Article
Immunology
Xuezhi Zhou, Rong Rong, Siqi Xiong, Weitao Song, Dan Ji, Xiaobo Xia
Summary: In this study, a ceRNA regulatory network related to SKCM was identified and potential diagnostic and prognostic markers were identified. Two ceRNA axes were established as prognostic models, providing a novel and important approach for the diagnosis and prognosis of SKCM.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anshika Goenka, Deanna Marie Tiek, Xiao Song, Rebeca Piatniczka Iglesia, Minghui Lu, Bo Hu, Shi-Yuan Cheng
Summary: Research in cancer biology has predominantly focused on protein-coding genes, but the discovery of non-coding RNAs (ncRNAs) has shed light on their crucial role in various biological processes and human diseases including cancer. Dysregulated ncRNA expression affects cancer initiation, progression, and therapy resistance. This review emphasizes the recent developments and advances in ncRNA biology relevant to glioma tumorigenesis and therapy response, highlighting the potential of ncRNAs as biomarkers and therapeutic agents in glioma.
Review
Endocrinology & Metabolism
Guanqing Zhou, Mimi Zhang, Jingzhi Zhang, Yaofeng Feng, Zhishen Xie, Siyi Liu, Detu Zhu, Yumei Luo
Summary: Non-coding RNAs play important roles in cell differentiation, proliferation, apoptosis, and the pathogenesis of various diseases. Especially in non-obstructive azoospermia, the expression of non-coding RNAs is associated with pathological conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Estefania Lozano-Velasco, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: Heart failure is a complex clinical syndrome with increasing prevalence, and finding new molecular biomarkers is an interesting tool to improve its prevention, diagnosis, treatment, and prognosis. This review emphasizes the relevance of microRNAs, long non-coding RNAs, and circular RNAs as potential biomarkers in heart failure. Further studies in this field are crucial to support their widespread clinical use.
Review
Cell Biology
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Hamed Mirzaei
Summary: Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that can have severe consequences. Non-coding RNAs (ncRNAs) play important roles in the pathogenesis and development of RB, with different ncRNAs acting as either tumor promoters or suppressors. Understanding the regulatory mechanisms of ncRNAs provides new opportunities for RB therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Article
Multidisciplinary Sciences
Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brulle-Soumare, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O'Keefe, Michela Garofalo
Summary: This study reveals the role of KIMAT1 in maintaining KRAS signaling in lung cancer progression, suggesting that targeting it may be a strategy to prevent KRAS-induced tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Ligia I. Torsin, George E. D. Petrescu, Alexandru A. Sabo, Baoqing Chen, Felix M. Brehar, Mihnea P. Dragomir, George A. Calin
Summary: The text discusses the dysregulated levels and alterations of non-coding RNAs (ncRNAs) in cancer, as well as the emerging focus on modifications to ncRNAs as a potential part of the tumorigenic process. Understanding this extra regulatory layer is crucial in translating knowledge about ncRNAs and their modifications into clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Juhee Ryu, Youngkeun Ahn, Hyun Kook, Young-Kook Kim
Summary: This article reviews the role and therapeutic implications of non-coding RNAs (ncRNAs) in vascular calcification (VC). Studies suggest that ncRNAs, including miRNAs, lncRNAs, and circRNAs, play important roles in regulating VC and may be useful in clinical diagnosis and treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Oncology
Isabel F. Coira, Rafael Rincon, Muriel Cuendet
Summary: Recent research has led to improved therapies for multiple myeloma, but the problem of frequent relapse and drug resistance remains. Non-coding RNAs have been found to play a key role in the development and progression of multiple myeloma, and are therefore a promising target for new therapeutic approaches. This review provides a comprehensive overview of the current knowledge on this topic and suggests new strategies for treatment.
