Article
Neurosciences
Stephano J. Chang, Iahn Cajigas, James D. Guest, Brian R. Noga, Eva Widerstrom-Noga, Ihtsham Haq, Letitia Fisher, Corneliu C. Luca, Jonathan R. Jagid
Summary: A new deep brain stimulation method targeting the CnF region has been proposed to alleviate freezing of gait in Parkinson's Disease patients. Clinical studies have shown that DTI-based targeting and intraoperative stimulation can help accurately and safely apply this method.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Yafei Wen, Bin Jiao, Yafang Zhou
Summary: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease with no effective symptomatic or neuroprotective treatment available. Although some cases may benefit from deep brain stimulation (DBS), there is not sufficient evidence proving its efficacy for PSP patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Marina Picillo, Carlo Ricciardi, Maria Francesca Tepedino, Filomena Abate, Sofia Cuoco, Immacolata Carotenuto, Roberto Erro, Gianluca Ricciardelli, Michela Russo, Mario Cesarelli, Paolo Barone, Marianna Amboni
Summary: This study aimed to describe gait parameters of PSP phenotypes at an early stage and found that Richardson's syndrome had worse cognitive function and gait parameters compared to other PSP phenotypes. The research also showed that computerized gait analysis can differentiate between PSP phenotypes and vPSP and PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Marianna Amboni, Carlo Ricciardi, Marina Picillo, Chiara De Santis, Gianluca Ricciardelli, Filomena Abate, Maria Francesca Tepedino, Giovanni D'Addio, Giuseppe Cesarelli, Giampiero Volpe, Maria Consiglia Calabrese, Mario Cesarelli, Paolo Barone
Summary: Progressive supranuclear palsy (PSP) is a rare and rapidly progressing disease, and this study demonstrates that gait analysis can effectively differentiate early PSP patients from Parkinson's disease (PD) patients, providing speculative clues for rehabilitation strategies.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Yasuo Miki, Eiki Tsushima, Sandrine C. Foti, Kate M. Strand, Yasmine T. Asi, Adam Kenji Yamamoto, Conceicao Bettencourt, Marcos C. B. Oliveira, Eduardo De Pablo-Fernandez, Zane Jaunmuktane, Andrew J. Lees, Koichi Wakabayashi, Thomas T. Warner, Niall Quinn, Janice L. Holton, Helen Ling
Summary: The study focused on patients with multiple system atrophy who presented symptoms closely resembling Parkinson's disease or progressive supranuclear palsy, pointing out the difficulties in diagnosing these mimicking cases accurately using current criteria. Differences in red flag features and autonomic dysfunction were observed in these atypical cases compared to typical ones.
Article
Clinical Neurology
Arvid Herwig, Almedin Agic, Hans-Jurgen Huppertz, Randolf Klingebiel, Frederic Zuhorn, Werner X. Schneider, Wolf-Ruediger Schaebitz, Andreas Rogalewski
Summary: Assessing eye movements in a head-mounted display (HMD) proved to be an effective tool in differentiating patients with progressive supranuclear palsy (PSP) from those with Parkinson's disease (PD). By multiplying the ratios of vertical to horizontal eye movements, a novel diagnostic index showed high sensitivity in distinguishing PSP from PD. Additionally, correlations were found between oculomotor abnormalities and midbrain volume in PSP patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Marian L. Dale, Austin L. Prewitt, Graham R. Harker, Grace E. McBarron, Martina Mancini
Summary: This study reviewed the methodology of previous balance studies in PSP and discussed the feasibility of objective balance assessment in PSP. Lessons learned and future approaches were highlighted.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Stephen Joza, Richard Camicioli, W. R. Wayne Martin, Marguerite Wieler, Myrlene Gee, Fang Ba
Summary: The study found that there may be a correlation between gait dysfunction in Parkinson's disease and connectivity deficits in the PPN network involving the right caudate nucleus and amygdala, which could be investigated in future larger studies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Dimitri Ryczko
Summary: The mesencephalic locomotor region (MLR) is a crucial area for controlling locomotion in vertebrates, and decreased activity in this region has been associated with locomotor deficits in Parkinson's disease patients. Deep brain stimulation targeting the MLR has shown variable results, and identifying the best cell types to target is still in the early stages. Activation of certain glutamatergic and cholinergic neurons in the MLR has shown promise in improving locomotor function in animal models of Parkinson's disease, while activation of GABAergic neurons should be avoided. The MLR is also considered a potential target for other neurological disorders.
