facilitates the prevention of dermatophytosis of animal origin in humans.
Review
Dermatology
Shyam B. Verma, Saumya Panda, Pietro Nenoff, Archana Singal, Shivaprakash M. Rudramurthy, Silke Uhrlass, Anupam Das, Kavita Bisherwal, Dipika Shaw, Resham Vasani
Summary: T. mentagrophytes has become the predominant cause of dermatophytosis in India, with a new Indian genotype being isolated. Traditional diagnostic methods are inadequate, necessitating the use of molecular diagnosis. The rapid shift from T. rubrum to T. mentagrophytes is unprecedented in history.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2021)
Article
Dermatology
Jin-Chul Ahn, Sang Joon Mo, Min Choi, Bora Kim, Sung Bin Cho
Summary: The antifungal effects of 405-nm and 635-nm dual-band diode lasers were evaluated using a guinea pig model of dermatophytosis. The results showed that the laser treatment effectively eliminated fungal infection without noticeable inflammatory reactions.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Dermatology
Junichiro Hiruma, Hiromitsu Noguchi, Midori Hase, Yumie Tokuhisa, Tatsuya Shimizu, Takasuke Ogawa, Masataro Hiruma, Kazutoshi Harada, Rui Kano
Summary: Research investigated TRF-resistant Trichophyton interdigitale and T. rubrum strains isolated from Japanese patients, identifying some TRF-resistant strains and revealing genetic mutations in these strains.
JOURNAL OF DERMATOLOGY
(2021)
Article
Mycology
Xiu-Jiao Xia, Hong Shen, Hui-Lin Zhi, Yan Zhong, Bo Sang, Wen-Wen Lv, Qiu-Ping Li, Ze-Hu Liu
Summary: Deep cutaneous fungal infections, such as deep dermatophytosis, can cause significant morbidity and mortality, particularly in immunocompromised patients. The use of direct microscopy for rapid bedside diagnosis of disseminated deep dermatophytosis has shown promising results. Purulence sampling and direct microscopy can facilitate early diagnosis and prevent disease progression.
Review
Infectious Diseases
Henan Si, Yang Li, Zhiyang Huang, Yan Cui, Shanshan Li
Summary: This article reports a case of erythroderma combined with deeper dermal dermatophytosis in a patient with myasthenia gravis. It highlights the increased risk of developing invasive dermatophytic infections or disseminated fungal infections in immunosuppressed patients with long histories of superficial mycoses. Dermatologists should be alert to this condition and promptly treat superficial dermatophytosis.
BMC INFECTIOUS DISEASES
(2023)
Article
Dermatology
Amit Jain, Suyog Dhamale, Vidyadhar Sardesai
Summary: A study in Pune, India found that factors contributing to difficult to treat dermatophytosis include past history of the disease, use of topical steroids or keratolytic agents, consultation with non-dermatologists, hyperhidrosis, obesity, positive family history, tight clothing, and chronic diseases. Treatment by dermatologists/ trained physicians and increasing public awareness about tinea could help alleviate the current crisis.
Article
Infectious Diseases
Akihiro Nakamura, Satoko Hirakawa, Hiroaki Nagai, Katsuhiro Inagaki
Summary: This study compared the efficacy of two topical antifungal drugs in a guinea pig onychomycosis model infected with Trichophyton mentagrophytes. The results showed that LLCZ has a longer-lasting antifungal effect in the nails of guinea pigs compared to EFCZ.
Article
Biotechnology & Applied Microbiology
Namrata K. Bhosale, R. Prabha, Rajesh Munuswamy, S. Pramodhini, Joshy M. Easow
Summary: Dermatophytosis is a superficial infection caused by a group of fungi called dermatophytes. Identification based on gene sequencing is sensitive and reliable, and can replace traditional phenotypic identification methods. This study compared the performance of two methods in the identification of clinical samples in Puducherry, India.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2022)
Article
Dermatology
Remya Rajamohanan, Renu Raj, Janaki Chellam, Madhu Rengasamy
Summary: This study investigated the epidemiology, clinical types, and factors associated with chronicity in patients with chronic dermatophytosis. The findings showed that extensive area of involvement, atopy, diabetes, and long-term use of systemic corticosteroids were associated with chronicity in these patients. Additionally, the most common etiological agent of chronic dermatophytosis in this study was Trichophyton mentagrophytes.
INDIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Claudia J. Posso-De los Rios, Enas Tadros, Richard C. Summerbell, James A. Scott
Summary: This study presents clinical characteristics, diagnosis, and treatment approach of Canadian patients with superficial mycosis caused by T. indotineae, an antifungal resistant strain. The lack of treatment guidelines for this new strain highlights the importance of providing practical approach and treatment recommendations for clinicians encountering such cases in Canada.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2022)
Article
Pharmacology & Pharmacy
Ali Abdul Hussein S. Al-Janabi, Falah Hasan Obayes Al-Khikani
Summary: The study demonstrated that the prepared vaccine has both prophylactic and therapeutic abilities against Trichophyton mentagrophytes infection, providing protection for over 6 months without the need for adjuvants.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Dermatology
Andreas Ebert, Michel Monod, Karine Salamin, Anke Burmester, Silke Uhrlass, Cornelia Wiegand, Uta-Christina Hipler, Constanze Krueger, Daniela Koch, Franziska Wittig, Shyam B. Verma, Archana Singal, Sanjeev Gupta, Resham Vasani, Abir Saraswat, Rengarajan Madhu, Saumya Panda, Anupam Das, Mahendra M. Kura, Akshy Kumar, Shital Poojary, Sibylle Schirm, Yvonne Graeser, Uwe Paasch, Pietro Nenoff
Article
Dermatology
Jochen Brasch, Vera Beck-Jendroschek, Karin Voss, Alexander Achenbach, Hans-Gerhard Berger, Melanie Harder, Yvonne Graeser, Thomas Schwarz
Summary: This study reports on three cases of Arthroderma (A.) crocatum isolated from human skin in Germany. The characteristics and epidemiology of this geophilic and likely apathogenic dermatophyte are described, emphasizing the importance of a combination of KOH mount, culture, and genetic analysis for clinically meaningful conclusions. The study suggests that the prevalence of A. crocatum may be currently underestimated.
Article
Biotechnology & Applied Microbiology
Susanne Nieland, Susann Barig, Julian Salzmann, Frauke Gehrau, Arief Izzairy Zamani, Annabell Richter, Julia Ibrahim, Yvonne Graeser, Chyan Leong Ng, Klaus-Peter Stahmann
Summary: By comparing different fungi, it was found that Aspergillus fumigatus AR04 had a faster hyphal growth rate at higher temperatures, and could even grow at 49 degrees Celsius. The fungus reached a steady state at a higher dilution rate of 0.7 h(-1) at 40 degrees Celsius compared to other fungi.
MICROBIAL BIOTECHNOLOGY
(2021)
Article
Microbiology
Xue Kong, Chao Tang, Ashutosh Singh, Sarah A. Ahmed, Abdullah M. S. Al-Hatmi, Anuradha Chowdhary, Pietro Nenoff, Yvonne Graser, Steven Hainsworth, Ping Zhan, Jacques F. Meis, Paul E. Verweij, Weida Liu, G. Sybren de Hoog
Summary: A decade-long outbreak of dermatophytosis due to a terbinafine-resistant novel species has spread to several countries, with investigations into the molecular background of the SQLE gene revealing high resistance levels in certain isolates. Antifungal susceptibility tests on isolates from different countries identified three species and highlighted the limited distribution of high terbinafine resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Klaus-Peter Wojak, Gertrud F. Ungermann, Ichsan Ichsan, Emilia Gomez-Molero, Klaus Jung, Michael Weig, Friedemann Nauck, Dirk Ziebolz, Yvonne Graeser, Roland Nau, Uwe Gross, Bernd Alt-Epping, Oliver Bader
Summary: Elderly patients with multiple morbidities or medical treatments are more susceptible to fungal infections, particularly from azole-resistant yeasts like Candida glabrata. Factors such as age and denture-wearing influence the distribution of colonizing fungal species in the oral cavity, with non-albicans Candida species being more common in the elderly.
