Article
Oncology
Tatsushi Yoshida, Kenta Yamasaki, Kenjiro Tadagaki, Yasumichi Kuwahara, Akifumi Matsumoto, Adem Ejub Sofovic, Noriko Kondo, Toshiyuki Sakai, Tsukasa Okuda
Summary: The study identified RUNX1 as a transcriptional regulator of TRAIL, showing that TRAIL expression is decreased in acute myeloid leukemia patients and inhibited by RUNX1-ETO.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Veterinary Sciences
Guoxing Ou, Xianyu Jiang, Ang Gao, Xiaolong Li, Zijun Lin, Shimin Pei
Summary: Canine mammary tumor is a serious disease that can also serve as a research model for human breast cancer. This study discovered the potential of celastrol, an extract from Tripterygium wilfordii, in inhibiting canine mammary tumor cells by inducing apoptosis and cell cycle arrest.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Suneela Zaigham, Magnus Dencker, Magnus K. Karlsson, Ola Thorsson, Per Wollmer
Summary: This study found that elevated TRAIL levels are associated with impaired lung function in school-aged children, especially with significant associations with markers of pulmonary airflow obstruction.
RESPIRATORY MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Jing-jing Qin, Meng-da Niu, Zhe Cha, Qing-hua Geng, Yu-lin Li, Chun-guang Ren, David P. Molloy, Hua-rong Yu
Summary: The combination treatment of celastrol and tumor necrosis factor-related apoptosis-induced ligand (TRAIL) can effectively inhibit the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of glioblastoma cells. This effect is achieved by suppressing the Wnt/beta-catenin pathway.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
K. M. A. Zinnah, Sang-Youel Park
Summary: The study demonstrated the mechanism behind the synergistic anticancer effect of amitriptyline and TRAIL, showing that amitriptyline increases TRAIL-induced apoptosis by upregulating death receptors DR4 and DR5. Inhibition of autophagy by amitriptyline was also shown to enhance DR4 and DR5 expression.
Article
Biochemistry & Molecular Biology
Jingnan Zhang, Fan Yang, Xiyu Mei, Rui Yang, Bin Lu, Zhengtao Wang, Lili Ji
Summary: Toosendanin (TSN) and isotoosendanin (ITSN) are natural triterpenoids that inhibit the growth of triple-negative breast cancer (TNBC) by inducing necrosis, apoptosis, and autophagy in tumor cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Raedeh Saraei, Heshu Sulaiman Rahman, Masoud Soleimani, Mohammad Asghari-Jafarabadi, Adel Naimi, Ali Hassanzadeh, Saeed Solali
Summary: The study found that kaempferol can enhance the cytotoxic and pro-apoptotic effects of TRAIL on CML cells by regulating the expression of specific genes, providing a new approach for leukemia therapy.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ting Zhang, Tianhua Zhang, Chuanzhou Gao, Sajid Jalal, Ruqiang Yuan, Hongming Teng, Cong Li, Lin Huang
Summary: This study revealed the antitumor effects of beta-elemene derived from Curcuma wenyujin plant or lemon grass on Ewing sarcoma family tumors (ESFTs). It was found that autophagy plays an important role in the beta-elemene-induced apoptosis in ESFT cells. This research provides novel insights for the development of ESFT treatments.
DNA AND CELL BIOLOGY
(2023)
Article
Neurosciences
Xiaokun Zhou, Liang Lv, Yuan Tan, Zhongyi Zhang, Shuyang Wei, Shaowen Xiao
Summary: The study demonstrates that Tanshinone IIA enhances TRAIL-induced apoptosis in glioblastoma cells by modulating the expression of STAT3, DR4, and DR5. In vivo experiments show that cotreatment with T-IIA and TRAIL effectively inhibits tumor growth and induces apoptosis in nude mice.
Article
Biochemistry & Molecular Biology
Shuyao Zhang, Wei He, Aiguo Li, Chengkuan Zhao, Yun Chen, Chengcheng Xu, Qiuzhen Zhang, Danling Zheng, Meini Chen, Haixiong Miao, Yihui Huang
Summary: In this study, it was found that Risperidone affects the functions of osteoblasts by regulating TNF-alpha and SATB2. Risperidone promotes TNF-alpha expression, inhibiting SATB2 and leading to inhibited differentiation, enhanced autophagy, and apoptosis of osteoblasts.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chrysi Koliaki, Nicholas Katsilambros
Summary: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has a protective role in the development of diabetes mellitus, but further research is needed to understand the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hyeonwoo Je, Gi-Hoon Nam, Gi Beom Kim, Wonjun Kim, Soo Rin Kim, In-San Kim, Eun Jung Lee
Summary: TRAIL shows promising anti-tumor activity, but faces challenges such as resistance and delivery issues. A nanocage has been developed to efficiently deliver TRAIL and a re-sensitizing drug (DOX) to overcome TRAIL-resistant tumors, demonstrating potential as an effective antitumor agent.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Jian Liu, Huijuan Lu, Xiaowen Wang, Keming Chen, Jinzhi Lu, Cunjian Yi
Summary: TRAIL receptor is widely expressed in the decidual interface and plays a crucial role in regulating cell function and inducing inflammatory cell differentiation in early pregnancy. Abnormal expression of TRAIL receptor can lead to early abortion and other pregnancy complications.
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tianshan She, Fen Yang, Shiyuan Chen, Hao Yang, Ze Tao, Huimin Xing, Jie Chen, Huansheng Chang, Hongyu Lu, Tao Su, Youmei Jin, Yi Zhong, Jingqiu Cheng, Hong Zhu, Xiaofeng Lu
Summary: The clinical application of TRAIL is limited by its inefficient induction of apoptosis in tumor cells. Superglue-mediated hyperoligomerization of TRAIL can increase its valency and improve its efficacy. In this study, minimal superglue peptide pairs were fused to the TRAIL promoter to create superglue-fusion TRAIL variants. These variants showed high expression and trimerization similar to native TRAIL. With the help of Snoopligase or SpyStapler, these variants could be crosslinked into hexavalent TRAIL variants. The hexavalent SnHexaTR variant produced by Snoopligase showed the highest yield and exhibited 10-40 times greater cytotoxicity than native TRAIL in tumor cells. It also had a longer half-life and greater tumor uptake, leading to the eradication of tumor xenografts. Hexavalent SnHexaTR, as a novel anticancer agent candidate, has great potential for clinical application in cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Medicine, Research & Experimental
Fan Wen, Dandan Liu, Mingming Wang, Shujie Zhang, Wenhua Kuang, Lixia Yuan, Jigang Wang, Gang Liu
Summary: This study investigates the ovarian toxicity of Celastrol and its underlying mechanism. It is found that Celastrol directly binds to high mobility group box 1 and interferes with its biological function to regulate p21 transcription, leading to apoptosis of granulosa cells and premature ovarian insufficiency.
BIOMEDICINE & PHARMACOTHERAPY
(2023)