Article
Clinical Neurology
Blas Couto, Ivan Martinez-Valbuena, Seojin Lee, Isabel Alfradique-Dunham, Richard J. Perrin, Joel S. Perlmutter, Carlos Cruchaga, Ain Kim, Naomi Visanji, Christine Sato, Ekaterina Rogaeva, Anthony E. Lang, Gabor G. Kovacs
Summary: This study reveals a broader range of disease courses in progressive supranuclear palsy (PSP) than previously known. Time to gait dependence and cognitive impairment are proposed as prognostic milestones. Genetic polymorphisms in TRIM11 and SLC2A13 genes are associated with longer disease duration. The study suggests a subtype of PSP with protracted course and explores its relationship with protein misfolding, seeding activity, and propagation.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Otorhinolaryngology
James C. C. Borders, Jordanna S. S. Sevitz, James A. A. Curtis, Nora Vanegas-Arroyave, Michelle S. S. Troche
Summary: Dysphagia is a common symptom in both PSP and PD, but this study found that individuals with PSP experience more severe impairments in swallowing safety and efficiency compared to those with PD. These findings provide important clinical insights and overcome limitations of previous studies through the use of new measurement methodology and statistical approaches.
Article
Multidisciplinary Sciences
Maxime Fougere, Cornelis Immanuel van der Zouwen, Joel Boutin, Kloe Neszvecsko, Philippe Sarret, Dimitri Ryczko
Summary: In a mouse model of PD, selective optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus increased the number of locomotor initiations, extended the time spent in locomotion, and controlled locomotor speed. This suggests that glutamatergic neurons in the cuneiform nucleus may be a potential clinically relevant target to improve locomotor activity in parkinsonian conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neuroimaging
Marie-Laure Welter, Alexandre Vasseur, Regine Edragas, Hugo Chaumont, Fanny Pineau, Graziella Mangone, Claire Olivier, Isabelle Leber, Sophie Rivaud-Pechoux, Stephane Lehericy, Cecile Gallea, Lydia Yahia-Cherif, Annie Lannuzel
Summary: This study investigates the relationship between gait and balance disorders and brain lesions in Caribbean AP and PSP-RS patients. The results show that both patient groups have severe gait and balance disorders that are mainly related to structural changes in specific brain areas. In Caribbean AP patients, gait disorders are also related to additional changes in cortical brain areas, while in PSP-RS patients, additional white matter changes are involved.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Shinsuke Fujioka, Takashi Morishita, Koichi Takano, Nobutaka Takahashi, Kanako Kurihara, Akihiro Nishida, Takayasu Mishima, Midori Suenaga, Yoichi Matsunaga, Yoshi Tsuboi
Summary: After analyzing and comparing the volumes of the subthalamic nucleus and whole cerebrum in patients with PSP, MSA, PD, and CBS, it was found that the volume of the subthalamic nucleus may be a useful diagnostic marker for PSP to differentiate it from other neurodegenerative parkinsonian disorders.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Olivia Samotus, Andrew Parrent, Mandar Jog
Summary: This study found that spinal cord stimulation (SCS) therapy can improve freezing of gait (FOG) and gait symptoms in Richardson's syndrome PSP patients, suggesting early intervention with SCS for dopaminergic-resistant gait should be considered.
