Article
Nanoscience & Nanotechnology
Ke Du, Qiuyu Xia, Jian Sun, Fude Feng
Summary: A strategy to cage MTIC by N-acylation of the triazene moiety was introduced to boost MTIC stability. A diblock copolymer-based MTIC prodrug installed with a disulfide linkage was designed for self-assembled polymer micelles that could release MTIC through stimuli factors such as glutathione (GSH) and visible light irradiation. The microenvironment-responsive polymeric micelles showed benefits in suppressing both TMZ-sensitive and TMZ-resistant GBM cells, providing a new option for glioma treatment based on TMZ.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Jie Ren, Chloe E. Jepson, Sarah L. Nealy, Charles J. Kuhlmann, Satoru Osuka, Stella Uloma Azolibe, Madison T. Blucas, Yoshiko Nagaoka-Kamata, Eugenia Kharlampieva, Masakazu Kamata
Summary: In this study, a novel platform for brain delivery of therapeutic antibodies was developed by conjugating PMPC to the antibody, which maintained the key functionalities of the original antibody. The platform exhibited enhanced brain delivery while retaining epitope recognition, cellular internalization, and antibody-dependent cellular phagocytic activity. This simple formulation addresses the issues of the previous nanocapsule platform and paves the way for PMPC-based brain delivery strategies for antibodies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Xueyu Huang, Cheng Zheng, Kailei Ding, Shumang Zhang, Qingrong Wei, Li Yang, Yunbing Wang
Summary: In this study, a modification strategy for bioprosthetic heart valves (BHV) based on cocrosslinking and copolymerization was developed. The modified BHVs showed improved endothelial cells' proliferation and resistance to platelet adhesion compared to traditional cross-linked BHVs. Furthermore, the modified BHVs exhibited enhanced anticalcification properties in a rat subcutaneous implantation model. These findings suggest that the modification strategy has the potential for clinical application.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Xueyu Huang, Cheng Zheng, Kailei Ding, Shumang Zhang, Qingrong Wei, Li Yang, Yunbing Wang
Summary: A modification strategy based on cocrosslinking and copolymerization was developed to improve the lifespan and anti-thrombotic property of bioprosthetic heart valves. The results showed that the new porcine pericardium exhibited better endothelial cells' proliferation, resistance to platelet adhesion, and anticalcification property compared to traditional glutaraldehyde cross-linked pericardium.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Saurabh Mittal, Sadia Shah, Harlokesh Narayan Yadav, Javed Ali, Madan Mohan Gupta, Sanjula Baboota
Summary: This study aimed to develop a novel drug formulation for the treatment of glioblastoma, targeting drug delivery to the brain through intranasal route. The optimized lipid nanoparticles showed high drug entrapment efficiency and permeation, making them effective in treating glioblastoma.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Reena Jatyan, Prabhjeet Singh, Deepak Kumar Sahel, Y. G. Karthik, Anupama Mittal, Deepak Chitkara
Summary: Temozolomide (TMZ) is an important first-line treatment drug for glioblastoma multiforme (GBM), but it has limitations. Nanocarriers and conjugation approaches have been used to improve the therapeutic potential of TMZ.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Daiki Ihara, Yuji Higaki, Norifumi L. Yamada, Fumiya Nemoto, Yasuhiro Matsuda, Ken Kojio, Atsushi Takahara
Summary: The molecular mechanisms underlying the cononsolvency of PMPC in ethanol-water mixtures were studied through a combination of statistical mechanical models and neutron reflectivity experiments. The preferential interaction of water and the strong cooperativity of ethanol were identified, resulting in the collapsed PMPC chains being more solvated with water than the bulk mixed solvent at an ethanol volume fraction of 0.90.
Article
Multidisciplinary Sciences
Negar Sadeghipour, Sukumar Uday Kumar, Tarik F. Massoud, Ramasamy Paulmurugan
Summary: This study aims to improve the therapeutic efficacy of glioblastoma (GBM) by targeting multiple oncogenic pathways. The researchers identified a panel of five miRNAs and their oncogenic targets that cover four different signaling pathways in GBM. They observed a significant enhancement of therapeutic efficiency in GBM models using this combination therapy.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Amanda de Fraga Dias, Danieli Rosane Dallemole, Franciele Aline Bruinsmann, Luiz Fernando Lopes Silva, Olga Cruz-Lopez, Ana Conejo-Garcia, Ana Maria Oliveira Battastini, Joaquin Maria Campos, Silvia Staniscuaski Guterres, Adriana Raffin Pohlmann, Fabricio Figueiro
Summary: This study aimed to develop and characterize bozepinib-loaded lipid-core nanocapsules as a potential treatment for glioblastoma. The results showed that the nanocapsules had good performance and synergistic effect with temozolomide, reducing in vivo glioma growth effectively.
