Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Food Science & Technology
Shen Zhuang, Ke Ming, Ning Ma, Jinrui Sun, Dehai Wang, Mingxing Ding, Yi Ding
Summary: A specific polysaccharide fraction (POPZ) from Portulaca oleracea L. was found to inhibit LPS-induced barrier injury and inflammatory responses in porcine intestinal epithelial monolayer, possibly through inactivating TLR4/NF-κB pathway and activating EGF/EGFR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Ya-Nan Gao, Song-Li Li, Xue Yang, Jia-Qi Wang, Nan Zheng
Summary: The study found that lactoferrin (LF) can reduce the increased intestinal permeability caused by aflatoxin M1 (AFM1) and repair the damaged intestinal barrier. In addition, the research revealed that LF acts through regulating multiple pathways related to intestinal cell survival and intestinal integrity. These findings suggest that LF may be a potential option for treating compromised intestinal barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Agriculture, Dairy & Animal Science
Saad Gilani, Peter Chrystal, Reza Barekatain
Summary: Maintaining and optimizing intestinal barrier function in poultry is crucial for bird health and performance, with intestinal permeability mainly controlled by tight junction proteins. Disruption of these proteins can lead to gut leakage, bacterial translocation, inflammation, and compromised health in birds. Research on intestinal permeability in broiler chickens is still limited, but nutrition modulation may offer promising outcomes for improving poultry health and performance.
Review
Biochemistry & Molecular Biology
Tracy Paradis, Herve Begue, Louise Basmaciyan, Frederic Dalle, Fabienne Bon
Summary: Tight junctions are crucial for maintaining the integrity and impermeability of the intestinal barrier, making them an ideal target for pathogens to breach the barrier. Pathogens use various strategies to destabilize the junctional network or modulate signaling pathways to attack the tight junctions and compromise gut barrier permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huaping Tao, Zhiwei Bao, Zhengwei Fu, Yuanxiang Jin
Summary: Exposure to chlorothalonil (CTL) can induce structural and functional damage to the human IEB, leading to barrier dysfunction through the activation of the mitogen-activated protein kinase pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Medicine, Research & Experimental
Haishan Wu, Rong Huang, Jinjin Fan, Ning Luo, Xiao Yang
Summary: Low potassium diet may increase intestinal permeability, leading to bacterial translocation, suspected to be due to impaired intestinal epithelial barrier and biological barrier.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yuju Kim, Yunna Lee, Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Jin-Wook Yoo, Yunjin Jung, Eunok Im
Summary: The study found that PAR2-induced autophagy can maintain mucosal barrier integrity by regulating intestinal epithelial permeability, possibly through the β-arrestin-ERK1/2 pathway. Therefore, regulating PAR2 can be a suitable strategy for treating intestinal diseases.
Article
Multidisciplinary Sciences
Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Lea Jean-Francois, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith
Summary: This study investigates the effects of S408 phosphorylation on occludin protein structure and demonstrates its role in regulating intercellular junction function through interactions with other components.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Veterinary Sciences
Ruibiao Wang, Yuheng Zhang, Jingbo Zhen, Jinpeng Zhang, Zixuan Pang, Xuewei Song, Lihao Lin, Feng Sun, Yixin Lu
Summary: This study explored the effect of exosomes derived from Trichinella spiralis infective larvae (TsExos) on the barrier function of porcine small intestinal epithelial cells (IPEC-J2). The results showed that TsExos ingestion decreased cell viability, increased FITC-dextran content, lactate dehydrogenase and reactive oxygen species levels. TsExos also induced apoptosis, nuclear pyknosis, and nuclear rupture. In addition, TsExos disrupted tight junctions and altered gene expression.
VETERINARY RESEARCH
(2022)
Article
Microbiology
Yi Zhou, Ling Duan, Yan Zeng, Xu Song, Kangcheng Pan, Lili Niu, Yang Pu, Jiakun Li, Abdul Khalique, Jing Fang, Bo Jing, Dong Zeng, Bairong Shen, Xueqin Ni
Summary: The intestinal microbiota of captive pandas, characterized by a high abundance of Enterobacteriaceae, has led to intestinal infection. Probiotic supplement Lactiplantibacillus plantarum BSG201683 (L. plantarum G83) has shown effectiveness in improving intestinal barrier function and inflammation. In vitro studies demonstrated that L. plantarum G83 reduced paracellular permeability, decreased proinflammatory cytokines, and enhanced anti-inflammatory responses through Toll-like receptor 4/ nuclear factor kappa-B (TLR4/NF-?B) signaling pathways.