JOURNAL OF NEUROLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Fernando Perez-Garcia, Rachel Sparks, Sebastien Ourselin
Summary: TorchIO is an open-source Python library for efficient loading, preprocessing, augmentation and patch-based sampling of medical images for deep learning. It encourages good open-science practices, supports experiment reproducibility, and is version-controlled for precise citation. The modular library is compatible with other frameworks for deep learning with medical images.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Neurosciences
Mathilde Boussac, Christophe Arbus, Helene Klinger, Alexandre Eusebio, Elodie Hainque, Jean Christophe Corvol, Olivier Rascol, Vanessa Rousseau, Estelle Harroch, Charlotte Scotto D'Apollonia, Aurelie Croiset, Fabienne Ory-Magne, Amaury De Barros, Margherita Fabbri, Caroline Moreau, Anne-Sophie Rolland, Isabelle Benatru, Mathieu Anheim, Ana-Raquel Marques, David Maltete, Sophie Drapier, Bechir Jarraya, Cecile Hubsch, Dominique Guehl, Mylene Meyer, Tiphaine Rouaud, Bruno Giordana, Melissa Tir, David Devos, Christine Brefel-Courbon
Summary: This study found that personality dimensions before deep brain stimulation surgery may affect the improvement of quality of life in Parkinson's disease patients afterwards. Novelty Seeking and Cooperativeness scores were positively associated with quality of life improvement, while patients with discrepancies between motor state and quality of life changes showed differences in personality dimensions.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Julie Bourilhon, Claire Olivier, Hana You, Antoine Collomb-Clerc, David Grabli, Hayat Belaid, Yannick Mullie, Chantal Francois, Virginie Czernecki, Brian Lau, Fernando Perez-Garcia, Eric Bardinet, Sara Fernandez-Vidal, Carine Karachi, Marie-Laure Welter
Summary: This study suggests that two months of PPN-DBS or CuN-DBS does not effectively improve dopa-resistant gait and balance disorders in PD patients. However, CuN-DBS has a significant positive impact on step length and velocity, while PPN-DBS has a negative impact on step length and velocity.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Quentin Devignes, Sami Daoudi, Romain Viard, Renaud Lopes, Nacim Betrouni, Gregory Kuchcinski, Anne-Sophie Rolland, Caroline Moreau, Luc Defebvre, Eric Bardinet, Marie Bonnet, Christine Brefel-Courbon, Christine Delmaire, Fouzia El Mountassir, Frederique Fluchere, Anne Fradet, Caroline Giordana, Elodie Hainque, Jean-Francois Houvenaghel, Bechir Jarraya, Helene Klinger, David Maltete, Ana Marques, Mylene Meyer, Olivier Rascol, Tiphaine Rouaud, Melissa Tir, Thomas Wirth, Jean-Christophe Corvol, David Devos, Kathy Dujardin
Summary: The study found that a significant proportion of candidates for subthalamic deep brain stimulation (STN-DBS) have Parkinson's disease mild cognitive impairment (PD-MCI), which is associated with cortical and subcortical alterations. Among the PD-MCI subtypes, patients with posterior cortical deficits (PD-PC) had lower global efficiency and worse performance on visuospatial functions, episodic memory, and language, suggesting a higher risk of dementia. There were no significant differences between the PD-MCI subtypes.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Stephane Prange, Zhengyu Lin, Mikail Nourredine, Teodor Danaila, Chloe Laurencin, Ouhaid Lagha-Boukbiza, Mathieu Anheim, Helene Klinger, Nadine Longato, Clelie Phillipps, Jimmy Voirin, Gustavo Polo, Emile Simon, Patrick Mertens, Anne-Sophie Rolland, David Devos, Elise Metereau, Christine Tranchant, Stephane Thobois
Summary: This study compared the risk and etiological factors, clinical management, and consequences of Parkinson's disease patients with or without mania following STN-DBS surgery. The study found that postoperative mania was related to ventral limbic subthalamic stimulation, and relocating the stimulation to the sensorimotor STN, reducing or discontinuing dopamine agonists, and using low-dose clozapine could alleviate mania symptoms, with similar motor and nonmotor outcomes.
ANNALS OF NEUROLOGY
(2022)
Article
Neurosciences
Nacim Betrouni, Caroline Moreau, Anne-Sophie Rolland, Nicolas Carriere, Romain Viard, Renaud Lopes, Gregory Kuchcinski, Alexandre Eusebio, Stephane Thobois, Elodie Hainque, Cecile Hubsch, Olivier Rascol, Christine Brefel, Sophie Drapier, Caroline Giordana, Franck Durif, David Maltete, Dominique Guehl, Lucie Hopes, Tiphaine Rouaud, Bechir Jarraya, Isabelle Benatru, Christine Tranchant, Melissa Tir, Marie Chupin, Eric Bardinet, Luc Defebvre, Jean-Christophe Corvol, David Devos
Summary: The study aimed to develop a predictive model combining clinical scores and imaging to estimate dopa-sensitivity in patients with Parkinson's disease. The results showed that adding imaging features to the model improved its performance, but further validation is required in a larger population.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Gizem Temiz, Cyril Atkinson-Clement, Brian Lau, Virginie Czernecki, Eric Bardinet, Chantal Francois, Yulia Worbe, Carine Karachi
Summary: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics, often accompanied by psychiatric comorbidities. This study used tractography to investigate the connectivity of different brain regions in TS patients and found increased limbic cortical connectivity in the subthalamic area, particularly with the insular cortex, which may contribute to higher levels of impulsivity and anxiety observed in TS.