Article
Dermatology
Jochen Brasch, Yvonne Graeser, Vera Beck-Jendroscheck, Karen Voss, Kaspar Torz, Grit Walther, Thomas Schwarz
Summary: Indian strains of Trichophyton mentagrophytes with reduced susceptibility to itraconazole were found in Germany as early as 2011, earlier than previously assumed. This variant of the pathogen cannot be phenotypically distinguished from customary strains and requires genetic identification. The variant is anthropophilic and may lead to further dissemination.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Jochen Brasch, Yvonne Graeser, Vera Beck-Jendroscheck, Karen Voss, Kaspar Torz, Grit Walther, Thomas Schwarz
Summary: Study reports on Indian strains of Trichophyton mentagrophytes with reduced susceptibility to itraconazole due to genetic mutations in Germany, raising concerns about potential wider spread of this variant and the need for rapid and accurate antifungal testing.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Immunology
Sven-Niklas Burmann, Frank Oellig, Yvonne Graeser, Alena-Lioba Michalowitz, Alexandros Paschos, Alexander Kreuter
Summary: Tinea corporis is a common superficial fungal infection, whereas tinea of the anogenital region is rare and mostly found in tropical countries. A distinctive variant of pubogenital tinea (PT) characterized by deep tissue infiltration and systemic symptoms has been reported, with transmission via sexual contacts hypothesized. In this case report, PT caused by T. quinckeanum experienced a strong inflammatory reaction following successful treatment with itraconazole.
INTERNATIONAL JOURNAL OF STD & AIDS
(2022)
Review
Microbiology
Silke Uhrlass, Shyam B. Verma, Yvonne Graeser, Ali Rezaei-Matehkolaei, Maryam Hatami, Martin Schaller, Pietro Nenoff
Summary: T. indotineae is a newly identified dermatophyte species that has spread in an epidemic form on the Indian subcontinent. It causes inflammatory and itchy dermatophytosis and displays resistance to terbinafine, with itraconazole being the most effective treatment.
Letter
Dermatology
Jochen Brasch, Yvonne Graeser, Katharina Drerup, Karen Voss, Thomas Schwarz
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Pietro Nenoff, Dieter Reinel, Peter Mayser, Dietrich Abeck, Guntram Bezold, Philipp P. Bosshard, Jochen Brasch, Georg Daeschlein, Isaak Effendy, Gabriele Ginter-Hanselmayer, Yvonne Graeser, Gudrun Hamm, Ulrich Hengge, Uta-Christina Hipler, Peter Hoeger, Alexandra Kargl, Annette Kolb-Maeurer, Constanze Krueger, Bartosz Malisiewicz, Johannes Mayer, Hagen Ott, Uwe Paasch, Martin Schaller, Silke Uhrlass, Miriam Zidane
Summary: Onychomycosis is a fungal infection of the fingernails and toenails. The updated German S1 guideline aims to simplify the selection and implementation of appropriate diagnostics and treatment for this condition. It is based on current international guidelines and a literature review conducted by a multidisciplinary committee.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Chemistry, Medicinal
Manjunath M. Shenoy, Abhishek De, Bela Shah, Anupam Das, Abir Saraswat, Koushik Lahiri, Sheetal Yadav, Aarti Sarda, Disha Chakraborty, J. Dharmender, Shruti Kamat, Yashika Doshi, Nelry Gonsalves, Ankita Choudhary, Dhiraj Dhoot, Namrata Mahadkar, Sumit Bhushan, Rujuta Gadkari, Hanmant Barkate
Summary: This study evaluated the efficacy and safety of super-bioavailable itraconazole 130 mg and conventional itraconazole 200 mg once daily compared to conventional itraconazole 100 mg twice daily in the treatment of glabrous tinea. The results showed moderate efficacy with all doses of itraconazole, but once daily dosing was more effective.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Dermatology
Murlidhar Rajagopalan, Sunil Dogra, Kiran Godse, Bikash Ranjan Kar, Sai Krishna Kotla, Shekhar Neema, Abir Saraswat, Swapnil Deepak Shah, Nina Madnani, Vidyadhar Sardesai, Rajiv Sekhri, Sachin Varma, Sandeep Arora, Pallavi Kawatra
Summary: The study reveals gaps in knowledge and attitude between dermatologists and patients in the treatment and management of plaque psoriasis in India. Patients often resort to home remedies before seeking medical help, while most dermatologists prefer combination therapy for their patients.
PSORIASIS-TARGETS AND THERAPY
(2022)
Article
Dermatology
Shyam Bhanushankar Verma, Abir Saraswat, P. Narsimha Rao, Sunil Dogra
INDIAN DERMATOLOGY ONLINE JOURNAL
(2020)