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Luz del Carmen Martinez-Sanchez, Phuong Anh Ngo, Rashmita Pradhan, Lukas-Sebastian Becker, David Boehringer, Despina Soteriou, Marketa Kubankova, Christine Schweitzer, Tatyana Koch, Veronika Thonn, Lena Erkert, Iris Stolzer, Claudia Guenther, Christoph Becker, Benno Weigmann, Monika Klewer, Christoph Daniel, Kerstin Amann, Stefan Tenzer, Raja Atreya, Martin Bergo, Cord Brakebusch, Alastair J. M. Watson, Jochen Guck, Ben Fabry, Imke Atreya, Markus F. Neurath, Rocio Lopez-Posadas
Summary: Abnormal cell shedding is associated with intestinal barrier dysfunction and inflammatory bowel diseases. Deletion of PGGTase and RAC1 in intestinal epithelial cells leads to cell overcrowding and epithelial leakage, resulting in chronic intestinal inflammation. RAC1 plays a crucial role in regulating cytoskeletal dynamics, cell mechanics, and intestinal cell shedding.
Article
Food Science & Technology
Jae Hoon Lee, Sera Kim, Min-Cheol Kang, Yong Gi Chun, Bum-Keun Kim, Kyung-Mo Song
Summary: This study confirms the protective effect of four nut oils on the damaged intestinal epithelial barrier. Nut oils improve barrier function, inhibit inflammatory response and cytokine production, and enhance the expression and distribution of tight junction proteins in damaged cells.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Geriatrics & Gerontology
Kevin M. Najarro, Devin M. Boe, Travis M. Walrath, Juliet E. Mullen, Madison T. Paul, John H. Frankel, Holly J. Hulsebus, Juan-Pablo Idrovo, Rachel H. McMahan, Elizabeth J. Kovacs
Summary: The study demonstrates that advanced age exacerbates intestinal epithelial permeability after burn injury. Increased apoptosis may lead to elevated intestinal leakiness and bacterial accumulation in mesenteric lymph nodes, while S100a8/9 may serve as a biomarker for heightened inflammation in the intestine.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daqing Sun, Hongfei Li, Dawei Song, Liping Zhang, Xiao Zhao, Xiaoxi Xu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Microbiology
Xinyu Wu, Jinzhao Xu, Xiaoying Yang, Danping Wang, Xiaoxi Xu
Summary: This research reveals that Fusobacterium nucleatum bacteria and their metabolites contribute to the development of colorectal cancer (CRC). Extracellular vesicles secreted by F. nucleatum are endocytosed by CRC cells, promoting their proliferation, migration, invasion, inhibiting apoptosis, and enhancing resistance to oxidative stress. The study also identifies differentially expressed genes and metabolites that may serve as potential therapeutic targets for CRC.
Article
Food Science & Technology
Yinlong Ma, Jinzhao Xu, Ruibin Guo, Guoxin Teng, Yidan Chen, Xiaoxi Xu
Summary: With the increase in global life expectancy, research on the digestive patterns of the elderly is highly essential. We simulated the digestion process of older individuals in vitro and studied the effects of different high hydrostatic pressure (HHP) treatments on whey protein isolate (WPI). HHP treatment specifically affected the protein structure, digestibility, and antioxidant activity of WPI, with the highest observed after treatment at 600 MPa for 30 min. In the intestinal digest, 15 antioxidant peptides were identified, of which the LGSDMEDLR peptide sequence showed the highest bioactivity and interaction with important binding sites.
Article
Biochemistry & Molecular Biology
Jinzhao Xu, Mengqi Tang, Xinyu Wu, Xiangli Kong, Yini Liu, Xiaoxi Xu
Summary: Lactobacillus rhamnosus (L. rhamnosus) zz-1 has been found to prevent and alleviate depression caused by chronic stress by regulating the gut microbiota and improving intestinal environment. This study provides new evidence for the mental benefits of probiotics.