Article
Polymer Science
Tatiana Nekrasova, Olga Nazarova, Elena Vlasova, Andrei Fischer, Yuliya Zolotova, Marina Bezrukova, Evgeniy Panarin
Summary: It has been demonstrated that poly(methacryloyloxyethyl phosphorylcholine) can form hydrogen bonded interpolymer complexes with carboxylic acids and poly(vinylphosphonic) acid in aqueous solutions. Hydrogen bonds play a dominant role in the formation of these complexes, while hydrophobic interactions serve as an additional stabilizing factor. The poly(methacryloyloxyethyl phosphorylcholine)/poly(vinylphosphonic) acid complex exhibits a looser structure compared to complexes with polycarboxylic acids due to electrostatic repulsion between charged groups.
Review
Pharmacology & Pharmacy
Kele Cristina Ferreira Dantas, Jania Dos Santos Rosario, Priscila Pereira Silva-Caldeira
Summary: Nanotechnology-based approaches for targeted delivery of metal-based therapeutic agents have shown significant potential in enhancing their therapeutic effect and reducing systemic toxicities. Polymer-based nanosized systems have been employed to physically load or covalently conjugate metal-based agents, improving their bioavailability and anticancer efficacy. While initially used for platinum-based chemotherapeutic agents, these nanocarriers are now being explored for nonplatinum-containing agents. Furthermore, they have been extensively studied as polymeric nanocarrier-assisted metal-based photosensitizers in photodynamic therapy for almost three decades. This review focuses on non-platinum systems and highlights recent advances in polymeric nanosystems coupled with metal-based compounds, which hold promise for successful clinical applications.
Review
Medicine, Research & Experimental
A. M. Moras, J. G. Henn, L. Steffens Reinhardt, G. Lenz, D. J. Moura
Summary: Glioblastoma is a common and malignant brain tumor with a short survival period and low cure rate. Research on resistance mechanisms related to DNA damage repair pathways, glioma stem cells, blood-brain barrier, and systemic treatment, as well as the development of localized treatments, could improve survival rates and quality of life for patients.
Article
Polymer Science
Trevor Gilbert, Matthew A. Campea, Nahieli Preciado Rivera, Michael Majcher, Richard Alsop, Mouhanad Babi, Thomas Kalab, Jose Moran-Mirabal, Maikel Rheinstadter, Todd Hoare
Summary: In this study, injectable PNIPAM/PVP interpenetrating polymer networks were fabricated and characterized. The results show that the internal structure of the injectable IPNs can be controlled by adjusting the PVP molecular weight and degree of thiolation. The PNIPAM gelation drives the formation of domains, with PNIPAM mainly located in the PVP-rich domains and PVP entrapped in the PNIPAM-rich domain. Additionally, the structural reconfiguration of the IPNs can be achieved by heating above the volume phase transition temperature of the PNIPAM phase, which is influenced by the molecular weight and thiolation degree of the PVP precursor polymers.
Article
Chemistry, Multidisciplinary
Lu Ye, Wei Lv, Weichong He, Shengnan Li, Zhiyi Min, Le Gong, Qi Zhang, Chuanhui Teng, Shanbo Sun, Lingyan Lv, Yi Guo, Hongliang Xin
Summary: Infiltrative glioma growth leads to incomplete surgical excision and rapid proliferation of residual tumor cells. These cells evade phagocytosis by macrophages through upregulation of the CD47-SIRPα pathway. Blocking this pathway is a potential strategy for post-resection glioma treatment. The combination of anti-CD47 antibody (α-CD47) and temozolomide (TMZ) enhances the pro-phagocytic effect, but systemic combination therapy is hindered by the blood-brain barrier. A temperature-sensitive hydrogel system called α-CD47 & TMZ@Gel was designed for local administration in postoperative cavities. Through in vitro and in vivo evaluations, α-CD47 & TMZ@Gel effectively inhibited glioma recurrence by enhancing macrophage pro-phagocytosis, and recruiting and activating CD8+ T cells and NK cells.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Applied
Vytautas Klimavicius, Vaidas Klimkevicius, Kestutis Aidas, Sergejus Balciunas, Juras Banys, Ricardas Makuska, Vytautas Balevicius
Summary: In this study, the synthesis and characterization of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), one of the most biocompatible synthetic polymers, was performed using various experimental techniques. The optimized synthesis conditions ensured high yield, purity, and narrow molecular weight distribution. The fine structural details, protonation behavior, and thermal activation of proton conduction in the polymer were deduced. Comparison and discussion with a related proton conducting polymer were also included.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