Review
Biochemistry & Molecular Biology
Julie Xia Zhou, Xiaogang Li
Summary: Recent advances in molecular genetics have revealed single-gene defects as the etiologies of many kidney diseases, with microRNAs playing a key role in the progression of ADPKD and emerging as potential therapeutic targets. Studies have also focused on microRNAs as potential biomarkers for ADPKD and other hereditary kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ida Manna, Francesco Fortunato, Selene De Benedittis, Ilaria Sammarra, Gloria Bertoli, Angelo Labate, Antonio Gambardella
Summary: Temporal lobe epilepsy is the most common form of focal epilepsy, considered a network disorder associated with structural changes. Non-coding RNAs, acting as epigenetic factors, participate in the regulation of the pathophysiological processes of epilepsy and can be used as biomarkers for diagnosis and treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Zhaobo Zhang, Sishi Zhang, Guoshuai Wang, Siyu Feng, Kexin Han, Limei Han, Liping Han
Summary: Marek's disease virus (MDV) causes Marek's disease (MD), which involves highly infectious tumor lesions. Noncoding RNAs play a significant role in the pathogenesis of MD, with specific miRNAs and lncRNAs participating in various cellular processes.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Huiwen Ren, Qiuyue Wang
Summary: Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes with a complex pathological process involving multiple factors. Non-coding RNAs, such as micro RNA (miRNA), play a role in disease regulation and may serve as potential biomarkers for disease prediction. The research on long coding RNA (lncRNA) and circular RNA (circRNA) is still challenging and in early stages.
DNA AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
C. E. Fletcher, L. Deng, F. Orafidiya, W. Yuan, M. P. G. S. Lorentzen, O. W. Cyran, A. Varela-Carver, T. A. Constantin, D. A. Leach, F. M. Dobbs, I Figueiredo, B. Gurel, E. Parkes, D. Bogdan, R. R. Pereira, S. G. Zhao, A. Neeb, F. Issa, J. Hester, H. Kudo, Y. Liu, Y. Philippou, R. Bristow, K. Knudsen, R. J. Bryant, F. Y. Feng, S. H. Reed, I. G. Mills, J. de Bono, C. L. Bevan
Summary: miR-346 induces rapid and extensive DNA damage in prostate cancer cells through transcriptional hyperactivation, R-loop formation, and replication stress. It disrupts the interaction between NORAD and PUM2, leading to PUM2 stabilization and increased turnover of DNA damage response transcripts. miR-346 downregulates target transcripts preferentially at binding sites of highly transcriptionally active transcription factors. Targeting miR-346 may enhance the sensitivity of prostate cancer cells to DNA-damaging drugs and induce tumor regression as a monotherapy.
Letter
Dermatology
Martina Lambertini, Francesca Comito, Barbara Melotti, Maria Francesca Baracca, Emi Dika
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Maria Mannino, Alfredo Piccerillo, Gabriella Fabbrocini, Pietro Quaglino, Giuseppe Argenziano, Emi Dika, Paolo Antonio Ascierto, Giovanni Pellacani, Caterina Longo, Maria Concetta Fargnoli, Luca Bianchi, Piergiacomo Calzavara-Pinton, Iris Zalaudek, Paolo Fava, Massimiliano Scalvenzi, Enrico Bocchino, Alessandro Di Stefani, Ketty Peris
Summary: This study describes the clinical characteristics of a cohort of Italian patients with aBCC and investigates the effectiveness and safety of HHI. The results demonstrate that HHI is effective and safe in this patient population and replicate the results of pivotal trials in a real-life clinical setting.