Article
Clinical Neurology
Mathilde Boussac, Christophe Arbus, Olivier Colin, Chloe Laurencin, Alexandre Eusebio, Elodie Hainque, Jean Christophe Corvol, Nathalie Versace, Olivier Rascol, Vanessa Rousseau, Estelle Harroch, Fabienne Ory-Magne, Margherita Fabbri, Caroline Moreau, Anne-Sophie Rolland, Bechir Jarraya, David Maltete, Sophie Drapier, Ana-Raquel Marques, Nicolas Auzou, Thomas Wirth, Mylene Meyer, Bruno Giordana, Melissa Tir, Tiphaine Rouaud, David Devos, Christine Brefel-Courbon
Summary: This study aimed to evaluate personality dimensions in Parkinson's disease patients and compare them with a French cohort. The results showed significant differences in certain personality dimensions between Parkinson's disease patients and the French normative cohort. Moreover, some personality dimensions were found to be associated with anxiety-depressive state, quality of life, and impulsivity.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Gizem Temiz, Marie des Neiges Santin, Claire Olivier, Antoine Collomb-Clerc, Sara Fernandez-Vidal, Elodie Hainque, Eric Bardinet, Brian Lau, Chantal Francois, Carine Karachi, Marie-Laure Welter
Summary: This study investigates the clinical and anatomical features that could explain post-operative freezing of gait (FOG). The results suggest that recruiting right sensorimotor fibers and avoiding right prefrontal cortico-subthalamic fibers can explain reduced post-operative FOG.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Mathematical & Computational Biology
Fernando Perez-Garcia, Ali Alim-Marvasti, Gloria Romagnoli, Matthew J. Clarkson, Rachel Sparks, John S. Duncan, Sebastien Ourselin
Summary: Around one third of epilepsies are drug-resistant and may require surgical removal of the brain region causing seizures. Intracranial electroencephalography (iEEG) electrodes can be implanted to localize the epileptogenic zone (EZ) if noninvasive data is insufficient. However, the choice of iEEG targets varies across epilepsy centers. To support and standardize surgical planning, an open-source software tool is developed to suggest EZ locations based on retrospective clinical cases.
FRONTIERS IN NEUROINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Antoine Collomb-Clerc, Maelle C. M. Gueguen, Lorella Minotti, Philippe Kahane, Vincent Navarro, Fabrice Bartolomei, Romain Carron, Jean Regis, Stephan Chabardes, Stefano Palminteri, Julien Bastin
Summary: This study analyzed intra-thalamic electrophysiological recordings from human participants during a reinforcement learning task. The results showed that the thalamus is involved in estimating expected value and signaling reward prediction errors during reward-based and punishment-based learning. The study also revealed the neural mechanisms underlying action inhibition in punishment avoidance learning.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Jerome R. Munuera, Marta Ribes Agost, David R. Bendetowicz, Adrien Kerebel, Valerian R. Chambon, Brian Lau
Summary: When deciding between options that do or do not lead to future choices, humans often choose to choose. We explained individual variability in choice seeking using reinforcement learning models incorporating risk sensitivity and overvaluation of rewards obtained through choice. Our results show that preference for choice can be modulated by extrinsic reward properties including reward probability and risk as well as by controllability of the environment.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Fernando Perez-Garcia, Catherine Scott, Rachel Sparks, Beate Diehl, Sebastien Ourselin
Summary: GESTURES architecture combines CNNs and RNNs to learn deep representations of epileptic seizure videos, achieving high accuracy in seizure classification and providing important information for epilepsy patient management.
MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2021, PT V
(2021)