Review
Biochemistry & Molecular Biology
Terenzio Cosio, Filadelfo Coniglione, Valeria Flaminio, Roberta Gaziano, Deborah Coletta, Rosalba Petruccelli, Emi Dika, Luca Bianchi, Elena Campione
Summary: Immunotherapy in oncology is replacing traditional therapies due to its specific action and limited side effects. However, bacterial infections can still occur as side effects. This case report highlights the importance of considering lifestyle and cutaneous background before starting immunotherapy for cancer treatment, with a focus on pharmacogenomics and the possibility of modified skin microbiota predisposing to cutaneous infections in patients treated with PD-1 inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dermatology
Martina Lambertini, Costantino Ricci, Barbara Corti, Giulia Veronesi, Pietro Quaglino, Simone Ribero, Giovanni Pellacani, Bor Hratin Stancic, Elena Campione, Emi Dika
Summary: This article discusses the follicular colonization in melanoma and melanocytic nevi, as well as the related facts and controversies. The lentiginous spread of melanocytes into the hair follicle is observed in various benign melanocytic neoplasms such as nevi, sun-induced melanocytic hyperplasia, and melanoma. The role of follicular colonization in melanoma pathologic staging is still debated, despite its description being recommended by the International Collaboration on Cancer Reporting.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Editorial Material
Dermatology
Simone Ribero, Martina Lambertini, Manuela Ferracin, Emi Dika
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Editorial Material
Dermatology
M. Lambertini, L. Lambertini, E. Dika
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Emi Dika, Federico Venturi, Giulia Veronesi
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Linda Tognetti, Elisa Cinotti, Francesca Farnetani, Aimilios Lallas, John Paoli, Caterina Longo, Riccardo Pampena, Elvira Moscarella, Giuseppe Argenziano, Danica Tiodorovic, Ignazio Stanganelli, Serena Magi, Mariano Suppa, Veronique del Marmol, Emi Dika, Enrico Zelin, Iris Zalaudeck, Maria Antonietta Pizzichetta, Giovanni Pellacani, Jean Luc Perrot, Martina Bertello, Gennaro Cataldo, Gabriele Cevenini, Pietro Rubegni, Alessandra Cartocci
Summary: There is currently no dedicated registry for aPFL, and this study established a database for collecting clinical data through a web platform. The study found that compared to other aPFL cases, patients with LM/LMM were predominantly male, older, had larger lesions, and reported a history of sunburn in childhood.
TELEMEDICINE AND E-HEALTH
(2023)
Letter
Dermatology
Francesca Comito, Ambrogio Gagliano, Francesca Sperandi, Emi Dika, Francesco Savoia, Barbara Melotti
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Biagio Scotti, Barbara Melotti, Carlotta Baraldi, Francesca Comito, Federico Venturi, Martina Lambertini, Emi Dika
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Pathology
Costantino Ricci, Emi Dika, Barbara Corti, Martina Lambertini, Francesca Ambrosi, Simone Cappilli, Marco Grillini, Giorgia Di Filippo, Eugenia Franchini, Thais Maloberti, Michelangelo Fiorentino, Giovanni Tallini, Dario de Biase
Summary: This study reported a case series of cutaneous melanoma (CM) with p16 overexpression and analyzed their clinicopathologic features, immunohistochemical expression of cell cycle regulatory molecules, and mutational landscape. The results showed that p16 overexpression is a rare event occurring in advanced-stage, clinically and histologically heterogeneous CM. The cases could be classified into three groups based on the expression of cell cycle regulatory molecules and mutational profiles, and zonal p16 overexpression may indicate molecular progression.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Letter
Dermatology
Alice Nadia Rossi, Giulia Veronesi, Emi Dika
SKIN RESEARCH AND TECHNOLOGY
(2023)
Meeting Abstract
Medicine, Research & Experimental
Costantino Ricci, Maria Sirolli, Francesca Ambrosi, Martina Lambertini, Emi Dika, Michelangelo Fiorentino, Thais Maloberti, Giovanni Tallini, Dario de Biase
LABORATORY INVESTIGATION
(2023)
Article
Dermatology
Maria Mannino, Alfredo Piccerillo, Emi Dika, Sabina Vaccari, Pietro Quaglino, Marco Rubatto, Caterina Longo, Stefania Borsari, Giovanni Pellacani, Maria Concetta Fargnoli, Chiara Caponio, Giuseppe Argenziano, Giulia Briatico, Luca Bianchi, Cosimo Di Raimondo, Pier Giacomo Calzavara Pinton, Iris Zalaudek, Alessandro Di Stefani, Ketty Peris
Summary: This study describes the clinical characteristics and treatment strategies of a real-life Italian cohort of advanced cutaneous squamous cell carcinoma (aCSCC) patients. The majority of patients received surgical and radiation treatments, while only a small number of patients received immunotherapy.
Letter
Dermatology
Biagio Scotti, Giulia Veronesi, Cosimo Misciali, Federico Venturi, Emi Dika
SKIN RESEARCH AND TECHNOLOGY
(2023)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)
